Author: Jessica.F

Synthetic Route of 624-76-0, These common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 4a (617mg, 4.6mmol) was reacted with 2-Iodoethanol (0.54mls, 6.9mmol) and diisopropylethylamine (1.2mls, 6.9mmol) in ACN (20mls) at 30oC for 48 hours. The solvent was evaporated and the residue was purified by silica gel column chromatography with hexane and EtOAc to provide the compound (483mg, 2.7mmol, 59% yield) as a light brown oil. HRMS (ESI, positive) m/z calcd. for C11H18N1O1 [M+H]+: 180.13829, found: 180.13829. 1H NMR (400 MHz, CDCl3) delta 7.28 – 7.19 (t, J = 8.0 Hz, 2H), 6.92 – 6.85 (d, J = 8.2 Hz, 2H), 6.83 – 6.75 (t, J = 7.3 Hz, 1H), 4.03 – 3.88 (hept, J = 6.6 Hz, 1H), 3.70 – 3.62 (t, J = 6.2 Hz, 2H), 3.34 – 3.24 (m, 2H), 1.19 – 1.12 (d, J = 6.6 Hz, 6H).

Statistics shows that 2-Iodoethanol is playing an increasingly important role. we look forward to future research findings about 624-76-0.

Reference:
Article; Bell-Horwath, Tiffany R.; Vadukoot, Anish K.; Thowfeik, Fathima Shazna; Li, Guorui; Wunderlich, Mark; Mulloy, James C.; Merino, Edward J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 10; (2013); p. 2951 – 2954;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,2-Difluoro-4-iodobenzene

A a solution of /Patent; CENTAURUS THERAPEUTICS; ROMERO, Donna, L.; BLITZER, Jeremy; (242 pag.)WO2019/140188; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 97456-81-0,Some common heterocyclic compound, 97456-81-0, name is 1-Bromo-3-iodo-2-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A microwave vial under Ar was charged with ieri-butyl 1-piperazinecarboxylate (154 mg, 0.825 mmol), NaO-i-Bu (95.2 mg, 0.990 mmol), (rac)-BINAP (39.3 mg, 0.0619 mmol, 7.5% mol), Pd2(dba)3 (19.2 mg, 0.0206 mmol, 2.5% mol in Pd), and degassed toluene (2.1 mL). 2-Bromo-6-iodotoluene (121 muL, 0.825 mmol) was then added, and the mixture was heated in sealed vial at 80 C for 19 h, cooled to rt, diluted with CH2CI2, filtered over Celite, and concentrated. The mixture was purified by chromatography on S1O2 (10% EtOAc hexanes) to afford the product as a yellow oil (95 mg, 0.27 mmol, 32%): NMR (500 MHz, CDCI3) delta 7.30 (d, J = 8.0 Hz, 1 H), 7.02 (t, J = 8.0 Hz, 1 H), 6.95 (d, J = 7.5 Hz, 1 H), 3.57 (m, 4 H), 2.83 (t, J = 4.5 Hz, 4 H), 2.40 (s, 3 H),

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-iodo-2-methylbenzene, its application will become more common.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; SKODA, Erin, M.; WANG, Zhou; WO2015/42297; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 28547-29-7, name is 2-Bromo-4-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28547-29-7, Recommanded Product: 2-Bromo-4-iodobenzoic acid

