Category: 696-41-3

Reference of 696-41-3,Some common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, molecular formula is C7H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

14.4: (3-iodo-benzyl)-dimethyl-amine To a cold (0C) solution of 3-iodo-benzaldehyde (3g, 12.9 mmol) in anhydrous dichloromethane (130 ml) were added acetic acid (1.9ml) and N,N-dimethylacetamide. The yellow solution is stirred 10 minutes at 0C and sodium triacetoxyborohydride (6.85g, 32.33 mmoles) is added by portions. The resulting mixture is stirred at room temperature for 90 minutes and evaporated to dryness under reduced pressure. Ethyl acetate and a saturated aqueous hydrogen carbonate solution were added to the residue and the two layers were separated The organic phase was washed with water, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to yield (3-iodo-benzyl)-dimethyl-amine (3.05g, 90%) as a brown oil. LC/MS (Method LC8): Rt = 0.86 min; m/z = 262 [M+H]+.

The synthetic route of 696-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; Loehn, Matthias, Dr.; Mendez-Perez, Maria, Dr.; Pfeiffer-Marek, Stefania, Dr.; Kannt, Aimo, Dr.; Begis, Guillaume, Dr.; Jeannot, Frederic, Dr.; Duclos, Olivier; EP2567959; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 696-41-3,Some common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, molecular formula is C7H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

14.4: (3-iodo-benzyl)-dimethyl-amine To a cold (0C) solution of 3-iodo-benzaldehyde (3g, 12.9 mmol) in anhydrous dichloromethane (130 ml) were added acetic acid (1.9ml) and N,N-dimethylacetamide. The yellow solution is stirred 10 minutes at 0C and sodium triacetoxyborohydride (6.85g, 32.33 mmoles) is added by portions. The resulting mixture is stirred at room temperature for 90 minutes and evaporated to dryness under reduced pressure. Ethyl acetate and a saturated aqueous hydrogen carbonate solution were added to the residue and the two layers were separated The organic phase was washed with water, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to yield (3-iodo-benzyl)-dimethyl-amine (3.05g, 90%) as a brown oil. LC/MS (Method LC8): Rt = 0.86 min; m/z = 262 [M+H]+.

The synthetic route of 696-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; Loehn, Matthias, Dr.; Mendez-Perez, Maria, Dr.; Pfeiffer-Marek, Stefania, Dr.; Kannt, Aimo, Dr.; Begis, Guillaume, Dr.; Jeannot, Frederic, Dr.; Duclos, Olivier; EP2567959; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 696-41-3, name is 3-Iodobenzaldehyde, A new synthetic method of this compound is introduced below., Quality Control of 3-Iodobenzaldehyde

General procedure: In the glove box, zinc powder (206.0 mg, 3.15 mmol) was added into a Schlenk tube. Anhydrous DMF (10.5 mL) was added and the mixture was stirred at room temperature. Chlorotrimethylsilane (66.5 muL, 0.52 mmol) was then added into the mixture to activate zinc powder. Five minutes later, PhSO2CF2Br (2) (2.1 mmol) was added into the suspension. The reaction proceeded smoothly in 15 min to give (phenylsulfonyl)difluoromethylzinc reagent (?XZnCF2SO2Ph?, 3). The mixture was kept at room temperature to precipitate the remaining zinc powder, and the solution was directly used for next step. In the glove box, 2-naphthaldehyde (156.2 mg, 1.0 mmol) was added into another Schlenk tube. Anhydrous DMF (5 mL) was added and the mixture was stirred at room temperature. The DMF solution of ?XZnCF2SO2Ph? (3) (10 mL, corresponding to the reaction of ca. 2.0 mmol of PhSO2CF2Br and ca. 3.0 mmol of zinc powder) was added to the solution of 2-naphthaldehyde dropwise. The mixture was stirred at room temperature for 5 h, and aqueous HCl (2 M, 10 mL) was added to quench the reaction. After extraction with ethyl acetate for three times, the organic phase was washed with brine, and then dried over anhydrous Na2SO4. After the solution was filtered and evaporated under vacuum, the residue was subjected to silica gel column chromatography (eluting with petroleum ether/ethyl acetate) to give the corresponding difluoromethylated carbinol 4a as a white solid (307.5 mg, 88%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Jiang, Fanzhou; Ni, Chuanfa; Hu, Jinbo; Journal of Fluorine Chemistry; vol. 198; (2017); p. 67 – 75;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 696-41-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 696-41-3, name is 3-Iodobenzaldehyde belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1) 1-(3-Iodo-phenyl)-pent-4-en-1-ol To a stirred solution of 3-iodo-benzaldehyde (3.0 g, 12.93 mmol) in dry THF (45 mL) at -78 C. under nitrogen was added 0.5 M 3-butenyl magnesium bromide in THF (25.86 mL, 12.93 mmol) over 20 min. The reaction was stirred for 0.5 h and allowed to warm to -30 C. over 1 h and then quenched with sat ammonium chloride (20 mL). The reaction was diluted with water (10 mL) and then extracted with ethyl acetate (2*50 mL). The extracts were dried (MgSO4) and concentrated in vacuo. Purification by flash chromatography (5% to 10% ethyl acetate/petroleum ether) gave the title compound as a clear oil (3.5 g, 95%) and was used directly in the next step.

