Author: Jessica.F

Aqueous N-Heterocyclization of Primary Amines and Hydrazines with Dihalides: Microwave-Assisted Syntheses of N-Azacycloalkanes, Isoindole, Pyrazole, Pyrazolidine, and Phthalazine Derivatives was written by Ju, Yuhong;Varma, Rajender S.. And the article was included in Journal of Organic Chemistry in 2006.Reference of 10297-05-9 This article mentions the following:

The synthesis of nitrogen-containing heterocycles from alkyl dihalides (ditosylates) and primary amines and hydrazines via a simple and efficient cyclocondensation in an alk. aqueous medium that occurs under microwave irradiation is described. This improved greener synthetic methodol. provides a simple and straightforward one-pot approach to the synthesis of a variety of heterocycles, such as substituted azetidines, pyrrolidines, piperidines, azepanes, N-substituted 2,3-dihydro-1H-isoindoles, 4,5-dihydropyrazoles, pyrazolidines, and 1,2-dihydrophthalazines. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Azaindole-1,2,3-triazole conjugate in a tripod for selective sensing of Cl^–, H₂PO₄^– and ATP under different conditions was written by Ghosh, Kumaresh;Kar, Debasis;Joardar, Soumen;Samadder, Asmita;Khuda-Bukhsh, Anisur Rahaman. And the article was included in RSC Advances in 2014.Related Products of 1227270-32-7 This article mentions the following:

A new tripodal sensor 1 has been designed and synthesized. The cavity of the tripod selectively recognizes Cl^– and H₂PO₄^– over a series of other anions in CH₃CN containing 0.01% DMSO by exhibiting a significant change in emission. Between H₂PO₄^– and Cl^– ions, H₂PO₄^– is distinguished by 1 through a ratiometric change in emission. In comparison, the indole-based tripod 2 did not show any binding-selectivity with the same anions. Compound 1, furthermore, selectivity recognizes phosphate based biomol. ATP over ADP and AMP in semi aqueous solvent (CH₃CN containing 0.01% DMSO : H₂O, 1 : 1, volume/volume) at pH 7.3. The tripod 1 is cell permeable and detects ATP by showing quenching of emission. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Related Products of 1227270-32-7).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 1227270-32-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of medium-bridged twisted lactams via cation-π control of the regiochemistry of the intramolecular Schmidt reaction was written by Szostak, Michal;Yao, Lei;Aube, Jeffrey. And the article was included in Journal of Organic Chemistry in 2010.Computed Properties of C4H8ClI This article mentions the following:

Medium-bridged twisted amides can be synthesized i. e., I by the intramol. Schmidt reaction of 2-azidoalkyl ketones. In these reactions, the regiochem. of the Schmidt reaction is diverted into a typically disfavored pathway by the presence of an aromatic group at the α-position adjacent to the ketone, which stabilizes the predominantly reactive conformation of the azidohydrin intermediate by engaging in a nonbonded cation-π interaction with the pos. charged diazonium cation. This results in the rarely observed rearrangement of the C-C bond distal to the azidoalkyl chain. This reaction pathway also requires the azide-containing tether to be situated in the axial orientation in the key azidohydrin intermediate. Examination of the effect of substitution of aromatic rings on the regiochem. of the Schmidt reaction shows an increase in the migratory selectivity with more electron-rich aromatic groups. The selectivity is lower when an electron-withdrawing substituent is placed on the aromatic ring. The ability of cation-π interactions to act as a controlling element decreases when Lewis acids coordinate to substituents on the aromatic ring. The developed version of the Schmidt reaction provides a direct access to a family of medium-bridged twisted amides with a [4.3.1] bicyclic system, compounds which are very difficult to access with use of other currently available methods. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Octopolar Chromophores Based on Donor- and Acceptor-Substituted 1,3,5-Tris(phenylethynyl)benzenes: Impact of meta-Conjugation on the Molecular and Electronic Structure by Means of Spectroscopy and Theory was written by Moreno Oliva, Maria;Casado, Juan;Hennrich, Gunther;Lopez Navarrete, Juan T.. And the article was included in Journal of Physical Chemistry B in 2006.Application of 3268-21-1 This article mentions the following:

