Category: iodides-buliding-blocks

Abd El-Aal, R. M. published the artcileThe use of oxonium salts in the synthesis of mono-, β-substituted dimethine and styryl cyanine dyes, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Dyes and Pigments (2005), 66(3), 201-209, database is CAplus.

Pyrazolopyrylium perchlorate salt derivatives were obtained from the reaction of 5-chloro-4-formyl-3-methyl-1-phenylpyrazole with methylphenylpyrazolone, 4(2-propenyl)-1,6-ene-2-cyclohexanone, and cyclohexanone. Reaction of the salts with 2(4)-Me-substituted heterocyclic quaternary salts gave the pyrazolopyrylium 4[2(4)]-monomethine cyanine dyes. Meanwhile, reaction with amide compounds gives intermediate compounds which when reacted with 2(4)-Me-substituted heterocyclic quaternary salts gave the pyrazolopyrylium 4[2(4)]-β-substituted dimethines. Reaction of the intermediate compounds with various aromatic aldehydes followed by the reaction with 2-methylquinolinium ethiodide gave bis styryl cyanine dyes. Elemental analyses and visible absorption, IR, ¹H NMR, and mass spectra established the structures of these compounds The relationship between the structure and properties of these dyes is discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abed El-Aal, R. M. published the artcileSynthesis and photophysics in organic solvents of mesosubstituted pentamethine and related metal complexes cyanine dyes, Computed Properties of 606-55-3, the publication is Dyes and Pigments (2002), 54(2), 121-129, database is CAplus.

The reaction in a ratio of 1 mol of diacetylchloromethane with 1 mol of heterocyclic nitrogen bases afforded N-substituted heterocyclidinium ylide halides. Reaction at a ratio of 1 mol of ylides with 2 and 3 mol of 2(4)-methylheterocyclic quaternary salts in basic catalyst afforded meso-substituted pentamethine and monomethine meso-substituted pentamethine cyanine dyes, resp. Reaction of equimolar ratios of metal chloride adducts of the ylides with equi- (bi)molar ratios of 2(4)-methylheterocyclic quaternary salts in basic medium afforded asym. (sym.) meso-substituted mono- (bis)monomethine metal complex cyanine dyes. Elemental analyses and IR and ¹H NMR spectral data confirmed the structures of the newly synthesized compounds The electronic absorption spectra of these dyes in ethanol and their photophysics in different solvents are discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El-Aal, R. M. Abd published the artcileSynthesis, absorption spectra studies and biological activity of some novel conjugated dyes, COA of Formula: C12H14IN, the publication is Journal of the Chinese Chemical Society (Taipei) (2000), 47(2), 389-395, database is CAplus.

Novel monomethine, dimethine, and tetramethine cyanine dyes were prepared as conjugated dyes. Such dyes incorporated coumarin and/or quinoline derivatives These dyes were synthesized to study their spectral behavior, solvatochromism, and biol. activity. These dyes were characterized by elemental anal. and IR, ¹H NMR, and mass spectra.

Journal of the Chinese Chemical Society (Taipei) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, COA of Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haristos, Demetrius A. published the artcileStudy of the hydrolysis of halo-substituted benzoic acid hydrazides, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1981), 10(2), 163-74, database is CAplus.

Alk. hydrolysis kinetics of RC₆H₄CONHNH₂ (R = o-, m-, or p-F, Cl, Br, I) were spectrally determined at 40-60°. The reaction involves successive enolization and hydrolysis with rate constants ∼10³ s^-1 and ∼10⁵ mol L s^-1, resp. The enolization kinetics are slightly affected by temperature and substituents. The substituent, its position, and the temperature have a large effect on the hydrolysis.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Biilmann, Einar published the artcileBetaines. IV. The mechanism of the racemization of the salts of ethyl propiobetainate, Name: Ethyl 2-Iodopropionate, the publication is Bulletin de la Societe Chimique de France, Memoires (1936), 2295-2305, database is CAplus.

