Category: iodides-buliding-blocks

Gershon, H. published the artcileAntifungal activity of halophenols and halonitrophenols/, Computed Properties of 21784-73-6, the main research area is fungicide halophenol halonitrophenol.

Thirty one compounds (phenol, 12 monohalo derivatives and 18 nitrophenols, i.e. 2- and 4-nitrophenols, 4-, 5- and 6-halo-2-nitrophenols, 3-halo-4-nitrophenols) were tested for antifungal activity against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. The two most fungitoxic compounds were 5-fluoro- and 5-iodo-2-nitrophenol, which inhibited all the fungi at <10 μg/mL. 6-Iodo-2-nitrophenol inhibited 5 fungi at <10 μg/mL and M. cirinelloides at 10-100 μg/mL. Monatshefte fuer Chemie published new progress about Fungicides. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Computed Properties of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Huang, Jingjia published the artcileSynthesis of N-Alkylpyridin-4-ones and Thiazolo[3,2-a]pyridin-5-ones through Pummerer-Type Reactions, Category: iodides-buliding-blocks, the main research area is alkylpyridinone thiazolopyridinone preparation Pummerer.

N-Alkylated 4-pyridones were obtained through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride-activated sulfoxides and 4-fluoropyridine derivatives, followed by hydrolysis. However, triflic anhydride-activated benzyl 6-fluoro-2-pyridyl sulfoxide could react with alkenes or alkynes to afford thiazolo[3,2-a]pyridin-5-ones, via the pyridinium salt intermediates.

Journal of Organic Chemistry published new progress about Hydrolysis. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suzuki, Hitomi published the artcileJacobsen reaction. V. Direct iodination of polyalkylbenzenes by the crossed Jacobsen reaction, COA of Formula: C10H13I, the main research area is .

cf. CA 60, 6732f. Slow, simultaneous addition of H2SO4 and o-MeOC6H4I (I) to a stirred polyalkylbenzene (II), or its solution in cyclohexane (III), the mixture stirred some time and poured into H2O, and the organic material separated, washed with aqueous NaHSO3, and worked up by fractional distillation (if liquid hydrocarbon) or chromatography on Al2O3 (if solid hydrocarbon) gave a polyalkyliodobenzene (IV). Thus, 24.3 g. p-(iso-Pr)2C6H4 (V) at 35-40° treated, over 1.5 hrs., with 23.4 g. I and 15 g. H2SO4, stirring continued 4 hrs., and the mixture poured into H2O and worked up gave 13.8 g. V, 7.1 g. mixture of I and a dealkylated iodo compound, and 6.0 g. 2,5-(isoPr)2C6H3I, b22 143-6°. Similarly were prepared (II, g. II, hrs. stirring, reaction temperature, IV, g. IV, and m.p. or b.p./mm. IV given): p-(tert-Bu)2C6H4, 3.7 (in 25 ml. III, 3, 30-3°, 2,5-diiodo-1,4-di-tert-butylbenzene (?), –, 49-50°; 1,2,4-Me3C6H3, 12.0, –, –, monoiodo product, 14.5, 121-5°/17-18; 1,3,5-Et3C6H3, 24.3, overnight, 30-2°, 2,4,6-Me3C6H2I, 17.1, 169-70°/31; 1,3,5-(iso-Pr)3C6H3, 20.4, 3 (then left overnight), 35-8°, 2,4,6-(iso-Pr)3C6H2I, 5.9, 173-5°/28; 1,2,4,5-Me4C6H2, 4.0, 4, 30-5°, 2,-3,5,6-Me4C6HI, 5.2, 80-1°; 1,2,4,5-Et4C6H2, 28.5, 4, 30-3°, 2,3,5,6-Et4C6HI, 13.5, 186-8°/26; Me5C6H, 7.4 (in 10 ml. III), 4, 34-6°, Me5C6I, 7.9, 141-2°. 1,2,4,5-(iso-Pr)4C6H2 did not react under these conditions.

