Category: iodides-buliding-blocks

Takeuchi, Naoki’s team published research in Chemical & Pharmaceutical Bulletin in 32 | CAS: 31253-08-4

Chemical & Pharmaceutical Bulletin published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C38H74Cl2N2O4, Name: Ethyl 2-Iodopropionate.

Takeuchi, Naoki published the artcileSyntheses and anti-histaminic and anti-allergic activities of hexahydro-4-hydroxy-1-benzofuran-2-ones, Name: Ethyl 2-Iodopropionate, the publication is Chemical & Pharmaceutical Bulletin (1984), 32(6), 2249-61, database is CAplus and MEDLINE.

Benzofuranones I (R = H, R1 = β-HO; R = Me, R1 = α-HO, β-HO), which are related to the 6β-hydroxyeremophilenolides which show anti-histaminic and anti-allergic activities, were prepared from dimedone via dihydroxybenzofuranones II followed by dehydration reactions. I (R = H, Me; R1 = β-HO) have anti-histaminic activity and cause marked inhibition in the Schultz-Dale reaction.

Chemical & Pharmaceutical Bulletin published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C38H74Cl2N2O4, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Antia, M. B.’s team published research in Agra Univ. J. Research, Science in 3 | CAS: 31253-08-4

Agra Univ. J. Research, Science published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Antia, M. B. published the artcileReformatskiǐ condensation of ketonic esters with halo esters, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Agra Univ. J. Research, Science (1954), 197-201, database is CAplus.

Condensation of Et levulinate (I) with halo esters yields substituted butyrolactones. Thus 7.2, g. I, 8.1 g. MeCHBrCO2Et (b250 124°), and 3.3 g. Zn in dry C6H6 heated 0.5 hr. on a water bath, the mixture treated with 2N H2SO4, the C6H6 layer washed with 10% Na2CO3, dried, the C6H6 evaporated, and the residue distilled gave 4.4 g. O.CO.(CH2)2.CMeCHRCO2Et (II, R = Me) (III), b4 160°, b3 156°. The same reaction in xylene gave 4 g. III. MeCHICO2Et (b714 196°) did not react with I under either of the above conditions. Similarly 10 g. EtCHBrCO2Et (b75 106°) gave 3.5 g. II (R = Et), b6 183-5°, and 15 g. Et 2-bromolaurate (b10 172-4°) gave 2.0 g. II [R = Me(CH2)9], b4 162-4°. AcCH2CO2Et 6.5, ClCO2Et (IV) 5.4, Zn 3.2, reduced Cu powd. 0.2 g., and 30 ml. dry C6H6 refluxed 8 hrs., during which time 1 g. IV was added, gave 2 g. EtO2CCH2CMe(OH)CO2Et, b8 156-60°.

Agra Univ. J. Research, Science published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lim, Jongwon’s team published research in Journal of Medicinal Chemistry in 59 | CAS: 1260672-72-7

Journal of Medicinal Chemistry published new progress about 1260672-72-7. 1260672-72-7 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 6-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and the molecular formula is C6H3ClIN3, COA of Formula: C6H3ClIN3.

Lim, Jongwon published the artcileDiscovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers, COA of Formula: C6H3ClIN3, the publication is Journal of Medicinal Chemistry (2016), 59(13), 6501-6511, database is CAplus and MEDLINE.

The ERK/MAPK pathway plays a central role in the regulation of critical cellular processes and is activated in more than 30% of human cancers. Specific BRAF and MEK inhibitors have shown clin. efficacy in patients for the treatment of BRAF-mutant melanoma. However, the majority of responses are transient, and resistance is often associated with pathway reactivation of the ERK signal pathway. Acquired resistance to these agents has led to greater interest in ERK, a downstream target of the MAPK pathway. De novo design efforts of a novel scaffold derived from SCH772984 by employing hydrogen bond interactions specific for ERK in the binding pocket identified 1-(1H-pyrazolo[4,3-c]pyridin-6-yl)ureas as a viable lead series. Sequential SAR studies led to the identification of highly potent and selective ERK inhibitors with low mol. weight and high LE. Compound 21 exhibited potent target engagement and strong tumor regression in the BRAFV600E xenograft model.

Journal of Medicinal Chemistry published new progress about 1260672-72-7. 1260672-72-7 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 6-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and the molecular formula is C6H3ClIN3, COA of Formula: C6H3ClIN3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dacko, Christopher A. et al. published their research in Tetrahedron: Asymmetry in 2008 | CAS: 725266-66-0

1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 725266-66-0

Synthesis of tryptophan derivatives via a palladium-catalyzed N-heteroannulation was written by Dacko, Christopher A.;Akhmedov, Novruz G.;Soederberg, Bjoern C. G.. And the article was included in Tetrahedron: Asymmetry in 2008.SDS of cas: 725266-66-0 The following contents are mentioned in the article:

Tryptophan derivatives were prepared from 2-(2-nitrophenyl)-2-propen-1-yl substituted pyrazines, derived from Schoellkopf’s chiral auxiliary, using a palladium-catalyzed, carbon monoxide-mediated reductive N-heteroannulation reaction. A diastereomeric ratio of products ranging from 4:1 to >30:1 was observed This study involved multiple reactions and reactants, such as 1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0SDS of cas: 725266-66-0).

