Category: iodides-buliding-blocks

dos Santos Filho, Jose Mauricio published the artcileStereoselective, solvent free, highly efficient synthesis of aldo- and keto-N-acylhydrazones applying grindstone chemistry, Name: 4-Iodobenzohydrazide, the publication is Green Chemistry (2017), 19(9), 2212-2224, database is CAplus.

A mild and efficient synthesis of N-acylhydrazones, e.g., I has been developed by applying a simple grindstone procedure leading to a library of 51 examples exhibiting a broad variety of structural features, 21 of them described for the first time in this paper. This methodol. works without any organic solvent under the catalysis of acetic acid at room temperature, promotes the formation of essentially pure crude products, and avoids tedious work-up and the use of harmful solvents, as well as energy consumption. In addition, it leads to the stereoselective formation of N-acylhydrazones, as supported by NMR anal.

Green Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Andrew C. published the artcileA Ball Milling-Enabled Cross-Electrophile Coupling, Quality Control of 638-45-9, the publication is Organic Letters (2021), 23(16), 6337-6341, database is CAplus and MEDLINE.

The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochem. manifold, the reductive C-C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive set-ups, in reaction times of 2 h. The mech. action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yan published the artcileCobalt-catalysed enantioselective C(sp³)-C(sp³) coupling, Synthetic Route of 161370-66-7, the publication is Nature Catalysis (2021), 4(10), 901-911, database is CAplus.

Enantioselective C(sp³)-C(sp³) coupling substantially impacts organic synthesis but remains challenging. Cobalt has played an important role in the development of homogeneous organometallic catalysis, but there are few examples of its use in asym. cross-coupling. Here, a cobalt-catalyzed enantioselective C(sp³)-C(sp³) coupling reaction, namely, alkene hydroalkylation, to access chiral fluoroalkanes was reported. This reaction represents a catalyst-controlled enantioselective coupling mode in which a tailor-made auxiliary is unnecessary; via this reaction, an aliphatic C-F stereogenic center can be introduced at the desired position in an alkyl chain.

Nature Catalysis published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yan published the artcileCobalt-catalysed enantioselective C(sp³)-C(sp³) coupling, Application In Synthesis of 638-45-9, the publication is Nature Catalysis (2021), 4(10), 901-911, database is CAplus.

Enantioselective C(sp³)-C(sp³) coupling substantially impacts organic synthesis but remains challenging. Cobalt has played an important role in the development of homogeneous organometallic catalysis, but there are few examples of its use in asym. cross-coupling. Here, a cobalt-catalyzed enantioselective C(sp³)-C(sp³) coupling reaction, namely, alkene hydroalkylation, to access chiral fluoroalkanes was reported. This reaction represents a catalyst-controlled enantioselective coupling mode in which a tailor-made auxiliary is unnecessary; via this reaction, an aliphatic C-F stereogenic center can be introduced at the desired position in an alkyl chain.

Nature Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khaliullin, F. A. published the artcileSynthesis and Antidepressant Activity of 4-Alkyl-5-Bromo-2,4-Dihydro-2-(Thietan-3-yl)-1,2,4-Triazol-3-Ones, Quality Control of 638-45-9, the publication is Pharmaceutical Chemistry Journal (2021), 55(2), 123-129, database is CAplus.

A series of 4-alkyl-5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-ones I (R = Me, Bn, Et, etc.) were synthesized by reacting 5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-one (II) with alkyl halides RX (X = I, Br) and di-Me sulfate. The antidepressant activity of the synthesized compounds I in non-inbred male mice was investigated using tail-suspension and forced-swim tests. Compounds II and I (R = Me, n-Pr, Bn, 2-bromoethyl) after a single i.p. injection produced antidepressant effects in screening tests and did not cause sedative and/or psychostimulatory effects in the open-field test. Compound II produced an antidepressant effect comparable to that of fluoxetine, had low toxicity (class IV toxicity), and was superior to fluoxetine in therapeutic index and strength of the antidepressant effect after a course of administration. The calculated physicochem. properties and toxic risks showed that all synthesized compounds I complied fully with Lipinski’s rule of five. The calculated drug score and absence of predicted toxic risks for the most active compound II suggested that it was promising for creating a new pharmaceutical substance with antidepressant activity.

Pharmaceutical Chemistry Journal published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Augeri, David J. published the artcilePotent and Selective Non-Cysteine-Containing Inhibitors of Protein Farnesyltransferase, HPLC of Formula: 165534-79-2, the publication is Journal of Medicinal Chemistry (1998), 41(22), 4288-4300, database is CAplus and MEDLINE.

