Author: Jessica.F

Abd El-Aal, R. M. published the artcileThe use of oxonium salts in the synthesis of mono-, β-substituted dimethine and styryl cyanine dyes, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Dyes and Pigments (2005), 66(3), 201-209, database is CAplus.

Pyrazolopyrylium perchlorate salt derivatives were obtained from the reaction of 5-chloro-4-formyl-3-methyl-1-phenylpyrazole with methylphenylpyrazolone, 4(2-propenyl)-1,6-ene-2-cyclohexanone, and cyclohexanone. Reaction of the salts with 2(4)-Me-substituted heterocyclic quaternary salts gave the pyrazolopyrylium 4[2(4)]-monomethine cyanine dyes. Meanwhile, reaction with amide compounds gives intermediate compounds which when reacted with 2(4)-Me-substituted heterocyclic quaternary salts gave the pyrazolopyrylium 4[2(4)]-β-substituted dimethines. Reaction of the intermediate compounds with various aromatic aldehydes followed by the reaction with 2-methylquinolinium ethiodide gave bis styryl cyanine dyes. Elemental analyses and visible absorption, IR, ¹H NMR, and mass spectra established the structures of these compounds The relationship between the structure and properties of these dyes is discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Poleshschuk, O. K. published the artcileAb initio study of the bonding and nuclear quadrupole coupling in the Py-ICl complex, Category: iodides-buliding-blocks, the publication is Journal of Molecular Structure (1999), 513(1-3), 29-34, database is CAplus.

As a result of the ICl complexation with Py, the ¹⁴N- and ³⁵Cl-NQR frequencies are shifted towards lower values and ¹²⁷I-NQR frequency towards higher values. In order to explain this phenomenon, ICl, Py and Py-ICl complex have been subjected to Gaussian-94 anal. on the 6-31G** level of the theory. The ab initio calculations indicate a good correlation between the calculated and the exptl. e²Qq_zz as well as the values of the asymmetry parameter and their shifts upon complexation. As follows from the Townes-Dailey approximation, increasing ionicity of the I-Cl bond implies a decrease in ³⁵Cl- and ¹⁴N-NQR frequencies and an increase in the ¹²⁷I-NQR frequency, which has been confirmed by both exptl. and calculated results. The increase in the ionic character of the I-Cl bond can be observed as an increase in the neg. charge on the chlorine atom and a decrease in the pos. charge on the iodine atom. A decrease in the e²Qq_zz ¹⁴N can be explained by an increase in the population of the π orbital while the population of the σ orbital remains unchanged. Stability of ICl complexes is determined by the contribution of the unpopulated orbital of the acceptor and coupling between the populated orbitals of the acceptor and the donor. The frequency shifts have been explained by the redistribution of electron d. taking place on complexation.

Journal of Molecular Structure published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kratky, Martin published the artcileIodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents, Category: iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2021), 116209, database is CAplus and MEDLINE.

Here in, authors synthesized and screened twenty-two iodinated hydrazide-hydrazones I (R¹ = H, Me, t-Bu, etc.; R² = 2-OH, 4-OH), ten 1,2-diacylhydrazines II (R = H, t-Bu, CF₃, etc.)and their three reduced analogs for their antibacterial, antifungal, and cytotoxic properties. Hydrazide-hydrazones were prepared by condensation of 4-substituted benzohydrazides with 2-/4-hydroxy-3,5-diiodobenzaldehydes, diacylhydrazines from identical benzohydrazides and 3,5-diiodosalicylic acid via its chloride. These compounds were investigated in vitro against eight bacterial and eight fungal strains. The derivatives were found potent antibacterial agents against Gram-pos. cocci including methicillin-resistant Staphylococcus aureus with the lowest values of min. inhibitory concentrations (MIC) of 7.81μM. Four compounds inhibited also human pathogenic fungi (MIC of ≥ 1.95μM). The derivatives had different degrees of cytotoxicity for HepG2 and HK-2 cell lines (IC₅₀ values from 11.72 and 26.80μM, resp.) and normal human cells exhibited lower sensitivity. The apoptotic effect was also investigated. In general, the presence of 3,5-diiodosalicylidene scaffold in compd I (R² = 2-OH) is translated into enhanced both antimicrobial and cytotoxic properties whereas its 4-hydroxy isomers I (R² = 4-OH) share a low biol. activity. Compounds II have a non-homogeneous activity profile. Focusing on 4-substituted benzohydrazide part, the presence of an electron-withdrawing group (F, Cl, CF₃, NO₂) was found to be beneficial.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miao, Zhihui published the artcileSoluble Polymer Precursors via Ring-Expansion Metathesis Polymerization for the Synthesis of Cyclic Polyacetylene, Recommanded Product: 1-Iodohexane, the publication is Macromolecules (Washington, DC, United States) (2021), 54(17), 7840-7848, database is CAplus.

