Author: Jessica.F

Ohwada, Jun published the artcileSynthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin, Formula: C13H24INO4, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(8), 1703-5, database is CAplus and MEDLINE.

A new antifungal substance, azoxybacilin (I; R = OH), an unusual amino acid with an azoxy moiety and its derivatives were prepared from Boc-Asp-OCMe₃ utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative I (R = OCH₂Ph), Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.

Chemical & Pharmaceutical Bulletin published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Formula: C13H24INO4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xanthopoulos, C. E. published the artcileStructural properties and potential reactivity of substituted 3-aroyldithiocarbazates, Formula: C7H7IN2O, the publication is Structural Chemistry (1994), 5(3), 147-54, database is CAplus.

The substituted 3-aroyldithiocarbazates I (X = H, halo, nitro, alkyl, etc.) were prepared The corresponding acid dissociation constants were determined potentiometrically. Semiempirical PM3 MO calculations suggest the existence of several tautomeric forms of the compounds Geometrical parameters, proton affinities, and static reactivity indexes have been examined Structural properties and protonation sites are well described by calculations The strong correlations between the pK_a values and the Hammett σ constants as well as the N(3) calculated proton affinities indicate that the N(3) atom is the most probable protonation site. The thermodn. of the protonation process are mainly controlled by HOMO-LUMO rather than electrostatic interactions. According to PM3 results, 3-aroyldithiocarbazic acid should be quite stable in the gas phase, while a mechanism for its decomposition in solution is proposed.

Structural Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C5H6BNO2, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lightfoot, Andrew P. published the artcileOn the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICl-NaOMe or ICl-pyridine, Product Details of C5H5ClIN, the publication is Tetrahedron Letters (2004), 45(46), 8557-8561, database is CAplus.

Conversion of hindered alkenyl boronate esters into the corresponding iodoalkene, or alkenyl chloride can be carried out stereoselectively using ICl. In the presence of NaOMe, direct reaction of ICl is favored yielding the E-iodoalkene, however, the reaction with ICl followed by NaOMe can be used to give different major alkenyl iodide and chloride products, depending upon reaction temperature, ICl source and alkenyl boronate stereoelectronics.

Tetrahedron Letters published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Product Details of C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kashin, A. N. published the artcileReactivity of organotin compounds. XXVII. New method for the activation of organotin compounds in electrophilic substitution reactions. Study of the reaction kinetics of α-stannylated esters with iodine in the presence of triorganoiodostannanes, Synthetic Route of 31253-08-4, the publication is Zhurnal Organicheskoi Khimii (1984), 20(8), 1611-20, database is CAplus.

The kinetics of the reactions of R₃SnCHR¹CO₂R² (R = Me, Et, Bu; R¹ = H, Me, Ph; R² = Me, Et, Me₂CH, Me₃C) with iodine in DMF containing KI was studied. The reaction is autocatalytic with formation of R₃SnI, and the final product is ICHR¹CO₂R². In the presence of excess R₃SnI the reaction is 2nd order overall, 1st order in each reactant, and its rate is not dependent on the KI and R₃SnI concentrations

Zhurnal Organicheskoi Khimii published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tornero, J. D. published the artcileMixed halide complexes of tin(IV) with pyridine, Recommanded Product: Pyridine Iodochloride complex, the publication is Anales de Quimica, Serie B: Quimica Inorganica y Quimica Analitica (1986), 82(2), 145-9, database is CAplus.

By oxidative-addition reactions of X₂ (X = Br, I) and XI.py (X = Cl, Br) to SnCl₂ in the presence of pyridine, SnCl₂X₂py₂ (X = Br, I), SnCl₃Ipy₂ and SnCl₂BrIpy₂ were obtained and studied by vibrational and ¹¹⁹Sn Moessbauer spectroscopy. A C_2v symmetry, with the ligands in trans positions, was proposed for SnCl₂Br₂py₂, whereas Moessbauer spectra of the remaining species show the presence of some impurities. A linear regression between the position of some pyridine bands in the IR spectra and the average electronegativity of halogens was observed, the υ₄ frequency being the most sensitive with respect to the metal-ligand bond strength.

Anales de Quimica, Serie B: Quimica Inorganica y Quimica Analitica published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C3H5BN2O2, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Valente, Sergio published the artcile1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells, Application of 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2014), 57(14), 6259-6265, database is CAplus and MEDLINE.