To a stirred solution of 4-iodo-2-bromobenzoic acid (5 g, 15.29 mmol) in ethyl alcohol (EtOH; 100 mL) was added sulfuric acid (H2SO4; 5 mL), and the reaction mixture was heated at 80 C. for 18 h. The reaction mixture was cooled to 25 C. and concentrated under reduced pressure. The residue was diluted with EtOAc (2×100 mL) and washed with H2O (100 mL). The combined EtOAc extracts were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the compound as a pale yellow solid (5 g, 92%): 1H NMR (400 MHz, DMSO-d6) delta 8.04 (d, J=1.2 Hz, 1H), 7.71 (d, J=7.6 Hz, 1H), 7.51 (d, J=8.4 Hz, 1H), 4.41 (q, J=7.2 Hz, 2H), 1.41 (t, J=7.2 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Dow AgroSciences LLC; Lo, William C.; Hunter, James E.; Watson, Gerald B.; Patny, Akshay; Iyer, Pravin S.; Boruwa, Joshodeep; US2014/171308; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1437316-91-0,Some common heterocyclic compound, 1437316-91-0, name is 2,4-Difluoro-3-iodoaniline, molecular formula is C6H4F2IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-(2,4-difluoro-3-iodophenyl)propane-l -sulfonamideTo a solution of 2,4-difluoro-3-iodoaniline (255mg, lmmol) in 1,2-dichloroethane (3 mL) was added pyridine (lmL), followed by propane- 1-sulfonyl (157mg, 1. lmmol) and the resulting reaction mixture was heated to refluxing for 2 hrs. The solvent was removed in vacuo. The residue was dissolved in EtOAc, washed with aqueous NaHC03, brine, dried over Na2S04, filtered and concentrated in vacuo to afford the desired product (298mg, 83%>).1H NMR (CDCI3): ? 7.56-7.58 (1H, m), 6.90-6.95 (1H, m), 6.44 (1H, br), 3.03-3.07 (2H, m),1.84-1.90 (2H, m), 1.03-1.07 (3H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Difluoro-3-iodoaniline, its application will become more common.

Reference:
Patent; CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; LI, Jijun; ZHU, Yan; HU, Yuandong; WANG, Huting; WANG, Zhe; WANG, Zanping; WEI, Yongheng; SUN, Yinghui; WU, Qiong; ZHANG, Hui; PENG, Yong; KONG, Fansheng; SUN, Ying; LUO, Hong; HAN, Yongxin; WO2013/71865; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H9IO2

To a solution of 5-iodo-1,3-dimethoxybenzene (8, 20.98 g, 79.5 mmol) in dry DMF (75 mL), cooled to 0 C, was dropwise added POCl3 (42.64 g, 278.1 mmol). The reaction mixture was gradually warmed to room temperature and subsequently heated to 85 C. After stirring for 5 h at 75 C, the reaction mixture was poured into iced water (400 mL) and extracted with EtOAc (3*300 mL). The combined organic layer was washed with satd aq NaHCO3 (300 mL), dried over Na2SO4, and concentrated under reduced pressure. Recrystallization from hexanes/EtOAc (3/1) yielded benzaldehyde 9 (18.43 g, 79%) as a yellow solid; Rf 0.3 (hexanes/EtOAc=3/1); 1H NMR (200 MHz, CDCl3) delta 10.12 (s, 1H), 7.11 (d, J=2.3 Hz, 1H), 6.47 (d, J=2.2 Hz, 1H), 3.88 (s, 3H), 3.85 (s, 3H); 13C NMR (50 MHz, CDCl3) delta 190.6 (d, 1C), 164.6 (s, 1C), 163.3 (s, 1C), 119.2 (d, 1C), 118.3 (s, 1C), 99.1 (d, 1C), 98.6 (s, 1C), 56.0 (q, 1C), 55.9 (q, 1C); HRMS m/z calcd for [M+Na]+ 314.9489, found 314.9500; Anal. Calcd for C9H9IO3: C, 37.01; H, 3.11; found: C, 37.22; H, 3.14.

