Author: Jessica.F

El Ashry, E. S. H. published the artcileThe scope of the reactions of hydrazines and hydrazones. Part VI. Reaction of hydrazines with dimedone, Computed Properties of 39115-95-2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(10), 871-5, database is CAplus.

The reactions of dimedone (I) with hydrazines were studied. I and p-tolylhydrazine gave II (R = NHNHC₆H₄Me-p), which was deprotonated to give II (R = N:NC₆H₄Me-p). With excess p-tolylhydrazine, I gave III (Z¹ = Z³ = NNHC₆H₄Me-p, Z² = O) which was identified as its 2-p-nitrobenzoylhydrazone and III (Z¹-Z³ = NNHC₆H₄Me-p). Reactions of I and II (R = NHNHR¹, N:NR¹; R¹ = Ph, C₆H₄Me-p) with R²C₆H₄CONHNH₂ (R² = H, Me, OMe, Cl, Br, I, OH, NO₂) gave the corresponding hydrazones. Reaction of I with semicarbazide, thiosemicarbazide and gluconylhydrazines gave the monohydrazones.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kwun, Oh Cheun published the artcileThe thermodynamics of the formation of pyridine-halogen and interhalogen charge transfer complexes, Application In Synthesis of 6443-90-9, the publication is Taehan Hwahakhoe Chi (1982), 26(6), 363-8, database is CAplus.

UV spectra of systems of pyridine with iodine, iodine monobromide and iodine monochloride in CCl₄ reveal the formation of 1:1 complexes C₅H₅N·I₂, C₅H₅N·IBr and C₅H₅N·ICl. Equilibrium constants and thermodn. parameters were obtained. The relative stabilities of the complexes increase in the order given. This may be a measure of relative acidities of halogen and interhalogens toward pyridine and can be explained by the polarizabilities of electron acceptors and the difference of electronegativities of the halogen atoms.

Taehan Hwahakhoe Chi published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Application In Synthesis of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fan, Yi Chiao published the artcilePhosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol, SDS of cas: 500563-90-6, the publication is Organic Letters (2012), 14(13), 3264-3267, database is CAplus and MEDLINE.

In this study, we used sequential catalysis-PPh₃-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans, e.g., I (R¹ = H, R, R² = H, OCH₂Ph, OMe, CF₃, etc., R³ = H, OCH₂Ph, OMe, Me, R⁴ = H, Me, MeO), rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid II (X = none, Y = CO₂H) isoochracinic acid II (X = O, Y = CO₂H), and isoochracinol II (X = O, Y = CH₂OH).

Organic Letters published new progress about 500563-90-6. 500563-90-6 belongs to iodides-buliding-blocks, auxiliary class Nitro Compound,Iodide,Benzene,Alcohol, name is (2-Iodo-4-nitrophenyl)methanol, and the molecular formula is C7H6INO3, SDS of cas: 500563-90-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Shin Heon published the artcileMacrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme, Product Details of C10H7IN2, the publication is PLoS One (2021), 16(9), e0257375, database is CAplus and MEDLINE.

