Author: Jessica.F

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H4ClIO2

5g of 2-chloro-5-iodobenzoic acid and 30mL of methylene chloride were added into a 100mL reaction flask under nitrogen atmosphere, and then 0.13g of N, N-dimethylformamide was added, and 2.7g Oxalyl chloride, incubated at the end of the reaction dropwise 1h, and then warmed to 35-40 C for 2-3hrs, after the end of the reaction vacuum distillation, steamed to solvent-free fractions, and then added 30mL dichloromethane vacuum distillation, to be dried residual oxalyl chloride , Pale yellow viscous substance 5.3g, is 2-chloro-5-iodobenzoyl chloride, yield 100%.

According to the analysis of related databases, 19094-56-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chongqing Boteng Pharmaceutical Technology Co., Ltd.; Lin Wenqing; Zheng Hongjie; Lin Chuanhua; Shen Chenjian; Liu Shouxuan; (6 pag.)CN106316803; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 175278-00-9, name is 1-Iodo-2-(trifluoromethoxy)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175278-00-9, HPLC of Formula: C7H4F3IO

General procedure: A sealed tube containing a magnetic stirring bar was charged with aryl iodide (1.0 mmol), Te (0.13 g, 1.0 mmol), KOH (0.11 g, 2.0 mmol) and DMSO (2 mL) under nitrogen. The reaction mixture was heated in an oil bath at 110 C and stirred at this temperature for 10 h. The progress of the reaction was monitored by TLC via syringe. After the reaction was complete, the reaction mixture was allowed to cool, and treated with CH2Cl2 and H2O. The organic layer was washed with sat. NH4Cl and brine solution, dried with Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography on silica gel with an eluent consisting of hexanes and ethyl acetate to affording the corresponding diaryl tellurides in good yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Shaozhong; Kolluru, Lalitha; Vedula, Souseelya K.; Whippie, Drew; Jin, Jin; Tetrahedron Letters; vol. 58; 37; (2017); p. 3594 – 3597;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 69113-59-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69113-59-3, name is 3-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step-1: To the solution of compound obtained in step A of above example (1.4 g, 1.23 mmol) in DMF (40 ml) was added cesium carbonate (0.63 g, 3.2 mmol), bis-triphenylphosphine Palladium (II) chloride (0.10 g, 0.13 mmol), cuprous Iodide (0.05 g, 0.26 mmol) followed by 3-iodobenzonitrile (0.29 g, 1.27 mmol). The reaction mixture was stirred at 25-30 C. temperature under nitrogen atmosphere for 12 hrs. it was quenched with addition of ice-cold water (15 ml) to provide a suspension. Solid was filtered & dried under vacuum. The solid was purified by using silica gel column chromatography (20% ethyl acetate-Hexane) to provide step-1 product as a solid in 33% (0.5 g) yield. Mass: m/z: 1198 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sindkhedkar, Milind Dattatraya; Desai, Vijaya Narayan; Loriya, Rajesh Maganlal; Patel, Mahesh Vithalbhai; Trivedi, Bharat Kalidas; Bora, Rajesh Onkardas; Diwakar, Santosh Devidas; Jadhav, Ganesh Rajaram; Pawar, Shivaji Sampatrao; US2009/247478; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1829-28-3, A common heterocyclic compound, 1829-28-3, name is Ethyl 2-iodobenzoate, molecular formula is C9H9IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00319] 25.5 mg of PdCl2[dppf].CH2Cl2 was placed in a reaction tube under nitrogen and added 4 ml dioxane and 0.45 ml triethylamine. The mixture was heated at 80 C. for 23 h to give a brownish solution. To this solution was then added 286 mg (1.04 mmol) of ethyl 2-iodobenzoate and 0.23 ml (1.6 mmol) pinacolborane. The reaction mixture was heated with stirring to 80 C. for 16.5 h and then analysed by gc and the products identified by gc/ms. The gc solutions were prepared by washing an aliquot of the reaction solution dissolved in ethyl acetate with water and dried. The reaction was finished, the desired product peak in the gc had an area of 84percent with the only other significant peak being that due to the dehalogenation product, ethyl benzoate (14percent).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 14452-30-3,Some common heterocyclic compound, 14452-30-3, name is 1-(3-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled (-40 C) stirred solution of TiC4 (11 mL of a 1. OM sol in DCM, 11 mmol) in 5 mL of DCM was added dimethyl zinc (5. 5 mL of a 2 N sol. in toluene, 11 mmol). After stirring for 10 min iodoacetophenone (1. 23 g, 5.0 mmol) was added. After 2 h the reaction was warmed to 0 C and stirred for an additional 1 h. The reaction was poured onto ice and extracted with ether. The organic phase was washed with water and sat NaHCO3. The organic phase was dried over magnisium sulfate, filtered, and dried under reduced pressure. The material was distilled using a kugelrohr (80 C at 0.1 mm) to obtain 1.0 g (76% yield) of a clear oil.

