Author: Jessica.F

Wang, Long published the artcileHigh-Lying 3¹Ag Dark-State-Mediated Singlet Fission, Recommanded Product: 1-Iodohexane, the publication is Journal of the American Chemical Society (2021), 143(15), 5691-5697, database is CAplus and MEDLINE.

Singlet fission (SF), the conversion of one high-energy singlet to two low-energy triplets, provides the potential to increase the efficiency of photovoltaic devices. In the SF chromophores with C_2h symmetry, exemplified by polyenes, singlet-to-triplet conversion generally involves a low-lying 2¹A_g dark state, which serves as either a multiexciton (ME) intermediate to promote the SF process or a parasitic trap state to shunt excited-state populations via internal conversion. This controversial behavior calls for a deep understanding of dark-state-related photophysics involving the higher-lying singlet state. However, the optical “dark” and “transient” nature of these dark states and strong correlation feature of double exciton species make their characterization and interpretation challenging from both exptl. and computational perspectives. In the present work combining transient spectroscopy and multireference electronic structure calculations (XDW-CASPT2), we addressed a new photophys. model, i.e., a high-lying 3¹Ag dark-state-mediated ultrafast SF process in the benzodipyrrolidone (BDPP) skeleton. Such a 3¹Ag dark state with distinctive double excitation character, described as the ME state, could be populated from the initial 1¹Bu bright state on an ultrafast time scale given the quasi-degeneracy and intersection of the two electronic states. Furthermore, the suitable optical band gap and triplet energy, high triplet yield, and excellent photostability render BDPP a promising SF candidate for photovoltaic devices. These results not only enrich the arsenal of SF materials but also shed new insights into the understanding of dark-state-related photophysics, which could promote the development of new SF-active materials.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H13NO2, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Ling published the artcilePreparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement, Quality Control of 53279-83-7, the publication is Organic Letters (2021), 23(17), 6819-6824, database is CAplus and MEDLINE.

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Organic Letters published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Quality Control of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Eunkyung published the artcileIntegration of Cyanine, Merocyanine and Styryl Dye Motifs with Synthetic Bacteriochlorins, Application In Synthesis of 606-55-3, the publication is Photochemistry and Photobiology (2016), 92(1), 111-125, database is CAplus and MEDLINE.

Understanding the effects of substituents on spectral properties is essential for the rational design of tailored bacteriochlorins for light-harvesting and other applications. Toward this goal, three new bacteriochlorins containing previously unexplored conjugating substituents have been prepared and characterized. The conjugating substituents include two pos. charged species, 2-(N-Et 2-quinolinium)vinyl- (B-1) and 2-(N-Et 4-pyridinium)vinyl- (B-2), and a neutral group, acroleinyl- (B-3); the charged species resemble cyanine (or styryl) dye motifs whereas the neutral unit resembles a merocyanine dye motif. The three bacteriochlorins are examined by static and time-resolved absorption and emission spectroscopy and d. functional theor. calculations B-1 and B-2 have Q_y absorption bathochromically shifted well into the NIR region (822 and 852 nm), farther than B-3 (793 nm) and other 3,13-disubstituted bacteriochlorins studied previously. B-1 and B-2 have broad Q_y absorption and fluorescence features with large peak separation (Stokes shift), low fluorescence yields, and shortened S₁ (Q_y) excited-state lifetimes (∼700 ps and ∼100 ps). More typical spectra and S₁ lifetime (∼2.3 ns) are found for B-3. The combined photophys. and mol.-orbital characteristics suggest the altered spectra and enhanced nonradiative S₁ decay of B-1 and B-2 derive from excited-state configurations in which electron d. is shifted between the macrocycle and the substituents.

Photochemistry and Photobiology published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C10H15ClO3S, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Di published the artcileAcridinium-conjugated aromatic heterocycles as highly potent FtsZ inhibitors: Design, synthesis, and biological evaluation, Application In Synthesis of 638-45-9, the publication is Archiv der Pharmazie (Weinheim, Germany) (2022), 355(6), 2100400, database is CAplus and MEDLINE.

The epidemic of multidrug resistance (MDR) is a serious threat to public health, and new classes of antibiotics with novel mechanisms of action are in critical need. We rationally designed and efficiently synthesized three series of new chem. entities with potential antibacterial activity targeting filamenting temperature-sensitive mutant Z (FtsZ). Evaluation of these compounds against a panel of Gram-pos. bacteria including MDR and vancomycin-resistant Enterococcus strains indicated that most compounds showed enhanced antibacterial efficacy, comparable or even superior to the reference drugs. The newly synthesized compounds proved to be substrates of the Escherichia coli efflux pump AcrB, thus affecting the activity. Their structure-activity relationships were summarized in detail. The most potent compound 10f quickly eliminated bacteria in a bactericidal mode, with low susceptibility to induce bacterial resistance. Further mechanistic studies with the BsFtsZ protein revealed that 10f functioned as an effective FtsZ inhibitor through altering the dynamics of FtsZ self-polymerization via a stimulatory mechanism, which leads to inhibition of cell division and cell death. Besides, 10f not only displayed no obvious cytotoxicity to mammalian cells but also had a high efficacy in a murine model of bacteremia in vivo. Regarded as a whole, our findings highlight 10f as a promising new FtsZ-targeting bactericidal agent.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C5H10O2S, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Shan published the artcileEnantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations, Quality Control of 638-45-9, the publication is Nature Communications (2021), 12(1), 2771, database is CAplus and MEDLINE.

