Author: Jessica.F

Brownson, G. W. published the artcileFar-infrared intensity and normal coordinate studies on pyridine-halogen complexes, SDS of cas: 6443-90-9, the publication is Journal of Molecular Structure (1971), 10(1), 147-53, database is CAplus.

Absolute integrated intensity data were determined for the 2 low frequency bands due to ν(D-I) and ν(I-X) in pyridine-IX (X=I, Cl, Br) complexes. Along with the normal coordinates, calculated by using a linear triat. model, these data were used to calculate dipole derivatives * vecμ/* j values. Pyridine-d5-IBr spectra were used to estimate possible values of the interaction force constant k13. The dipole moment change * vecμ/* D-I calculated for the pyridine-I2 complex by using a simple model is considerably lower than that observed, implying that charge-transfer effects contribute significantly to the band intensities.

Journal of Molecular Structure published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, SDS of cas: 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Liu published the artcileSyntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity, Name: 2-Bromo-1-(bromomethyl)-3-iodobenzene, the publication is Journal of Medicinal Chemistry (2021), 64(12), 8391-8409, database is CAplus and MEDLINE.

A series of novel benzo[c][1,2,5]oxadiazole derivatives were designed, synthesized, and biol. evaluated as inhibitors of PD-L1. Among them, compound I [R = H] exhibited 1.8 nM IC₅₀ value in a homogeneous time-resolved fluorescence (HTRF) assay, which was 20-fold more potent than the lead compound BMS-1016 (II). In the surface plasmon resonance (SPR) assay, compound I [R = H] bound to human PD-L1 (hPD-L1) with a K_D value of 3.34 nM, without showing any binding to hPD-1. In the cell-based coculture assay, compound I [R = H] blocked PD-1/PD-L1 interaction with an EC₅₀ value of 375 nM, while BMS-1016 had an EC₅₀ value of 2075 nM. Moreover, compound I [R = Et] , an ester prodrug of compound I [R = H], was orally bioavailable and displayed significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice. Mechanistically, compound I [R = Et] exhibited significant in vivo antitumor effects probably through promoting antitumor immunity. Together, this series of benzoxadiazole PD-L1 inhibitors holds promise for tumor immunotherapy. Preclin. trials with selected compounds are ongoing in our laboratory

Journal of Medicinal Chemistry published new progress about 1261649-03-9. 1261649-03-9 belongs to iodides-buliding-blocks, auxiliary class Bromide,Iodide,Benzyl bromide,Benzene, name is 2-Bromo-1-(bromomethyl)-3-iodobenzene, and the molecular formula is C7H5Br2I, Name: 2-Bromo-1-(bromomethyl)-3-iodobenzene.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Deuker, Marius published the artcileTetraorganylargentate(III) Complexes: Key Intermediates in Silver-Mediated Cross-Coupling Reactions, COA of Formula: C6H13I, the publication is Organometallics (2021), 40(14), 2354-2363, database is CAplus.

The use of silver as a catalyst in cross-coupling reactions remains underdeveloped. Authors show by electrospray-ionization mass spectrometry that the diorganylargentates LiAgR’₂·Li(CN) (R’ = Me, Bu) formed in situ react with a wide scope of alkyl and aryl halides RX to afford the tetraorganylargentate(III) complexes R’₃AgR^–. Upon fragmentation in the gas phase, these high-valent species readily undergo reductive elimination. The trimethylorganylargentates Me₃AgR^– furnish the synthetically desired cross-coupling products MeR with high selectivity, whereas the tributylorganylargentates Bu₃AgR^– yield more of the homocoupling product Bu₂. Quantum chem. calculations reproduce the exptl. observed trends in reactivity and moreover provide insight into the structures and energetics of the species involved. Their findings indicate that the facile formation of tetraorganylargentate complexes and their high tendency toward reductive elimination can be exploited for the development of silver-mediated cross-coupling reactions as a viable alternative to established synthetic methods.

Organometallics published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dai, Shengfei published the artcileMetal-free and Selectfluor-mediated diverse transformations of 2-alkylthiobenzamides to access 2,3-dihydrobenzothiazin-4-ones, benzoisothiazol-3-ones and 2-alkylthiobenzonitriles, Recommanded Product: 1-Iodohexane, the publication is Organic Chemistry Frontiers (2022), 9(15), 4016-4022, database is CAplus.

Diverse transformations of 2-alkylthiobenzamides were established to synthesize 2,3-dihydrobenzothiazin-4-ones, benzoisothiazol-3-ones and 2-alkylthiobenzonitriles in the presence of Selectfluor. Both NaI-HI and TFA-Ac₂O systems control the selective C-S bond cleavage and C-H bond functionalization to access 2,3-dihydrobenzothiazin-4-ones and 2-substituted 2,3-dihydrobenzothiazin-4-ones, resp. Notably, this was the first example of using Selectfluor as a methylene source to construct important 2,3-dihydrobenzothiazin-4-ones. In the presence of HCl, benzoisothiazol-3-ones were obtained in good yields. Furthermore, 2-alkylthiobenzonitriles could also be prepared using the same NaI-HI system via a thioether-directed and Selectfluor-mediated dehydration of 2-alkylthiobenzamides.