1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 725266-66-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

An, Yang et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2019 | CAS: 139139-80-3

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application of 139139-80-3

Transition-metal-free 伪-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary 伪-aryl, 伪-nitro ketones was written by An, Yang;Zhang, Xiao-Ming;Li, Ze-Yu;Xiong, Wen-Hui;Yu, Run-Dong;Zhang, Fu-Min. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Application of 139139-80-3 The following contents are mentioned in the article:

Transition-metal-free 伪-arylation of 伪-nitroketones with diaryliodonium salts was realized for the first time. As an application of this methodol., a concise synthesis of the clin. drug tiletamine was also achieved via a three-step procedure from 2-nitrocyclohexanone without the isolation of intermediates. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Application of 139139-80-3).

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application of 139139-80-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Szekely, Anna et al. published their research in Synthesis in 2014 | CAS: 1204518-02-4

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Electric Literature of C17H18F3IO3S

Utilization of a copper on iron catalyst for the synthesis of biaryl systems and benzoxazines via oxidative arylation of anilide derivatives was written by Szekely, Anna;Sinai, Adam;Toth, Edina B.;Novak, Zoltan. And the article was included in Synthesis in 2014.Electric Literature of C17H18F3IO3S The following contents are mentioned in the article:

Heterogeneous copper on iron catalyst serves as an efficient alternative copper source for arylation reactions using hypervalent iodonium salts. The copper(0) catalyst affords meta-arylation of pivalanilides, while 2-ethynylanilides undergo oxidative carbo arylation-ring closure with diaryliodonium salts. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Electric Literature of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Electric Literature of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Qi-Sheng et al. published their research in Tetrahedron in 2017 | CAS: 1204518-02-4

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

P(NMe2)3-promoted ortho-selective arylation of phenols with diaryliodonium triflates via rhodium catalysis was written by Liu, Qi-Sheng;Wang, De-Yin;Yang, Jin-Fei;Ma, Zhong-Yi;Ye, Mengchun. And the article was included in Tetrahedron in 2017.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

Rh-catalyzed ortho-selective arylation of free phenol with diaryliodonium triflates to widely existed phenol-containing biaryls have been developed. The use of P(NMe2)3, tBuOLi and CH3CN proved to be critical for the ortho-selectivity of this reaction. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Qi-Sheng et al. published their research in Tetrahedron in 2017 | CAS: 139139-80-3

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Formula: C19H22F3IO3S

P(NMe2)3-promoted ortho-selective arylation of phenols with diaryliodonium triflates via rhodium catalysis was written by Liu, Qi-Sheng;Wang, De-Yin;Yang, Jin-Fei;Ma, Zhong-Yi;Ye, Mengchun. And the article was included in Tetrahedron in 2017.Formula: C19H22F3IO3S The following contents are mentioned in the article:

Rh-catalyzed ortho-selective arylation of free phenol with diaryliodonium triflates to widely existed phenol-containing biaryls have been developed. The use of P(NMe2)3, tBuOLi and CH3CN proved to be critical for the ortho-selectivity of this reaction. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Formula: C19H22F3IO3S).

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Formula: C19H22F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stang, Peter J. et al. published their research in Tetrahedron Letters in 1991 | CAS: 139139-80-3

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C19H22F3IO3S

Iodosyl trifluoromethanesulfonate – an efficient reagent for the single-step preparation of diaryliodonium triflate salts was written by Stang, Peter J.;Zhdankin, Viktor V.;Tykwinski, Rik;Zefirov, N. S.. And the article was included in Tetrahedron Letters in 1991.Electric Literature of C19H22F3IO3S The following contents are mentioned in the article:

Treatment of RSiMe3 [R = Ph, p-tolyl, 2,4,6-Me3C6H2, p-BrC6H4, 4-(4-BrC6H4)C6H4] with iodosyl triflate gave 57-93% R2I+聽–OTf. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Electric Literature of C19H22F3IO3S).

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C19H22F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Umierski, Natalie et al. published their research in Organic Letters in 2013 | CAS: 139139-80-3

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Formula: C19H22F3IO3S

Metal-free synthesis of diaryl sulfones from arylsulfinic acid salts and diaryliodonium salts was written by Umierski, Natalie;Manolikakes, Georg. And the article was included in Organic Letters in 2013.Formula: C19H22F3IO3S The following contents are mentioned in the article:

An efficient, high-yielding, and transition-metal-free synthesis of diaryl sulfones from arylsulfinic acid salts and diaryliodonium salts has been developed. The mild reaction conditions tolerate a range of functional groups, and unsym. diaryliodonium salts show high chemoselectivity. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Formula: C19H22F3IO3S).

Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Formula: C19H22F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com