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Bendelsmith, Andrew J.’s team published research in Journal of the American Chemical Society in 2019 | CAS: 624-73-7

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Formula: C2H4I2

In 2019,Journal of the American Chemical Society included an article by Bendelsmith, Andrew J.; Kim, Seohyun Chris; Wasa, Masayuki; Roche, Stephane P.; Jacobsen, Eric N.. Formula: C2H4I2. The article was titled 《Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis》. The information in the text is summarized as follows:

Chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of α-allyl amino esters is reported. The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allylation of readily accessible α-chloro glycinates. A variety of useful α-allyl amino esters were prepared, including crotylated products bearing vicinal stereocenters that are inaccessible through enolate alkylation, with high enantioselectivity (up to 97% ee) and diastereoselectivity (>10:1). The reactions display 1st-order kinetic dependence on both the α-chloro glycinate and the nucleophile, consistent with rate-limiting C-C bond formation. Computational anal. of the uncatalyzed reaction predicts an energetically inaccessible iminium intermediate, and a lower energy concerted SN2 mechanism. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Formula: C2H4I2)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mao, Min’s team published research in Journal of Materials Science: Materials in Electronics in 2020 | CAS: 516-12-1

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

《Enhancement of catalytic hydrogen evolution by NiS modification of ZnCo2O4 with cubic morphology》 was written by Mao, Min; Xu, Jing; Li, Jingjiao; Zhao, Sheng; Li, Xuanhao. Related Products of 516-12-1 And the article was included in Journal of Materials Science: Materials in Electronics in 2020. The article conveys some information:

A review. Abstract: It was the constant pursuit of researchers to explore catalysts with higher catalytic activity, and the use of co-catalysts to modify the performance of photocatalytic materials had a significant effect on charge separation In this paper, the non-precious metal NiS-modified ZnCo2O4 composite catalytic material prepared by hydrothermal method had high-efficiency catalytic performance. When the weight ratio of NiS to ZnCo2O4 was 12%, the optimal catalytic activity is 3.57 mmol g-1 h-1, which was more than twice that of ZnCo2O4. The presence of NiS not only improved the sp. surface area of the catalyst and its ability to respond to light, but the close interface formed by the combination of the two monomer phases accelerated the transfer and the utilization of the photocharge on ZnCo2O4 to NiS, thereby promoting the separation of electron holes and improving the photocatalytic activity of the catalyst. According to the research results, the mechanism of hydrogen production in the photocatalytic system was revealed. In this paper, NiS was used to modify the bimetallic oxide with cubic appearance, which provided a new strategy for the development of new photocatalysts. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ye, Ning’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 301673-14-3

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.COA of Formula: C10H18INO2

Ye, Ning; Wu, Bin; Zhao, Kangming; Ge, Xiaobin; Zheng, Yu; Shen, Xiaodong; Shi, Lei; Cortes-Clerget, Margery; Regnier, Morgan Louis; Parmentier, Michael; Gallou, Fabrice published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Micelle enabled C(sp2)-C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis》.COA of Formula: C10H18INO2 The article contains the following contents:

A robust and sustainable C(sp2)-C(sp3) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions. This protocol provided a general method to access alkylated arenes with good to excellent yields on a very large scale. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3COA of Formula: C10H18INO2)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tang, Shi’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 15164-44-0

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Formula: C7H5IO

Tang, Shi; Ding, Shumin; Li, Dan; Li, Lianjie; Zhao, Haixia; Chai, Minxue; Wang, Jian published an article in 2021. The article was titled 《Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Formula: C7H5IO The information in the text is summarized as follows:

A palladium-catalyzed construction of spiroindolines through dearomative spirocyclization of 3-(2-isocyanoethyl)indoles was developed. 2′-Aryl-, vinyl-, and alkyl-substituted spiroindolines were accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- and indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion and an imidoylative spirocyclization cascade. Addnl., a tandem dearomatization of two different indoles was realized with N-(2-bromobenzoyl)indoles as the electrophilic coupling partner of 3-(2-isocyanoethyl)indoles, affording polyindoline – spiroindoline bisheterocyclic scaffolds conveniently. Under the catalysis of Pd(OAc)2 and a spinol-derived phosphoramidite ligand, chiral spiroindolines were successfully accessed with up to 95% yield and 85% ee. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Formula: C7H5IO)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Arotsky, Judah’s team published research in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1973 | CAS: 41252-95-3

