Category: 63069-48-7

In 2022,Zhang, Di; Xiong, Youyuan; Guo, Yingjie; Zhang, Lei; Wang, Zheng; Ding, Kuiling published an article in Chemistry – A European Journal. The title of the article was 《Palladium-Catalyzed Enantioselective Intramolecular Heck Carbonylation Reactions: Asymmetric Synthesis of 2-Oxindole Ynones and Carboxylic Acids》.HPLC of Formula: 63069-48-7 The author mentioned the following in the article:

A Pd-catalyzed enantioselective domino Heck carbonylation reaction of o-iodoacrylanilides with terminal alkynes and water as the nucleophiles was discussed and afforded a diversity of β-carbonylated 2-oxindole derivatives bearing a 3,3-disubstituted all-carbon quaternary stereocenter, in high yields (55-99%) with good to excellent enantioselectivities (up to 99% ee). The synthetic utilities of the protocol was demonstrated in the gram-scale synthesis of 2-oxindole-derived ynone and carboxylic acid, as well as the facile synthesis of chiral 2-oxindoles with a pyrazole or isoxazole moiety. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

HPLC of Formula: 63069-48-7In 2021 ,《Cu(I)- and Au(I)-catalyzed regioselective oxidation of diynes: divergent synthesis of N-heterocycles》 appeared in Organic Chemistry Frontiers. The author of the article were Shen, Wen-Bo; Zhang, Ting-Ting; Zhang, Meng; Wu, Jing-Jing; Jiang, Xiao-Lei; Ru, Guang-Xin; Gao, Guang-Qin; Zhu, Xiu-Hong. The article conveys some information:

Catalyst-dependent oxidative cyclization of diynes 2-NH(C(O)R4)-4-R3C6H3CCCH2N(R2)CC(R1) [R1 = Ph, 2-phenylethenyl, thiophen-3-yl, etc.; R2 = Ts, Bs, Ms, benzenesulfonyl; R3 = H, Me, Cl, Br; R4 =Me, Ac, Bz, 4-fluorophenyl, etc.]/(R2)N(CH2CCR5)CCAr [R5 = Me, Et, pentyl, 3-phenylpropyl; Ar = Ph, 4-(trifluoromethyl)phenyl, 3,5-dichlorophenyl, etc.] with 3,5-dichloropyridine N-oxide is achieved using an amide directing group. Non-polarized and aminated alkyne could be selectively activated by copper and gold, thus leading to divergent synthesis of a range of pyrroles I and dihydroindeno[1,2-c]pyrrol-3(2H)-ones II (R6 = H, Cl, Me; R7 = H, Me, F, CF3, etc.; R8 = H, Cl, Me, etc.). It should be noted that this difference might be attributed to the multicoordinated Cu center and the linearly aligned dicoordinated Au center. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《C(sp2)-H Functionalization of Imidazole at the C2- and C4-Position via Palladium-Catalyzed Isocyanide Insertion Leading to Indeno[1,2-d]imidazole and Imidazo[1,2-a]indole Derivatives》 was written by Ren, Zhi-Lin; Cai, Shuang; Liu, Ying-Ying; Xie, Yin-Qing; Yuan, Ding; Lei, Min; He, Ping; Wang, Long. HPLC of Formula: 63069-48-7 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient strategy for the construction of fused imidazole derivatives through a palladium-catalyzed isocyanide insertion reaction has been accomplished. The methodol. provides an operationally simple and versatile route for the synthesis of indeno[1,2-d]imidazole and imidazo[1,2-a]indole skeletons which are rarely reported. The key features of the protocol are construction of sequential C-C/C-C/C-N bonds via C(sp2)-H functionalization of imidazole at the C2- and C4-position, resp. The compounds can be synthesized with diverse scaffolds, easily accessible starting materials, and moderate to good yields.4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rong, Nianxin; Yuan, Yongsheng; Chen, Huijie; Yao, Changguang; Li, Teng; Wang, Yantao; Yang, Weiran published an article in 2021. The article was titled 《A practical route to 2-iodoanilines via the transition-metal-free and base-free decarboxylative iodination of anthranilic acids under oxygen》, and you may find the article in Organic Chemistry Frontiers.SDS of cas: 63069-48-7 The information in the text is summarized as follows:

A simple and practical procedure for synthesizing 2-iodoanilines ArNH2 [Ar = 2-IC6H4, 2-I-4-BrC6H3, 2-I-4-MeOC6H3, etc.] had been developed. A series of highly regioselective 2-iodoanilines ArNH2 was obtained in satisfactory to good yields (of up to 90%) by carrying out the decarboxylative iodination of readily available anthranilic acids with inexpensive KI and I2 as halogen donors under transition-metal-free and base-free conditions. Oxygen was shown to be necessary for the transformation. This practical decarboxylative iodination route was operationally scalable and shown to exhibit high functional-group tolerance. Control experiments suggested that a radical pathway was involved in the transformation. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Mutra, Mohana Reddy; Wang, Jeh-Jeng published an article in Nature Communications. The title of the article was 《Photoinduced ynamide structural reshuffling and functionalization》.Application In Synthesis of 4-Chloro-2-iodoaniline The author mentioned the following in the article:

In this paper, photoinduced radical trigger regio- and chemoselective ynamide bond fission, structural reshuffling and functionalization of 2-alkynyl-ynamides 4-R-2-(CCR1)C6H3N(Ts)CCR2 (R = H, Me, Et, n-bu, Cl, Br; R1 = Ph, n-Bu, cyclopropyl, etc.; R2 = Ph, 2H-1,3-benzodioxol-5-yl, 2-phenylethyl, etc.) to prepare synthetically inaccessible/challenging chalcogen-substituted indole derivatives I [R3 = tosyl, ethanesulfonyl, cyclopropanesulfonyl, etc.; R4 = I, SeC6H5, Se(CH2)4CH3, etc] with excellent step/atom economy were observed The key breakthroughs of this work include, ynamide bond cleavage, divergent radical precursors, broad scope, easy to handle, larger-scale reactions, and generation of multiple bonds (N-C(sp2), C(sp2)-C(sp2), C(sp2)-SO2R/C-SR, and C-I/C-Se/C-H) in a few minutes without photocatalysts, metals, oxidants, additives. Control experiments and 13C-labeling experiments support the conclusion that sulfone radicals contribute to ynamide structural reshuffling processes via a radical pathway. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 63069-48-7In 2021 ,《Photocatalytic three-component annulation enabling stereoselective generation of (Z)-thiochromene 1,1-dioxides》 was published in Organic Chemistry Frontiers. The article was written by Song, Ke-Xian; Qin, Xiao-Yan; Ma, Zi-Xuan; Geng, Fang-Zhou; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo. The article contains the following contents:

A new photocatalytic three-component annulation of 2-alkynylaryldiazonium tetrafluoroborates with γ-hydroxyl terminal alkynes and sodium metabisulfite is reported using fac-Ir(ppy)3 as the photocatalyst for the first time and used to produce a series of (Z)-thiochromene 1,1-dioxides I (R1 = H, 6-Me, 6-Cl, etc.; R2 = C6H5, 4-MeC6H4, 4-ClC6H4, etc.; R3 = H, 4-Me; R4 = Et, n-Bu, C6H5, etc.) bearing an exocyclic double bond with moderate to good yields in a highly stereoselective manner. A wide variety of easily available substrates with substituent diversity could successfully participate in this photocatalysis with good functional group tolerance. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Application of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Enshen; Chen, Chen; Wang, Xueling; Wang, Jian; Shang, Yongjia published an article in Organic Chemistry Frontiers. The title of the article was 《Palladium-catalyzed dearomative 1,4-arylmethylenation of naphthalenes》.Quality Control of 4-Chloro-2-iodoaniline The author mentioned the following in the article:

An efficient palladium-catalyzed construction of E-exocyclic-double-bond-containing spirooxindoles via 1,4-arylmethylenation of naphthalenes has been developed. Aryl aldehyde-derived N-tosylhydrazones were successfully applied as carbene precursors to capture the endocyclic π-allylpalladium intermediate, which was generated via an arylative Heck reaction of the naphthalene-masked conjugated diene, followed by a highly regioselective β-hydride elimination. This reaction features broad functional group tolerance and excellent chemo- and E/Z selectivities. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Quality Control of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium-catalyzed three-component carbonylative synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones from trifluoroacetimidoyl chlorides and amines》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Chen, Zhengkai; Wang, Le-Cheng; Zhang, Jiajun; Wu, Xiao-Feng. Quality Control of 4-Chloro-2-iodoaniline The article mentions the following:

A palladium-catalyzed three-component carbonylative reaction of trifluoroacetimidoyl chlorides and amines for the synthesis of valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones was developed. Broad substrate scope (41 examples), high efficiency (up to 99% yield) and no manipulation of CO gas constituted the notable features of this reaction. The present strategy was applied to the late-stage modification of natural mols. and to the synthesis of the bioactive alkaloid mol. rutaecarpine. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Quality Control of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Quality Control of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mishra, Ashish A.; Bhanage, Bhalchandra M. published their research in New Journal of Chemistry in 2021. The article was titled 《Ru-Tethered (R,R)-TsDPEN with DMAB as an efficient catalytic system for high enantioselective one-pot synthesis of chiral β-aminol via asymmetric transfer hydrogenation》.Electric Literature of C6H5ClIN The article contains the following contents:

This work reflected Ru-tethered-TsDPEN as an active chiral catalyst for one pot selective synthesis of optically active α-substituted alcs. ArCH(OH)CH2NHAr1 [Ar = Ph, 2-FC6H4, 2,3-(MeO)2C6H3, etc.; Ar1 = Ph, 4-MeC6H4, 4-ClC6H4, 4-Cl-2-I-C6H3, etc.; stereo = S] and its derivatives from α-bromo ketones ArCOCH2Br in presence of dimethylamine borane (DMAB) as hydrogen source. Various Ru-chiral catalysts were screened and methodol. proceeded via a (R,R) Ru-tethered TsDPEN catalyst through asym. transfer hydrogenation (ATH) of in-situ formed ketones to corresponding chiral β-aminol product. Thus, Ru-tethered TsDPEN-DMAB catalytic system works efficiently with higher yield and high enantiomeric excess over others for ATH process. Based on a study of ortho, meta and para substituted α-bromo acetophenone derivatives, effective enantioselectivity was observed for ortho substituted β-aminol. The mechanism was optimized depending on product anal. with help of its kinetic AT-IR study. This work also focused on synthesis of various β-amino alc. derivatives where effect of an EWG and EDG on enantio-selectivity was studied.4-Chloro-2-iodoaniline(cas: 63069-48-7Electric Literature of C6H5ClIN) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Karmakar, Swastik; Das, Prasanta; Kundu, Sandip published their research in New Journal of Chemistry in 2021. The article was titled 《Silver-catalyzed tandem 5- and 6-endo-cyclizations via concomitant yne-ol-imine activation: selective entry to 2-aryldihydrofuroquinolines》.Electric Literature of C6H5ClIN The article contains the following contents:

A silver(I) catalyzed domino imination-intramol. biheterocyclization-aromatization cascade has been developed to construct 2-aryl/-heteroaryl dihydrofuroquinolines in moderate to good yield using an aldehydes and unprotected 4-(2-aminophenyl)but-3-yn-1-ols as precursors. Sequential Ag-(I)-induced 5-endo-dig cyclization of the yne-ol part and 6-endo-trig cyclization of a proposed Ag-bound imine, followed by aromatization, furnish the furoquinoline derivatives In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Electric Literature of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com