The synthetic route of 3-Iodobenzaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; US2009/48320; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 696-41-3, name is 3-Iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 696-41-3, SDS of cas: 696-41-3

General procedure: Benzaldehyde (1.0 mmol), TMTD (1.1 mmol), CuI (10 mol%), and DTBP (4.0 equiv) were added to a dried sealed tube equipped with a septum and magnetic stirrer bar, EtOAc (2 mL) was then added. (Caution. The sealed tube is a pressure-proof tube with a septum.) The mixture was stirred at 120 C and checked by thin-layer chromatography (TLC) until the starting material was consumed (ca. 7-8 h). The reaction was cooled to r.t., quenched with sat. NH4Cl solution (5 mL), and then extracted with EtOAc (3 × 10 mL). The crude solution was dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography to afford the desired product.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 696-41-3, name is 3-Iodobenzaldehyde, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Iodobenzaldehyde

Reference Example 134 1-(3-iodobenzyl)pyrrolidine To pyrrolidine (0.2 mL) in methanol (10 mL) was added a solution of 3-iodobenzaldehyde (565 mg) in tetrahydrofuran (5 mL), and the mixture was stirred at room temperature for 12 hr. Sodium borohydride (109 mg) was added at 0 C., and the mixture was stirred at room temperature for 2 hr, and concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. 1 mol/L Hydrochloric acid was added to the extract, and the aqueous layer was washed with ethyl acetate. The obtained aqueous layer was basified with 1 mol/L aqueous sodium hydroxide solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound as a yellow oil (382 mg, yield 55%). 1H-NMR (CDCl3) delta: 1.76-1.82 (4H, m), 2.46-2.51 (4H, m), 3.54 (2H, s), 7.03 (1H, t, J=7.5 Hz), 7.27-7.30 (1H, m), 7.55-7.58 (1H, m), 7.69-7.70 (1H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 696-41-3, name is 3-Iodobenzaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C7H5IO

A 10 mL Schenk tube was dried in oven and loaded under N2 with K3PO4 (2.37 g,11.16 mmol) and DMA (2.0 mL). 3-iodobenzaldeide (1.85 g, 7.97 mmol) and n- butylacrylate (2.28 mL, 15.94 mmol) were then added by syringe. A solution of EPO Pd(OAc)2 (0.18 g, 0.797 mmol) in DMA (0.5 mL) was further added by syringe. The Schlenk tube was then sealed under nitrogen and placed in a pre-heated oil bath at 140 0C, and the reaction mixture was stirred for 24 h. After cooling to room temperature, the reaction mixture was poured in water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were washed with brine, dried (Na2SO4), and concentrated under vacuum to dryness. The crude product was purified by chromatographic column on silica gel, eluting with n- hexane/ethylacetate/methanol 12/3/1 (yield: 47%). 1H NMR (CDCI3) delta: 0.91-0.96 (t, 3H, OCH2CH2CH2CH3), 1.39-1.42 (m, 2H, OCH2CH2CH2CH3), 1.65-1.68 (m, 2H, OCH2CH2CH2CH3), 4.17-4.21 (m, 2H, OCH2CH2CH2CH3), 6.48-6.53 (d, 1 H, ArCH=CHCO), 7.52-7.54 (m, 1 H, benzene H-5), 7.53-7.75 (m, 2H, ArCH=CHCO and benzene H-6), 7.84-7.86 (m, 1 H, benzene H-4), 7.99 (m, 1 H, benzene H-2), 10.01 (s, 1 H1 CHO).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DAC S.R.L.; WO2006/37761; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 696-41-3, name is 3-Iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Iodobenzaldehyde