Bulletin of the Chemical Society of Japan published new progress about Iodination. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, COA of Formula: C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bartos, Paulina published the artcileSubstituent effects on the electronic structure of the flat Blatter radical: correlation analysis of experimental and computational data, Application of 4-Iodo-2-nitrophenol, the main research area is phenyl triazinophenoxazinyl preparation crystal structure substituent effect.

A series of C(10)-substituted derivatives of 2-Ph-3H-[1,2,4]triazino[5,6,1-kl]phenoxazin-3-yl was obtained using the aza-Pschorr, photochem. and radical-induced cyclization reactions, and through functional group transformations of the C(10)-amino and C(10)-iodo derivatives The iodo derivative underwent Pd-catalyzed C-C cross coupling reactions leading to the installation of Ph, 2-thienyl and ethynylbenzene groups at the C(10) position effectively extending electronic conjugation. The substituent effect on the electronic properties of the 3H-[1,2,4]triazino[5,6,1-kl]phenoxazin-3-yl was investigated in twenty one derivatives with a diverse range of functional groups by spectroscopic (UV-vis and EPR) and electrochem. methods augmented with DFT calculations Results show that the lowest energy electronic absorption and redox potentials correlate well with the σp substituent parameter, while aN hfcc and the N-H bond dissociation energy (BDE) are well described by the σm parameter. In general, increasing the electron donating ability of the C(10)-X substituent lowers the π-π*(1) excitation energy, cathodically shifts the redox potentials, increases spin delocalization beyond the [1,2,4]triazinyl ring and lowers BDE. The latter two parameters are important indicators of the overall radical stability. Mol. and crystal structures of three radicals were established with the single crystal XRD method.

New Journal of Chemistry published new progress about Acylation. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yibiao published the artcileAccess to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride, Computed Properties of 153034-78-7, the main research area is pyridinylamide preparation; fluoropyridine amidation amidine hydrochloride chemoselective; imidazopyridine preparation chemoselective regioselective.

Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridines and amidine derivatives as the starting materials. Simultaneously, the copper-catalyzed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.

Organic & Biomolecular Chemistry published new progress about Amidation. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, Computed Properties of 153034-78-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tasch, Boris O. A. published the artcileOne-Pot Synthesis of Camalexins and 3,3′-Biindoles by the Masuda Borylation-Suzuki Arylation (MBSA) Sequence, Formula: C13H13ClINO2, the main research area is camalexin biindole Masuda borylation Suzuki arylation.

The Masuda borylation/Suzuki arylation (MBSA) sequence starting from N-protected 3-iodoindoles has successfully been extended to the coupling of five-membered heterocycles and indoles in the arylation step, which could not be achieved with previously developed MBSA methods. By this approach the one-pot nature of the method and the use of a simple catalyst system was retained. The applicability of the method was demonstrated by the facile synthesis of camalexins and 3,3′-biindoles, compounds of special interest due to their pronounced antifungal, antimicrobial and cytotoxic activities.

European Journal of Organic Chemistry published new progress about Arylation. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Formula: C13H13ClINO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mineno, Masahiro published the artcileIntegrated Cross-Coupling Strategy for an α-Carboline-Based Aurora B Kinase Inhibitor, Quality Control of 153034-78-7, the main research area is ethylsulfonylphenyldimethylmethylpiperidinylpyridoindolecarboxamide preparation Aurora B kinase inhibitor; aniline Buchwald Hartwig amination arylation Suzuki coupling Sandmeyer iodination.

An efficient and practical synthetic process for an α-carboline-based Aurora B kinase inhibitor I was achieved using an integrated Pd-catalyzed cross-coupling strategy. The process features a mild and efficient method for construction of the α-carboline core by employing a Pd-catalyzed sequence of Buchwald-Hartwig amination and intramol. direct C-H arylation at the ortho position of an unsubstituted aniline moiety, which is a key functionality for further derivatization with a Suzuki coupling via Sandmeyer iodination. The process has eliminated expensive starting materials and column chromatog. purifications and enabled considerable enhancement of the total yield from 11% to 48%.

