Author: Jessica.F

Total Synthesis of Isohericenone J via a Stille Coupling Reaction was written by Cao, Wei;Chen, Ping;Tang, Yu. And the article was included in Journal of Natural Products in 2020.Recommanded Product: Methyl 3,5-dihydroxy-4-iodobenzoate This article mentions the following:

The first total synthesis of isohericenone J is reported. Key features of this synthetic strategy are a Friedel-Crafts reaction to construct the isobenzofuranone unit and a Pd-catalyzed Stille coupling reaction for the formation of the C5-C1′ bond, generating the natural product, as well as one of its isomers, in 6.0% overall yield in eight steps. This strategy provides a foundation for the synthesis of challenging isobenzofuranone and isoindolinone-type derivatives In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Recommanded Product: Methyl 3,5-dihydroxy-4-iodobenzoate).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: Methyl 3,5-dihydroxy-4-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A Novel, Exceptionally Selective, Potent δ Opioid Receptor Agonist with Oral Bioavailability and Its Analogues was written by Wei, Zhong-Yong;Brown, William;Takasaki, Bryan;Plobeck, Niklas;Delorme, Daniel;Zhou, Fei;Yang, Hua;Jones, Paul;Gawell, Lars;Gagnon, Helene;Schmidt, Ralf;Yue, Shi-Yi;Walpole, Chris;Payza, Kemal;St-Onge, Stephane;Labarre, Maryse;Godbout, Claude;Jakob, Andrea;Butterworth, Joanne;Kamassah, Augustus;Morin, Pierre-Emmanuel;Projean, Denis;Ducharme, Julie;Roberts, Edward. And the article was included in Journal of Medicinal Chemistry in 2000.Category: iodides-buliding-blocks This article mentions the following:

The design, synthesis, and pharmacol. evaluation of a novel class of δ opioid receptor agonists, N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (I) and its analogs, are described. These compounds, formally derived from SNC-80 by replacing the piperazine ring with a piperidine ring containing an exocyclic carbon carbon double bond, were found to bind with high affinity and exhibit excellent selectivity for the δ opioid receptor as full agonists. I, the simplest structure in the class, exhibited an IC₅₀ = 0.87 nM for the δ opioid receptors and extremely high selectivity over the μ receptors (μ/δ = 4370) and the κ receptors (κ/δ = 8590). Rat liver microsome studies on a selected number of compounds show these olefinic piperidine compounds to be considerably more stable than SNC-80. This novel series of compounds appear to interact with δ opioid receptors in a similar way to SNC-80 since they demonstrate similar SAR. Two general approaches have been established for the synthesis of these compounds, based on dehydration of benzhydryl alcs. and Suzuki coupling reactions of vinyl bromide. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Category: iodides-buliding-blocks).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Triflic acid catalysed regioselective synthesis of substituted naphthalenes by benzannulation of carbonyls with alkynes was written by Gudla, Vanajakshi;Sudheer, Mokhamatam;Rao, Chinthu Joginarayana;Sanasi, Paul Douglas;Battula, Venkateswara Rao. And the article was included in Tetrahedron in 2021.Name: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

An interesting and facile triflic acid catalyzed annulation of α-aryl carbonyls with arylalkynes was presented for the regioselective synthesis of substituted naphthalenes. The annulation reaction involved a sequence of electrophilic attack of carbonyl on arylalkyne and benzannulation catalyzed by triflic acid. The present catalyst effects this transformation at room temperature itself. Intramol. version of the present Bronsted acid catalysis furnished compounds containing 1-arylnaphthalene core fused with ring systems in excellent yields. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Name: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Name: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electrochemical Fluorination of Vinyl Boronates through Donor-Stabilized Vinyl Carbocation Intermediates was written by Wigman, Benjamin;Lee, Woojin;Wei, Wenjing;Houk, Kendall N.;Nelson, Hosea M.. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 5460-32-2 This article mentions the following:

The electrochem. generation of vinyl carbocations RC(F)=C(R¹)R² (R = 4-methoxyphenyl, thiophen-2-yl, 2,2-dimethyl-2H-1,3-benzodioxol-5-yl, etc.; R¹ = R² = n-Bu, 4-methoxyphenyl; R¹R² = -(CH₂)₄-, -(CH₂)₅-) from alkenyl boronic esters and boronates RC(Bpin)=C(R¹)R² is reported. Using easy-to-handle nucleophilic fluoride reagents, these intermediates are trapped to form fully substituted vinyl fluorides. Mechanistic studies support the formation of dicoordinated carbocations through sequential single-electron oxidation events. Notably, this electrochem. fluorination features fast reaction times and Lewis acid-free conditions. This transformation provides a complementary method to access vinyl fluorides with simple fluoride salts such as TBAF. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Total syntheses of the meta,meta-bridged biphenyls (±)-myricanol and myricanone, and of an isomeric biphenyl ether, a 14-oxa[7,1]metaparacyclophane was written by Whiting, Donald A.;Wood, Andrew F.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1980.Computed Properties of C8H7IO2 This article mentions the following:

Intramol. reductive coupling with (Ph₃P)₄Ni of the bisiodides I (R = R³ = iodo, R¹ = H, R² = OAc; R = R³ = iodo, R¹R² = O), derived from the phenols I (R = R¹ = R³ = H, R² = OH; R = R³ = H, R¹R² = O) gave the meta,meta-bridged biphenyls myricanone (II; R = R¹ = H, R² = OH) and (±)-myricanol (II; R = R¹ = H, R² = OH), resp., in low yields. The bridged biphenyls II (R = Me, R¹R² = O; R = Me, R¹ = H, R² = OH) were similarly prepared Irradiation at 254 nm of the bromides I (R = Br, R¹ = R³ = H, R² = OAc; R = Br, R¹R² = O, R³ = H) also induced aryl-aryl coupling to form the bridged biphenyls II (R = PhCH₂, R¹ = H, R² = OH; R = PhCH₂, R¹R² = O), resp. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Computed Properties of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines was written by Zhang, Shuai;Xiao, Jun-Zhao;Li, Yan-Bo;Shi, Chang-Yun;Yin, Liang. And the article was included in Journal of the American Chemical Society in 2021.Formula: C4H8ClI This article mentions the following:

A Cu(I)-catalyzed asym. alkylation of HPAr¹Ar² with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr¹Ar²) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some ³¹P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr¹Ar² does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,R_P)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Small organic molecules with tailored structures: initiators in the transition-metal-free C-H arylation of unactivated arenes was written by Liu, Zhenghui;Wang, Peng;Chen, Yu;Yan, Zhenzhong;Chen, Suqing;Chen, Wenjun;Mu, Tiancheng. And the article was included in RSC Advances in 2020.Recommanded Product: 22918-03-2 This article mentions the following:

In this article, an optimized catalytically active mol., (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides RI (R = 2-fluorophenyl, thiophen-3-yl, pyridin-4-yl, etc.) could be converted into the corresponding arylated products RR¹ (R¹ = Ph, 4-methylphenyl) at 100°C over 24 h with good to excellent yields. Mechanistic experiments verified that radicals participated in this catalytic transformation and that the cleavage of the aromatic C-H bond was not the rate determining step. A K⁺ capture experiment by 18-crown-6 emphasized the significance of the cation species of the strong base. Fourier transform IR spectroscopy proved that the catalytic system was activated by the hydrogen bonds between small organic mols. and ^tBuOK. Also, a clear mechanism was proposed. This transition-metal-free method affords a promising system for efficient and inexpensive synthesis of biaryls via a user-friendly approach, as confirmed by scale-up experiments In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodopyridine (cas: 22918-03-2Recommanded Product: 22918-03-2).