The mol. and electronic structures of all-meta-substituted phenylacetylene mesitylenes peripherally substituted with donor or acceptor (D-A) groups are studied. The impact of meta- and para-substitution patterns is also analyzed by employing Raman and optical spectroscopies in conjunction with theor. calculations Outer Ph rings display a partial quinoid character induced by two different motifs: (i) outer phenyls â†?triple bond charge transfer for the cases where these phenyls are substituted with electron-donors; (ii) double electron withdrawing effect in the mols. with the peripheral phenyls substituted with electron acceptors. A moderate tuning of the optical gap is observed in agreement with the partial blockade of π-electron conjugation exerted by the meta disposition. The orbital structure of the compounds partially preserves that of the mesitylene group showing extra-conjugation due to the addition of the arms, so that conjugation is not entirely obstructed but partially impeded in the ground electronic state (i.e., electron occupied orbitals). As for the excited states, the low-lying energy empty orbitals offer better conditions for full conjugation over the whole mol. scaffold. Interesting optical properties such as overlapping centers along the lowest energy optical excitations and enhanced optical transparency with importance for the application of these materials in optoelectronics were justified from the electronic structure. A greater degree of quinoidization, and more allowed π-electron delocalization, over the entire mol. is recognized in the case of linear phenylacetylenes substituting in para positions the central core. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Application of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New Indolo[3,2-b]indole based small organic molecules for Organic Thin Film Transistors (OTFTs): A combined experimental and DFT Study was written by Puli, Venkat Swamy;Subburu, Mahesh;Bhongiri, Yadagiri;Tripathi, Anuj;Prasad, K. R. S.;Chatterjee, Anindita;Pola, Someshwar;Chetti, Prabhakar. And the article was included in Journal of Molecular Structure in 2021.Application of 220185-63-7 This article mentions the following:

Synthesis of new indolo[3,2-b]indoles in presence of Ag-doped ZnO and (Diacetoxyiodo) benzene system under visible-light were reported. All the new fused linear heterocyclic indolo[3,2-b]indole systems thoroughly characterized by spectroscopic methods like mass, UV-visible, NMR and C, H, N elemental anal. Further, their photophys. properties were carried out by combined exptl. and theor. studies. Thermogravimetric studies were carried out to confirm the thermal stability of mols. The frontier MOs of mols. were characterized with the help of cyclic voltammetry. Addnl., the compounds of series 5 were used for the fabrication of organic thin-film transistors, which indicated the hole mobilities in the range of 0.11 – 0.85 cm²/Vs and with on/off ratio 10⁵ on ODTS-SiO₂ substrate at 50°C and are also supported by DFT studies. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Application of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed enantioselective C(sp²)-H arylation of ferrocenyl ketones enabled by a chiral transient directing group was written by Xu, Jiancong;Liu, Yang;Zhang, Jinling;Xu, Xiaohua;Jin, Zhong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Electric Literature of C11H14INO This article mentions the following:

Palladium-catalyzed enantioselective C(sp²)-H activation of ferrocenyl ketones is achieved through utilizing catalytic, inexpensive L-tert-leucine as a chiral transient directing group. The transformation allows rapid access to ferrocene scaffolds simultaneously possessing planar- and stereogenic central chirality, widely applied in the ferrocene-based chiral ligand families. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Electric Literature of C11H14INO).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C11H14INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) was written by Lagu, Bharat;Kluge, Arthur F.;Tozzo, Effie;Fredenburg, Ross;Bell, Eric L.;Goddeeris, Matthew M.;Dwyer, Peter;Basinski, Andrew;Senaiar, Ramesh S.;Jaleel, Mahaboobi;Tiwari, Nirbhay Kumar;Panigrahi, Sunil K.;Krishnamurthy, Narasimha Rao;Takahashi, Taisuke;Patane, Michael A.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Recommanded Product: 15813-09-9 This article mentions the following:

Arylheterocyclylmethylphenoxyalkanoic and -alkenoic acids such as I were prepared as selective activators of PPARδ for potential use in improving mitochondrial function and for treatment of Duchenne muscular dystrophy (DMD); the heterocyclyl moiety was designed to mimic the cis-amide conformation found in the crystal structure of a previously prepared PPARδ activator to the ligand binding domain of PPARδ. The activation of PPARδ, selectivities for PPARδ over PPARα and PPARγ, and pharmacokinetics (half-lives, clearance, and AUC) in mice were determined for the compounds I (MA-0204) was a potent, selective PPARδ modulator with good pharmacokinetic properties. I was tested in vivo in mice and in myoblasts isolated from a DMD patient; I altered the expression of PPARδ target genes and improved fatty acid oxidation, indicating that I may be useful for treating DMD. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of diaryl ethers from tyrosine derivatives was written by Crimmin, Michael J.;Brown, Allan G.. And the article was included in Tetrahedron Letters in 1990.Related Products of 2314-37-6 This article mentions the following:

Diaryl ethers of tyrosine, maintaining optical activity, have been formed through the reaction of a tyrosine derivative with an aryl iodonium salt. Thus, iodonium salt I was treated with tyrosine derivative II in refluxing DMF to give 59% ether III. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Related Products of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Related Products of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration was written by Ruzi, Rehanguli;Ma, Junyang;Yuan, Xiang-Ai;Wang, Wenliang;Wang, Shanshan;Zhang, Muliang;Dai, Jie;Xie, Jin;Zhu, Chengjian. And the article was included in Chemistry – A European Journal in 2019.Application of 20776-54-9 This article mentions the following:

An unprecedented deoxygenative arylation of aromatic carboxylic acids was achieved, allowing the construction of an enhanced library of unsym. diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chem. allows for precise cleavage of a stronger C-O bond and formation of a weaker C-C bond by 1,5-aryl migration under mild reaction conditions. This new protocol was independent of substrate redox-potential, electronic, and substituent effects. It afforded a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Application of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Encapsulation of polyoxotungstate into dendrimers by ionic bonding and their use as oxidation catalyst was written by Jahier, Claire;Plault, Lauriane;Nlate, Sylvain. And the article was included in Israel Journal of Chemistry in 2009.Related Products of 10297-05-9 This article mentions the following:

A family of 36-armed dendrimers containing six internal amino groups was synthesized and used to incorporate polyoxometalates (POMs) into their structures by ionic bonding. Allyl-terminated dendrimer 17 (with oxidizable end groups) and methylphenyl-terminated dendrimer 18 (with non-oxidizable end groups) were used for these studies. It was found that the electrostatic incorporation of the tri-anionic POM [PO₄{WO(O₂)₂}₄]^3- into the methylphenyl-terminated dendrimer 18, in an acidic medium, leads to the dendritic POM hybrid 19, bearing two POM units in its structure. In contrast, attempts to encapsulate POMs into allyl-terminated dendrimer 17 gave unsatisfactory results. Indeed, the epoxidation kinetics of the 36-olefinic terminated dendrimer 17 was too slow, and the expected 36-epoxy-dendritic POM framework 20 was not obtained. Lengthening the reaction up to six hours led to the decomposition of POM species. The solubility in organic solvents of the dendritic POM hybrid 19, combined with its NMR and IR data, indicate that POM units are clearly connected to the dendritic structure. The catalytic performance of this hybrid material in the oxidation of cyclooctene shows that the properties of POM are retained. The POM-encapsulated dendrimer 19 was found to be an effective catalyst in the oxidation of cyclooctene. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Related Products of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Related Products of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com