Journal of Organic Chemistry published new progress about Arylation. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, Quality Control of 153034-78-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Wen-Pei published the artcileAcid-Free Copper-Catalyzed Electrophilic Nitration of Electron-Rich Arenes with Guanidine Nitrate, SDS of cas: 21784-73-6, the main research area is arene guanidine nitrate copper catalyst electrophilic nitration; nitroarene preparation.

A practical copper-catalyzed nitration of electron-rich arenes with trimethylsilyl chloride and guanidine nitrate is reported. A variety of nitrated products were generated in moderate to excellent yields (32%-99%) at ambient temperature under acid free, open-flask and operationally simple conditions.

Journal of Organic Chemistry published new progress about Nitration. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, SDS of cas: 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Blanksma, J. J. published the artcileSweet taste of 4-nitro-2-aminotoluene, 4-nitro-2-aminobenzoic acid, and 2-nitro-4-aminobenzoic acid, Recommanded Product: 4-Iodo-3-nitroaniline, the main research area is .

4,2-O2N(H2N)C6H3Me, m. 107°, is 330 times as sweet as sucrose. 2,4-O2N(H2N)C6H3Me, m. 78°, is tasteless with a faintly bitter after-taste. The Ac derivatives of the 2 isomers are tasteless. 4,2-O2N(AcHN)C6H3Me (1 g.) in 250 cc. H2O, oxidized with 1.6 g. KMnO4 in 100 cc. H2O (refluxing 3 hrs.), and the Ac derivative (m. 215°) hydrolyzed with concentrated HCl in EtOH, gives 4,2-O2N(H2N)C6H3CO2H, m. 264°, which is 25 times as sweet as sugar; the Ac derivative, the Me ester, and its Ac derivative, m. 144°, are tasteless. 2,4-O2N(H2N)C6H3CO2H, m. 239°, is 120 times as sweet as sucrose; the Na salt is also very sweet but the Ac derivative is tasteless. o-HOC6H4CO2H has a relative degree of sweetness of 4 but the Na salt is 28 times as sweet as sucrose. There is no noticeable relation between the sweet taste and the local anesthetic activity of these compounds

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about Sweetness. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Recommanded Product: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Blanksma, J. J. published the artcileSweet taste of the 1-halo-2-amino-4-nitrobenzenes, Application In Synthesis of 105752-04-3, the main research area is .

2,4-(O2N)2C6H3F (10 g.) in 50 cc. EtOH and 100 cc. H2O, reduced with 30 g. SnCl2 in dilute HCl and the reduction product distilled with steam, gives, as the nonvolatile fraction, 2,4-O2N(H2N)C6H3F, m. 96°, which is tasteless (Ac derivative, m. 139°, also tasteless); the volatile fraction is 2,4-H2N(O2N)C6H3F, m. 102°; 1 g. in 100 cc. H2O is 40 times as sweet as a solution of 1 g. of sucrose in 100 cc. H2O (used as a standard in all tests); the Ac derivative, m. 178°, is tasteless, as is the 3,5-di-Br derivative, pale yellow, m. 119°. 2,4-H2N(O2N)C6H3Cl is 400 times as sweet as glucose; 100 mg. are soluble in 1 l. H2O at 17°, and 1.5 g. distill with 1000 g. steam; the di-Ac derivative, m. 70°, is tasteless, as is the 3,5-di-Br derivative, m. 99°. 2,4-H2N(O2N)C6H3Br is 800 times as sweet as sucrose; 60 mg. is soluble in 1 l. of H2O at room temperature; 600 mg. pass over with 1 l. steam; the di-Ac derivative, m. 105°; the Bz derivative m. 168°; the carbomethoxy derivative m. 164°; these, as well as the mono-Ac derivative, are tasteless. 2,4-O2N(H2N)C6H3Br and its derivatives are tasteless. 2,4-H2N(O2N)C6H3I, m. 158°, is 1250 times as sweet as sucrose; only 25 mg. pass over with 1 l. H2O and 10 mg. dissolve in 1 l. H2O at room temperature; the 4,2-isomer, m. 142°, is tasteless, as are the Ac and 1,5-I2 derivatives

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about Sweetness. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Application In Synthesis of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com