Cyclic polyacetylene (c-PA) is the cyclic derivative of the semiconducting linear polyacetylene. As with the linear derivative, cyclic polyacetylene is insoluble, making its characterization and processing challenging. Herein, we report the synthesis of c-PA via an indirect approach, employing ring-expansion metathesis polymerization of cyclic alkenes to form soluble polymer precursors. Subsequent retro-Diels-Alder elimination through heating provides c-PA. Dilute solution characterizations of the polymer precursors including ¹H NMR spectroscopy, gel permeation chromatog., and IR and Raman spectroscopy confirm their cyclic structure and, by inference, the cyclic topol. of the resulting c-PA. Solid-state thermal analyses via thermogravimetric anal. and differential scanning calorimetry reveal the chem. and phys. transformations occurring during the retro-Diels-Alder elimination step and concurrent isomerization. Freestanding films are attainable via the soluble precursors, and when doped with I₂, the films are semiconducting.

Macromolecules (Washington, DC, United States) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koenigstein, Christian published the artcileOrigin of the high-energy emission of 1,1′-diethyl-2,2′-cyanine dye, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (1994), 84(3), 245-8, database is CAplus.

In addition to the yellow emission ascribed to the J aggregates of 1,1′-diethyl-2,2′-cyanine, this compound also exhibits a high-energy emission around 400 nm in dilute aqueous solutions (c<10^-3 mol l^-1). It was found using time-resolved emission measurements that protonation of 1,1′-diethyl-2,2′-cyanine is responsible for this emission. At pH<4, the excited state protolytic reaction competes with ground state protonation. Both pathways give the same excited species, luminescing at 400 nm. The non-protonated form shows only weak fluorescence. The excited state lifetime of the protonated form is 4.5 ns.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yamakawa, Koji published the artcileStudies on the terpenoids and related alicyclic compounds. XXIII. Total synthesis of (±)-phomenone, (±)-3-epiphomenone, (±)-ligularenolide, and (±)-furanoligularanone, Application In Synthesis of 31253-08-4, the publication is Chemical & Pharmaceutical Bulletin (1980), 28(11), 3265-74, database is CAplus.

(±)-Phomenone (I, Z = α-OH,β-H), (±)-3-epiphomenone (I, Z = α-H,β-OH) (±)-ligularenolide (II), and (±)-furanoligularanone (III) were prepared from naphthalenedione IV via the monoketals V (R = CMe:CH₂) or VI. E.g., epoxidation of V (R = CMe:CH₂) gave V (R = 2-methyl-2-oxiranyl), whose ring cleavage in the presence of LiNEt₂ gave V [R = HOCH₂C(:CH₂)], epoxidation of which gave I (Z = OCH₂CH₂O), whose deketalization followed by NaBH₄ reduction gave (±)-3-epiphomenone (I, Z = α-H, β-OH).

