Category: 625-99-0

In 2022,Rakshit, Amitava; Dhara, Hirendra Nath; Sahoo, Ashish Kumar; Alam, Tipu; Patel, Bhisma K. published an article in Organic Letters. The title of the article was 《Pd(II)-Catalyzed Synthesis of Furo[2,3-b]pyridines from β-Ketodinitriles and Alkynes via Cyclization and N-H/C Annulation》.Application of 625-99-0 The author mentioned the following in the article:

A Pd(II)-catalyzed synthesis of furopyridines, e.g., I has been developed from β-ketodinitriles, e.g., 2-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)propanedinitrile and alkynes, e.g., diphenylacetylene via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C=C, C-O, C-N, and C=N bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Application of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C6H4ClIIn 2019 ,《Three-Component Aminoselenation of Arynes》 was published in Organic Letters. The article was written by Gaykar, Rahul N.; Guin, Avishek; Bhattacharjee, Subrata; Biju, Akkattu T.. The article contains the following contents:

The three-component coupling of tertiary amines, arynes, and aryl selenium bromide or diaryl diselenide as an electrophilic selenium source allowing the synthesis of 2-selanyl aniline derivatives is reported. This aminoselenation reaction of arynes installs a C-N and C-Se bond under mild conditions, and the products are formed in moderate to good yields. This reaction is compatible with various functional groups, and the preliminary studies on the mechanism of the reaction is also provided. In the experiment, the researchers used 1-Chloro-3-iodobenzene(cas: 625-99-0Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C6H4ClI Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Kan; Yang, Mingming; Yao, Yanxiu; Yu, Binxun; Wang, Yanyan; Sun, Huaming; Zhang, Weiqiang; Zhang, Guofang; Gao, Ziwei published an article in New Journal of Chemistry. The title of the article was 《One-pot synthesis of benzo[b][1,4]diazepines via the carbonylative Sonogashira reaction and aza-Michael addition cyclocondensation》.Synthetic Route of C6H4ClI The author mentioned the following in the article:

A highly efficient synthetic method for benzodiazepines was reported, which involved a ppm-level Pd-catalyzed carbonylative coupling of iodobenzenes with terminal alkynes to afford 1,3-ynones as key intermediates and a subsequent Cp2TiCl2/m-phthalic acid/ethanol-catalyzed cyclocondensation in one-pot conditions. The new approach proceeded with a broad substrate scope under mild reaction conditions, provided benzo[b][1,4]diazepines in up to 90% yield. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Synthetic Route of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Synthetic Route of C6H4ClI Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 625-99-0In 2020 ,《Palladium catalysed C-H arylation of pyrenes: access to a new class of exfoliating agents for water-based graphene dispersions》 appeared in Chemical Science. The author of the article were Just-Baringo, Xavier; Shin, Yuyoung; Panigrahi, Adyasha; Zarattini, Marco; Nagyte, Vaiva; Zhao, Ling; Kostarelos, Kostas; Casiraghi, Cinzia; Larrosa, Igor. The article conveys some information:

A new and diverse family of pyrene derivatives was synthesized via palladium-catalyzed C-H ortho-arylation of pyrene-1-carboxylic acid. The strategy afforded easy access to a broad scope of 2-substituted and 1,2-disubstituted pyrenes. The C1-substituent was easily transformed into carboxylic acid, iodide, alkynyl, aryl or alkyl functionalities. This approach gives access to arylated pyrene ammonium salts, which outperformed their non-arylated parent compound during aqueous Liquid Phase Exfoliation (LPE) of graphite and compare favorably to state-of-the-art sodium pyrene-1-sulfonate PS1. This allowed the production of concentrated and stable suspensions of graphene flakes in water. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 625-99-0Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Advanced Synthesis & Catalysis included an article by Lu, Hao; Li, Zheng. Safety of 1-Chloro-3-iodobenzene. The article was titled 《Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source》. The information in the text is summarized as follows:

Palladium-catalyzed one-pot four-component synthesis of β-cyano-α,β-unsaturated ketones (Ar)(CN)C=CH(C(O)Ar1) [Ar = Ph, 4-MeC6H4, 2-FC6H4, etc.; Ar1 = Ph, 3-BrC6H4, 4-F3CC6H4, etc.] was reported via reaction of aryl halides, calcium carbide, potassium hexacyanoferrate(II) and aroyl chlorides. The salient features of this protocol were the direct use of easy-to-handle acetylene source and eco-friendly cyanide source, wide scope of substrates with good functional group tolerance and simple work-up procedure. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Safety of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1-Chloro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Xu; Guo, Xiao-Qiang; Chen, Lian-Mei; Kang, Tai-Ran published their research in Chemistry – A European Journal in 2021. The article was titled 《Synthesis, Characterization of Spirocyclic λ3-Iodanes and Their Application to Prepare 4,1-Benzoxazepine-2,5-diones and 1,3-Diynes》.Related Products of 625-99-0 The article contains the following contents:

Herein, a [3+2] cycloaddition of aza-oxyallylic cations I [R = H, 6-Cl, 5-NO2, 5-F; R1 = 2-bromophenyl, 4-(ethoxycarbonyl)benzen-1-yl, tris(propan-2-yl)silyl, etc.] with ethynylbenziodoxolones R2ONHC(O)C(CH3)2Br [R2 = allyl, i-Pr, Bn, (2,4-dichlorophenyl)methyl, etc.] for synthesis of new λ3-iodanes containing spirocyclic 4-oxazolidinone II is described. This cyclic λ3-iodanes II display stability in air and excellent solubility in organic solvent. Using the above compounds as substrate II, both the 4,1-benzoxazepine-2,5-diones III [R3 = Me, allyl, (2,4-dichlorophenyl)methyl, etc.; R4 = H, 7-Me, 8-Cl, 7-CF3] and sym. 1,3-diynes derivatives R5CCCCR5 [R5 = Ph, 2-bromophenyl, 1-naphthyl, etc.] were afforded in high yield under copper(I)-catalyzed conditions. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Related Products of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Panting; Chen, Wenxing; Lu, Wangyang published an article in 2021. The article was titled 《Solar photothermal catalytic effect promotes carbonylation reaction based on palladium doped g-C3N4 catalyst》, and you may find the article in Materials Research Bulletin.Category: iodides-buliding-blocks The information in the text is summarized as follows:

Palladium catalyzed carbonylation reaction is used as an effective method in the industrial to prepare carbonyl-containing compounds Besides, the complex ligands are needed to improve the yields and selectivity of reactions, which will increase the cost for production Thus, it is very meaningful to build a simple and efficient catalytic system. Here, the graphitic carbon nitride (g-C3N4) nanosheets (ECN) doped with palladium metal (Pd/ECN) were prepared by microwave-assisted deposition method. The results indicated that the yield of Me benzoate was 77% based on Pd/ECN under the light irradiation with a wavelength of ≥ 400 nm, which was higher than that of the homogeneous catalysts and heterogeneous catalysts commonly used in commercialization such as palladium on activated charcoal (Pd/C) and palladium chloride (PdCl2). In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-3-iodobenzene(cas: 625-99-0Category: iodides-buliding-blocks)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Category: iodides-buliding-blocks Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Hu, Wenbo; Yan, Liqin; Zuo, Youpeng; Kong, Shuwen; Pu, Yue; Tang, Qiang; Wang, Xinyu; He, Xinwei; Shang, Yongjia published an article in Advanced Synthesis & Catalysis. The title of the article was 《Rhodium(III)-Catalyzed Three-Component Cascade Annulation for Modular Assembly of N-Alkoxylated Isoindolin-1-Ones with Quaternary Carbon Center》.Formula: C6H4ClI The author mentioned the following in the article:

A cascade C-H activation, annulation and etherification of N-hydroxybenzamides with propargylamines provided a flexible route to N-alkoxylated 3-arylisoindolin-1-ones. Three new bonds (C-C, C-N, and C-O) were generated to afford a series of isoindolin-1-ones bearing a tetrasubstituted carbon in 49-82% yield. The utility of this method was showcased by gram-scale synthesis and synthetic transformations of the product to access structurally diverse isoindolinones. In addition to this study using 1-Chloro-3-iodobenzene, there are many other studies that have used 1-Chloro-3-iodobenzene(cas: 625-99-0Formula: C6H4ClI) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles》 was written by Yao, Lingyun; Shang, Yan; Wang, Jian-Shu; Pan, Ailin; Ying, Jun; Wu, Xiao-Feng. Electric Literature of C6H4ClI And the article was included in Organic Chemistry Frontiers in 2021. The article conveys some information:

A palladium-catalyzed carbonylative synthesis of N-acyl indoles I (R = Ph, 2-methylphenyl, 4-chloropenyl, 3,4-dimethylphenyl, etc.; R1 = Ph, 3-methylphenyl, 4-methylphenyl, 4-methoxyphenyl, 4-fluorophenyl; R2 = H, F) from 2-alkynylanilines 2-NH25-R2C6H3CCR1 and aryl iodides RI has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles I in a facile manner with high yields. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Electric Literature of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.Electric Literature of C6H4ClI The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Structural Analysis and Development of Notum Fragment Screening Hits》 was written by Zhao, Yuguang; Mahy, William; Willis, Nicky J.; Woodward, Hannah L.; Steadman, David; Bayle, Elliott D.; Atkinson, Benjamin N.; Sipthorp, James; Vecchia, Luca; Ruza, Reinis R.; Harlos, Karl; Jeganathan, Fiona; Constantinou, Stefan; Costa, Artur; Kjaer, Svend; Bictash, Magda; Salinas, Patricia C.; Whiting, Paul; Vincent, Jean-Paul; Fish, Paul V.; Jones, E. Yvonne. Safety of 1-Chloro-3-iodobenzeneThis research focused ontriazzole pyrazole benzimidazole synthesis SAR Notum Wnt signaling; Diamond-SGC Poised Library (DSPL); Notum inhibitors; Wnt signaling; fragment screening; hit-to-lead development. The article conveys some information:

The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer′s disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallog. fragment screen with the Diamond-SGC Poised Library (DSPL) and identified 59 fragment hits from the anal. of 768 data sets. Fifty-eight of the hits were found bound at the enzyme catalytic pocket with potencies ranging from 0.5 to >1000 μM. Anal. of the fragments′ diverse binding modes, enzymic inhibitory activities, and chem. properties led to the selection of six hits for optimization, and five of these resulted in improved Notum inhibitory potencies. One hit, 1-phenyl-1,2,3-triazole 7, and its related cluster members, have shown promising lead-like properties. These became the focus of our fragment development activities, resulting in compound 7d (I)h IC50 0.0067 μM. The large number of Notum fragment structures and their initial optimization provided an important basis for further Notum inhibitor development. In the experimental materials used by the author, we found 1-Chloro-3-iodobenzene(cas: 625-99-0Safety of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Safety of 1-Chloro-3-iodobenzene Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com