Radiation therapy is among the most essential treatment methods for glioblastoma multiforme (GBM). Radio-resistance and cancer stem cell properties can cause therapeutic resistance, cancer heterogeneity, and poor prognoses in association with GBM. Furthermore, the GBM subtype transition from proneural to the most malignant mesenchymal subtype after radiation therapy also accounts for high resistance to conventional treatments. Here, we demonstrate that the inhibition of macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) by 4-iodo-6-phenylpyrimidine (4-IPP), a dual inhibitor targeting MIF and DDT, downregulates stemness phenotype, intracellular signaling cascades, mesenchymal trans-differentiation, and induces apoptosis in proneural glioma stem cells (GSCs). In an anal. of The Cancer Genome Atlas, high MIF and DDT expression were associated with poor prognosis. GSC growth was effectively inhibited by 4-IPP in a time- and dose-dependent manner, and 4-IPP combined with radiation therapy led to significantly reduced proliferation compared with radiation therapy alone. The expression of stemness factors, such as Olig2 and SOX2, and the expression of pAKT, indicating PI3K signaling pathway activation, were decreased in association with both 4-IPP monotherapy and combination treatment. The expression of mesenchymal markers, TGM2 and NF-κB, and expression of pERK (indicating MAPK signaling pathway activation) increased in association with radiation therapy alone but not with 4-IPP monotherapy and combination therapy. In addition, the combination of 4-IPP and radiation therapy significantly induced apoptosis compared to the monotherapy of 4-IPP or radiation. In vivo results demonstrated a significant tumor-suppressing effect of 4-IPP when combined with radiation therapy. Collectively, our results showed that the targeted inhibition of MIF and DDT has the potential to strengthen current clin. strategies by enhancing the anticancer effects of radiation therapy.

PLoS One published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Product Details of C10H7IN2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Imamoto, Tsuneo published the artcileCarbon-carbon bond-forming reactions using cerium metal or organocerium(III) reagents, HPLC of Formula: 31253-08-4, the publication is Journal of Organic Chemistry (1984), 49(21), 3904-12, database is CAplus.

Cerium amalgam is an effective reagent for the chemoselective preparation of homoallylic alcs. from allyl halides and carbonyl compounds and for the Reformatskii-type reaction of α-halo esters with carbonyl compounds Organocerium(III) reagents were conveniently generated by the reaction of organolithiums with CeI₃ or CeCl₃ and they react cleanly at -78 to -65° with various carbonyl compounds to afford the addition products in high yields. The substrates are susceptible to enolization or metal-halogen exchange with simple organolithiums. The same reagents also react with α,β-unsaturated carbonyl compounds to yield 1,2-addition products in high selectivity.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hattori, Yoshihide published the artcileSynthesis and evaluation of the compounds containing ¹⁰B and ¹⁹F atoms as boron carrier and imaging agent, Category: iodides-buliding-blocks, the publication is Peptide Science (2006), 337-340, database is CAplus.

Boron-neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, resp. In order to develop practical tools both for BNCT and MRI, novel compounds containing both ¹⁹F and ¹⁰B atoms in a single mol. were designed and synthesized. Furthermore, the incorporated amount into cancer cells and tumor cell killing effect against cancer cells of these compounds by neutron irradiation were elucidated.

Peptide Science published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhuang, Zhi-Ping published the artcileSyntheses of two potential ligands for Tc-99m labeling as diagnosis agents of Alzheimer’s disease, Formula: C7H8INO, the publication is Chinese Journal of Chemistry (2003), 21(7), 824-832, database is CAplus.

Two ligands, I and II, which can be labeled with Tc-99m for the diagnosis of Alzheimer’s disease (AD) have been synthesized. The key steps in these two syntheses involved Suzuki and Wittig reactions, resp. A newly discovered debromination reaction may be extended to compounds with a double or triple bond adjacent to the carbon atom bearing the bromine atoms. These syntheses provide a route to biphenyl and stilbene derivatives that will benefit the search of new imaging agents for AD.

Chinese Journal of Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C14H7F3OS, Formula: C7H8INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhuang, Zhi-Ping published the artcileBiphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain, Category: iodides-buliding-blocks, the publication is Nuclear Medicine and Biology (2005), 32(2), 171-184, database is CAplus and MEDLINE.

