Category: iodides-buliding-blocks

Lee, Geonho published the artcileSynthesis and Characterization of Diketopyrrolopyrrole-Based Aggregation-Induced Emission Nanoparticles for Bioimaging, Recommanded Product: 1-Iodohexane, the publication is Molecules (2022), 27(9), 2984, database is CAplus and MEDLINE.

Conventional fluorescent dyes have the property of decreasing fluorescence due to aggregation-caused quenching effects at high concentrations, whereas aggregation-induced emission dyes have the property of increasing fluorescence as they aggregate with each other. In this study, diketopyrrolopyrrole-based long-wavelength aggregation-induced emission dyes were used to prepare biocompatible nanoparticles suitable for bioimaging. Aggregation-induced emission nanoparticles with the best morphol. and photoluminescence intensity were obtained through a fast, simple preparation method using an ultrasonicator. The optimally prepared nanoparticles from 3,6-bis(4-((E)-4-(bis(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)phenyl)-2,5-dihexyl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (DP-R2) with two functional groups having aggregation-induced emission properties and addnl. donating groups at the end of the triphenylamine groups were considered to have the greatest potential as a fluorescent probe for bioimaging. Furthermore, it was found that the tendency for aggregation-induced emission, which was apparent for the dye itself, became much more marked after the dyes were incorporated within nanoparticles. While the photoluminescence intensities of the dyes were observed to decrease rapidly over time, the prepared nanoparticles encapsulated within the biocompatible polymers maintained their initial optical properties very well. Lastly, when the cell viability test was conducted, excellent biocompatibility was demonstrated for each of the prepared nanoparticles.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mehr-un-Nisa published the artcileSynthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors, Application In Synthesis of 39115-95-2, the publication is Bioorganic & Medicinal Chemistry (2015), 23(17), 6014-6024, database is CAplus and MEDLINE.

A novel series of escitalopram triazoles I and a tetrazole II have been synthesized and subjected to a study to establish the inhibitory potential of these compounds toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Some selectivity in inhibition has been observed The compound I (R = 4-Cl, IC₅₀, 6.71 ± 0.25 μM) and I (R = 2-Me, 70, IC₅₀, 9.52 ± 0.23 μM) escitalopram triazole derivatives depicted high AChE inhibition, while compound I (R = 2-F, IC₅₀ = 4.52 ± 0.17 μM) and I (r = 4-F, IC₅₀ = 5.31 ± 0.43 μM) have found to be excellent BChE inhibitors. It has also been observed that ortho, meta and para substituted electron donating groups increase the inhibition, while electron withdrawing groups reduce the inhibition. Docking analyses of inhibitors with AChE have depicted the binding energies for I (R = 2-Me, 4-Cl) as ΔG_bind -6.42 and -6.93 kcal/mol, resp., while ligands I (R = 2-F, 4-F) have shown the binding affinity ΔG_bind -9.04 and -8.51 kcal/mol, resp., for BChE.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nisa, Mehr-un published the artcileSynthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors, Quality Control of 39115-95-2, the publication is European Journal of Medicinal Chemistry (2017), 396-406, database is CAplus and MEDLINE.

A novel series of 5-(aroylhydrazinocarbonyl)escitalopram were designed, synthesized and tested for their inhibitory potential against cholinesterases. N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide is the most potent compound of this series having IC₅₀ 1.80 ± 0.11 μM for acetylcholinesterase (AChE) inhibition. For the butyrylcholinesterase (BChE) inhibition, N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide was the most active compound of the series with IC₅₀ 2.11 ± 0.31 μM. Structure-activity relation illustrated that mild electron donating groups enhanced enzyme inhibition while electron withdrawing groups reduced the inhibition except o-NO₂. However, size and position of the substituents affected enzyme inhibitions. In docking study of AChE, the ligands N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide, N’-(4-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide and N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide showed the scores of 5874, 5756 and 5666 and ACE of -64.92,-203.25 and -140.29 kcal/mol, resp. In case of BChE, ligands 71, 76 and 81 depicted high scores 6016, 6150 and 5994 with ACE values -170.91, -256.84 and -235.97 kcal/mol, resp.

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khan, Madiha Sahar published the artcileSynthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors, Application of 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(3), 1195-1200, database is CAplus and MEDLINE.

A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Some of the synthesized compounds showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, ¹H NMR, ¹³C NMR, mass spectrometry and elemental anal. techniques.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileHomolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of α-heteroarylacetic acids, Application of Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (1992), 57(25), 6817-20, database is CAplus.

Efficient and selective homolytic substitutions (55-90% yields) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe²⁺/H₂O₂ and α-cyano-, α-carbonyl-, and α,α’-dicarbonylalkyl iodides. The reaction is highly successful with pyrroles substituted by electron-withdrawing groups, which allowed an efficient synthesis of Tolmetin. A few extensions of this reaction to furan and thiophene are described. Thus, homolytic substitution of pyrrole with ICHRR¹ (R = H, R¹ = CO₂Me, cyano; R = R¹ = CO₂Me) gave 2-substituted pyrroles I.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileHomolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane, Name: Ethyl 2-Iodopropionate, the publication is Tetrahedron Letters (1993), 34(31), 5015-18, database is CAplus.