The synthetic route of 14452-30-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87215; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4387-36-4, name is 2-Iodobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Iodobenzonitrile

2-iodobenzonitrile (1.5mmol) was dissolved in a 3:2 mixture of Net3/THF (10 mL) and degassed for 30 min at room temperature. After adding of PdCl2(PPh3)2 (0.2 mol percent) and CuI (0.2mol percent), alkyne (1.8mmol) was added dropwise to the reaction suspension. Subsequently the reaction mixture was stirred at room temperature until completion was indicated by TLC. After the completion of the reaction, the reaction mixture was filtered, and concentrated by rotary evaporation. The crude product was purified by column chromatography (petroleum ether : ethyl acetate = 30:1) to provide 1a (yield: 78percent), 1k-1s (in 77?85percent yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4387-36-4.

Reference:
Article; Liu, Xiaodong; Deng, Guobo; Liang, Yun; Tetrahedron Letters; vol. 59; 29; (2018); p. 2844 – 2847;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 16932-44-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16932-44-8 as follows.

0.2 mmol of potassium carbonate, 0.005 mmol of tris (dibenzylideneacetone) dipalladium,1,3-bis (diphenylphosphine) propane 0.02mmol, 18-crown-6-ether 0.1mmol,1,3-dimethoxy-2-iodobenzene 0.1 mmol,1-phenyl-1-pentyne 0.25 mmol and1 mL of N, N-dimethylformamide was added to a 15 mL reaction tube, Repeatedly filled with nitrogen 10 times, stirred at room temperature for 15min, added 0.5mmol of water,Then placed in a reaction dish at 100 C for 16h; cooled to room temperature, the reaction solution was diluted with ethyl acetate, washed with water, the organic phase was dried over anhydrous Na2SO4, filtered, concentrated, and purified by thin layer chromatography to obtain 8.9mg of the target product Color oil, 32% yield.

According to the analysis of related databases, 16932-44-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Huaqiao University; Cheng Guolin; Lv Weiwei; (12 pag.)CN110256184; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13194-68-8, name is 4-Iodo-2-methylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Iodo-2-methylaniline

EXAMPLE 1 4-Fluoro-2-(4-iodo-2-methylphenylamino)benzoic Acid To a stirring solution comprised of 3.16 g (0.0133 mol) of 2-amino-5-iodotoluene in 5 mL of tetrahydrofuran at -78 C. was added 10 mL (0.020 mol) of a 2.0 M lithium diisopropylamide in tetrahydrofuran/heptane/ethenylbenzene (Aldrich) solution. The resulting green suspension was stirred vigorously for 15 minutes, after which time a solution of 1.00 g (0.00632 mol) of 2,4-difluorobenzoic acid in 10 mL of tetrahydrofuran was added. The reaction temperature was allowed to increase slowly to room temperature, at which temperature it was stirred for 2 days. The reaction mixture was concentrated. Aqueous HCl (10%) was added to the concentrate, and the solution was extracted with dichloromethane. The organic phase was dried (MgSO4) and then boiled over a steambath to low volume and cooled to room temperature. The off-white fibers were collected by vacuum filtration, rinsed with hexanes, and vacuum-oven dried. (76 C.; ca. 10 mm of Hg) to afford 1.10 g (47%) of the desired material; mp 224-229.5 C.; 1H NMR (400 MHz; DMSO): delta 9.72 (s, 1H), 7.97 (dd, 1H, J=7.0, 8.7 Hz), 7.70 (d, 1H, J=1.5 Hz), 7.57 (dd, 1H, J=8.4, 1.9 Hz), 7.17 (d, 1H, J=8.2 Hz), 6.61-6.53 (m, 2H), 2.18 (s, 3H); 13C NMR (100 MHz; DMSO): delta 69.87, 167.60, 165.12, 150.17, 150.05, 139.83, 138.49, 136.07, 135.31, 135.20, 135.07, 125.60, 109.32, 105.09, 104.87, 99.72, 99.46, 89.43, 17.52; 19F NMR (376 MHz; DMSO): delta -104.00 to -104.07 (m); IR (KBr) 1670 (C=O stretch) cm-1; MS (CI) M+1=372. Analysis calculated for C14H11FINO2: C, 45.31; H, 2.99; N, 3.77. Found: C, 45.21; H, 2.77; N, 3.64.

