Author: Jessica.F

Canonica, Luigi published the artcileReformatskiǐ reactions. V. Further data on the stereochemical aspects of the Reformatskiǐ reaction, COA of Formula: C5H9IO2, the publication is Gazzetta Chimica Italiana (1955), 130-6, database is CAplus.

cf. C.A. 50, 6377d. In 3 cases already studied, α,β-disubstituted hydracrylic acids, obtained by alk. saponification of esters prepared by the Reformatskiǐ condensation, were found to be mixtures of 2 racemic stereoisomers, as predicted by theory. The present work shows that the esters are sterically unitary and that the inversion of configuration takes place within the esters themselves and precedes saponification The racemic HO acids are stable to alkalies. By the action of CH₂N₂ on the 2-iso-BuCH(OH)CH(CHMe₂)CO₂H, the corresponding esters are obtained. Their sapon, verifies the configuration of an ester formed by the Reformatskiǐ condensation. The experiments show also the influence of the temperature on the relative velocities of the reactions and the relative yields of the saponification products. Condensation of Me₂CHCH₂CHO (I) with Me₂CHCHBrCO₂Me (II) was carried out as with the Et ester (III) in earlier work, but with (Me₂CH)₂O as solvent. I (20 g.) and 40 g. II gave 33 g. crude product, which, rectified, yielded Me₂CHCH₂CH(OH)CH(CHMe₂)CO₂Me(IV), b₃ 103-4°, n_D²⁵ 1.4421. III, IV, PhCH(OH)CH(CHMe₂)CO₂Et (V), and PhCH(OH)CHEtCO₂Et (VI) were saponified by 10% NaOH at different temperatures (IV in MeOH; III, V, and VI in EtOH, and 10 cc. NaOH/g. ester). The time and temperature of saponification, yields of acids, % demolition to aldehydes, and % esters recovered are tabulated. Each acid (200 mg.) was refluxed 5 hrs. with 8 cc. 10% NaOH in MeOH, the free NaOH neutralized, the solution evaporated, H₂SO₄ added, and the mixture extracted with Et₂O. After crystallization, almost 100% of the acid was recovered; no stereoisomeric acid was found. The form of Me₂CHCH₂CH(OH)CH(CHMe₂)CO₂H m. 88° (900 mg.) in 6 cc. Et₂O treated slowly with 360 mg. CH₂N₂ in 7 cc. Et₂O (kept ice-cold), evaporated in vacuo, and the ester and 10 cc. 10% NaOH in MeOH heated 5 hrs. at 65° and treated as usual give, from petr. ether, an acid fraction, m. 88°, and, from C₆H₆-petr. ether, a fraction, m. 126°. The mother liquor contains Me₂CHCH₂CO₂H.

Gazzetta Chimica Italiana published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nauroozi, Djawed published the artcileSynthesis and solvent-free polymerisation of vinyl terephthalate for application as an anode material in organic batteries, Related Products of iodides-buliding-blocks, the publication is RSC Advances (2016), 6(112), 111350-111357, database is CAplus.

The synthesis and polymerization of di-Me 2-vinylterephthalate M1 for possible applications as an anode material in organic secondary batteries are reported. M1 exhibits a vinyl group as a polymerisable unit while the carboxylate moieties serve as cation (Li⁺, Na⁺) coordinating sites. The gram-scale synthesis of M1 is described via three different routes in order to evaluate the route with the highest overall yield. Furthermore, different conditions for free radical polymerization are investigated for obtaining polymer P1 with high mol. weights in order to study the impact of immobilizing the carboxylate redox-active centers in a polymer on the charge/discharge cycling stability when used in an organic battery. In order to synthesis suitable materials for battery investigations, P1 was post-functionalised to the corresponding lithium salt P1-Li, which was further electrochem. investigated. Cyclic voltammetry measurements showed for P1-Li redox activity in the range of 0.5-1.2 V vs. Li⁺/Li which assigns it as a candidate for the anode. Under the present exptl. conditions, the galvanostatic measurements of P1-Li exhibited a specific capacity of 64 mA h g^-1. It is further demonstrated that P1-Li shows an improved cycling stability of 83% discharge capacity remaining after 100 cycles compared to the parent monomer (44%).

RSC Advances published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bukshpan, S. published the artcileMoessbauer effect results for iodine, iodine, monobromide, and iodine monochloride in different chemical states, Safety of Pyridine Iodochloride complex, the publication is Journal of Chemical Physics (1975), 62(7), 2916-17, database is CAplus.