Organic Chemistry Frontiers published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Congrong published the artcilePalladium/Copper Cocatalyzed Coupling Reaction of Aroyl Hydrazides with Indoles, SDS of cas: 39115-95-2, the publication is Chinese Journal of Chemistry (2016), 34(12), 1213-1217, database is CAplus.

An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1:1 mixture of DMSO and nitromethane to give structurally diverse 2-arylindoles or 3-arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.

Chinese Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Hong-Liang published the artcilePalladium-Catalyzed Enantioselective C(sp³)-H Arylation of 2-Propyl Azaaryls Enabled by an Amino Acid Ligand, Product Details of C6H13I, the publication is Organic Letters (2022), 24(6), 1286-1291, database is CAplus and MEDLINE.

A palladium(II)-catalyzed enantioselective arylation of unbiased secondary C(sp3)-H bonds was developed. The enantioselectivity was controlled by the combination of a pyridyl or isoquinolinyl directing group and an amino acid, N-Boc-2-pentyl proline. A variety of 2-Pr azaaryls and biaryl iodides were employed to provide arylated products in moderate to good yields (up to 82%) with high enantioselectivities (up to 93:7 er). This reaction is a rare example of an amino-acid-enabled enantioselective acyclic methylene C(sp3)-H arylation. Furthermore, the reaction proceeded with high enantioselectivity even on a gram scale, and the product was transformed to a 5,6,7,8-tetrahydroisoquinoline bioactive mol. Kinetic isotope effect (KIE) experiments indicated that C-H activation is the rate-determining step for the enantioselective C(sp3)-H arylation.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Zhen-Qi published the artcileCopper-Catalyzed/Promoted Cross-coupling of gem-Diborylalkanes with Nonactivated Primary Alkyl Halides: An Alternative Route to Alkylboronic Esters, Synthetic Route of 161370-66-7, the publication is Organic Letters (2014), 16(24), 6342-6345, database is CAplus and MEDLINE.

The first copper-catalyzed/promoted sp³-C Suzuki-Miyaura coupling reaction of gem-diborylalkanes with nonactivated electrophilic reagents is reported. Not only 1,1-diborylalkanes but also some other gem-diborylalkanes can be coupled with nonactivated primary alkyl halides, offering a new method for sp³C-sp³C bond formation and, simultaneously, providing a new strategy for the synthesis of alkylboronic esters.

Organic Letters published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C6H8BNO3, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tian, Chengze published the artcileDiscovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity, Quality Control of 638-45-9, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128271, database is CAplus and MEDLINE.

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymic and cellular activities. Most compounds displayed nanomolar inhibitory activities against PI3Ks, among which 25 displayed high LLE and micromolar inhibitory potency against three human tumor cell lines (IC₅₀ = 0.264μM, 2.04μM, 1.14μM).

Bioorganic & Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H34N4O5S, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lazaro-Milla, Carlos published the artcileMetal-Free C-C/C-N/C-C Bond Formation Cascade for the Synthesis of (Trifluoromethyl)sulfonylated Cyclopenta[b]indolines, Formula: C7H8INO, the publication is Organic Letters (2021), 23(8), 2921-2926, database is CAplus and MEDLINE.

A bis(triflyl)ethylation [triflyl = (trifluoromethyl)sulfonyl] inserted into a sequential cyclization cascade resulted in the direct formation of gem-bis(triflyl)ated cyclopenta[b]indolines from anilide-derived allenols and alkenols. This catalyst- and irradiation-free sequence facilitated the efficient preparation of functionalized tricyclic indoline cores bearing two contiguous stereocenters. The formed cyclopenta[b]indolines was easily transformed into a wide variety of triflylated indolines, including the tetracycle ring system found in polyveoline.

Organic Letters published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Formula: C7H8INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miles, Dillon H. published the artcileDiscovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors, Category: iodides-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2020), 11(11), 2244-2252, database is CAplus and MEDLINE.

The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated macrophages, and its expression levels are associated with tumor immunosuppression and growth. Selective inhibition of PI3Kγ offers a promising strategy in immuno-oncol., which has led to the development of numerous potent PI3Kγ inhibitors with variable selectivity profiles. To facilitate further investigation of the therapeutic potential of PI3Kγ inhibition, we required a potent and PI3Kγ-selective tool compound with sufficient metabolic stability for use in future in vivo studies. Herein, we describe some of our efforts to realize this goal through the systematic study of SARs within a series of 7-azaindole-based PI3Kγ inhibitors. The large volume of data generated from this study helped guide our subsequent lead optimization efforts and will inform further development of PI3Kγ-selective inhibitors for use in immunomodulation.

ACS Medicinal Chemistry Letters published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com