Author: Jessica.F

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,1,1-Trifluoro-3-iodopropane

At room temperature, 190 g (1.4 mol) of potassium carbonate was weighed into 3 L of a three-necked flask and 500 g of DMF was added,100 g (0.7 mol) of compound 16 was added and stirring was started,20-25 C was added dropwise with 205 g (0.916 mol) of trifluoroproponium chloride, After the addition of stirring for 4.5h, the TLC reaction was completed. Add 1.6kg of methanol, stir for 30min,Suction filter. The filter cake was washed twice with methanol twice. Decompression steamed filtrate to no liquid,To the residue was added 1.5 kg of water, and 1N hydrochloric acid solution was added thereto to adjust the pH to 7,Ice bath 0 ~ 3 stirring 3h, filter, 45 drying to get 137g product, the yield of 81.8%Purity HPLC: 98.5%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 460-37-7.

Reference:
Patent; Beijing Guangbo Desai Pharmaceutical Technology Development Co., Ltd.; Yitai (Beijing) Pharmatech Co., Ltd.; Wu, Yuan; Tian, Hua; (14 pag.)CN106008633; (2016); A;,
Iodide – Wikipedia,
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Reference of 64248-58-4,Some common heterocyclic compound, 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, molecular formula is C6H3F2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A Schlenk flask equipped with asepta and a magnetic stir bar wasfilled with aryl halide (3.0 mmol), alkene (3.2 mmol), K2CO3(3.5 mmol) and PdLn-beta-CD 3 mol% catalyst in water (5 mL pure orplain). The reaction was refluxed for the appropriate time underaerobic conditions. After completion of the reaction was confirmedby TLC, the reaction mixturewas cooled to room temperature.The solvent was removed by rotary evaporator and extraction of theproduct was carried out using ethyl acetate. The ethyl acetate fractionwas separated and dried over anhydrous sodium sulphate. Theresulting crude product was purified using flash column chromatographyof silica gel 60-120mesh with n-hexane/ethyl acetate (8:2ratio) as the eluent and afforded the pure desired product. After extractionof product, catalyst was simply reprecipitated from theaqueous layer by the addition of 10 mL of acetone. The recoveredcatalyst was filtered, washed with acetone (3 × 5 mL) and dried ina vacuum at 70 C for 5 h and reused.

The synthetic route of 64248-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dindulkar, Someshwar D.; Jeong, Daham; Kim, Hwanhee; Jung, Seunho; Carbohydrate Research; vol. 430; (2016); p. 85 – 94;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 645-00-1, name is 1-Iodo-3-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Iodo-3-nitrobenzene

General procedure: Under air atmosphere, around-bottomed flask was charged with an aryl halide (1.0mmol), a terminal alkyne (1.0mmol), a base (1.0mmol), and the catalyst 2 (1mol%). The mixture was stirred at room temperature for 3h under aerobic conditions. After completion of the reaction, the mixture was filtered to recover the catalyst. The polymer was washed with water, methanol, and acetonitrile, vacuum-dried, and stored for a new run. After GC analysis, the solvent was removed under vacuum, and the crude product was subjected to silica gel column chromatography using CHCl3-CH3OH (97:3) as eluent to afford the pure product.

The synthetic route of 645-00-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bakherad, Mohammad; Keivanloo, Ali; Samangooei, Shahrzad; Omidian, Mina; Journal of Organometallic Chemistry; vol. 740; (2013); p. 78 – 82;,
Iodide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 31599-61-8

General procedure: Aryl thiourea (1, 0.5 mmol), aryl iodide (2, 0.6 mmol), CuSO4*5H2O (0.05 mmol), Cs2CO3 (2.0 equiv), 2,2?-bypyridine (0.05 mmol) were added in sealed tube equipped with a septum and magnetic stirring bar, H2O (2.0 mL) was then added. The mixture was stirred at 100 C and checked by TLC until the starting material was finished (about 3h). The reaction was terminated with sat. NH4Cl solution (3 mL) and then extracted with ethyl acetate. The crude solution was dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography to afford the desired product 3a.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31599-61-8.

Reference:
Article; Liu, Xing; Zhu, Hui; Zhang, Shi-Bo; Cheng, Yu; Peng, Han-Ying; Dong, Zhi-Bing; Tetrahedron Letters; vol. 59; 33; (2018); p. 3165 – 3170;,
Iodide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, A new synthetic method of this compound is introduced below., Quality Control of 4-Iodo-1,2-dimethylbenzene

General procedure: A mixture containing styrene (3.5 mmol), aryl halide (3.5 mmol), the palladium complex [(L)PdCl] (0.001 mmol) and potassium carbonate (8.0 mmol) in methanol (10 ml) were heated to reflux for 4 h. After evaporation of solvent the product was poured into water and extracted with diethyl ether. The ether solution was dried over Na2SO4 and filtered. The ether solution were passed through silica column (60-120 mesh), the complex remain trapped. After extraction of desired compound complex was extracted using dichloromethane. Upon evaporation of the ether, solid of pure products were obtained. The yields of the products obtained from all the reactions were determined after isolation and characterized by 1H NMR spectra.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Pattanayak, Poulami; Pratihar, Jahar Lal; Patra, Debprasad; Lin, Chia-Her; Paul, Sobhana; Chakraborty, Kausiki; Polyhedron; vol. 51; 1; (2013); p. 275 – 282;,
Iodide – Wikipedia,
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Related Products of 696-41-3,Some common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, molecular formula is C7H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6(0.6 mmol,220 mg), K2CO3(1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMFwere added and mixture was stirred for appropriate reaction timeat 120C under argon atmosphere. The progress of the reactionwas monitored by GC analysis. After completion of the reaction,reaction mixture was washed with 5 mL water and crude productwas isolated using dichloromethane (5× 1 mL). Organic extractswere combined together, evaporated and purified by flash chro-matography using hexane/EtOAc to give the desired aryl cyanideproducts.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Iodobenzaldehyde, its application will become more common.