cf C. A. 29, 2916.5. d-and l-Et propiobetainate iodide, m. 130-1°, [α]_D⁴⁸ 19.64°, are racemized at the same rate by d-EtMeCHCH₂NEt₂ (I), b₇₆₅ 150-1°, d₄²⁰ 0.7515, [α]_D²⁰ 17.96°, and the racemic form of Et propiotrimethylbetainate is not rendered active by treatment with I or nicotine. This shows that there is no addition compound of the betainate and amine involved in the racemation. l-α-Phenylethyltrimethylammonium iodide, m. 157-7.5°, [α]_D²⁰ 19.60°, which cannot enolize, is not racemized by EtONa. This indicates that racemization occurs through the enol form, and reagents such as NaOEt and Me₃N which can react with enols, increase their concentration and so hasten racemization. This effect is complicated by the fact that the pos. N in the betaines also favors racemization. Thus, in alc. solution MeCH(NMe₃)CO₂EtI is racemized even by such weak bases as Et₃P. MeCHNH₂CO₂Et is not racemized by NaOEt or Et₃N, but MeCH(NMe₂)CO₂Et, b₇₆₇ 155.6-6.5°, d₄²⁰ 0.9207, [α]_D²⁰ 5.58°, is slowly racemized by NaOEt.

Bulletin de la Societe Chimique de France, Memoires published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Al-Amin, Mohammad published the artcileSelectivity, Compatibility, Downstream Functionalization, and Silver Effect in the Gold and Palladium Dual-Catalytic Synthesis of Lactones, Product Details of C10H9IO4, the publication is Organometallics (2014), 33(19), 5448-5456, database is CAplus and MEDLINE.

The chemo- and regioselectivity and functional group compatibility in Au and Pd cooperatively catalyzed cross-coupling reactions were determined in the synthesis of lactones; the selectivity in the Au and Pd dual-metal catalysis system was distinct from that available for the same class of substrates in systems with only Au catalysis or only Pd catalysis rather than dual catalysis. The dual-catalytic rearrangement reaction selectively promoted oxidative addition at the C-O bond over the C-Br bond, providing a useful C-Br bond handle for downstream functionalization showcased via Suzuki-Miyaura and Sonogashira coupling reactions. Product classes were expanded from isocoumarins to three previously unpublished ring classes: pyrone, indolepyrone, and furopyrone.

Organometallics published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Product Details of C10H9IO4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Duhamel, Jean published the artcileStudy of Energy Migration and Trapping in a Poly(ethylene 2,6-naphthalenedicarboxylate) Matrix by Fluorescence Spectroscopy, Quality Control of 165534-79-2, the publication is Macromolecules (2000), 33(17), 6344-6352, database is CAplus.

The efficiency of di-Me iodoterephthalate (I-DMT), 2,6-di-Me 1-benzoylnaphthalate (BZN), and 2,6-bis(2-hydroxyethylthio)naphthalene (NSEG) at quenching the fluorescence of the poly(ethylene 2,6-naphthalenedicarboxylate) (PEN) matrix has been investigated by steady-state and time-resolved fluorescence spectroscopy. All three quenchers are capable of capturing the energy migrating between naphthalene dimers. Steady-state fluorescence data indicate that, after the quencher has trapped the migrating energy, the excited quencher can relax either via nonradiative processes (I-DMT) or via radiative processes (BZN and NSEG). Fluorescence decay measurements show that NSEG quenches PEN fluorescence best, followed by BZN, and I-DMT is the worst quencher. Quenching efficiency of a given quencher increases linearly with quencher concentration, for quencher contents below the overlap concentration, for which the entire polymer matrix is covered by quenchers. Above the overlap concentration, quenching efficiency increases at a slower pace because any addnl. quencher quenches an already quenched volume Our exptl. results could be interpreted by compartmentalizing the quenching process in the polymer matrix. Compartmentalization could be handled by a blob model, which was applied to quantify the quenching efficiency of I-DMT and BZN.

Macromolecules published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Quality Control of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ishii, Marina published the artcileSynthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents, Recommanded Product: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2011), 19(21), 6292-6301, database is CAplus and MEDLINE.

