Category: 76801-93-9

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C14H18I3N3O6, 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, in an article , author is Rillema, JA, once mentioned of 76801-93-9.

Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants

We have recently reported that prolactin (PRL) stimulates iodide uptake into cultured mouse mammary tissues, This effect occurs in both TCA soluble and insoluble tissue fractions, The effect of PRL apparently involves an RNA-DNA-dependent mechanism, since actinomycin D and cyclohexamide abolish the PRL stimulation of iodide uptake and its incorporation into protein, Perchlorate and thiocyanate, inhibitors of the iodide transporter, also abolish the PRL effects on iodide uptake and incorporation. Similarly, propylthiouracil and aminotriazole, inhibitors of peroxidase, abolish both effects of PRL, Finally, the extent of iodide uptake in mammary cells is suppressed by about 50% in sodium-free medium, These studies thus suggest the existence of a sodium-iodide symporter in the mammary gland which has characteristics similar to the iodide transporter in the thyroid gland-that is, It is sodium dependent and is inhibited by perchlorate and thiocyanate, The fact that both iodide transporter inhibitors and peroxidase inhibitors abolish PRL-stimulated iodide uptake and incorporation suggests that there may be a coupled mechanism involving the iodide transporter and the peroxidase enzyme.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 76801-93-9, you can contact me at any time and look forward to more communication. Computed Properties of C14H18I3N3O6.

Application of 76801-93-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, belongs to iodides-buliding-blocks compound. In a article, author is MURAKAMI, S, introduce new discover of the category.

PROPRANOLOL HAS DIRECT ANTITHYROID ACTIVITY – INHIBITION OF IODIDE TRANSPORT IN CULTURED THYROID-FOLLICLES

The effect of propranolol on the process of thyroid hormone formation was studied in a physiological culture system. Porcine thyroid follicles were preincubated with propranolol for 24 h. Iodide transport, iodine organification, and de novo thyroid hormone formation were measured by incubating these follicles with the mixture of carrier-free 0.1 muCi (NaI)-I-125 and 50 nm NaI for 2 to 6 h at 37-degrees-C. A concentration of propranolol greater than 100 mum inhibited iodide transport in a dose-dependent manner; this inhibition was non-competitive with iodide and independent of thyrotropin (TSH). Reduced iodine organification and thyroid hormone formation was seen with 150 mum propranolol or greater. The inhibitory action of propranolol was not caused by beta-blocking activity, since D-propranolol (devoid of beta-blocking activity) inhibited iodide transport, and other beta-blockers (metoprolol, atenolol, and labetalol) did not inhibit iodide transport. The inhibition of iodide transport was most likely caused by membrane stabilizing activity since quinidine, which possesses the same membrane stabilizing activity as propranolol, also inhibited iodide transport. TSH-mediated cAMP generation and Na+K+ATPase activity, membrane functions for iodide transport, were unaffected by propranolol. Our study has shown, for the first time, that propranolol has a direct antithyroid action, namely inhibition of iodide transport in the intact thyroid follicle.

Application of 76801-93-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 76801-93-9.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6. In an article, author is Nambu, Hisanori,once mentioned of 76801-93-9, SDS of cas: 76801-93-9.

Iodide-Catalyzed Ring-Opening Cyclization of Cyclohexane-1,3-dione-2-spirocyclopropanes

The ring-opening cyclization of 2′,3′-nonsubstituted and 2′-electron-withdrawing group (EWG)-substituted cyclohexane-1,3-dione-2-spirocyclopropanes was accomplished using iodide as a catalyst. The nonsubstituted derivatives afforded 3,5,6,7-tetrahydro-1-benzofuran-4(2H)-ones in high yields in the presence of trimethylsilyl iodide at room temperature. The EWG-substituted spirocyclopropanes, in turn, underwent regioselective ring opening followed by cyclization, which gave rise to 2-substituted tetrahydrobenzofuran-4-ones when a combination of tetrabutylammonium iodide catalyst and trifluoromethanesulfonic acid was used, whereas calcium iodide afforded the 3-substituted derivatives.

Interested yet? Keep reading other articles of 76801-93-9, you can contact me at any time and look forward to more communication. SDS of cas: 76801-93-9.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, belongs to iodides-buliding-blocks compound. In a document, author is Van Renterghem, W, introduce the new discover, COA of Formula: C14H18I3N3O6.