We describe 1,3,4-oxadiazole-containing hydroxamates and 2-aminoanilides as histone deacetylase inhibitors. Among them, N-hydroxy-3-(4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)phenyl) acrylamide (1), N-hydroxy-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (2), and N-(2-aminophenyl)-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (3) were the most potent and selective against HDAC1. In U937 leukemia cells, (1) was more potent than vorinostat (SAHA) in inducing apoptosis, and (3) displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, (3) showed higher antiproliferative effects than SAHA.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C14H10N2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mendoza, Manuel published the artcileIndolactam dipeptides as nanomolar Gli inhibitors, Recommanded Product: 1-Iodohexane, the publication is ACS Medicinal Chemistry Letters (2022), 13(7), 1036-1042, database is CAplus and MEDLINE.

The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including the majority of basal cell carcinomas. Here we describe a novel set of indolactam dipeptides that target protein kinase C (PKC), exploiting the unique capacity of PKC isoenzymes to act as regulators of Gli. We devised an efficient synthetic route for the indolactam-based natural product (-)-pendolmycin and a series of analogs, and we evaluated these analogs in mechanistically distinct Gli reporter assays. The lead compound from these studies, N-hexylindolactam V (I), exhibits superior Gli suppression relative to clin. inhibitors and blocks the growth of Gli-dependent basal cell carcinoma cells. More broadly, our structure-activity studies provide inroads for the development of novel Gli antagonists and new avenues for combating Gli-driven cancers.

ACS Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rousseau, Lidie published the artcileRelevance of Single-Transmetalated Resting States in Iron-Mediated Cross-Couplings: Unexpected Role of σ-Donating Additives, Application In Synthesis of 638-45-9, the publication is Inorganic Chemistry (2021), 60(11), 7991-7997, database is CAplus and MEDLINE.

Control of the transmetalation degree of organoiron(II) species is a critical parameter in numerous Fe-catalyzed cross-couplings to ensure the success of the process. In this report, we however demonstrate that the selective formation of a monotransmetalated Fe^II species during the catalytic regime counterintuitively does not alone ensure an efficient suppression of the nucleophile homocoupling side reaction. It is conversely shown that a fine control of the transmetalation degree of the transient Fe^III intermediates obtained after the activation of alkyl electrophiles by a single-electron transfer (SET), achievable using σ-donating additives, accounts for the selectivity of the cross-coupling pathway. This report shows for the first time that both coordination spheres of Fe^II resting states and Fe^III short-lived intermediates must be efficiently tuned during the catalytic regime to ensure high coupling selectivities.

Inorganic Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shigemitsu, Yasuhiro published the artcileDevelopment of novel functional dye using computed-aided molecular design techniques and its application to reagents for clinical test, etc., Product Details of C12H14IN, the publication is Nagasaki-ken Kogyo Gijutsu Senta Kenkyu Hokoku (2001), 23-33, database is CAplus.

Novel functional cyanine/merocyanine dyes were synthesized using versatile reactivity of nucleophilic reagents, ketenedithioacetals and 4-methylthiomaleimides. Quantum chem. calculations based on the MO method were carried out for light absorption anal. of these dyes. Also, absorption spectra of photochromic spirooxazine compounds showing absorptions in the longer wavelength region were theor. analyzed aiming at the mol. design of new photochromic compounds

Nagasaki-ken Kogyo Gijutsu Senta Kenkyu Hokoku published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C14H10O4, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zingaro, Ralph A. published the artcileInfrared spectra of pyridine coördinated iodine(I) salts, Recommanded Product: Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1959), 1353-7, database is CAplus.

The spectra of (Ipy)X (py = C₅H₅N and X = OAc, BzO, CN, F, Cl, Br, ClO₄, and NO₃), (Ipy₂)ClO₄ and NO₃, and (pyH)I are determined and compared with those of py and solutions of I₂ in py. The results are related to data from studies of ultraviolet spectra and conductivities of I₂-py solutions The py-I₂ complex must be very polar. On the basis of the spectral change resulting from coördination of py with I₂ it is suggested that the 990-cm.^-1 band of py be assigned to a H deformation mode. (Ipy)CN is prepared by adding I₂ to AgCN suspended in a CHCl₃ solution of py. AgI and AgCN are separated and the filtrate evaporated at 1 mm. Hg and Dry-Ice temperature The compound forms orange crystals which can be kept as long as 10 days in vacuo at Dry-Ice temperature Decomposition begins at 34° and is rapid at 50-3°. It is colored only in nonpolar solvents. (Ipy)F is prepared similarly from AgF. It forms pale yellow crystals which decompose over the range 80-97°. It is soluble in EtOH and Me₂O with subsequent decomposition It is insoluble in CCl₄, CHCl₃, or CS₂. Decomposition is instantaneous on contact with water.

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com