A series of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives was synthesized and their activity screened in vitro against Staphylococcus aureus, Trypanosoma cruzi, and Candida albicans. The bioactivity was expressed as min. inhibitory concentration (MIC) for S. aureus strains, and as IC₅₀ of parasite population growth for T. cruzi. A mol. modeling approach was performed to establish qual. relationships regarding the biol. data and the compounds’ physicochem. properties. Oxadiazole derivatives I [R = OBu, OAc] were the most active compounds for S. aureus ATCC 25923 (MIC = 1.95 -1.25 μg/mL) and T. cruzi (IC₅₀ = 7.91 μM), resp. Also, a preliminary evaluation against C. albicans involving some compounds was performed and I [R = CF₃] was the most active compound (MIC = 3.28-2.95 μg/mL). In this preliminary study, all synthesized 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives were active against all microorganisms tested.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palace-Berl, Fanny published the artcile5-Nitro-2-furfuriliden derivatives as potential anti-Trypanosoma cruzi agents: Design, synthesis, bioactivity evaluation, cytotoxicity and exploratory data analysis, Product Details of C7H7IN2O, the publication is Bioorganic & Medicinal Chemistry (2013), 21(17), 5395-5406, database is CAplus and MEDLINE.

The anti-Trypanosoma cruzi activity of 5-nitro-2-furfuriliden derivatives as well as the cytotoxicity of these compounds on J774 macrophages cell line and FN1 human fibroblast cells were investigated in this study. The most active compounds of series I and II were 4-butyl-[N’-(5-nitrofuran-2-yl) methylene] benzidrazide (3g; IC₅₀ = 1.05 μM ± 0.07) and 3-acetyl-5-(4-butylphenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro,1,3,4-oxadiazole (4g; IC₅₀ = 8.27 μM ± 0.42), resp. Also, compound 3g was more active than the standard drugs, benznidazole (IC₅₀ = 22.69 μM ± 1.96) and nifurtimox (IC₅₀ = 3.78 μM ± 0.10). Regarding the cytotoxicity assay, the 3g compound presented IC₅₀ value of 28.05 μM (SI = 26.71) against J774 cells. For the FN1 fibroblast assay, 3g showed IC₅₀ value of 98 μM (SI = 93.33). On the other hand, compound 4g presented a cytotoxicity value on J774 cells higher than 400 μM (SI >48), and for the FN1 cells its IC₅₀ value was 186 μM (SI = 22.49). Moreover, an exploratory data anal., which comprises hierarchical cluster (HCA) and principal component anal. (PCA), was carried out and the findings were complementary. The mol. properties that most influenced the compounds’ grouping were C log P and total dipole moment, pointing out the need of a lipophilic/hydrophilic balance in the designing of novel potential anti-T. cruzi mols.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zorzi, Rodrigo Rocha published the artcileExploring 5-nitrofuran derivatives against nosocomial pathogens: synthesis, antimicrobial activity and chemometric analysis, Name: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(10), 2844-2854, database is CAplus and MEDLINE.

The burden of nosocomial or health care-associated infection (HCAI) is increasing worldwide. According to the World Health Organization (WHO), it is severalfold higher in low- and middle-income countries. Considering multidrug-resistant infections, the development of new and more effective drugs is crucial. Here, two series (I and II) of 5-nitrofuran derivatives were designed, synthesized and assayed against microorganisms, including Gram-pos. and -neg. bacteria, and fungi. Sets I and II were composed by substituted-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide and 3-acetyl-5-(substituted-phenyl)-2-(5-nitro-furan-2-yl)-2,3-dihydro-1,3,4-oxadiazole compounds, resp. The selection of the substituent groups was based upon physicochem. properties, such as hydrophobicity and electronic effect. The compounds exhibited good activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis. It is noteworthy that the compound 4-butyl-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide had a similar MIC value to vancomycin, which is the reference drug for multidrug-resistant S. aureus infections.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H14O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com