Author: Jessica.F

COA of Formula: C2H4I2In 2019 ,《A Practical Synthesis of Ammonia from Nitrogen Gas, Samarium Diiodide and Water Catalyzed by a Molybdenum-PCP Pincer Complex》 appeared in Synthesis. The author of the article were Ashida, Yuya; Kondo, Shoichi; Arashiba, Kazuya; Kikuchi, Takamasa; Nakajima, Kazunari; Kakimoto, Seizo; Nishibayashi, Yoshiaki. The article conveys some information:

A practical method for ammonia synthesis is described. The reaction of atm. pressure of nitrogen gas with samarium diiodide as a reducing reagent and water as a proton source in the presence of a catalytic amount of a molybdenum trichloride complex bearing a PCP [1,3-bis(di- tert-butylphosphinomethyl)benzimidazol-2-ylidene]-type pincer ligand occurs under ambient conditions to afford ammonium sulfate after treatment with sulfuric acid. After reading the article, we found that the author used 1,2-Diiodoethane(cas: 624-73-7COA of Formula: C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2020 ,《A pyranoxanthone as a potent antimitotic and sensitizer of cancer cells to low doses of paclitaxel》 appeared in Molecules. The author of the article were Franca, Fabio; Silva, Patricia M. A.; Soares, Jose X.; Henriques, Ana C.; Loureiro, Daniela R. P.; Azevedo, Carlos M. G.; Afonso, Carlos M. M.; Bousbaa, Hassan. The article conveys some information:

Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors the integrity of the mitotic spindle and proper chromosome attachments to microtubules in order to ensure accurate chromosome segregation and timely anaphase onset. However, the cytotoxic activity of MTAs is restrained by drug resistance and/or toxicities, and had motivated the search for new compounds and/or alternative therapeutic strategies. Here, we describe the synthesis and mechanism of action of the xanthone derivative pyranoxanthone 2 that exhibits a potent anti-growth activity against cancer cells. We found that cancer cells treated with the pyranoxanthone 2 exhibited persistent defects in chromosome congression during mitosis that were not corrected over time, which induced a prolonged SAC-dependent mitotic arrest followed by massive apoptosis. Importantly, pyranoxanthone 2 was able to potentiate apoptosis of cancer cells treated with nanomolar concentrations of paclitaxel. Our data identified the potential of the pyranoxanthone 2 as a new potent antimitotic with promising antitumor potential, either alone or in combination regimens.2-Iodobenzoic acid(cas: 88-67-5Category: iodides-buliding-blocks) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Category: iodides-buliding-blocks In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Green Chemistry included an article by Ke, Fang; Xu, Yiwen; Zhu, Suning; Lin, Xiaoyan; Lin, Chen; Zhou, Sunying; Su, Huimin. Related Products of 88-67-5. The article was titled 《Electrochemical N-acylation synthesis of amides under aqueous conditions》. The information in the text is summarized as follows:

An electrochem. N-acylation of carboxylic acids with amines was reported for the synthesis of amides I [R1 = H, 4-CN, 2-I, etc.; R2 = H, 4-Me, 4-Cl, etc.]. The sustainable TBAB electrocatalysis proceeded with excellent chemoselectivity and positional selectivity, and with ample scope, allowing electrochem. N-acylation under mild reaction conditions at room temperature in water. Moreover, the synthetic utility of the current method was demonstrated by the synthesis of melatonin. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Related Products of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 88-67-5Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Green Chemistry included an article by Ge, Xin; Zhang, Shihui; Chen, Xinzhi; Liu, Xuemin; Qian, Chao. Name: 1-Iodo-4-methylbenzene. The article was titled 《A designed bi-functional sugar-based surfactant: micellar catalysis for C-X coupling reaction in water》. The information in the text is summarized as follows:

A bi-functional sugar-based surfactant ALA14 was designed as the ligand and micelle constructor and demonstrated to promote the copper-catalyzed C-X coupling reaction in water. The nature of this micelle, formed by sugar-based surfactants, was investigated with CMC, DLS, and TEM, by which encapsulation and aggregation of the substrates in micelles were verified. Addnl., it was addressed by 1H-NMR anal. that the enrichment position of the substrates is in the lipophilic alkyl chain. Finally, moderate to excellent yields of the aimed products were obtained in this work. This remarkably simple strategy expanded the scope of C-X coupling reaction in water; most notably, both water and ALA14 can be recycled and reused. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Name: 1-Iodo-4-methylbenzene) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Name: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,ChemistrySelect included an article by Liu, Na; Tian, An-Qi; Ren, Zhi-Lin; Wang, Long. Related Products of 591-18-4. The article was titled 《Efficient Synthesis of Sulfonyl Diphenylsulfides Catalyzed via Cu-MOF of PCN-6’》. The information in the text is summarized as follows:

A metal organic framework of PCN-6′ was used, prepared from copper compound and triazine-2,4,6-triyl-benzoate (H3TATB) ligand, to catalyze the tandem reaction of disulfide with aryl iodide and sulfonyl chloride to synthesize of sulfonyl diphenylsulfides. A series of sulfonyl diphenylsulfide derivatives were synthesized with medium or high yields. The results came from multiple reactions, including the reaction of 1-Bromo-3-iodobenzene(cas: 591-18-4Related Products of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Related Products of 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis and Bacteriostatic Activities of Modified Flutriafol Derivatives》 were Guo, Haoquan; Dong, Yuguo; Zhou, Xuliang; Lu, Xinyu; Zhu, Xiaojun; Que, Han; Wu, Zhipeng; Cheng, Kanghua; Gu, Xiaoli. And the article was published in ACS Omega in 2019. Application In Synthesis of Trimethylsulfoxonium iodide The author mentioned the following in the article:

This study aimed to evaluate the preservative ability of modified flutriafol derivatives against decay fungi. The bacteriostatic effect of flutriafol on Trichoderma viride was not efficient as expected. Flutriafol was modified as a parent substrate to improve its broad spectrum performance. Six triazole compounds were synthesized by Friedel-Crafts reaction, oxygen-sulfur-ylide reaction, and ring-opening addition reaction. The structures of the target products were determined by 1H NMR and MS. Antibacterial and antileakage tests were performed to optimize the most efficient agents among triazole target products. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6Application In Synthesis of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Application In Synthesis of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《3-(4-Iodophenyl)pentanedinitrile》 were Nanpo, Yuuki; Okuno, Tsunehisa. And the article was published in IUCrData in 2019. Application In Synthesis of 4-Iodobenzaldehyde The author mentioned the following in the article:

In the title pentanedinitrile derivative, C11H9IN2, the iodophenyl group is connected at the 3-position. The central propylene chain of the pentanedinitrile moiety contains one gauche conformation as a result of steric repulsion with the Ph ring. Intermol. close contacts in the crystal comprise a weak Csp3-H···N hydrogen bond and a C-I···N halogen bond. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzaldehyde(cas: 15164-44-0Application In Synthesis of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Application In Synthesis of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Recyclable Heterogeneous Palladium-Catalyzed Carbonylative Cyclization of 2-Iodoanilines with Aryl Iodides Leading to 2-Arylbenzoxazinones》 was published in Synthesis in 2020. These research results belong to Xu, Zhaotao; Huang, Bin; Zhou, Zebiao; Cai, Mingzhong. Synthetic Route of C6H5ClIN The article mentions the following:

A highly efficient and practical heterogeneous palladium-catalyzed carbonylative coupling of 2-iodoanilines R-2-IC6H3NH2 (R = H, 4-Me, 5-Cl, 4-CN, etc.) with aryl iodides ArI (Ar = Ph, naphthalen-1-yl, thiophen-3-yl, etc.) has been developed. The reaction occurs smoothly in toluene at 110°C with N,N-diisopropylethylamine as base under carbon monoxide (5 bar) and offers a general and powerful tool for the construction of various valuable 2-arylbenzoxazinones I (R1 = H, 6-Me, 7-Cl, 6-CN, etc.) with excellent atom-economy, high functional group tolerance, good to high yields, and easy recyclability of the palladium catalyst. The reaction is the first example of heterogeneous palladium-catalyzed carbonylative coupling for the preparation of diverse 2-arylbenzoxazinones I from com. easily available 2-iodoanilines and aryl iodides. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《CuBr-Catalyzed One-Pot Three-Component Synthesis of Novel 2-(Carbazolyl)benzothiazoles》 was published in Synlett in 2020. These research results belong to Meesala, Ramu; Lee, Yean Kee; Arshad, Ahmad Saifuddin Mohamad; Abdullah, Iskandar; Mordi, Mohd Nizam; Abd Rahman, Noorsaadah. Product Details of 63069-48-7 The article mentions the following:

A facile synthesis of various 2-(carbazolyl)benzothiazoles were synthesized by one-pot CuBr-catalyzed three-component reactions of 2-iodoanilines, aryl aldehydes and elemental sulfur. Reaction exhibited a good functional group tolerance to produce the corresponding 2-(carbazolyl)benzothiazoles in good yields in the absence of any additive. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Hierarchically hollow structured NiCo2S4@NiS for high-performance flexible hybrid supercapacitors》 was written by Qu, Guangmeng; Li, Chuanlin; Hou, Peiyu; Zhao, Gang; Wang, Xiao; Zhang, Xiaoli; Xu, Xijin. SDS of cas: 516-12-1 And the article was included in Nanoscale in 2020. The article conveys some information:

Hierarchical nanostructures with outstanding electrochem. properties and mech. stability are ideal for constructing flexible hybrid supercapacitors. Herein, hierarchically hollow NiCo2S4@NiS nanostructures were designed and synthesized by sulfurizing the hierarchical NiCo double hydroxides (DHs) coated with nickel hydroxide nanostructures on carbon fabrics (NiCo-DHs@Ni(OH)2/CF), which trigger excellent electrochem. performances. The NiCo2S4@NiS/CF exhibits a high specific capacity of 1314.0 C g-1 at a c.d. of 1 A g-1, and maintains the rate performance at about 79.2% of the initial capacity at 30 A g-1. The hybrid supercapacitors of NiCo2S4@NiS//AC display a high energy d. of 62.4 W h kg-1 at a power d. of 800 W kg-1 with a remarkable cycling stability (96.2% of initial capacitance after 5000 cycles) and robust mech. flexibility (no obvious decay of specific capacitance during various deformations). Consequently, NiCo2S4@NiS electrodes are expected to be a promising candidate for new smart energy storage devices with high security, stability and flexibility. The experimental part of the paper was very detailed, including the reaction process of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1SDS of cas: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. SDS of cas: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com