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Application of 41252-95-3 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

The author of 《Iodination and iodo compounds. IV. Effect of substituents and solvent composition on the rate of aromatic iodination by the triiodine cation》 were Arotsky, Judah; Darby, A. Carl; Hamilton, John B. A.. And the article was published in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1973. Application of 41252-95-3 The author mentioned the following in the article:

The rate and products of the reaction of deactivated substituted benzenes (e.g., 4-ClC6H4CO2h) and I3+ in H2SO4 were studied. The rate constants were correlated by the electrophilic substituent constants σ+ to give the reaction constant ρ = -6.4. The kinetic isotope effect for the iodination of benzoic acid was kH/kD = 2. The rate of iodination increased as the proportion of H2O in the solvent increased. The results came from multiple reactions, including the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Application of 41252-95-3)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ren, Jing’s team published research in Chinese Chemical Letters in 2022-11-30 | 1391728-13-4

Chinese Chemical Letters published new progress about Benzoic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Synthetic Route of 1391728-13-4.

Ren, Jing; Jia, Meng-Cheng; Du, Feng-Huan; Zhang, Chi published the artcile< A general method for one-step synthesis of monofluoroiodane(III) reagents using silver difluoride>, Synthetic Route of 1391728-13-4, the main research area is iodobenzene silver difluoride oxidative fluorination; aryl monofluoroiodane preparation.

A new general method for one-step synthesis of four kinds of fluoroiodane(III) reagents by treating the corresponding aryl iodides with silver difluoride (AgF2) was reported. This is the first method applicable for the synthesis of all four fluoroiodane(III) reagents including p-iodotoluene difluoride, fluoro-benziodoxoles, fluoro-benziodoxolones and fluoro-N-acetylbenziodazole. AgF2 was firstly employed in the direct oxidative fluorination of iodobenzene and thus has shown its outstanding oxidation and fluorine-transfer ability. The use of AgF2 has improved the synthesis of fluoroiodane(III) reagents by shortening the reaction steps, avoiding the use of hazardous reagents and simplifying the exptl. operations. It was worth noting that the developed first one-step direct synthetic method for fluoro-benziodoxolones, while fluoro-benziodoxolones can only be synthesized through Cl→F ligand exchange reaction previously.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Polivkova, Jana’s team published research in Synthetic Communications in 2013-03-01 | 2265-92-1

Synthetic Communications published new progress about Diastereoselective synthesis. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Category: iodides-buliding-blocks.

Polivkova, Jana; Piotrowski, David W. published the artcile< Stereodefined Cyclopentanes by Hydroarylation-Ring Opening>, Category: iodides-buliding-blocks, the main research area is stereodefined cyclopentane preparation; hydroarylation azabicycloheptenone nucleophilic ring opening.

The hydroarylation of 2-azabicyclo[2.2.1]hept-5-en-3-one followed by nucleophilic ring opening was employed as an operationally simple route to stereodefined trisubstituted cyclopentane analogs. This synthetic sequence was successfully executed using a variety of nucleophiles including hydroxide, alkoxide, hydride, Grignard reagents, and amines. E.g., hydroarylation of rac-2-azabicyclo[2.2.1]hept-5-en-3-one with PhI, followed by reaction with di-tert-Bu dicarbonate, gave 15% I and 25% II. Ring opening of II with LiOH in water gave 71% cyclopentane derivative (III). This methodol. facilitated the preparation of a constrained version of dipeptidylpeptidase 4 inhibitor sitagliptin.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Yuliang’s team published research in Organic Letters in 2021-01-15 | 887266-99-1

Organic Letters published new progress about Aralkyl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 887266-99-1 belongs to class iodides-buliding-blocks, and the molecular formula is C7H3FIN, HPLC of Formula: 887266-99-1.

