Author: Jessica.F

On May 6, 2016, Welz, Claudia; Koehler, Adeline; Boerngen, Kirsten; Kulke, Daniel; Goergens, Ulrich; Schwarz, Hans-Georg; Ilg, Kerstin published a patent.Computed Properties of 364-12-5 The title of the patent was Preparation of arylamide compounds for use in anthelmintic treatment. And the patent contained the following:

Disclosed are compounds of formula I which possess anthelmintic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or prevention of infections with helminths in animals and humans. Compounds of formula I wherein n is 1, 2 and 3; m is 0, 1, 2, 3 and 4; R1 is H, CHO, OH, C1-4 alkyl,e tc.; each X is independently halo, NO2, CN, amino, etc.; each Y is independently H, halo, NO2, CN, OH, SH, etc.; A is (un)substituted Ph, (un)substituted pyridinyl and (un)substituted pyrazinyl; and salts, solvates, solvates of salts, N-oxides, metal complexes and metalloid complexes thereof, are claimed. Example compound II was prepared by amidation of 2-trifluoromethylbenzoyl chloride with 2-(4-bromo-2- chloro-phenyl)-2,2-difluoro-ethanamine; the resulting N-[2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide underwent cross-coupling with 4-fluorophenylboronic acid to give compound II. The invention compounds were evaluated for their anthelmintic activity (some data given). The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Computed Properties of 364-12-5

The Article related to arylamide preparation anthelmintic, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Computed Properties of 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 31, 2004, Cannon, Amy S.; Jian, Tianying; Wang, Jun; Warner, John C. published an article.Related Products of 144970-30-9 The title of the article was Synthesis of tetrahedral carboxamide hydrogen bond acceptors. And the article contained the following:

Tetracarboxamides were prepared from tetraphenylnmethane and 1,3,5,7-tetraphenyladamantane via the halides, nitriles, and carboxylic acids. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Related Products of 144970-30-9

The Article related to tetraphenylmethane tetracarbamoyl preparation, tetraphenyladamantane tetracarbamoyl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Related Products of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 15, 2002, Tobe, Yoshito; Utsumi, Naoto; Kawabata, Kazuya; Nagano, Atsushi; Adachi, Kiyomi; Araki, Shunji; Sonoda, Motohiro; Hirose, Keiji; Naemura, Koichiro published an article.Safety of Ethyl 4-amino-3-bromo-5-iodobenzoate The title of the article was m-Diethynylbenzene Macrocycles: Syntheses and Self-Association Behavior in Solution. And the article contained the following:

M-Diethynylbenzene macrocycles (DBMs), buta-1,3-diyne-bridged [4n]metacyclophanes, have been synthesized and their self-association behaviors in solution were investigated. Cyclic tetramers, hexamers, and octamers of DBMs having exo-annular octyl, hexadecyl, and 3,6,9-trioxadecyl ester groups were prepared by intermol. oxidative coupling of dimer units or intramol. cyclization of the corresponding open-chain oligomers. The aggregation properties were investigated by two methods, the 1H NMR spectra and the vapor pressure osmometry (VPO). Although some discrepancies were observed between the association constants obtained from the two methods, the qual. view was consistent with each other. The anal. of self-aggregation by VPO revealed unique aggregation behavior of DBMs in acetone and toluene, which was not elucidated by the NMR method. Namely, the association constants for infinite association are several times larger than the dimerization constant, suggesting that the aggregation is enhanced by the formation of dimers (a nucleation mechanism). In polar solvents, DBMs aggregate more strongly than in chloroform due to the solvophobic interactions between the macrocyclic framework and the solvents. Moreover, DBMs self-associate in aromatic solvents such as toluene and o-xylene more readily than in chloroform. In particular, the hexameric DBM having a large macrocyclic cavity exhibits extremely large association constants in aromatic solvents. By comparing the aggregation properties of DBMs with the corresponding acyclic oligomers, the effect of the macrocyclic structure on the aggregation propensity was clarified. Finally, it turned out that DBMs tend to aggregate more readily than the corresponding phenylacetylene macrocycles, acetylene-bridged [2n]metacyclophanes, owing to the withdrawal of the electron d. from the aromatic rings by the butadiyne linkages which facilitates 蟺-蟺 stacking interactions. The experimental process involved the reaction of Ethyl 4-amino-3-bromo-5-iodobenzoate(cas: 437707-51-2).Safety of Ethyl 4-amino-3-bromo-5-iodobenzoate