Potent and selective non-thiol-containing inhibitors of protein farnesyltransferase are described. FTI-276 was transformed into the pyridyl ether analog. The potency of the pyridyl ether was improved by modification of the biphenyl core to that of an o-tolyl substituted biphenyl core. In addition to 0.4 nM in vitro potency, this compound displayed 350 nM potency in whole cells as the parent carboxylic acid. The o-tolyl biphenyl core dramatically and unexpectedly enhanced the potency of other compounds

Journal of Medicinal Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, HPLC of Formula: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kischkewitz, Marvin published the artcileRadical-polar crossover reactions of vinylboron ate complexes, HPLC of Formula: 31253-08-4, the publication is Science (Washington, DC, United States) (2017), 355(6328), 936-938, database is CAplus and MEDLINE.

Vinyl boronic esters are valuable substrates for Suzuki-Miyaura cross-coupling reactions. However, boron-substituted alkenes have drawn little attention as radical acceptors, and the radical chem. of vinylboron ate complexes is underexplored. We show here that carbon radicals add efficiently to vinylboron ate complexes and that their adduct radical anions undergo radical-polar crossover: a 1,2-alkyl/aryl shift from boron to the α-carbon sp² center provides secondary or tertiary alkyl boronic esters. In contrast to the Suzuki-Miyaura coupling, a transition metal is not required, and two carbon-carbon bonds are formed. The valuable boronic ester moiety remains in the product and can be used in follow-up chem., enlarging the chem. space of the method. The cascade uses com. starting materials and provides access to perfluoroalkylated alcs., γ-lactones, γ-hydroxy alkylnitriles, and compounds bearing quaternary carbon centers.

Science (Washington, DC, United States) published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Arsen’ev, V. G. published the artcileAcetals and vinyl ethers of unsaturated aldehydes and ketones in new syntheses of heterocyclic compounds: IX. Ethoxyvinyl-1,3-dioxinyl cations: synthesis and reactions with nucleophiles, Name: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (1998), 34(12), 1779-1785, database is CAplus.

A new highly reactive ethoxyvinylphenyldioxinyl perchlorate salt I · ClO₄^– was prepared by reaction of dioxinylium perchlorate II · ClO₄^– with excess tri-Et orthoformate in the presence of 16% perchloric acid. The reaction of I · ClO₄^– with electron-rich aromatic and heteroaromatic substrates result in formation of the corresponding aryl(hetaryl)vinyldioxinylium derivatives III · ClO₄^– [R = 4-Me₂NC₆H₄, 2,4-(AcO)₂-1-naphthyl, 2-methyl-3-indolyl]; with compounds possessing an activated methylene group, 1,3-dioxinylidene merocyanines and trimethinecyanines such as IV are formed, and with amines or amides, iminium derivs such as V. Merocyanines such as VI with a chiral center were synthesized for the first time from chiral racemic ethoxyvinyldioxinyl cations.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Name: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Panchaud, Philippe published the artcileRadical Carboazidation: Expedient Assembly of the Core Structure of Various Alkaloid Families, HPLC of Formula: 31253-08-4, the publication is Journal of Organic Chemistry (2004), 69(8), 2755-2759, database is CAplus and MEDLINE.

A procedure for one-pot intermol. radical addition of 2-iodo esters to terminal alkenes followed by azidation of the radical adduct has been developed. This sequential reaction represents an alkene carboazidation process. Its efficacy is demonstrated by the two-step preparation of various lactams such as pyrrolidinones, pyrrolizidinones, and indolizidinones. An easy access to spirolactams bearing an amino-substituted quaternary carbon center is also described. These compounds are important building blocks for the synthesis of numerous alkaloids such as, for instance, FR901483.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Renaud, Philippe published the artcileRadical carboazidation of alkenes: an efficient tool for the preparation of pyrrolidinone derivatives, Synthetic Route of 31253-08-4, the publication is Angewandte Chemie, International Edition (2002), 41(18), 3460-3462, database is CAplus and MEDLINE.

A one-pot intermol. radical carboazidation of alkenes is reported. The utility of the reaction is demonstrated by the development of a three-component preparation of pyrrolidinones, pyrrolizidinones, and indolizidinones starting from benzenesulfonyl azide, terminal alkenes, and 2-iodo esters.

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com