Anal. of the literature 129I Moessbauer effect data for I2, IBr, and ICl mols. as isolated mols. in inert gas matrixes, as solids, and in pyridine complexes gave evidence of the electronic structure in the compounds. The matrix isolated mols. have the electronic structure of the gas phase mols. The pyridine complexes have linear py+.X-I+ form with 0.13 electrons transferred from the py to the X-I+ mol. The py.I2 mol. has 2 different states assigned to I+ and I-.

Journal of Chemical Physics published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Safety of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miller, Joseph published the artcileThe S_N mechanism in aromatic compounds. XXII. The activating power of para CHO and CN groups, SDS of cas: 101420-79-5, the publication is Journal of the American Chemical Society (1957), 93-5, database is CAplus.

cf. C.A. 51,264g. The rate constants (k₂ × 10⁵ l./mole sec.) for the reactions of a number of 4-substituted 1-iodo-2-nitrobenzenes (I) with NaN₃ (both 0.05M) in MeOH were determined at various temperatures (substituent of I, rate constants at the indicated temperature in parentheses, and activation energy in kcal. given): H, 93.2, 98.2 (131.6°), 335 (150.0°), 570 (155.5°), 693 (157.5°), 1050 (166.1°), 24.7; CHO (m. 141°), 16.7, 17.0 (52.4), 62.1, 62.8 (64.0°), 390, 396, 400 (82.4°), 24.25; CN (m. 133.5°), 15.3 (44.95°), 25.9 (49.85°), 118, 119 (66.0°), 757 (86.1°), 774 (96.2°), 21.5; NO₂, 19.0 (20.05°), 90.6, 92.0 (35.25°), 226 (44.25°), 856, 889 (59.3°), 18.95. The same data were determined for the reaction of I with KSCN in MeOH: Ac, 21.5, 22.2 (110.6°), 89.6 (131.3°), 91.6 (131.4°), 137, 140 (137.8°), 21.3; CHO, 23.3 (100.4°), 25.0 (100.5°), 558, 564 (110.7°), 236 (131.4°), 240 (131.6°), 21.85; CN, 9.48, 10.2 (82.0°), 28.6, 39.0 (100.3°), 357 (131.2°), 392 (131.6°), 21.2; NO₂, 13.1, 13.3 (60.2°), 83.5, 84.9 (81.9°), 330,332 (100.0°), 20.05.

Journal of the American Chemical Society published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, SDS of cas: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Geonho published the artcileSynthesis and Characterization of Diketopyrrolopyrrole-Based Aggregation-Induced Emission Nanoparticles for Bioimaging, Recommanded Product: 1-Iodohexane, the publication is Molecules (2022), 27(9), 2984, database is CAplus and MEDLINE.

Conventional fluorescent dyes have the property of decreasing fluorescence due to aggregation-caused quenching effects at high concentrations, whereas aggregation-induced emission dyes have the property of increasing fluorescence as they aggregate with each other. In this study, diketopyrrolopyrrole-based long-wavelength aggregation-induced emission dyes were used to prepare biocompatible nanoparticles suitable for bioimaging. Aggregation-induced emission nanoparticles with the best morphol. and photoluminescence intensity were obtained through a fast, simple preparation method using an ultrasonicator. The optimally prepared nanoparticles from 3,6-bis(4-((E)-4-(bis(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)phenyl)-2,5-dihexyl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (DP-R2) with two functional groups having aggregation-induced emission properties and addnl. donating groups at the end of the triphenylamine groups were considered to have the greatest potential as a fluorescent probe for bioimaging. Furthermore, it was found that the tendency for aggregation-induced emission, which was apparent for the dye itself, became much more marked after the dyes were incorporated within nanoparticles. While the photoluminescence intensities of the dyes were observed to decrease rapidly over time, the prepared nanoparticles encapsulated within the biocompatible polymers maintained their initial optical properties very well. Lastly, when the cell viability test was conducted, excellent biocompatibility was demonstrated for each of the prepared nanoparticles.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sil, Diptesh published the artcileSelf-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents, SDS of cas: 638-45-9, the publication is Molecules (2022), 27(8), 2441, database is CAplus and MEDLINE.

Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure-activity relationship study of the PG11047 analogs (HPGs) containing alkyl chains of varying length, while keeping the unsaturated spermine backbone unchanged. Synthesis of higher sym. homologues was achieved through a synthetic route with fewer steps than the previous route to PG11047. The amphiphilic HPG analogs underwent self-assembly and formed spherically shaped nanoparticles whose size increased with the hydrophobic alkyl group′s increasing chain length. Assessment of the in vitro anticancer activity showed more than an eight-fold increase in the cancer cell inhibition activity of the analogs with longer alkyl chains compared to PG11047 in human colon cancer cell line HCT116, and a more than ten-fold increase in human lung cancer cell line A549. Evaluation of the inhibition of spermine oxidase (SMOX) showed no activity for PG11047, but activity was observed for its higher sym. homologues. Comparison with a reference SMOX inhibitor MDL72527 showed nine-fold better activity for the best performing HPG analog.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C15H15OP, SDS of cas: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fluch, Ulrike published the artcileUniform distribution of post-synthetic linker exchange in metal-organic frameworks revealed by Rutherford backscattering spectrometry, Category: iodides-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(48), 6516-6519, database is CAplus and MEDLINE.