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mikula, Hannes; Skrinjar, Philipp; Sohr, Barbara; Ellmer, Doris; Hametner, Christian; Froehlich, Johannes; Tetrahedron; vol. 69; 48; (2013); p. 10322 – 10330;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 135050-44-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 135050-44-1, name is 3-Chloro-4-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

STEP A: 2,4′-dichloro-2′-methyl-[1,1′-biphenyl]-4-amine 3-Chloro-4-iodoaniline (3.0 g, 11.8 mmol), (4-chloro-2-methylphenyl)boronic acid (2.4 g, 14.2 mmol), Pd(dppf)Cl2 (1.0 g, 1.2 mmol), and K2CO3 (3.3 g, 23.7 mmol) were dissolved in 1,4-dioxane (40 mL) and water (10 mL) and the resulting mixture was heated to 80 C. After 16 h the resulting mixture was cooled to room temperature, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chakravarty, Devraj; Greco, Michael; Shook, Brian; Xu, Guozhang; Zhang, Rui; US2012/302641; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 160938-18-1, name is 4-Chloro-2-iodo-1-nitrobenzene, A new synthetic method of this compound is introduced below., Formula: C6H3ClINO2

4-chloro-2-iodo-1-nitrobenzene (77.66 g, 274 mmol), 9-phenyl-9H-carbazol- 2- ylboronic acid (157.34 g, 548 mmol), NaOH (5.48 g, After THF / H2O (800 ml / 400 ml) was mixed, Pd (PPh3) 4 (4.36 g, 5 mol%) was added at 40 C At 80 CStir for 12 hours.After completion of the reaction, the reaction mixture was extracted with methylene chloride, and then MgSO 4 was added thereto, followed by filtration to obtain an organic layer. In the obtained organic layer,The residue was purified by column chromatography (Hexane: EA = 3: 1 (v / v)) to give 2- (5-chloro-2-nitrophenyl) -9-phenyl-9H-carbazole (114.8 g, yield 73%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DoosanCorporation; Kim, Tae Hyung; Han, Song Eii; Lee, Chang Jun; Sin, Jin Yong; Jo, Hyun Jong; Baek, Young Mi; (56 pag.)KR2015/47858; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, A new synthetic method of this compound is introduced below., Recommanded Product: 1,1,1-Trifluoro-3-iodopropane

a) rac-2-(3-Chloro-phenyl)-5,5,5-trifluoro-pentanoic acid To a stirred solution of m-chlorophenylacetic acid (2.38 g, 14 mmol) in tetrahydrofuran (85 ml) was added at -78 0C lithium diisopropylamide solution (31 ml IM in THF, 31 mmol). After stirring the mixture for 20 min l-iodo-3,3,3-trifluoropropane (4.38 g, 20 mmol) was added and the mixture was allowed to warm to room temperature overnight. Water (5 ml) was added followed by 2N hydrochloric acid (10 ml). The reaction mixture was extracted twice with ethyl acetate. The combined organic layers were dried over MgSCU and evaporated and the residue was purified by column chromatography (Sitheta2, heptane/EtOAc= 9:1) to yield a colourless oil, (1.75 g, 47 %); MS (EI): 264.9 (M+ ).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/92785; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 7681-82-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7681-82-5 name is Sodium iodide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: We used a simple method (branched tube glass) in order to design and preparation of suitable single crystals for X-ray diffraction. The one-pot reaction of a 1:1 M ratio of Cd(II) salts and L in the mixture of EtOH and MeOH afforded the compounds 1-3 in good yields. Cd(NO3)2·4H2O (0.154g, 0.5mmol), NaHal (Hal=Cl, 0.058g; Br, 0.103g; I, 0.150g; 1mmol) and the ligand L (0.208g, 0.5mmol) were placed in the main arm of a branched tube. A mixture of MeOH (7.5mL) and EtOH (7.5mL) was carefully added to fill the arms. The tube was sealed and immersed in an oil bath at 60C while the branched arm was kept at ambient temperature. X-ray suitable crystals were formed during the next days in the cooler arm and were filtered off, washed with acetone and diethyl ether, and dried in air.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Reference:
Article; Akbari Afkhami, Farhad; Mahmoudi, Ghodrat; White, Jonathan M.; Lipkowski, Janusz; Konyaeva, Irina A.; Safin, Damir A.; Inorganica Chimica Acta; vol. 484; (2019); p. 481 – 490;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com