Category: iodides-buliding-blocks

El Ashry, E. S. H. published the artcileThe scope of the reactions of hydrazines and hydrazones. Part VI. Reaction of hydrazines with dimedone, Computed Properties of 39115-95-2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(10), 871-5, database is CAplus.

The reactions of dimedone (I) with hydrazines were studied. I and p-tolylhydrazine gave II (R = NHNHC₆H₄Me-p), which was deprotonated to give II (R = N:NC₆H₄Me-p). With excess p-tolylhydrazine, I gave III (Z¹ = Z³ = NNHC₆H₄Me-p, Z² = O) which was identified as its 2-p-nitrobenzoylhydrazone and III (Z¹-Z³ = NNHC₆H₄Me-p). Reactions of I and II (R = NHNHR¹, N:NR¹; R¹ = Ph, C₆H₄Me-p) with R²C₆H₄CONHNH₂ (R² = H, Me, OMe, Cl, Br, I, OH, NO₂) gave the corresponding hydrazones. Reaction of I with semicarbazide, thiosemicarbazide and gluconylhydrazines gave the monohydrazones.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dorian, Andreas published the artcileIron-Catalyzed Halogen Exchange of Trifluoromethyl Arenes, Application of 5-Bromo-2-iodobenzotrifluoride, the publication is Chemistry – A European Journal (2021), 27(42), 10839-10843, database is CAplus and MEDLINE.

The facile production of ArCF₂X and ArCX₃ from ArCF₃ using catalytic iron(III)halides is reported, which constitutes the first iron-catalyzed halogen exchange for non-aromatic C-F bonds. Theor. calculations suggest direct activation of C-F bonds by iron coordination. ArCX₃ and ArCF₂X products of the reaction are synthetically valuable due to their diversification potential. In particular, chloro- and bromodifluoromethyl arenes (ArCF₂Cl, ArCF₂Br resp.) provide access to a myriad of difluoromethyl arene derivatives (ArCF₂R). To optimize for mono-halogen exchange, a statistical method called Design of Experiments was used. Optimized parameters were successfully applied to electron rich and electron deficient aromatic substrates, and to the late stage diversification of flufenoxuron, a com. insecticide. These methods are highly practical, being run at convenient temperatures and using inexpensive common reagents.

Chemistry – A European Journal published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Application of 5-Bromo-2-iodobenzotrifluoride.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simon, P. published the artcileNew NIR dyes for ammonia sensing, Computed Properties of 606-55-3, the publication is Sensors and Actuators, B: Chemical (2003), 90(1-3), 9-14, database is CAplus.

Three series of new cyanine dyes were synthesized and the visible-NIR spectra of the dyes were measured and interpreted by semi-empirical methods of quantum chem. As a basic building block for the synthesis, 4-(dimethylaminomethylene)-5-oxo-2-furfurylidenedimethyliminium perchlorate (I) was used. The dyes were prepared by condensing I with appropriate salts. The tests for sensitivity to ammonia showed that mono-substituted dyes III are reversibly sensitive to ammonia in ethanol solutions The dyes exhibit a peak at 620-680 nm arising from the interaction with ammonia and, hence, these dyes are promising as chem. transducers for distributed fiber-optic ammonia sensors.

Sensors and Actuators, B: Chemical published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H13BO3, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zengerling, Lydia published the artcileA Palladium-free Sonogashira coupling protocol employing an in situ prepared copper/chelating 1,2,3-triazolylidene system, Safety of 1-Iodohexane, the publication is Synlett (2021), 32(6), 616-620, database is CAplus.

A new, palladium-free Sonogashira coupling reaction protocol using a catalytic system that comprises a simple, cheap, widely available copper salt and a chelating 1,2,3-triazolylidene ligand precursor is reported. This protocol provides the desired coupling products in moderate to very good yields.

Synlett published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C26H25N5O3, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reddy, M. L. Chenna published the artcileSynthesis of New Sulfoximine-Tethered Alkynones and Further Extension towards Metal-Free Synthesis of Pyrimidines, Amino Pyrimidines, Pyrazoles and Isoxazoles, Category: iodides-buliding-blocks, the publication is ChemistrySelect (2019), 4(33), 9573-9577, database is CAplus.

A metal-free and divergent synthetic method has been successfully developed for the synthesis of sulfoximine-tethered pyrimidines, aminopyrimidines, pyrazoles and isoxazoles. Two key sulfoximine tethered alkynone intermediates ((tert-butyldiphenylsilyl)imino)(2-oxo-4-phenylbut-3-yn-1-yl)(phenyl)-λ6-sulfanone and ((tert-butyldiphenylsilyl)imino)(2-oxopent-3-yn-1-yl)(phenyl)-λ6-sulfanone were reported for the first time and were used as the common building blocks to construct these heterocycles. Good functional group tolerability was observed and the products were isolated in excellent yields.