Formation and accumulation of excess aggregates of β-amyloid (Aβ) plaques in the brain are critical factors contributing to the development and progression of Alzheimer’s disease (AD). There is an urgent need for in vivo imaging agents that can specifically demonstrate the location and d. of Aβ plaques in the brain. The aim of this study was to develop potential technetium 99m (^99mTc)-labeled diagnostic imaging agents specific for the detection of Aβ plaques. Based on previously obtained Aβ plaque-specific biphenyls containing a p-N, N-dimethylaminophenyl group, a series of ^99mTc and Re-N₂S₂-biphenyl derivatives was prepared The stable neutral and lipophilic ^99mTc complexes, [^99mTc]19 and [^99mTc]23, A+B, were successfully obtained. As surrogates for the ^99mTc complexes, the corresponding surrogates, Re complexes of 23, were also prepared Surprisingly, it was found that the Re complexes showed distinctively different retention profiles as compared with the corresponding ^99mTc complexes. Biodistribution studies indicated that [^99mTc]23A readily passed through the blood-brain barrier (1.18% dose/brain at 2 min) in contrast to the low brain penetration of [^99mTc]19 (0.29% dose/brain at 2 min). Initial results suggested that [^99mTc]23A showed selective binding to the Aβ plaque-like structures in the brain sections from transgenic mice but not in the postmortem human brain tissue of patients with confirmed AD. The results provide encouraging evidence that development of a ^99mTc-labeled agent for imaging Aβ plaques in the brain may be feasible. Caution should be taken when comparing these ^99mTc complexes with the corresponding surrogates – the Re complexes.

Nuclear Medicine and Biology published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C8H10S, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fine, Jonathan published the artcileGraph-based machine learning interprets and predicts diagnostic isomer-selective ion-molecule reactions in tandem mass spectrometry, COA of Formula: C7H5I2NO3, the publication is Chemical Science (2020), 11(43), 11849-11858, database is CAplus and MEDLINE.

Diagnostic ion-mol. reactions employed in tandem mass spectrometry experiments can frequently be used to differentiate between isomeric compounds unlike the popular collision-activated dissociation methodol. Selected neutral reagents, such as 2-methoxypropene (MOP), are introduced into an ion trap mass spectrometer where they react with protonated analytes to yield product ions that are diagnostic for the functional groups present in the analytes. However, the understanding and interpretation of the mass spectra obtained can be challenging and time-consuming. Here, we introduce the first bootstrapped decision tree model trained on 36 known ion-mol. reactions with MOP. It uses the graph-based connectivity of analytes′ functional groups as input to predict whether the protonated analyte will undergo a diagnostic reaction with MOP. A Cohen kappa statistic of 0.70 was achieved with a blind test set, suggesting substantial inter-model reliability on limited training data. Prospective diagnostic product predictions were exptl. tested for 13 previously unpublished analytes. We introduce chem. reactivity flowcharts to facilitate chem. interpretation of the decisions made by the machine learning method that will be useful to understand and interpret the mass spectra for chem. reactivity.

Chemical Science published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, COA of Formula: C7H5I2NO3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Karthigha, S. published the artcileSynthesis, growth, crystal structure, optical and third order nonlinear optical properties of quinolinium derivative single crystal: PNQI, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Physics and Chemistry of Solids (2018), 133-140, database is CAplus.

An organic quinolinium derivative nonlinear optical (NLO) crystal, 1-ethyl-2-[2-(4-nitro-phenyl)-vinyl]-quinolinium iodide (PNQI) was synthesized and successfully grown by slow evaporation solution growth technique. Formation of a crystalline compound was confirmed by single crystal X-ray diffraction. The quinolinium compound PNQI crystallizes in the triclinic crystal system with a centrosym. space group of P-1 symmetry. The mol. structure of PNQI was confirmed by ¹H NMR and ¹³C NMR spectral studies. The thermal properties of the crystal have been investigated by thermogravimetric (TG) and differential scanning calorimetry (DSC) studies. The optical characteristics obtained from UV-Vis-NIR spectral data were described and the cut-off wavelength observed at 506 nm. The etching study was performed to analyze the growth features of PNQI single crystal. The third order NLO properties such as nonlinear refractive index (n₂), nonlinear absorption coefficient (β) and nonlinear susceptibility (χ ⁽³⁾) of the crystal were investigated using Z-scan technique at 632.8 nm of He-Ne laser.

Journal of Physics and Chemistry of Solids published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com