4-Chloro-2-iodopyridine (cas: 22918-03-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 22918-03-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A reusable palladium/cationic 2,2′-bipyridyl system-catalyzed double Mizoroki-Heck reaction in water was written by Chen, Yu-Chi;Wu, Chien-Chi;Liao, Wei-Ting;Liu, Ling-Jun;Tsai, Fu-Yu. And the article was included in Catalysts in 2017.Product Details of 5460-32-2 This article mentions the following:

A reusable PdCl₂(NH₃)₂/cationic 2,2′-bipyridyl system was used to catalyze the double Mizoroki-Heck reaction of aryl iodides with electron-deficient alkenes in water in the absence of inert gas, giving U+03B2,U+03B2-diarylated carbonyl derivatives in good to excellent yields. The formation of unsym. U+03B2,U+03B2-diarylated alkenes were also studied by coupling aryl iodides with the corresponding aryl-substituted U+03B1,U+03B2-unsaturated carbonyl compounds This water-soluble catalyst can be swiftly separated from the organic layer using simple extraction for the further reuse, and, thus, makes it an operationally-simple and environmentally-benign procedure. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Product Details of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Product Details of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Development and preclinical evaluation of new ¹²⁴I-folate conjugates for PET imaging of folate receptor-positive tumors was written by AlJammaz, I.;Al-Otaibi, B.;Al-Rumayan, F.;Al-Yanbawi, S.;Amer, S.;Okarvi, S. M.. And the article was included in Nuclear Medicine and Biology in 2014.Related Products of 58481-10-0 This article mentions the following:

In an attempt to develop new folate radiotracers with favorable biochem. properties for detecting folate receptor-pos. cancers, we have synthesized [¹²⁴I]-SIB- and [¹²⁴I]-SIP-folate conjugates using a straightforward and two-step simple reactions. Radiochem. yields for [¹²⁴I]-SIB- and [¹²⁴I]-SIP-folate conjugates were greater than 90 and 60% resp., with total synthesis time of 30-40 min. Radiochem. purities were always greater than 98% without HPLC purification These synthetic approaches hold considerable promise as rapid and simple method for ¹²⁴I-folate conjugate preparation with high radiochem. yield in short synthesis time. In vitro tests on KB cell line showed that the significant amounts of the radioconjugates were associated with cell fractions. In vivo characterization in normal Balb/c mice revealed rapid blood clearance of these radioconjugates and favorable biodistribution profile for [¹²⁴I]-SIP-folate conjugate over [¹²⁴I]-SIB-folate conjugate. Biodistribution studies of [¹²⁴I]-SIP-folate conjugate in nude mice bearing human KB cell line xenografts, demonstrated significant tumor uptake. The uptake in the tumors was blocked by excess injection of folic acid, suggesting a receptor-mediated process. These results demonstrate that [¹²⁴I]-SIP-folate conjugate may be useful as a mol. probe for detecting and staging of folate receptor-pos. cancers, such as ovarian cancer and their metastasis as well as monitoring tumor response to treatment. In the experiment, the researchers used many compounds, for example, 2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0Related Products of 58481-10-0).

2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Related Products of 58481-10-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer′s Disease was written by Ratni, Hasane;Alker, Andre;Bartels, Bjoern;Bissantz, Caterina;Chen, Weichun;Gerlach, Irene;Limberg, Anja;Lu, Mingqiu;Neidhart, Werner;Pichereau, Solen;Reutlinger, Michael;Rodriguez-Sarmiento, Rosa-Maria;Jakob-Roetne, Roland;Schmitt, Georg;Zhang, Eric;Baumann, Karlheinz. And the article was included in ACS Medicinal Chemistry Letters in 2020.Safety of 1-Chloro-4-iodobutane This article mentions the following:

γ-Secretase (GS) is a key target for the potential treatment of Alzheimer′s disease. While inhibiting GS led to serious side effects, its modulation holds a lot of potential to deliver a safe treatment. Herein, we report the discovery of a potent and selective gamma secretase modulator (GSM) (S)-3 (RO7185876), belonging to a novel chem. class, the triazolo-azepines. This compound demonstrates an excellent in vitro and in vivo DMPK profile. Furthermore, based on its in vivo efficacy in a pharmacodynamic mouse model and the outcome of the dose range finding (DRF) toxicol. studies in two species, this compound was selected to undergo entry in human enabling studies (e.g., GLP toxicol. and scale up activities). In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Safety of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com