Reference:
Article; Gholinejad, Mohammad; Aminianfar, Afsaneh; Journal of Molecular Catalysis A: Chemical; vol. 397; (2015); p. 99 – 105;,
Iodide – Wikipedia,
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Application of 69113-59-3, These common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The title compound (40 mg, 66.4 %, white solid) was obtained from [4- [1- (5-] [TRIBUTYLSTANNANYL-ISOXAZOL-3-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLIC] acid ethyl ester (109 mg, 0.2 mmol) and Pd (PPh3) [2C12] (2.0 mg) with 3-iodo-benzonitrile (45.7 mg, 0.17 mmol) in dioxane [(LUT)] at [110 C OVERNIGHT. LH-NMR (CDCL3) B] (ppm): [8.] 07 (s, 1H), 8.05 (d, 1H), 7.63 (d, 1H), 7.62 (t, [1H),] 6.62 (s, [1H),] 4.12 (q, 2H), 3.88 (q, [1H),] 3.50 (m, 4H), 2.52 (m, 4H), 1.47 (d, 3H) and 1.25 (t, 3H).

Statistics shows that 3-Iodobenzonitrile is playing an increasingly important role. we look forward to future research findings about 69113-59-3.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14370; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 645-00-1, name is 1-Iodo-3-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 645-00-1

General procedure: A mixture of the aryl halide (0.5 mmol), phenylacetylene(0.5 mmol), piperidine (1 mmol), ortho-palladated catalyst(0.2 mol %) was added to NMP (3 mL) in round-bottom flask equipped with condenser and placed into the Milestone microwave. Initially using a microwave power of 600 W the temperature was ramped from room temperature to 100 C and then held at this temperature until the reaction was completed. During this time, the power was modulated automatically to keep the reaction mixture at 100 C. The mixture was stirred continuously during the reaction and monitored by both TLC and GC. After the reaction was complete, the mixture was cooled to room temperature and was diluted with n-hexane and water. The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure using rotary evaporator. The residue was purified by silica gel column chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 645-00-1.

Reference:
Article; Hajipour, Abdol R.; Rafiee, Fatemeh; Journal of the Iranian Chemical Society; vol. 12; 7; (2015); p. 1163 – 1169;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 624-75-9, name is 2-Iodoacetonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C2H2IN

To a mixture of 5-bromo-2-isopropyl-4-methoxy-phenol from step 4 (0.831 g, 3.4 mmol) and K2CO3 (0.562 g, 4.1 mmol) in 17 mL dimethyl formamide (DMF) was added iodoacetonitrile (0.594 g, 3.6 mmol). The mixture was warmed to 60 C. for 30 minutes and then allowed to cool to room temperature. After cooling to room temperature the mixture was taken up in 50 mL of H2O and extracted with 1:1 toluene/ethyl acetate, washed with H2O and then with brine. The combined organic layers were dried over Na2SO4, filtered and conectrated in vacuo to give a crude solid. Purification via flash chromatography (1:1 hexane/CH2Cl2) afforded (5-bromo-2-isopropyl-4-methoxy-phenoxy)-acetonitrile (0.611 g, 63%) as a while solid.

The synthetic route of 624-75-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Roche Palo Alto LLC; US2005/209260; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 19718-49-1, name is Methyl 4-amino-3-iodobenzoate, molecular formula is C8H8INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 4-amino-3-iodobenzoate

A solution of 3.00 g (10.8 mmol) of methyl 4-amino-3-iodobenzoate and 1.30 g (54.1 mmol) of lithium hydroxide in 150 ml of a dioxane/water mixture (1:1) was stirred at room temperature for 6 h. The dioxane was distilled off in vacuo, and the remaining aqueous phase was adjusted to pH 5 with 1 M hydrochloric acid. The precipitate was filtered off with suction and washed with water. 2.80 g (98%) of the title compound were obtained as a solid. HPLC (Kromasil RP-18, 60*2.1 mm, eluent=A: H2O+5 mL HClO4/L; B: acetonitrile; gradient=0-4.5 min 98% A-90% B; 4.5-6.5 min 90% B; 0.75 mL/min; temp.: 30 C., UV detection at 21 nm): Rt=3.51 min 1H-NMR (300 MHz in D6-DMSO) delta=5.98 (s, 2H), 6.74 (d, 1H), 7.63 (m, 1H), 8.10 (s, 1H), 12.33 (s, broad, 1H) MS (ESI+): m/z=281 [M+NH4]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19718-49-1, its application will become more common.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Hendrix, Martin; Boebeta, Frank-Gerhard; Erb, Christina; Krueger, Joachim; Luithle, Joachim; Methfessel, Christoph; Schreiber, Rudy; Wiese, Welf-Burkhard; US9139579; (2015); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com