The synthetic route of 13194-68-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US6696440; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, A new synthetic method of this compound is introduced below., name: 1,2-Difluoro-4-iodobenzene

In a glassware flask equipped with a condenser and a magnetic stirrer, were put 85.7 g (357 mmol) of 3,4-difluoroiodobenzene, 43.2 g (680 mmol) of copper powder, and 86 g of N-methylpyrrolidinone (NMP). The mixture was stirred under nitrogen atmosphere on an oil bath at 190 C for 5 h. After cooling to room temperature, the reaction mixture was mixed with 300 mL of tert-butyl methyl ether and filtered in order to remove copper and its salt. The filtrate was washed with water (300 mL x 3) and then with saturated aqueous sodium chloride solution (300 mL x 1), and dried with magnesium sulfate and filtered. The filtrate was evaporated and the resulting residue was column-chromatographed using hexane as an eluent to give a white solid (35 g, 87% yield) of product 4. The spectral data agreed with those of the authentic sample: 19F NMR (CDCl3) (with 1H decoupling) delta -136.88 (d, J = 21 Hz, 2F), -139.64 ppm (d, J = 21 Hz, 2F); 1H NMR (CDCl3) delta 7.25 (m, 4H), 7.34 ppm (m, 2H).

The synthetic route of 64248-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Umemoto; Zhou, Xiaocong; Li, Yuanqiang; Journal of Fluorine Chemistry; vol. 226; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 128140-82-9,Some common heterocyclic compound, 128140-82-9, name is 1-(Difluoromethoxy)-4-iodobenzene, molecular formula is C7H5F2IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 110; Preparation of 1-(difluoromethoxy)-4-ethynylbenzene; A solution of 1-(difluoromethoxy)-4-iodobenzene (12.7 g, 50 mmol) in triethylamine is treated with tetrakis(triphenylphosphine)palladium (4.0 g, 3.5 mmol), copper iodide (925 mg, 4.85 mmol), and a solution of ethynyl(trimethyl)silane (6.9 mL, 50 mmol) in acetonitrile at room temperature, stirred for 1 h at 60 C. and concentrated in vacuo. The resultant residue was dissolved in Et2O and filtered. The filtrate was concentrated and the concentrate was purified by chromatography (silica gel, EtOAc/hexane: 5/95) to give {[4-(difluoromethoxy)phenyl]ethynyl}(trimethyl)silane (11.5 g, 96%) as an oil. A solution of {[4-(difluoromethoxy)phenyl]ethynyl}(trimethyl)silane (10.0 g, 41.7 mmol) in MeOH/CH2Cl2 (1/1) was treated with cesium carbonate (16.3 g, 50 mmol) at room temperature, stirred for 1.5 h, diluted with CH2Cl2 and filtered through a pad of silica gel. The filtrate was concentrated to dryness to give the title compound (6.8 g, 97%) as an oil. MS (+) EI: 168.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(Difluoromethoxy)-4-iodobenzene, its application will become more common.

Reference:
Patent; Wyeth; US2007/4730; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com