The influence of the precipitation method on defect formation in multishell AgBrI (111) tabular crystals.

Multishell tabular grains have a higher speed than pure AgBr tabular grains. Usually the shells differ in size and iodide content, but also the precipitation method for the iodide containing shells has an influence on the iodide incorporation. A TEM investigation was performed to determine the defect structure of multishell AgBr (111) tabular crystals containing a shell with a low iodide concentration and one with a high iodide concentration. The twins that induce tabular growth and stacking fault contrast in the region of the iodide shells have been observed, similar to previously studied AgBr/Ag(Br,I) coreshell crystals. Moreover in some of the crystals dislocations have been observed, sometimes even an entire network. The number of dislocations formed varies for the different methods of iodide addition. Also variations in average thickness between the different iodide addition methods have been observed. A higher number of dislocations and thicker crystals point towards a higher local concentration of iodide. These observations allow deciding which iodide incorporation method is most useful for a preferred dislocation pattern.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 76801-93-9 is helpful to your research. COA of Formula: C14H18I3N3O6.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C14H18I3N3O6, 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, belongs to iodides-buliding-blocks compound. In a document, author is IGAU, A, introduce the new discover.

SYNTHESIS AND CHEMISTRY OF SECONDARY ALKYL IODIDE COMPLEXES OF THE FORMULA [(ETA-5-C5H5)RE(NO)(PPH3)(ICHRR’)]+BF4-

Reactions of deuterodichloromethane complex [(eta-5-C5H5)Re(NO)(PPh3) (ClCD2Cl)]+BF4- with (a) isopropyl iodide, (b) sec-butyl iodide, (c) cyclopentyl iodide, and (d) cyclohexyl iodide give secondary alkyl iodide complexes [(eta-5-C5H5)Re(NO) (PPh3)(ICHRR’)]+BF4- (3a-d) in good to high NMR yields, depending upon the quantity of alkyl iodide employed. These compounds are much less stable than analogous primary alkyl iodide complexes, but analytically pure 3d can be isolated from the reaction of (eta-5-C5H5)Re(NO)(PPh3)(CH3) and HBF4.OEt2 in neat cyclohexyl iodide (73%). Complex 3d decomposes in CD2Cl2 to give cyclohexyl fluoride, cyclohexene (74% total) and bridging halide complexes [(eta-5-C5H5)Re(NO)(PPh3)]2X+BF4- (X = I, 33%; Cl, 36%). The formation of cyclohexyl fluoride suggests BF4- participation in carbon-iodine bond cleavage. Reaction of 3d and PPh3 gives the substitution product [Ph3PC6H11]+BF4- (24%), cyclohexyl fluoride (24%), cyclohexene (30%) and (eta-5-C5H5)Re(NO)(PPh3)(I) (7, 95%). An analogous reaction of 3d and PPN+BR- gives cyclohexene (57%) and 7 (99%).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 76801-93-9. HPLC of Formula: C14H18I3N3O6.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: iodides-buliding-blocks, 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, belongs to iodides-buliding-blocks compound. In a document, author is Dingli, D, introduce the new discover.

Dynamic iodide trapping by tumor cells expressing the thyroidal sodium iodide symporter

The thyroidal sodium iodide symporter (NIS) in combination with various radioactive isotopes has shown promise as a therapeutic gene in various tumor models. Therapy depends on adequate retention of the isotope in the tumor. We hypothesized that in the absence of iodide organification, isotope trapping is a dynamic process either due to slow efflux or re-uptake of the isotope by cells expressing NIS. Iodide efflux is slower in ARH-77 and K-562 cells expressing NIS compared to a thyroid cell line. Isotope retention half times varied linearly with the number of cells expressing NIS. With sufficient NIS expression, iodide efflux is a zero-order process. Efflux kinetics in the presence or absence of perchlorate also supports the hypothesis that iodide re-uptake occurs and contributes to the retention of the isotope in tumor cells. Iodide organification was insignificant. In vivo studies in tumors composed of mixed cell populations confirmed these observations. (C) 2004 Elsevier Inc. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 76801-93-9. Category: iodides-buliding-blocks.

Reference of 76801-93-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 76801-93-9 as follows.