Liu, Yuliang; Li, Haoyu; Chiba, Shunsuke published the artcile< Photoinduced Cross-Coupling of Aryl Iodides with Alkenes>, HPLC of Formula: 887266-99-1, the main research area is aryl iodide alkene photoinduced cross coupling UV absorption.

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes was developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes was proposed. The method enabled iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sugihara, Naoki’s team published research in Journal of the American Chemical Society in 2021-06-30 | 887266-99-1

Journal of the American Chemical Society published new progress about Allylation (defluoro-. 887266-99-1 belongs to class iodides-buliding-blocks, and the molecular formula is C7H3FIN, Name: 3-Fluoro-4-iodobenzonitrile.

Sugihara, Naoki; Suzuki, Kensuke; Nishimoto, Yoshihiro; Yasuda, Makoto published the artcile< Photoredox-Catalyzed C-F Bond Allylation of Perfluoroalkylarenes at the Benzylic Position>, Name: 3-Fluoro-4-iodobenzonitrile, the main research area is pperfluoroalkylarene allylic stannane defluoroallylation iridium photoredox catalyst.

Site-selective and direct C-F bond transformation of perfluoroalkylarenes was achieved with allylic stannanes via an iridium photoredox catalyst system. The present defluoroallylation proceeds exclusively at the benzylic position through perfluoroalkyl radicals generated by a single-electron transfer from an excited photoredox catalyst to perfluoroalkylarenes. A variety of perfluoroalkyl groups are applicable: linear perfluoroalkyl-substituted arenes such as Ar-nC4F9 and Ar-nC6F13 and heptafluoroisopropylarenes (Ar-CF(CF3)2) underwent site-selective defluoroallylation. DFT calculation studies revealed that the in situ generated Bu3SnF traps F- to prevent a retroreaction from the unstable perfluoroalkyl radical intermediate, and the radical intermediate favorably reacts with allylic stannanes. The synthesis of a bis(trifluoromethyl)methylene unit containing compound, which is an analog that is useful as a pharmaceutical agent for the prophylaxis or treatment of diabetes and inflammatory diseases, demonstrated the utility of this reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Granados, Albert’s team published research in Journal of Organic Chemistry in 2020-08-21 | 1391728-13-4

Journal of Organic Chemistry published new progress about Absolute configuration. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Name: 1-Fluoro-3,3-dimethyl-1,2-benziodoxole.

Granados, Albert; Ballesteros, Anna; Vallribera, Adelina published the artcile< Enantioenriched quaternary α-pentafluoroethyl derivatives of alkyl 1-indanone-2-carboxylates>, Name: 1-Fluoro-3,3-dimethyl-1,2-benziodoxole, the main research area is enantioenriched pentafluoroethylated alkyl indanone carboxylate preparation pybox ligand catalyst; pentafluoroethylation alkyl indanone carboxylate pybox ligand catalyst.

An electrophilic enantioselective catalytic method for the α-pentafluoroethylation of 3-oxoesters is described. Under the use of La(OTf)3 in combination with a (S,R)-indanyl-pybox ligand, good results in terms of yield and enantioselectivities were achieved (up to 89% ee). The reaction proceeds under mild conditions, leading to the formation of enantioenriched quaternary centers. This methodol. uses an hypervalent iodine(III)-CF2CF3 reagent, and mechanistic investigations are consistent with the involvement of a radical pathway. An electrophilic enantioselective catalytic method for the α-pentafluoroethylation of alkyl 1-indanone-2-carboxylates is described. Under the use of La(OTf)3 in combination with (S,R)-indanyl-pybox ligand good results in terms of yield and enantioselectivities were achieved (up to 89% ee). The reaction proceeds under mild conditions leading to the formation of enantioenriched quaternary centers. This methodol. uses an hypervalent iodine(III)-CF2CF3 reagent and mechanistic investigations are consistent with the involvement of a radical pathway.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com