Chemical & Pharmaceutical Bulletin published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C6H17NO3Si, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sapountzis, Ioannis published the artcileGeneral preparation of functionalized o-nitroarylmagnesium halides through an iodine-magnesium exchange, Recommanded Product: 4-Iodo-3-nitrobenzonitrile, the publication is Angewandte Chemie, International Edition (2002), 41(9), 1610-1611, database is CAplus and MEDLINE.

Highly functionalized aryl Grignard reagents with an ortho-nitro substituent were synthesized from 2-iodonitroaryl compounds through an I-Mg exchange reaction with PhMgCl or mesityl Mg bromide. These Grignard reagents are stable (T < – 20° for several hours) and undergo various cross-coupling reactions in the presence of Cu or Pd catalysts (dba = trans,trans-dibenzylideneacetone; tfp = tri-o-furylphosphine). E.g., ClMgC₆H₄NO₂-2 reacted with PhCHO at -40° to give 2-NO₂C₆H₄CH(OH)Ph in 87% yield.

Angewandte Chemie, International Edition published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Recommanded Product: 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Richard H. published the artcileColossal thermal expansion and negative thermal expansion in simple halogen bonded complexes, COA of Formula: C5H5ClIN, the publication is CrystEngComm (2014), 16(2), 237-243, database is CAplus.

The crystal structures of the simple monoclinic halogen-bonded complexes pyridine-ICl and pyridine-IBr have been redetermined using modern X-ray and neutron diffraction techniques. The representation quadric surfaces for the thermal expansion tensor have been found to consist of a hyperboloid of one sheet. Neg. thermal expansion occurs parallel to the crystallog. b axis, while there is colossal thermal expansion in a direction approx. parallel to the a* direction. These effects arise because of a decrease in the strength of an already weak C-H···X (X = Br, Cl) hydrogen bond with increasing temperature The decrease in strength of the hydrogen bonding originates because of the reduction in the strength of the halogen bond formed between the nitrogen atom and the IX moiety with increasing temperature Thus since at 298 K the I-X bonds are shorter than at 110 K, there will be a smaller partial neg. charge on the X halogen at 298 K, leading to a weaker C-H···X hydrogen bond.

CrystEngComm published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, COA of Formula: C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pacardo, Dennis B. published the artcileExploring the mechanism of Stille C-C coupling via peptide-capped Pd nanoparticles results in low temperature reagent selectivity, Product Details of C7H4ClIO2, the publication is Catalysis Science & Technology (2013), 3(3), 745-753, database is CAplus.

Stille coupling of PhSnCl₃ with aryl halides was catalyzed by palladium 2 nm nanoparticles, capped with Pd4 peptide, TSNAVHPTLRHL, the effects of halogen, substitution and temperature being qual. evaluated. The atom-leaching mechanism of Pd nanoparticle-driven Stille coupling is suggested, comprising initial oxidative addition at the particle surface, Pd atom abstraction and further reactions in solution The fate of the highly active Pd⁰ atoms released in solution was further elucidated. As a result, two reaction sites are present, the particle surface and pre-leached Pd atoms, thus different degrees of reactivity are possible. This effect was probed via aryl halide combinations that varied the halogen identity allowing for oxidative addition of two substrates simultaneously. The results demonstrate that the system was highly reactive for iodo-based compounds in the mixture at room temperature; however, reactivity at bromo-based substrates was only observed at slightly elevated temperatures of 40.0°. As such, substrate selectivity was evident from the catalytic materials that can be controlled based upon the aryl halide composition and reaction temperature Furthermore, both intermol. and intramol. selectivity is possible, thus raising the degree of reaction complexity that can be achieved.

Catalysis Science & Technology published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Product Details of C7H4ClIO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Puleo, Thomas R. published the artcileNucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer, Formula: C6H6INO, the publication is Journal of the American Chemical Society (2021), 143(32), 12480-12486, database is CAplus and MEDLINE.

A general protocol for the direct C-H etherification of N-heteroarenes is reported. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alc. substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcs. with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.

Journal of the American Chemical Society published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Formula: C6H6INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com