Author: Jessica.F

On November 21, 1994, Reichert, Veronica R.; Mathias, Lon J. published an article.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Expanded Tetrahedral Molecules from 1,3,5,7-Tetraphenyladamantane. And the article contained the following:

The goal of this paper was to investigate the effects of rigid tetrahedral cores (such as adamantane) on the properties of aramid and poly(phenylene) dendrimers as well as dendrimers that form single mol. micelles. This paper deals with model compound studies dealing with generating tetrasubstituted derivatives of adamantane. A previously reported procedure (for making tetraphenyladamantane) using tert-Bu bromide-AlCl3 catalyzed arylation of 1-bromoadamantane was found not to be a general synthetic method for the preparation of other substituted adamantane derivatives Adamantane derivatives with multiple Ph substituents were isolated only when benzene and bromobenzene were used in the Friedel-Crafts reaction. Tetraphenyl-substituted adamantane derivatives were formed, however, by the traditional Friedel-Crafts arylation of 1,3,5,7-tetrabromoadamantane with bromobenzene and 1,3-dibromobenzene. A lack of regioselectivity for these reactions (isolated mixtures of the meta/para isomers or ortho/meta isomers) was observed Large quantities (50-100 g) of 1,3,5,7-tetraphenyladamantane (1) were prepared from 1-bromoadamantane using a slightly modified literature procedure. This organic insoluble compound was iodinated with [bis(trifluoroacetoxy)iodo]benzene to give the all-para-substituted compound, 5. Compound 5 was further reacted to give numerous derivatives and used as a core in the synthesis of first generation dendrimers. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to tetraphenyladamantane derivative preparation dendrimer preparation modeling, polyphenylene dendrimer preparation model tetramethyladamantane derivative, core tetraphenyladamantane derivative polyamide polyphenylene dendrimer, polyamide dendrimer preparation model tetramethyladamantane derivative and other aspects.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 2, 2018, Morales, Guilermo A.; Garlich, Joseph R.; Durden, Donald L. published a patent.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate The title of the patent was Preparation of thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors. And the patent contained the following:

The title compounds I-VI [M = (independently) S or O; R1 = H, halo, alkyl, etc.; R2 = VII, VIII (wherein X = C, N, P, P(O), SiRb; n = 0-2; Y = CR1, O, S, NRa, etc.; Z = O or S; R1 = H or independently at each instance any group defined in R1; Rb = H or independently at each instance any group defined in R1; and wherein R2 in III excludes morpholine; Cyc = (un)substituted aryl, heterocycle, carbocycle); R3 = R1; R4 = R1; Rc = a hydrolyzable linker group which is optionally substituted with a targeting agent; Ar = an aryl, heterocycle, or heteroaryl group unsubstituted beyond the attachment to thiophene (or furan) ring; and the R3 substituent is in the meta- or para-positions], useful for treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-dependent disorder by modulating biol. processes by the inhibition of cell cycle checkpoint targets CDKs, and/or PI3 kinase, and/or bromodomain protein binding to substrates, were prepared E.g., a multi-step synthesis of IX, starting from 6-chloro-1-cyclopentyl-1,5,7-triaza-1H-indene-2-carboxylic acid and dimethylamine hydrochloride salt, was described. Representative compounds I were tested for their affinity toward CDK6, PI3K and BRD4 (data given). Pharmaceutical composition comprising compound I-VI was disclosed. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate

The Article related to thienopyranone furanopyranone preparation kinase bromodomain checkpoint inhibitor antitumor antiviral, proliferative autoimmune disease sepsis treatment antiatherosclerotic thienopyranone furanopyranone preparation, antidiabetic antiobesity antiinflammatory thienopyranone furanopyranone preparation and other aspects.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fyfe, James W. B.; Valverde, Elena; Seath, Ciaran P.; Kennedy, Alan R.; Redmond, Joanna M.; Anderson, Niall A.; Watson, Allan J. B. published an article in 2015, the title of the article was Speciation control during Suzuki-Miyaura cross-coupling of haloaryl and haloalkenyl MIDA boronic esters.Application of 1287221-36-6 And the article contains the following content:

Effects of aryl halide, water, base, reaction temperature, catalyst precursor and ligand on chemoselectivity of Suzuki coupling of PhBpin with 4-HalC6H4BMIDA, producing 4-PhC6H4Bpin with up to 92% selectivity, were evaluated. Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives The reaction is contingent upon control of the basic biphase and is thermodynamically driven: temperature control provides highly chemoselective access to either BMIDA adducts at room temperature or boronic acid pinacol ester (BPin) products at elevated temperature Control experiments and solubility analyses have provided some insight into the mechanistic operation of the formal homologation process. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).Application of 1287221-36-6

