Category: 60827-45-4

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Journal of Fermentation and Bioengineering called Isolation of a bacterium assimilating (R)-3-chloro-1,2-propanediol and production of (S)-3-chloro-1,2-propanediol using microbial resolution, Author is Suzuki, Toshio; Kasai, Naoya; Yamamoto, Ryoichi; Minamiura, Noshi, the main research direction is Alcaligenes chloropropanediol metabolism resolution.Recommanded Product: 60827-45-4.

A bacterium capable of assimilating 3-chloro-1,2-propanediol was isolated from soil by enrichment culture. The strain was identified as Alcaligenes sp. by taxonomic studies. The crude extracts of the cells had dehalogenating activities and converted various halohydrins to the corresponding epoxides. 3-Chloro-1,2-propanediol was degraded stereospecifically by the strain, liberating Cl-. The residual isomer was found by use of this strain in 38% yield, and (S)-glycidol (99.4% enantiomeric excess) was subsequently synthesized from the obtained (S)-3-chloro-1,2-propanediol by alk. treatment.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2S)-(+)-3-Chloropropane-1,2-diol(SMILESS: OC[C@H](O)CCl,cas:60827-45-4) is researched.HPLC of Formula: 111-18-2. The article 《Study on acute toxicity of R,S and (R,S)-3-chloro-1,2-propanediol》 in relation to this compound, is published in Weisheng Yanjiu. Let’s take a look at the latest research on this compound (cas:60827-45-4).

The aim of the paper was to investigate the acute toxicity of R,S and (R,S)-3-chloro-1,2-propanediol (3-MCPD). Ten, seven and seven groups of sexually mature ICR mice were employed for testing the acute toxicity of R, S and (R,S)-3-MCPD, at the doses of 176.78 mg/kg, 198.43 mg/kg, 222.73 mg/kg, 250 mg/kg, 280.61 mg/kg, 314.98 mg/kg, 353.55 mg/kg, 396.84 mg/kg, 445.44 mg/kg, and 499.99 mg/kg for R-3-MCPD, 89.09 mg/kg, 100 mg/kg, 112.25 mg/kg, 125.99 mg/kg, 141.42 mg/kg, 158.74 mg/kg and 178.18 mg/kg for S-3-MCPD, and 130.25 mg/kg, 150 mg/kg, 172.75 mg/kg, 198.95 mg/kg, 229.13 mg/kg, 263.88 mg/kg and 303.91 mg/kg for (R,S)-3-MCPD, resp. The mice were given three forms of 3-MCPD once by gavage and observed for 14 days, the LD50 was calculated by the modified Karber’s method, and organ/body weight ratios were measured and morphol. changes of liver and kidney were examined Results showed that the LD50 (95% CI) of R, S and (R,S)-3-MCPD was 290.54 mg/kg (280.74-300.68), 117.57 mg/kg (113.82-121.45) and 190.73 mg/kg (177.76-204.59), resp. The kidney/weight ratios in R-3-MCPD treated groups were higher than controls at the doses of 250-353.55 mg/kg (P < 0.05), and the brain weight ratios also had an significant increase in the 353.55 mg/kg, 445.44 mg/kg and above doses (P < 0.05). However, no significant changes on organ/body weight ratio of any organs in S-3-MCPD treated groups were observed The kidney/body weight ratio in (R,S)-3-MCPD treated groups increased significantly at the doses of 198.95-303.91 mg/kg (P < 0.05), and the brain weight ratios also had a significant increase at the doses of 229.13-303.91 mg/kg. At the doses of 353.55-499.99mg/kg, R-3-MCPD caused obvious swell of liver cells and the swell and congestion of the liver sinus. At the dose 229.13 mg/kg and above, (R,S)-3-MCPD also induced the swell of liver cells and congestion of the liver sinus. No obvious morphol. change of kidney after administration of R, S and (R,S)-3-MCPD was observed In conclusion, the acute toxicity of S-3-MCPD might be much higher than those of (R,S)-3-MCPD and R-3-MCPD, and both R-3-MCPD and S-3-MCPD seemed to possess neurotoxicity. Here is a brief introduction to this compound(60827-45-4)HPLC of Formula: 60827-45-4, if you want to know about other compounds related to this compound(60827-45-4), you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Synthesis of polymeric salen complexes and application in the enantioselective hydrolytic kinetic resolution of epoxides as catalysts. Author is Kwon, Mi-Ae; Kim, Geon-Joong.

The polymeric (salen) Co(III) catalysts containing various counter anions have been synthesized, and the asym. catalytic activities of these newly synthesized polymer-type salen complexes were investigated in the HKR of terminal epoxides. The polymeric chiral salen Co(III) complexes catalyze the hydrolysis of epichlorohydrin, 1,2-epoxybutane, 1,2-epoxyhexane and epoxystyrene with very high enantioselectivities under mild conditions. The catalysts could be recovered and reused several times without further treatment after reaction, showing no loss of activity and enantioselectivity.

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Iodide – Wikipedia,
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Related Products of 60827-45-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about A new ligand class for the asymmetric dihydroxylation of olefins.

1,4-Bis(dihydroquinidinyl)- and 1,4-bis(dihydroquininyl)anthraquinone are new ligands which show superior enantioselectivity in the asym. dihydroxylation of almost all olefins having only aliphatic substituents.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hu, Ji; Malic, Nino; Scott, Janet L.; Strauss, Christopher R. published the article 《Potential impacts of deep-sea injection of CO2 on marine organic chemistry》. Keywords: deep sea injection carbon dioxide effect marine organic chem; carbon dioxide epoxide effect marine organic chem seawater injection.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.