Rutherford backscattering spectrometry (RBS) has been used for the first time to study post-synthetic linker exchange (PSE) in metal-organic frameworks. RBS is a non-invasive method to quantify the amount of introduced linker, as well as providing a means for depth profiling to identify the preferred localization of the introduced linker. The exchange of benzenedicarboxylate (bdc) by similarly sized 2-iodobenzenedicarboxylate (I-bdc) proceeds considerably slower than migration of I-dbc through the UiO-66 crystal [Zr₆(OH)₄O₄(C₈H₄O₄)₆]. Consequently, the I-bdc is found evenly distributed throughout the UiO-66 samples, even at very short PSE exposure times.

Chemical Communications (Cambridge, United Kingdom) published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bolchi, Cristiano published the artcilePeptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency, HPLC of Formula: 165534-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(22), 6192-6196, database is CAplus and MEDLINE.

2-O-Tolyl or 2-o-anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, resp., are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixteen compounds, resulting from the substitution pattern of benzamide and the configuration of the two stereocenters, seven inhibited FTase activity with potencies in the nanomolar range. They were all 2-oxymethylpyridodioxane ethers and, among them, the four o-tolyl substituted stereoisomers also showed micromolar antiproliferative effect on human aortic smooth muscle cells interfering with Ras farnesylation. The docking anal. enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, HPLC of Formula: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jorge, Salomao Doria published the artcileLigand-based design, synthesis, and experimental evaluation of novel benzofuroxan derivatives as anti-Trypanosoma cruzi agents, Computed Properties of 39115-95-2, the publication is European Journal of Medicinal Chemistry (2013), 200-214, database is CAplus and MEDLINE.

A set of substituted [N’-(benzofuroxan-5-yl)methylene]benzohydrazides (I; R¹ = H, Me, NH₂, CF₃, etc.; R² = H, Cl, CF₃; R³ = H, Cl), previously designed and synthesized, was exptl. assayed against Trypanosoma cruzi, the etiol. agent of Chagas’ disease, one of the most neglected tropical diseases. Exploratory data anal., Hansch approach and VolSurf formalism were applied to aid the ligand-based design of novel anti-T. cruzi agents. The best 2D-QSAR model showed suitable statistical measures [n = 18; s = 0.11; F = 42.19; R² = 0.90 and Q² = 0.77 (SDEP = 0.15)], and according to the optimum 3D-QSAR model [R² = 0.98, Q² = 0.93 (SDEP = 0.08)], three latent variables explained 62% of the total variance from original data. Steric and hydrophobic properties were pointed out as the key for biol. activity. Based upon the findings, six novel benzofuroxan derivatives I (R¹ = Pr, Me₂CH, Me₃C, Bu, OPr, OBu; R² = R³ H) were designed, synthesized, and in vitro assayed to perform the QSAR external prediction. Then, the predictability for the both models, 2D-QSAR (R_pred² = 0.91) and 3D-QSAR (R_pred² = 0.77), was exptl. validated, and compound I (R¹ = Pr; R² = R³ = H) was identified as the most active anti-T. cruzi hit (IC₅₀ = 3.04 μM).

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Niki, Aya published the artcileConstruction of acyclic all-carbon quaternary stereocenter based on asymmetric Michael addition of chiral amine, Name: Pyridine Iodochloride complex, the publication is Chemical & Pharmaceutical Bulletin (2021), 69(9), 926-930, database is CAplus.

Acyclic asym. quaternary stereocenters, which are composed of four carbon-carbon bonds, were finely constructed by utilizing a face-selective alkylation of enolate intermediates derived from an asym. Michael addition reaction of a chiral lithium amide with trisubstituted (E)-α,β-unsaturated esters. The present face-selective alkylation was able to employ diverse alkyl halides as an electrophile to afford various Michael adducts having an all-carbon quaternary stereocenter. With regard to the deprotection of the chiral auxiliary, N-iodosuccinimide used in our previous study did not work in the present cases; however, the pyridine iodine monochloride in the presence of H₂O was found effective to remove the bornyl group and the benzyl group on the amino group to provide the β-amino ester derivative

Chemical & Pharmaceutical Bulletin published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Name: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com