The Article related to suzuki coupling chemoselectivity pinacol mida boronate preparation biaryl, aryl halide solvent base temperature effect chemoselectivity suzuki coupling, homologation boronate arylene insertion chemoselective suzuki coupling pinacol mida, boron, chemoselectivity, cross-coupling, palladium, speciation and other aspects.Application of 1287221-36-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 18, 2007, Saavedra, Oscar Mario; Claridge, Stephen William; Zhan, Lijie; Raeppel, Franck; Vaisburg, Arkadii; Raeppel, Stephane; Deziel, Robert; Mannion, Michael; Zhou, Nancy Z.; Isakovic, Ljubomir published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Thienopyridine and thienopyrimidine derivatives and their preparation, pharmaceutical compositions, and use as inhibitors of VEGF receptor and HGF receptor signaling for treatment of proliferative diseases. And the patent contained the following:

The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling. The invention provides compounds of formula I and methods for inhibiting VEGF receptor signaling and HGF receptor signaling for treatment of proliferative diseases. Compounds of formula I, wherein T is (un)substituted (hetero)aryl(alkyl), cycloalkyl or heterocyclyl; W is O, S, NH, or NMe; Z is O, S, or NH; X and X1 are independently H, (un)substituted C1-6 alkyl, halo, CN, or NO2; or X and X1 together may form C3-7 cycloalkyl; R1, R2, R3, R4 are independently H, halo, trihalomethyl, CN, NO2, NH2 and derivatives, OH and derivatives, CO2H and derivatives, COH and derivatives, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; R5 is H, CN, (un)substituted (CH2)2-5 (hetero)aryl, (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl, C2-6 alkynyl, CH2(CH2)0-4T2, (un)substituted C1-4 alkylcarbonyl, (un)saturated 3- to 7-membered carboxycyclic or heterocyclic group; where T2 is OH, OMe, OEt, NH2, NHMe, or NMe2; Q is CH2, O, S, NH, N(C1-6 alkyl), N(alkyl)aryl, NOMe, NCH2OMe, or NBn; D is C-E or N; L is N or CR where R is H, halo, CN, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; E is E1, E2 or E3 wherein E1 is H, halo, NO2, azido, (un)substituted C1-6 alkyl, C3-10 cycloalkyl, etc.; E2 is (un)substituted alkynes; E3 is (un)substituted heterocyclyl(ene); and the pharmaceutically acceptable salts and complexes thereof are claimed in this invention. Example compound II was prepared by chlorination of thieno[3,2-b]pyridine-7-ol followed by carboxylation and the resulting lithium carboxylate was converted into the corresponding acid chloride, which reacted with dimethylamine to give compound III; compound III underwent coupling with 2-fluoro-4-nitrophenol, and the resulting 7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthienopyridinecarboamide was reduced to give the corresponding arylamine, which was reacted with phenylacetyl isocyanate to give example compound II. Addnl. 329 examples were prepared in this invention. The example compounds were tested for their in vitro HGF receptor and VEGF receptor signaling inhibition and solid tumor growth inhibition. The invention compounds showed inhibitory activity and was reported to have IC50 values less than 50 nM, ≥50 but <250 nM, ≥250 but <500 nM, ≥ 500 nM, or no activity in various assays. Example compound II showed and IC50 of >50 nM for inhibition of VEGF receptors, and this compound also showed tumor growth inhibition (TGI) against several types of tumors. Example compound II had greater than 100% TGI against U87MG, which indicated tumor shrinkage. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to thienopyridine preparation pharmaceutical composition, thienopyrimidine preparation vegf hgf receptor signaling inhibitor, thieno pyridine preparation vegf hgf receptor signaling inhibitor, pyridine thieno preparation treatment proliferative disease, pyrimidine thieno preparation treatment proliferative disease and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Katherine M. E.; Mahmoudkhani, Amir H.; Chandler, Brett D.; Shimizu, George K. H. published an article in 2006, the title of the article was An adamantane-based tetraphosphonic acid that forms an open diamondoid net via a hydrogen-bonded phosphonic acid-water cluster.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane And the article contains the following content:

An adamantane-based tetraphosphonic acid (1,3,5,7-tetrakis(4-phosphonophenyl)adamantane·4H2O·2CHCl3) H-bonds into unprecedented tetrahedral clusters with H2O to form a 4-fold interpenetrated diamondoid net, incorporating both hydrophobic and hydrophilic domains. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to phosphonophenyladamantane hydrate chloroform crystal self assembly preparation structure, adamantane tetrakisphosphonophenyl diamondoid net hydrogen bonded water cluster preparation, crystal structure phosphonophenyladamantane hydrate chloroform assembly, mol structure phosphonophenyladamantane hydrate chloroform assembly and other aspects.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Grigg, Ronald; Elboray, Elghareeb E.; Aly, Moustafa F.; Abbas-Temirek, Hussien H. published an article in 2012, the title of the article was Exploiting adamantane as a versatile organic tecton: multicomponent catalytic cascade reactions.Application of 144970-30-9 And the article contains the following content:

3- And 9-component Pd(0) catalyzed assembly of allenes, aryl iodides and N-nucleophiles with concomitant installation of trisubstituted Z-alkenes is readily achieved. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application of 144970-30-9

The Article related to adamantane z alkene organic tecton stereoselective preparation, adamantanamine iodoarene allene palladium multicomponent catalytic diastereoselective cascade, iodophenyladamantane amine amino acid allene palladium multicomponent diastereoselective cascade, multicomponent catalytic diastereoselective cascade catalyst palladium and other aspects.Application of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 5, 2014, Valera, Silvia; Taylor, James E.; Daniels, David S. B.; Dawson, Daniel M.; Athukorala Arachchige, Kasun S.; Ashbrook, Sharon E.; Slawin, Alexandra M. Z.; Bode, Bela E. published an article.Category: iodides-buliding-blocks The title of the article was A Modular Approach for the Synthesis of Nanometer-Sized Polynitroxide Multi-Spin Systems. And the article contained the following:

Rigid sym. poly(tetramethylpyrrolinyloxy) radicals such as I were prepared for studying the effect of distance on interradical interactions; their room temperature continuous wave (CW) EPR spectra are reported. The nitroxide polyradicals were prepared using the esterification of the tetramethylpyrrolinyloxycarboxylic acid II with polyphenols as a key step. Sym. di- and trinitroxides with aromatic cores and a tetranitroxide with an adamantane core were prepared by this method. The structures of I and a bis(tetramethylpyrrolidinecarboxylate) diester of resorcinol were determined by X-ray crystallog. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

The Article related to rigid methylpyrrolinyloxy diradical triradical tetraradical preparation cw epr spectrum, nitroxide rigid diradical triradical tetraradical preparation, esterification polyphenol methylpyrrolinyloxycarboxylic acid modular preparation polyradical, methylpyrrolinyloxycarboxylate resorcinol phloroglucinol ester mol crystal structure and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 27, 2003, Vasylyev, Maxym; Popovitz-Biro, Ronit; Shimon, Linda J. W.; Neumann, Ronny published an article.Synthetic Route of 144970-30-9 The title of the article was Inorganic-organic hybrid materials based on Keggin type polyoxometalates and organic polyammonium cations. And the article contained the following:

Co-crystallization of a triammonium cation with short and somewhat flexible ‘arms’, [N,N,N-tris[2-(dimethylamino)ethyl]-1,3,5-benzenetricarboxamide]3+, with a polyoxometalate trianion, PW12O403-, yielded an insoluble channeled or microporous structure (crystal data reported). The polyoxometalate clusters are arranged in a layered and zigzag fashion along the xy plane. Looking along the x-axis, channels of a dimension of ∼3.5×∼6.5 Å are observed C-H···O bonds aided in determining the crystal packing by providing directionality to the anion-cation interaction. However, the co-crystallization of a tetraammonium cation with an extended and rigid tetrahedral configuration, 1,3,5,7-tetrakis{4-[(E)-2(N-methylpyridinium-4-yl)vinyl]phenyl}adamantane tetraiodide, with a polyoxometalate tetracation, SiW12O404-, yielded a lamellar structure with alternating layers with spacing of 16.6 Å of the inorganic-organic hybrid material. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Synthetic Route of 144970-30-9

The Article related to structure control organic cation polyoxometalate salt, crystal structure trisdimethylaminoethylbenzenetricarboxamide phosphotungstate, silicotungstate tetrakismethylpyridiniumylvinylphenyladamantane salt preparation, tungstate phospho silico organic cation preparation structure control, microporous polyoxometalate organic cation structure control and other aspects.Synthetic Route of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 29, 2010, Lee, Chi-Hang; Zhang, Yongyi; Romayanantakit, Apiwat; Galoppini, Elena published an article.Computed Properties of 144970-30-9 The title of the article was Modular synthesis of ruthenium tripodal system with variable anchoring groups positions for semiconductor sensitization. And the article contained the following:

The authors describe an improved synthetic approach to access tripodal compounds with variable footprints and anchor groups. Two Ru(II) bipyridine tripodal complexes with three carboxylic acid groups in meta (Ru-m-COOH, 1; I) and para (Ru-p-COOH, 2; II) positions, and with large (180-250 Å2) footprints were synthesized and bound to the surface of nanostructured TiO2. Selected properties of 1 and 2 in solution and bound are reported. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Computed Properties of 144970-30-9

The Article related to bipyridineethynylphenyladamantane carboxylate derivative preparation ruthenium complex, electrochem ruthenium bipyridineethynylphenyladamantane carboxylic ester complex, fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid complex, quenching fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid titanium dioxide and other aspects.Computed Properties of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com