An efficient homolytic aromatic substitution of pyrroles, furan, and thiophene by ^{â€?/sup>CH₂CO₂Et and â€?/sup>CH(CH₃)CO₂Et has been carried out, the radicals being generated by autoxidation of BEt₃ in the presence of XCH₂CO₂Et and XCH(CH₃)CO₂Et (X = Br, I). Thus, homolytic aromatic substitution reaction of pyrrole with BrCH₂CO₂Et in the presence of BEt₃ in C₆H₆ or DMSO and hexane gave 47% substituted pyrrole I.}

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileSynthesis of γ-haloesters and γ-ketoesters by homolytic addition of carbon radicals generated by α-haloesters and triethylborane to alkenes and silyl enol ethers, HPLC of Formula: 31253-08-4, the publication is Tetrahedron Letters (1994), 35(17), 2763-6, database is CAplus.

γ-Haloesters are efficiently prepared under very mild conditions by addition of electrophilic carbon radicals ·CH(R)CO₂Et (R=H, Me, CO₂Et) generated by XCH(R)CO₂Et (X=Br, iodo)/BEt₃/air in DMSO to alkenes and cycloalkenes. Thus, stirring ICH₂CO₂Et with 1-decene in DMSO in air gave 90% Me(CH₂)₇CHICH₂CH₂CO₂Et. γ-Ketoesters are obtained when silyl enol ethers are used as the substrates.

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohmomo, Yoshiro published the artcileSynthesis and evaluation of iodinated benzamide derivatives as selective and reversible monoamine oxidase B inhibitors, Related Products of iodides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(7), 1789-92, database is CAplus and MEDLINE.

A new series of iodinated analogs of N-(2-aminoethyl)benzamide were synthesized and evaluated for inhibitory potency and specificity toward monoamine oxidase type-B (MAO-B). Among them, N-(2-aminoethyl)-2-chloro-4-iodobenzamide hydrochloride (I) showed high inhibitory potency and selectivity against MAO-B. The type of MAO-B inhibition by I was noncompetitive and the inhibition constant (K_i) was 0.80 μM. Strong and selective in vivo MAO-B inhibition by I was also confirmed. The brain MAO-B inhibition by I was reversible and the enzyme activity completely returned to the control value 24h after administration. Compound I was, therefore, considered to be a candidate for advanced development as a radioiodinated ligand that may be useful for functional MAO-B studies in the living brain using single photon emission computer tomog.

Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohmomo, Yoshiro published the artcileRadioiodinated N-(2-aminoethyl)-2-chloro-4-iodobenzamide: a new ligand for monoamine oxidase B studies with single photon emission computed tomography, Synthetic Route of 145343-76-6, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(4), 913-16, database is CAplus.

In developing monoamine oxidase (MAO)-B specific radioligands, N-(2-aminoethyl)-2-chloro-4-[¹²⁵I]iodobenzamide ([¹²⁵I]FIBA) was conveniently synthesized from its tributylstannyl precursor by an iodostannylation reaction using sodium [¹²⁵I]iodide and hydrogen peroxide with high radiochem. yield. The method should be applicable for labeling with ¹²⁵I, a suitable radioisotope for in vivo imaging with single photon emission computed tomog. (SPECT). In vitro binding studies using mouse brain mitochondrial preparations showed that the specific binding of [¹²⁵I]FIBA was saturable and of high affinity. Calculated values for K_D and B_max were 201 nM and 2.5 pmol/mg protein, resp. The [¹²⁵I]FIBA binding was effectively prevented by MAO-B specific inhibitors (l-deprenyl, Ro 16-6491, FIBA) or substrate (β-phenethylamine). However, MAO-A specific inhibitor (clorgyline) and substrate (serotonin) had no significant effect. After an i.v. injection into mice, [¹²⁵I]FIBA showed high brain uptake (1.64% dose/g at 15-30 min postinjection) and long retention (1.11% dose/g at 120 min postinjection) in the brain. Good brain-to-blood radioactivity ratios of 2.19 and 2.41 at 60 and 120 min after injection, resp., were obtained. The in vitro binding data and in vivo characteristics suggested that [¹²⁵I]FIBA is potentially useful as a probe for biol. studies including specific labeling of MAO-B in vivo as well as in vitro. Moreover, the ¹²³I-labeled counterpart, [¹²⁵I]FIBA, might be valuable for noninvasive imaging and mapping of MAO-B in the living brain with SPECT.

Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Synthetic Route of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fialkov, Ya. A. published the artcilePhysicochemical investigation of the system iodine chloride-pyridine, Safety of Pyridine Iodochloride complex, the publication is Zhurnal Obshchei Khimii (1948), 1205-14, database is CAplus.

The elec. conductivity-concentration curves at both 35 and 50° showed maximum at about 8 mol.% pyridine. At 35° they rose from 4.82 × 10^-3 ohm^-1 for pure ICl to a maximum of 21.39 × 10^-3, and then dropped to 3.37 × 10^-3 ohm^-1 at 34.65 mol.% pyridine. Thermal analysis revealed 2 compounds in the system, having formulas C₅H₅N.ICl and C₅H₅N.2ICl and m.ps. of 128.50 and 35.10°, resp. There are 3 eutectics with concentrations (in mol.% pyridine) and temperatures, resp., of 20.73, -6.30°; 35.11, 23.60°; and 98.90, -50.20°. Electrolysis studies indicated that the following reactions occur: C₅H₅N + ICl = (C₅H₅-N.I)⁺ + Cl^–. During electrolysis the reactions at the electrodes are: 2 (C₅H₅N.I)⁺ + 2e = 2C₅H₅N + I₂, and 2Cl^– = Cl₂ + 2e.

Zhurnal Obshchei Khimii published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Safety of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com