The above white powder compound (10 g, 14.2 mmol) was dissolved in 20 mL of DMAcIn a mixture with acetonitrile (1:1), the temperature is lowered to 10 C, and the temperature is controlled below 30 C.Dropping (the purpose of dropping is controlled to a temperature not exceeding 30 C) Chloroacetyl chloride(9.65g, 92.3mmol), after the addition was completed, the temperature was raised to 50 C, and after stirring for 3 hours,Cool to 15 C, drop (the purpose of the drop control temperature does not exceed 25 C)20mL 10mol / L NaOH aqueous solution, stirring reaction at 25 C for 1 h,After the reaction was completed, the pH was adjusted to 4 with dilute hydrochloric acid, and the mixture was allowed to stand overnight at 0 C, and filtered.The filter cake is washed several times with water and dried (dried to sample to 85 C).GotN,N-(2′,3′)-Dihydroxypropyl-3,5-dimethylformamide-(2,4,6-)beta-amino group.

According to the analysis of related databases, 76801-93-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Calculate University; Wu Zhiping; Bai Xueyan; Wu Yuqi; (13 pag.)CN108727376; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 76801-93-9 name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 76801-93-9

In Example 2, the solution was cooled in a reactor jacket to 70 C immediately after reaching the maximum temperature of approximately 120-125 C. The cooling rate was about 1 C/minute, and the solution was held at 70 C overnight to form over-acetylated Compound A before moving on to the next deacetylation process step to form Compound A. Deacetylation: After acetylation, the reaction solution containing over-acetylated Compound A was concentrated under reduced pressure, before methanol and water was added prior to the deacetylation step. Sodium hydroxide was then added to methanol- water reaction mixture to carry out the deacetylation. The resulting reaction mixture was then further diluted with water before crystallization. Crystallization: To achieve crystallization, hydrochloric acid was first added until the reaction mixture until it was slightly turbid, and then the reaction mixture was seeded with Compound A. The resulting slurry was stirred for 45 minutes before additional hydrochloric acid was added until about pH 7. The slurry was then cooled to 15 C over night. Next day the slurry was filtered, and the filter cake was washed with methanol and then dried in a vacuum oven.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, and friends who are interested can also refer to it.

Reference:
Patent; GE HEALTHCARE AS; SAANUM, Inger, Dagny; HAALAND, Torfinn; KALLEBERG, Rita; WO2015/82719; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 76801-93-9

The white powdery product S4 (10 g, 14.2 mmol) obtained in Example 3.Dissolved in 20mL DMAc and acetonitrile mixture (1:1 volume ratio),Cool down to 10 C, control temperature below 30 C,3-chloropropanediol-(1,2) or 2-chloroethanol-1 (10.2 g, 92.3 mmol) was added dropwiseOr 9.55g, 92.3mmol), after the addition is completed, the temperature is raised to 50 C,After stirring for 3 h, it was cooled to 15 C, 20 mL of 10 mol/L NaOH aqueous solution was added dropwise, and the reaction was further stirred at 25 C for 1 h. After the reaction was completed, the pH was adjusted to 4 with dilute hydrochloric acid.Allow to stand at 0 C overnight, filter, filter cake washed with water several times,Drying (drying to constant weight at 85 C),Recrystallization (recrystallization in DMAc mixed with acetonitrile),A white gray or dark gray powder compound is obtained.

The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Calculate University; Wu Zhiping; Bai Xueyan; Wu Yuqi; (13 pag.)CN108727376; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 76801-93-9.

5-amino-N,N’-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (500 g) was taken in N-methylpyrrolidone (500 ml). Chloroacetyl chloride (500 ml) was then added over three hours maintaining the temperature below 35 0C. After addition, the reaction mixture was stirred for three hours at 50 0C. Water (1.3 L) was added to the reaction mass and the precipitated product was filtered, washed and dried. Yield: 97%Purity: 96% (by HPLC)

The synthetic route of 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WOCKHARDT RESEARCH CENTRE; KULKARNI, Dilip, Ganesh; SINHA, Rohit, Kumar; SHINDE, Prakash, Sakharam; SIDDIQUI, Mohammed, Jaweed, Mukarram; ZAKIR, Gafoor, Shaikh; MOHAMMED, Ismail, Shafi; ANIS, Mushtaqe, Ali, Saiyad; KHAN, Nasim; WO2008/104853; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com