Author: Jessica.F

Sviripa, Vitaliy M.; Zhang, Wen; Kril, Liliia M.; Liu, Alice X.; Yuan, Yaxia; Zhan, Chang-Guo; Liu, Chunming; Watt, David S. published the artcile< Halogenated diarylacetylenes repress c-myc expression in cancer cells>, Recommanded Product: 1,4-Difluoro-2-iodobenzene, the main research area is halogenated diarylacetylene preparation cmyc inhibitor cancer; Antineoplastic agents; Colon cancer; Diarylacetylenes; c-myc.

Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiproliferative agents. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Recommanded Product: 1,4-Difluoro-2-iodobenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cortes Gonzalez, Miguel A.; Jiang, Xingguo; Nordeman, Patrik; Antoni, Gunnar; Szabo, Kalman J. published the artcile< Rhodium-mediated 18F-oxyfluorination of diazoketones using a fluorine-18-containing hypervalent iodine reagent>, Electric Literature of 1391728-13-4, the main research area is alpha fluoro ether preparation; diazoketone trimethyl orthoformate oxyfluorination rhodium catalyst.

Geminal 18F-oxyfluorination of diazoketones was performed in the presence of rhodium catalyst and hypervalent iodine-based [18F]fluoro-benziodoxole reagent to get various α-[18F]fluoro ethers I [R = Ph, 2-furyl, 4-MeC6H4, etc.] in high radiochem. yield (up to 98%) and molar activity (216 GBq μmol-1).

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Benniston, Andrew C.; Harriman, Anthony; Li, Peiyi; Rostron, James P.; Harrington, Ross W.; Clegg, William published the artcile< A spectroscopic study of the reduction of geometrically restrained viologens>, COA of Formula: C5H4INO, the main research area is spectroscopy reduction geometry restrained viologen.

A small series of N,N’-dimethyl-4,4′-bipyridinium dication derivatives (commonly known as viologens) has been synthesized and fully characterized; a short dialkoxy tether attached at the 3,3′-positions is used to alter the central dihedral angle. These angles were determined by both single-crystal X-ray diffraction and by computational studies made for the dication, radical cation, and neutral species in a solvent reservoir. The dihedral angle derived for the dication controls the first reduction potential, whereas the geometry of the resultant π-radical cation determines the magnitude of the second reduction potential. The optical absorption spectra recorded for the various species, and especially those of the radical cations, and the EPR spectral parameters of the π-radical cations also depend on the mol. geometry. In particular, the central dihedral angle influences the spin d. distribution around the aromatic nucleus and, by way of comparison to the parent viologen, it has been possible to resolve the angle dependence from the inherent inductive effect of the strap. These results are considered in terms of the degree of electronic communication between the two aromatic rings, as controlled by the length of the tether.

Chemistry – A European Journal published new progress about Crystal structure. 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, COA of Formula: C5H4INO.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fyfe, Tim J.; Kellam, Barrie; Sykes, David A.; Capuano, Ben; Scammells, Peter J.; Lane, J. Robert; Charlton, Steven J.; Mistry, Shailesh N. published the artcile< Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor>, HPLC of Formula: 2265-92-1, the main research area is structure pharmacokinetics haloperidol dopamine D2 receptor.

Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side-effects (EPS) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with contrasting kinetic profiles. Haloperidol displays fast association/slow dissociation at the D2R whereas clozapine exhibits relatively slow association/fast dissociation Recently, the authors have provided evidence that slow dissociation from the D2R predicts hyperprolactinemia, whereas fast association predicts EPS. Unfortunately, clozapine can cause severe side-effects independent of its D2R action. The results suggest an optimal kinetic profile for D2R antagonist APDs that avoids EPS. To begin exploring this hypothesis, the authors conducted a structure-kinetic relationship study of haloperidol and reveal that subtle structural modifications dramatically change binding kinetic rate constants, affording compounds with a clozapine-like kinetic profile. Thus, optimization of these kinetic parameters may allow development of novel APDs based on the haloperidol scaffold with improved side-effect profiles.

Journal of Medicinal Chemistry published new progress about Dopamine D2 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jie, Jingrui; Xu, Qinqin; Yang, Guang; Feng, Yaqing; Zhang, Bao published the artcile< Porphyrin sensitizers involving a fluorine-substituted benzothiadiazole as auxiliary acceptor and thiophene as π bridge for use in dye-sensitized solar cells (DSSCs)>, Category: iodides-buliding-blocks, the main research area is photosensitizing dye sensitized solar cell fluorine substitution zinc porphyrin.

Three ′donor-acceptor-π bridge-acceptor′ (D-A-π-A) type zinc porphyrin sensitizers TH-0F, TH-1F and TH-2F with a benzothiadiazole (BTD) unit bearing no fluorine, one fluorine and two fluorine atoms, resp., as the auxiliary acceptor and thiophene as the π bridge were designed and synthesized for use in dye-sensitized solar cells (DSSCs). The influence of fluorine atom and thiophene unit on the photophys. and photochem. properties of the sensitizers was investigated. It was shown that the photon to current conversion efficiencies (PCE) of three sensitizer-based devices increased in the order of TH-2F > TH-1F > TH-0F, with the highest PCE of 6.98% achieved for the TH-2F-based device. To further understand the mol. structure of the TH series of dyes, a d. functional (DFT) calculation was performed. The result suggests that the strong electron-withdrawing ability of the fluorine atom, along with the intramol. interaction between the auxiliary acceptor and thiophene, optimized the electronic configuration, thereby facilitating the intramol. charge transfer efficiency and ultimately improving the performance of the corresponding device.

Dyes and Pigments published new progress about Bond angle, dihedral. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Le Strat, Frederic; Harrowven, David C.; Maddaluno, Jacques published the artcile< New Approaches to Bicyclic Vinyl Heterocycles from Propargylic Acetals>, Name: 4-Iodopyridin-3-ol, the main research area is bicyclic vinyl heterocycle preparation; intramol carbolithiation propargylic acetal; palladium catalyst cyclization propargylic acetal.

The paper describes further studies on the intramol. carbolithiation of propargylic acetals with aryllithiums leading to 2-vinylbenzofurans and 3-vinylfuropyridines. E.g., isomerization of propargylic acetal I to the allene on treatment with t-BuOK, followed by treatment with BuLi gave the 3-vinylfuropyridine II (E:Z 9:1). Attempts to extend the cascade to [4.4.0] binuclear heterocycles met with limited success. An alternative, two-step entry to such ring systems has been developed using the palladium-induced cyclization/hydride capture methodol. E.g., Pd(OAc)2 catalyzed the cyclization of propargylic acetal III to give 51% chromene I (100% E). A new route to isoquinolinones from simple benzamides is also disclosed.

Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (propargylic). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Name: 4-Iodopyridin-3-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com