Category: iodides-buliding-blocks

Lesniak, Robert K. published the artcileDiscovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy, Safety of 4-Iodo-3-nitrobenzonitrile, the publication is European Journal of Medicinal Chemistry (2022), 114080, database is CAplus and MEDLINE.

The discovery and development of compound I, an indazole-based, G2019S-selective (>2000-fold vs. WT) LRRK2 inhibitor capable of entering rodent brain (K_p = 0.5) and selectively inhibiting G2019S-LRRK2 was reported. The compounds disclosed herein present a starting point for further development of brain penetrant G2019S selective inhibitors that hopefully reduce lung phenotype side-effects and pave the way to providing a precision medicine for people with PD who carry the G2019S mutation.

European Journal of Medicinal Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Safety of 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kolmel, Dominik K. published the artcileOn-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water, HPLC of Formula: 145343-76-6, the publication is ACS Combinatorial Science (2019), 21(8), 588-597, database is CAplus and MEDLINE.

A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a water-compatible nickel catalysis platform, which is a crucial requirement for the preparation of DNA-encoded libraries (DELs). Together with an iridium-based photocatalyst and a powerful light source, this dual catalysis approach enabled the efficient decarboxylative arylation of α-amino acids with DNA-tagged aryl halides. This C(sp²)-C(sp³) coupling tolerates a wide variety of functional groups on both the amino acid and the aryl halide substrates. Due to the mild and DNA-compatible reaction conditions, the presented transformation holds great potential for the construction of DELs. This was further evidenced by showing that well plate-compatible LED arrays can serve as competent light sources to facilitate parallel synthesis. Lastly, we demonstrate that this procedure can serve as a blueprint toward the adaptation of other established nickel metallaphotoredox transformations to the idiosyncratic requirements of a DEL.

ACS Combinatorial Science published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, HPLC of Formula: 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Feng, Huan published the artcileResponsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemistry – An Asian Journal (2018), 13(18), 2611-2618, database is CAplus and MEDLINE.

The development of effective bioanal. methods for rapid, sensitive and specific detection of HOCl in vitro and in vivo plays a key role for better understanding the roles of this mol. in normal and diseased conditions, but remains challenging due to the highly reactive nature of HOCl and the complicated biol. conditions. A new fluorescence probe, PQI(I), was developed for monitoring of the HOCl level in biol. samples. PQI was easily synthesized by a one-step condensation reaction. Upon addition of HOCl, significant changes in the absorption spectra and the color of the solution were noticed, facilitating the “naked eye” detection of HOCl in PBS buffer. The fluorescence of PQI is significantly increased within a few seconds, leading to “OFF-ON” fluorescence response towards HOCl. The sensing mechanism, oxidation of thioether by HOCl, was confirmed by HRMS titration anal. PQI features a large Stokes shift, high sensitivity and selectivity, and rapid fluorescence response towards HOCl. Quant. detection of HOCl in single live cells was demonstrated through fluorescence imaging and flow cytometry anal. PQI was then successfully used in visualization of HOCl in live zebrafish and nude mice.

Chemistry – An Asian Journal published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Wei published the artcileEnhancing Transition Dipole Moments of Heterocyclic Semiconductors via Rational Nitrogen-Substitution for Sensitive Near Infrared Detection, Formula: C6H13I, the publication is Advanced Materials (Weinheim, Germany) (2022), 34(28), 2201600, database is CAplus and MEDLINE.

Designing ultrastrong near-IR (NIR) absorbing organic semiconductors is a critical prerequisite for sensitive NIR thin film organic photodetectors (OPDs), especially in the region of beyond 900 nm, where the absorption coefficient of com. single crystalline silicon (c-Si) is below 10³ cm^-1. Herein, a pyrrolo[3,2-b]thieno[2,3-d]pyrrole heterocyclic core (named as BPPT) with strong electron-donating property and stretched geometry is developed. Relative to their analog Y6, BPPT-contained mols., BPPT-4F and BPPT-4Cl, show substantially upshifted and more delocalized highest occupied MOs, and larger transition dipole moments, leading to bathochromic and hyperchromic absorption spectra extending beyond 1000 nm with very large absorption coefficients (up to 3.7-4.3 x 10⁵ cm^-1) as thin films. These values are much higher than those (10⁴ to 1 x 10⁵ cm^-1) of typical organic semiconductors, and 1-2 orders higher than those of com. inorganic materials, such as c-Si, Ge, and InGaAs. The OPDs based on BPPT-4F or BPPT-4Cl blending polymer PBDB-T show high detectivity of above 10¹² Jones in a wide wavelength range of 310-1010 nm with excellent peak values of 1.3-2.2 x 10¹³ Jones, resp., which are comparable with and even better than those com. inorganic photodetectors.

Advanced Materials (Weinheim, Germany) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H14BrNO5S2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iwasaki, Masayuki published the artcileRegioselective Synthesis of γ-Lactones by Iron-Catalyzed Radical Annulation of Alkenes with α-Halocarboxylic Acids and Their Derivatives, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Organic Letters (2018), 20(13), 3848-3852, database is CAplus and MEDLINE.

An abundant and low toxicity iron catalyst has enabled regioselective annulation of alkenes with α-halocarboxylic acids and their derivatives The reaction proceeds smoothly without any addnl. ligands, bases, and additives to afford a variety of γ-lactones in good yields. A proposed reaction pathway through radical annulation is supported by some mechanistic studies, involving radical clock and isotope labeling experiments The present method was applied to the practical iron-powder-promoted synthesis of γ-lactones.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rodriguez-Muniz, Gemma M. published the artcileModulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols, HPLC of Formula: 638-45-9, the publication is Molecules (2022), 27(4), 1245, database is CAplus and MEDLINE.

Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently attaching the active moiety onto a triphenylphosphonium (TPP) cation. In this regard, luminol (probably the most widely known chemiluminescent mol.) has been employed for a number of biol. applications, including ROS detection. Hence, the photophys. interaction between the light-emitting species 3AP * and TPP cations needs to be evaluated, as it can add valuable information on the design of novel emission-based mitotropic systems. Author’s herein investigate the quenching effect of ethyltriphenylphosphonium cation onto substituted 3-aminophthalates. These were prepared in situ upon hydrolysis of the corresponding anhydrides, which were synthesized from 3-aminophthalimides. Steady-state fluorescence and time-resolved experiments were employed for the evaluation of a possible electron transfer quenching by phosphonium ions. A minor contribution of static quenching that was also detected is attributed to complex formation in the ground state. Accordingly, the chemiluminescence of luminol was indeed strongly reduced in the presence of phosphonium ions. Author’s results have to be taken into account during the design of new chemiluminescent mitotropic drugs or diagnostic agents of the luminol family.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gupta, Jeetendra Kumar published the artcileAntimicrobial screening of some newly synthesized triazoles, Category: iodides-buliding-blocks, the publication is Journal of Pure & Applied Microbiology (2017), 11(2), 1067-1077, database is CAplus.

4-Iodobenzoic acid was taken as initial reactant material which was converted into Me ester then to hydrazide and finally into triazole via dithiocarbazate salt. This triazole was treated with chloroacetyl chloride and further with secondary amines which yielded amine linked triazoles I [R = pyrrolidin-1-yl, 2-methyl-piperidin-1-yl, 4-benzyl-1-piperazinyl, etc.]. The synthesized compounds were screened for their antibacterial and antifungal activities. The study was carried out against four bacteria and three fungi by disk diffusion method using ciprofloxacin and fluconazole as reference drug for antibacterial and antifungal activities resp. Among the synthesized compounds, compounds I [R = 4-methyl-1-piperazinyl, 4-benzyl-1-piperazinyl] showed highest antibacterial and antifungal activities.

Journal of Pure & Applied Microbiology published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat K. published the artcileSynthesis and antimicrobial screening of some 1,3,4-oxadiazoles and their molecular properties prediction through ‘rule of five’, SDS of cas: 39115-95-2, the publication is Pakistan Journal of Pharmaceutical Sciences (2019), 32(3), 1025-1032, database is CAplus and MEDLINE.

In the current study, a series of 5-(4-substituted phenyl)-1,3,4-oxadiazole-2-thiols I (R = F, Cl, Br, I, Me, OMe, OH, OEt) were prepared from 4-substituted benzoic acid hydrazides 4-RC₆H₄C(O)NHNH₂. All these synthesized compounds I were investigated for their antibacterial activities against bacterial strains i.e. Staphylococcus aureus, Bacillus substilis, Escherichia coli and Pseudomonas aeruginosa. The strains, Aspergillus niger and Candida albicans were also examined for antifungal screening. The zone of inhibition was measured and percentage inhibition was calculated by comparing with standard drug. The min. inhibitory concentrations (MICs) of potent synthesized compounds I were determined Then, all the synthesized compounds I were computed to assess the drug-like properties through Lipinski’s rule of five. The results of in-vitro assay showed that the compounds I (R = F, Cl, I) possess significant antibacterial activity, whereas compounds I (R = F, OMe, OEt) possess significant antifungal activity. The predicted drug likeness score of all these compounds I were also meritorious among 1,3,4-oxadiazoles. The results recommended that these compounds I might be used in future to generate derivatives for emergent antimicrobial agents with improved pharmacokinetic profile.

Pakistan Journal of Pharmaceutical Sciences published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C18H28B2O4, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat Kumar published the artcileMicrowave assisted synthesis and evaluation of some substituted 1,3,4-oxadiazoles as free radical scavenger, Category: iodides-buliding-blocks, the publication is Journal of the Indian Chemical Society (2018), 95(6), 661-666, database is CAplus.

A series of 5-(4-substituted phenyl)-1,3,4-oxadiazoles I [R = Me, Br, OH, etc.] was synthesized from 4-substituted benzoic acid hydrazides and carbon disulfide. Structures of the synthesized compounds were confirmed on the basis of IR, ¹³C NMR, mass spectral methods and elemental anal. The compounds were screened for antioxidant activities using hydrogen peroxide scavenging method comparing with ascorbic acid as standard antioxidant. The results revealed that the compounds possess significant free radical scavenging activities, among them compound I [R = OH] showed highest scavenging activity.

Journal of the Indian Chemical Society published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C12H25Br, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haristos, Demetrius A. published the artcileKinetic study of the oxidation of benzoic acid hydrazide by mercury(II) acetate, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1982), 11(3), 193-200, database is CAplus.

The oxidation kinetics of RC₆H₄CONHNH₂ (I; R = H, p-F, m-Cl, p-Cl, m-Br, p-Br, p-iodo, m-MeO, p-MeO, m-NO₂) by Hg(OAc)₂ are not dependent on inductive or resonance effects. Two possible mechanisms can explain the kinetics. In one of these, the NH₂ group N atom is involved as an electron donor in a complex with Hg²⁺. This electron transfer reaction leads to the C-N bond cleavage which gives RC₆H₄C⁺(O) and •NHNH₂. The alternative mechanism involves a 4-electron transfer in which RC₆H₄CON:NH is an intermediate.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com