General procedure: A mixture of 2-acetyl-5-chlorothiophene (0.01 mol) and substituted benzaldehyde (0.01 mol) wasdissolved in methanol (20 mL). A catalytic amount of NaOH was added to the solution dropwise withvigorous stirring. The reaction mixture was stirred for about 3-4 h at room temperature. The resultantcrude products were filtered, wash successively with distilled water and recrystallized from ethanol to get the corresponding chalcone. Crystals suitable for X-ray diffraction studies were obtained by the slowevaporation technique using a suitable solvent.

According to the analysis of related databases, 696-41-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chidan Kumar; Loh, Wan-Sin; Ooi, Chin Wei; Quah, Ching Kheng; Fun, Hoong-Kun; Molecules; vol. 18; 10; (2013); p. 11996 – 12011;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 696-41-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 696-41-3, name is 3-Iodobenzaldehyde belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

DAST (27mL, 172.41 mmol) was added to a solution of 3-lodo benzaldehyde (lOg, 43.l0mmol) in DCM (l5OmL) at 0C over a period of 10 mm. The RM was warmed to RT and stirred for 19 h.The RM was carefully quenched into ice water and extracted with DCM (2×1 5OmL).The combined organic layer waswashed with sat. NaHCO3 solution, water(lOOmL), brine(lOOmL), dried over Na2SO4 and concentrated toget crude. The crude compound was purified by CC (0-5% EtOAc in PE) to obtain 9.Og (82.5%) of 1-(difluoromethyl)-3-iodobenzene as yellow oil.

The synthetic route of 3-Iodobenzaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 696-41-3, name is 3-Iodobenzaldehyde belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3-Iodobenzaldehyde

General procedure: Triton B (40% in MeOH, 7.30 mL, 17.5 mmol) was added dropwise to a solution of ethyl 2-[bis(2-isopropylphenoxy) phosphoryl]acetate (5.30 g, 13.1 mmol) in THF (150 mL) at -78 C under Ar. After 15 min of stirring, a solution of 2-methylbenzaldehyde (59) (1.50 g, 12.5 mmol) in THF (50 mL) was added dropwise to the solution. After 10 h of stirring, the mixture was quenched with satd. aq. NH4Cl (30 mL) and extracted with EtOAc (3 x 30 mL). The organic layer was washed successively with H2O, satd. aq. (20 mL) NaHCO3 (20 mL) and brine (20 mL), then dried (MgSO4), filtered and concentratedin vacuo.; Z-selective olefination of 3-iodobenzaldehyde (87) was performedusing the procedure described above to provide (Z)-ethyl3-(3-iodophenyl)acrylate (cis-143) (94%, Z:E = 98:2, determinedby 1H-NMR spectrum) (silica gel CC, EtOAc/hexane, 5:95) as acolorless oil: 1H-NMR (CDCl3, 270 MHz) d: 1.26 (t, J = 7.2 Hz, 3H,-CH3), 4.19 (q, J = 7.2 Hz, 2H, -CH2-), 5.98 (d, J = 12.6 Hz, 1H,CH-CO2-), 6.85 (d, J = 12.6 Hz, 1H, Ar-CH), 7.10 (t, J = 7.8 Hz,1H, Ar-H), 7.53, 7.66 (d, J = 7.8 Hz, each 1H, Ar-H), 7.90 (s, 1H,Ar-H).

The synthetic route of 696-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nishikawa, Keisuke; Fukuda, Hiroshi; Abe, Masato; Nakanishi, Kazunari; Taniguchi, Tomoya; Nomura, Takashi; Yamaguchi, Chihiro; Hiradate, Syuntaro; Fujii, Yoshiharu; Okuda, Katsuhiro; Shindo, Mitsuru; Phytochemistry; vol. 96; (2013); p. 132 – 147;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com