The Article related to nmr vapor pressure osmometry selfassocn preparation thermodn diethynylbenzene macrocycle, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Safety of Ethyl 4-amino-3-bromo-5-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 25, 2003, Egbertson, Melissa; Langford, H. Marie; Melamed, Jeffrey Y.; Wai, John S.; Han, Wei; Perlow, Debbie S.; Zhuang, Linghang; Embrey, Mark; Young, Steven D. published a patent.Application of 70931-59-8 The title of the patent was Preparation of N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors for treatment of HIV infection/AIDS. And the patent contained the following:

Title compounds I [wherein R1 = H or F; R2 = carbamoylalkyl, carbamoyl, triazolyl or tetrazolyl, acylamino and derivatives, 2-oxopyrrolidin-1-yl and analogs, (cyclo)alkoxycarbonyl, COY; Y = azetidinyl, pyrrolidinyl, piperidinyl, morpholino; R3 = H, carbamoyl and derivatives, acylamino, carbamoyl(alkyl/methylthioxy/methyloxy/amino/alkylamino/alkenyl), (un)substituted 5- to 7-membered saturated heterocyclic ring containing 1 to 4 heteroatoms (N, O or S), (un)substituted 7- to 9-bridged azabicycloalkyl saturated ring; or their pharmaceutically acceptable salts] were prepared as HIV-integrase inhibitors for preventing and treating infection by HIV and for preventing, treating or delaying the onset of AIDS. For example, II鈥a was prepared via TEA-acylation of III鈥Cl (preparation given) with 5-(1,1-dioxo-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid (IV) in DMF at room temperature overnight, followed by sodium salt formation by reaction with NaOH at room temperature for 30 min. IV was prepared from 8-hydroxy-1,6-naphthyridine-7-carboxylic acid Me ester in 5 steps by NBS-bromination in CHCl3, O-tosylation in CHCl3, condensation of the bromide with 1,4-butanesultam in DMF in the presence of Cu2O/2,2′-bipyridyl at 120掳 for 4 h, deprotection of tosyl group, and base-catalyzed hydrolysis in MeOH overnight at 60掳. Selected invention compounds inhibited the strand transfer activity of HIV integrase with IC50 < 0.5 渭M. The same compounds inhibited HIV replication in T-lymphoid cells with IC95 < 5 渭M. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Application of 70931-59-8

The Article related to naphthyridinecarboxamide hiv integrase inhibitor aids composition antiviral, carboxamide naphthyridine hiv replication inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 25, 2003, Egbertson, Melissa; Langford, H. Marie; Melamed, Jeffrey Y.; Wai, John S.; Han, Wei; Perlow, Debbie S.; Zhuang, Linghang; Embrey, Mark published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Preparation of N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors for treatment of HIV infection/AIDS. And the patent contained the following:

Title compounds I [wherein R1 = H or F; R2 = carbamoylalkyl, carbamoyl, triazolyl or tetrazolyl, acylamino and derivatives, 2-oxopyrrolidin-1-yl and analogs, (cyclo)alkoxycarbonyl, COY; Y = azetidinyl, pyrrolidinyl, piperidinyl, morpholino; R3 = H, carbamoyl and derivatives, acylamino, carbamoyl(alkyl/methylthioxy/methyloxy/amino/alkylamino/alkenyl), (un)substituted 5- to 7-membered saturated heterocyclic ring containing 1 to 4 heteroatoms (N, O or S), (un)substituted 7- to 9-bridged azabicycloalkyl saturated ring; or their pharmaceutical acceptable salts] were prepared as HIV-integrase inhibitors for preventing and treating infection by HIV and for preventing, treating or delaying the onset of AIDS. For example, II鈥a was prepared via TEA-acylation of III鈥Cl (preparation given) with 5-(1,1-dioxo-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid (IV) in DMF at room temperature overnight, followed by sodium salt formation by reaction with NaOH at room temperature for 30 min. IV was prepared from 8-hydroxy-1,6-naphthyridine-7-carboxylic acid Me ester in 5 steps by NBS-bromination in CHCl3, O-tosylation in CHCl3, condensation of the bromide with 1,4-butanesultam in DMF in the presence of Cu2O/2,2′-bipyridyl at 120掳 for 4 h, deprotection of tosyl group, and base-catalyzed hydrolysis in MeOH overnight at 60掳. Selected invention compounds inhibited the strand transfer activity of HIV integrase with IC50 < 0.5 渭M. The same compounds inhibited the replication of HIV in T-lymphoid cells with IC95 < 5 渭M. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to naphthyridinecarboxamide hiv integrase inhibitor aids composition antiviral, carboxamide naphthyridine hiv replication inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Can; Zhu, Xianjin; Han, Yongzhen; Yang, Haijun; Zhu, Changjin; Fu, Hua published an article in 2019, the title of the article was Superbase-promoted selective carbon-carbon bond cleavage driven by aromatization.Application of 70931-59-8 And the article contains the following content:

A novel selective carbon-carbon single bond cleavage has been disclosed through the copper-catalyzed reaction of 1-alkyl-3-alkylindolin-2-imine hydrochlorides I鈥Cl (R1 = 7-CH3, 5-OCH3, 5-Cl, etc.; R2 = CH3, CH2C6H5, CH2CH=CH2, etc.; R3 = C2H5, CH2C6H5, 4-ClC6H4CH2, etc.) with substituted 1-(bromomethyl)-2-iodobenzenes R4-2-(X)C6H3CH2Br (R4 = H, 5-OCH3, 4-F, 5-F, 5-Cl; X = I, Br) leading to fused N-heterocycles II (R5 = 7-CH3, 9-OCH3, 9-Cl, etc.; R6 = 2-OCH3, 3-F, 2-F, 2-Cl). Mechanistic studies showed that the intrinsic drive of aromatization and the action of the superbase derived from sodium tert-butoxide and dimethylsulfoxide were the key factors leading to the carbon-carbon single bond cleavage. Furthermore, the obtained N-heterocycles are indoloquinoline derivatives II with wide biol. activities. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Application of 70931-59-8

The Article related to indoloquinoline preparation chemoselective, alkyl alkylindolin imine hydrochloride bromomethyl iodobenzene aromatization copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On July 31, 2003, Egbertson, Melissa; Melamed, Jeffrey Y.; Langford, H. Marie; Young, Steven D. published a patent.Application In Synthesis of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Preparation of hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors. And the patent contained the following:

Hydroxynaphthyridinone carboxamides (shown as I; variables defined below; e.g. N-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide) are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds were employed against HIV infection and AIDS as compounds per se or as pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions (one example given), optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described. Although the methods of preparation are not claimed, 27 example preparations of I are included; all have IC50’s <0.5 渭M in a HIV integrase assay and all have IC95's <5 渭M in an assay for inhibition of HIV replication. For I: L = linker connecting the C atom of the Ph ring to the N of the -NH- moiety = single bond, -(C1-6 alkyl)- (un)substituted with -C(O)N(RaRb), -(C0-3 alkyl)-C:C-(C1-3-alkyl)-, -(C0-3 alkyl)-C顚咰-(C1-3-alkyl)-, or -(C0-6 alkyl)-(C3-6 cycloalkyl)-(C0-6-alkyl)-. R1a, R1b, and R1c = H, halogen, -C1-6 alkyl, or -C1-6 haloalkyl; R2a and R2b = H, -C1-6 (un)substituted alkyl, -O-C1-6 (un)substituted alkyl, -OH, halo, -NO2, -CN, -C(O)Ra, -CO2Ra, -S(O)nRa, -SO2N(RaRb), -N(RaRb), -C(O)N(RaRb), -N(Ra)SO2Rb, -OC(O)N(RaRb), -N(Ra)C(O)N(RaRb), -N(Ra)-C1-6-alkyl-C(O)N(RaRb), -N(Ra)-C(O)-C1-6 alkyl-N(RaRb), -N(Ra)C(O)-C(O)N(RaRb), -OCO2Ra, -N(Ra)-SO2N(RaRb), -N(Ra)-SO2-C1-6 alkyl-N(RaRb), -N(Ra)C(O)Rb, -N(Ra)CO2Rb, -S-C1-6 alkyl-C(O)N(RaRb),or -N(SO2Ra)-C1-6 alkyl-C(O)N(RaRb). R3 = H, -C1-6-(un)substituted alkyl, -S(O)nRa, -SO2N(RaRb), -C2-6 (un)substituted alkenyl, -C2-5 (un)substituted alkynyl, -Rk, -S(O)n-C1-6 alkyl-Rk, -N(Ra)C(O)-Rk, or -N(Ra)C(O)-C1-6 alkyl-Rk; each of R4 and R5 = H, -C1-6 (un)substituted alkyl, -SO2N(RaRb), or -C1-6 alkyl-Rm; each Ra and Rb = H, -C1-6 alkyl, or -C3-8 cycloalkyl; Rk is a carbocycle or a heterocycle; each Rm = a carbocycle or a heterocycle; each n = 0, 1 or 2; addnl. details including provisos are given in the claims. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Application In Synthesis of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to hydroxynaphthyridinone carboxamide preparation hiv integrase inhibitor, aids drug hydroxynaphthyridinone carboxamide preparation hiv integrase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xu; Lu, Sheng-mei; Li, Jun; Liu, Yan; Li, Can published an article in 2015, the title of the article was Conjugated microporous polymers with chiral BINAP ligand built-in as efficient catalysts for asymmetric hydrogenation.Category: iodides-buliding-blocks And the article contains the following content:

A series of chiral conjugated microporous polymers (CMPs) based on the chiral (R)-BINAP ligand (BINAP-CMPs) were synthesized with tunable BET surface areas. These solid catalysts show high activities and enantioselectivities for the asym. hydrogenation of 尾-keto esters after coordination with ruthenium species. Moreover, CMPs can realize spatial isolation. Through preventing the formation of dimers and trimers, BINAP-CMPs show much higher activity than BINAP for the Ir-catalyzed asym. hydrogenation of quinaldine. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

The Article related to cmp ruthenium binap catalyst asym hydrogenation ketoester sem tga, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On December 31, 1982, Bolton, Roger; Moore, Clive; Sandall, John P. B. published an article.Computed Properties of 364-12-5 The title of the article was Nucleophilic displacement in polyhaloaromatic compounds. Part 11. Kinetics of protiodeiodination of iodoarenes in dimethyl sulfoxide-methanol. And the article contained the following:

The kinetics were determined of the MeO–induced protiodeiodination of 15 polychloroiodobenzenes and 6 of their Br- or CF3-substituted analogs in 9:1 (volume) DMSO-MeOH at 323.2 K. The true reagent is the DMSO anion. The reaction rates in some cases approached the diffusion-controlled process. Cl and CF3 substituents promote the reaction in the order ortho > meta > para and ortho > para > meta, resp. Protiodeiodinaton is promoted by o-NO2 groups, but the p-NO2 group encourages methoxydeiodination. Unlike polychloroiodobenzenes, polychlorobenzenes underwent methoxydechlorination. A mechanism involving nucleophilic attack by a carbanion was proposed. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Computed Properties of 364-12-5

The Article related to aryl iodide protiodeiodination kinetics, substituent effect protiodeiodination iodoarene, chlorobenzene methoxydechlorination kinetics, iodochlorobenzene substitution methanol kinetics and other aspects.Computed Properties of 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Hui; Zhang, Qing-Yong; Lu, Xiao-Bing published an article in 2016, the title of the article was Synthesis and catalytic application of N-heterocyclic carbene copper complex functionalized conjugated microporous polymer.HPLC of Formula: 934008-48-7 And the article contains the following content:

A N-heterocyclic carbene copper(I) complex functionalized conjugated microporous polymer (CMP-NHC-CuCl) was synthesized by palladium-catalyzed Sonogashira cross-coupling chem. The resulting CMP-NHC-CuCl proved to be a good heterogeneous catalyst in the hydrosilylation of functionalized terminal alkynes with boryldisiloxane to afford (β,β)-(E)-vinyldisiloxane with high stereoselectivity, and the catalyst could be used four times without obvious loss in catalytic activity. Moreover, CMP-NHC-CuCl was also efficient in catalyzing the hydrosilylation of CO2 with triethoxysilane to form silyl formate under mild conditions. The experimental process involved the reaction of 1H-Imidazolium, 1,3-bis[4-iodo-2,6-bis(1-methylethyl)phenyl]-, chloride (1:1)(cas: 934008-48-7).HPLC of Formula: 934008-48-7

The Article related to heterocyclic carbene copper functionalized conjugated microporous polymer preparation catalyst, terminal alkyne hydrosilylation conjugated microporous polymer imidazolidene copper catalyzed and other aspects.HPLC of Formula: 934008-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com