ChemistrySelect published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hong, Seunghee published the artcileDesign, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities, Synthetic Route of 757978-19-1, the publication is Journal of Medicinal Chemistry (2012), 55(11), 5337-5349, database is CAplus and MEDLINE.

Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. Thus, a series of novel 7-azaindole-based Trk kinase inhibitors, e. g. I, were designed and synthesized through the structure-based design strategy. By varying the functional groups at the 3 and 5 positions of a 7-azaindole scaffold, the structure-activity relationships (SAR) profiles were explored and a series of potent Trk inhibitors were identified. Representative derivatives, including I, showed desirable activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity.

Journal of Medicinal Chemistry published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Synthetic Route of 757978-19-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Willenbrink, J. published the artcileMechanism of excretion of urinary contrast media, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie (1959), 16-18, database is CAplus.

3,5-Di-iodo-4-pyridone-N-acetic acid (I) and 3,5-diacetamido-2,4,6-triiodobenzoic acid (II) labeled with radioiodine were injected into Hippocampus cudae, which had no glomeruli. The excretion of I was 5 times that of II. Excretion through bile and intestine was insignificant. The excretion of I in rabbits decreased with a plasma concentration up to 10 mg. % and remained constant between 20 and 1280 mg. %. Blocking the tubules with 200 mg. % p-aminohippuric acid (PAH) caused a depression of excretion to 1-10 mg. %. The rate of excretion of II remained unchanged within the range of 1 to 1280 mg. % in the plasma and was not influenced by PAH.

Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C5H12O2, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ichijo, Keisuke published the artcileCrystal Structures and Optical Properties of Cyanine Dyes Depending on Various Counter Anions, Product Details of C12H14IN, the publication is ACS Omega (2021), 6(42), 28421-28431, database is CAplus and MEDLINE.

In this study, cyanine cations with various counter anions were prepared as examples of ionic materials constructed using charged π-conjugated systems. A series of ion pairs was obtained by anion exchange reactions using iodide salts of carbocyanine dyes. The optical properties were measured by UV/vis absorption and fluorescence spectroscopy; measurements performed in CHCl₃ (less-polar solvent) were altered by the influence of the counter anions. The packing structures of nine crystals were determined by single-crystal X-ray anal. Moreover, the locations of the anions relative to the cations were stabilized by hydrogen bonding and categorized into two types. In addition, delocalization of the neg. charge of the anions on cyanine cations was explained by d. functional theory calculations Furthermore, it was concluded that the stack formation of cyanine cations depends on the size and structure of the anions.

ACS Omega published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tanner, George A. published the artcileReabsorption and secretion of p-aminohippurate and Diodrast in Necturus kidney, HPLC of Formula: 101-29-1, the publication is American Journal of Physiology (1966), 210(2), 221-31, database is CAplus and MEDLINE.

Intact animals spontaneously show net reabsorption, no net transport, or net secretion of p-aminohippurate(PAH) and Diodrast. Net reabsorption was converted to net secretion by intraarterial doses of fatty acids such as octanoate. In kidneys perfused with modified Ringer solution, strong net PAH reabsorption was observed; with 1mM octanoate, net secretion was usually produced. The action of octanoate is specific and reversible. With PAH-carboxyl-¹⁴C perfused from either the aortic or renal portal side and unlabeled PAH from the opposite side, urine PAH sp. activity differed from that of filtered PAH. Unidirectional PAH movements, calculated using a 2-compartment analysis, suggest that Diodrast inhibits reabsorptive and secretory movements, whereas octanoate inhibits primarily the reabsorptive movement. Tubular transport of PAH and Diodrast in Necturus kidney may involve active processes which move these compounds into proximal tubule cells from luminal and peritubular sides.

American Journal of Physiology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watari, Fumio published the artcileInfrared absorption spectra of molecular complexes of pyridine. III. Molecular complexes with iodine and iodine halides, Synthetic Route of 6443-90-9, the publication is Sci. Rept. Res. Inst., Tohoku Univ. (1962), Ser. A 14(No. 1), 64-9, database is CAplus.

cf. CA 56, 9594a. When I, ICl, or IBr were dissolved in pyridine (I), new bands were observed at 627-624, 1012-1007, 1213, 1246 and 1454 cm.^-1, which were assigned as the shifted bands of ν_6a, ν₁, ν₃, 2ν_6a, and ν_19b, resp., of I. They are well defined: others appear only as a shoulder of the pure I band; some may mutually enhance their intensity, others remain almost unaffected. The rest of the absorptions of the I solution were nearly the same in band location and intensity as those of pure I. Spectra of the solid complexes are analogous to the solution spectra, though in the latter there are the shifting and intensity-changing effects in the case of liquid I. The difference of shift of 624-627 and 1007-1012 cm.^-1 is parallel to the electronegativities of the added interhalogen compounds; ICl shifts a band most markedly from the pure I spectrum.

Sci. Rept. Res. Inst., Tohoku Univ. published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C14H28O5S, Synthetic Route of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com