A nickel-catalyzed enantioselective hydroalkylation of acyl enamines R¹C(O)N(R²)CH=CH₂ (R¹ = C₆H₅, 1-naphthyl, 2-furyl, etc.; R² = H, Me) and enol esters R³C(O)OCH=CH₂R⁴ (R³ = C₆H₅, 4-CH₃OC₆H₄, 2-naphthyl; R⁴ = H, C₄H₉, C₆H₁₃, (CH₂)₄Cl) with alkyl halides R⁵I [R⁵ = 2-phenylethyl, 3-(thiophen-2-yl)propyl, 3-(9H-carbazol-9-yl)propyl, etc.] to afford enantioenriched α-branched aliphatic acyl amines (R)-R¹C(O)N(R²)CH(R⁵)Me and esters R³C(O)OCH(R⁵)CH₂R⁴ in good yields with excellent levels of enantioselectivity has been described. The operationally simple protocol provides a straightforward access to chiral secondary alkyl-substituted amine and secondary alkyl-substituted alc. derivatives from simple starting materials with great functional group tolerance.

Nature Communications published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C17H16O2, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Roesch, Kevin R. published the artcileSynthesis of Isoquinolines and Pyridines by the Palladium-Catalyzed Iminoannulation of Internal Alkynes, Application In Synthesis of 165534-79-2, the publication is Journal of Organic Chemistry (2001), 66(24), 8042-8051, database is CAplus and MEDLINE.

A wide variety of substituted isoquinoline, tetrahydroisoquinoline, 5,6-dihydrobenz[f]isoquinoline, pyrindine, and pyridine heterocycles have been prepared in good to excellent yields via annulation of internal acetylenes with the tert-butylimines of o-iodobenzaldehydes and 3-halo-2-alkenals in the presence of a palladium catalyst. The best results are obtained by employing 5 mol % of Pd(OAc)₂, an excess of the alkyne, 1 equiv of Na₂CO₃ as a base, and 10 mol % of PPh₃ in DMF as the solvent. This annulation methodol. is particularly effective for aryl- or alkenyl-substituted alkynes. When electron-rich imines are employed, this chem. can be extended to alkyl-substituted alkynes. Trimethylsilyl-substituted alkynes also undergo this annulation process to afford monosubstituted heterocyclic products absent the silyl group.

Journal of Organic Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Application In Synthesis of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Jie published the artcileSynthesis and liquid crystalline properties of substituted 2,5-diaryl 1,3,4-oxadiazole derivatives without flexible chains, Recommanded Product: 4-Iodobenzohydrazide, the publication is Liquid Crystals (2008), 35(12), 1359-1365, database is CAplus.

A series of new compounds based on aromatically 2,5-disubstituted 1,3,4-oxadiazoles without flexible chains, formulated as p-R-C6H4-(OC2N2)-(p-C6H4)2-R’ with (i) R = CH3O, R’ = CH3O, CH3S, F, H (Ia-Id), (ii) R = CH3S, R’ = CH3O, CH3S, F, H (IIa-IId) and (iii) R = F, R’ = CH3O, CH3S, F, H (IIIa-IIId) (p-C6H4 and OC2N2 represent a p-phenylene spacer and a 1,3,4-oxadiazole ring, resp.), were synthesized and characterized by ¹H and ¹³C NMR, MS and HRMS techniques. Mesomorphic properties were investigated using differential scanning calorimetry and polarizing optical microscopy. All of the target compounds (except Id, IId, IIIc and IIId) exhibited an enantiotropic nematic mesophase with high melting temperatures The liquid crystalline properties of these compounds were influenced greatly by polarity, steric factors and positions of the terminal groups. The effect of the terminal groups on the liquid crystal properties is discussed.

Liquid Crystals published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Xiaojing published the artcileA FRET-based ratiometric fluorescent probe to detect cysteine metabolism in mitochondria, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Organic & Biomolecular Chemistry (2020), 18(7), 1487-1492, database is CAplus and MEDLINE.

As an important biothiol in living cells, cysteine is closely related to oxidative damage in living organisms. Sulfite from cysteine metabolism in living cells plays a crucial role in maintaining homeostasis in an organism, and the unbalance of sulfite in vivo would lead to multiple diseases. Thus the development of a new fluorescent probe for cysteine metabolism is needed urgently in mitochondria which are the main place of cysteine metabolism Herein the authors construct a novel targeting mitochondria fluorescent probe CP-K (I) based on the FRET mechanism to visualize sulfite in living MCF-7 cells. Probe CP-K displays a large Stokes shift of 150 nm, a low detection limit (26.3 nM) and “naked eye” detection after the addition of HSO₃^–. Importantly, it is appropriate for imaging the endogenous sulfite from cysteine metabolism in living cells.

Organic & Biomolecular Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Yu published the artcileGold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones, Name: (2-Amino-5-iodophenyl)methanol, the publication is Advanced Synthesis & Catalysis (2010), 352(2+3), 373-378, database is CAplus.

A highly efficient method has been developed for the one-pot synthesis of multiring heterocyclic compounds, e.g. I (R¹ = H, Ph, etc.; R² = H, Me; R³ = H, n-C₆H₁₃) and II (R⁴ = H, Cl, Ph, etc.) via a gold(I)-catalyzed tandem coupling/cyclization reaction of o-aminobenzyl alcs. with HCCCH₂CH(R³)CO₂H and HCC(CH₂)₃CO₂H, resp. The strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic mol. architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Advanced Synthesis & Catalysis published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C3H3Br2ClO, Name: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com