The extent of reaction of epoxides in salt water changed markedly following introduction of gaseous or liquid CO2. Higher concentrations of β-chlorohydrins in carbonated salt water vs. concentrations in salt water alone were attributed to greater acidity of the aqueous phase. This suggested regimes for sequestering CO2 by deep sea injection should account for potential effects on marine organic chem. No evidence was obtained for enhanced nucleophilicity of Cl- through potential desolvation at the CO2-water interface.

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Iodide – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation.Related Products of 60827-45-4.

The biochem. mechanism of toxicity of the exptl. astrocyte neurotoxicant and food contaminant S-3-chloro-1,2-propanediol (3-CPD) has been proposed to be via inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We have confirmed this action in liver, which shows inhibition to 6.0±0.7% control at the neuropathic dose of 140 mg/kg. However, GAPDH activity in brain only fell to a min. of 54±24% control, and the concentrations of lactate and pyruvate (the downstream products of GAPDH), showed no pre-neuropathic decreases in 3-CPD susceptible brain tissue. There was no inhibition of GAPDH activity in primary astrocyte cultures at sub-cytotoxic exposures. We therefore sought alternative mechanisms to explain its toxicity to astrocytes. We were able to show that 3-CPD is a substrate for glutathione-S-transferase and also that, after bioactivation by alc. dehydrogenase, it generates an irreversible inhibitor of glutathione reductase. In addition, incubation of brain slices from the 3-CPD-vulnerable inferior colliculus produces a depletion of glutathione and an inhibition of glutathione-S-transferase that is not seen in equivalent slices taken from the 3-CPD-resistant occipital neocortex. A smaller but significant and similarly regionally selective decrease in glutathione content is also seen in vivo. We conclude that 3-CPD does not produce its astrocytic toxicity via energy deprivation, and suggest that selective bioactivation and consequent disruption of redox state is a more likely mechanism.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, International Journal of Andrology called Inhibition of glucose catabolism in rat, hamster, rhesus monkey and human spermatozoa by α-chlorohydrin, Author is Ford, W. C. L.; Harrison, Anne; Takkar, G. L.; Waites, G. M. H., the main research direction is sperm glucose metabolism chlorohydrin; glycolysis sperm chlorohydrin.Electric Literature of C3H7ClO2.

Spermatozoa from the cauda epididymis of rats treated with RS-α-chlorohydrin [96-24-2] (10 mg/kg/day for 7 days, orally) had the same ATP [56-65-5] content as control spermatozoa immediately after collection, but were unable to metabolize glucose [50-99-7] in vitro and so their ATP content declined more rapidly than that of control spermatozoa. The in vitro metabolism of glucose by spermatozoa from rat, hamster, rhesus monkey, and human was inhibited by ≥80% after 15-30 min preincubation in the presence of RS-α-chlorohydrin concentrations of <1, >10, 5-10, and >50 mM, resp. Inhibition of glucose oxidation was correlated with a reduction in ATP concentration in the spermatozoa. α-Chlorohydrin may act as an antifertility agent by inhibition of sperm glycolysis, but RS-α-chlorohydrin would apparently not be an effective contraceptive in man. However, the glucose metabolism of human spermatozoa was significantly inhibited by <10 mM of S-α-chlorohydrin [60827-45-4]. Here is a brief introduction to this compound(60827-45-4)Electric Literature of C3H7ClO2, if you want to know about other compounds related to this compound(60827-45-4), you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C3H7ClO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Study on synthesis and properties of chloride-[1-ethyl-3-(1,2-dihydroxypropyl)]imidazole ionic liquid.

A method for the synthesis of the title compound is reported here. A chiral imidazole ionic liquid was prepared from 1-ethylimidazole and (2S)-3-chloro-1,2-propanediol. The resulting chiral ionic liquid was characterized by NMR. Its elec. conductivity in different solvents was determined The result shows that the ionic liquid can be dissolved in acetonitrile, acetone, ethanol, water, N, N-dimethylformamide (DMF) but not in Et acetate. The elec. conductivity of the ionic liquid is also measured at different temperatures and concentrations, and the result shows that the elec. conductivity value increases along with concentration and temperature, and the value of elec. conductivity K is different in different solvents. Its order is as follow: K(acetonitrile)=K(water)>K(DMF)>K(acetone)>K.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The male antifertility activity of 6-chloro-6-deoxyglucose, published in 1991-12-31, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Application of 60827-45-4.

6-Chloro-6-deoxy[U-14C]glucose is not metabolized by mature boar spermatozoa nor has it any specific inhibitory action on their metabolic activity in vitro. The compound is metabolized by the male rat and the identification of 2 urinary metabolites as α-chlorohydrin and 3-chlorolactate confirmed that (S)-3-chlorolactaldehyde is produced by this species in vivo. A tissue distribution study revealed that radioactivity from 6-chloro-6-deoxy[U-14C]glucose was more concentrated in rat caudal spermatozoa than in any other of the major tissues.

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COA of Formula: C3H7ClO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about p-Tolyl glycerol ether: is it possible to find more simple molecular organogelator with pronounced chirality driven properties?. Author is Bredikhin, Alexander A.; Bredikhina, Zemfira A.; Akhatova, Flyura S.; Gubaidullin, Aidar T..

P-Tolyl glycerol ether not belonging to any of the known gelator families forms stable transparent gels in hydrocarbon media showing very good quant. characteristics of gelling abilities, which are, in turn, strongly dependent on the chiral characteristics of the gelator. The crystal packing differences between the rac- and scal-substances could be the reason for such behavior.

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Iodide – Wikipedia,
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