Category: iodides-buliding-blocks

Nguyen, Viet D. et al. published their research in ACS Catalysis in 2022 |CAS: 1287221-36-6

The Article related to carboxylic acid aryl halide potassium metabisulfite acridine copper catalyst, aromatic halide carboxylic acid dabso acridine copper catalyst, aryl sulfone preparation tricomponent decarboxysulfonylative cross coupling reaction and other aspects.HPLC of Formula: 1287221-36-6

On July 15, 2022, Nguyen, Viet D.; Trevino, Ramon; Greco, Samuel G.; Arman, Hadi D.; Larionov, Oleg V. published an article.HPLC of Formula: 1287221-36-6 The title of the article was Tricomponent Decarboxysulfonylative Cross-coupling Facilitates Direct Construction of Aryl Sulfones and Reveals a Mechanistic Dualism in the Acridine/Copper Photocatalytic System. And the article contained the following:

A dual catalytic process that enabled the previously inaccessible, broad-scope, direct conversion of carboxylic acids to aromatic sulfones-centrally important carbonyl group bioisosteric replacements and synthetic intermediates-by a tricomponent decarboxysulfonylative cross-coupling with aryl halides was reported. Detailed mechanistic and computational studies revealed the roles of the copper catalysts, bases and halide anions in channeling the acridine/copper system via a distinct dual catalytic manifold. In contrast to the halide-free decarboxylative conjugate addition that involved cooperative dual catalysis via low-valent copper species, the halide counteranions divert the decarboxysulfonylative cross-coupling with aryl halides through a two-phase, orthogonal relay catalytic manifold, comprising a kinetically coupled (via antithetical inhibitory and activating roles of the base in the two catalytic cycles), mechanistically discrete sequence of a photoinduced, acridine-catalyzed decarboxylative process and a thermal copper-catalyzed arylative coupling. The study underscores the importance of non-innocent roles of counteranions and key redox steps at the interface of catalytic cycles for enabling previously inaccessible dual catalytic transformations. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).HPLC of Formula: 1287221-36-6

The Article related to carboxylic acid aryl halide potassium metabisulfite acridine copper catalyst, aromatic halide carboxylic acid dabso acridine copper catalyst, aryl sulfone preparation tricomponent decarboxysulfonylative cross coupling reaction and other aspects.HPLC of Formula: 1287221-36-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Boldog, Ishtvan et al. published their research in CrystEngComm in 2013 |CAS: 144970-30-9

The Article related to manganese lanthanum tetrazolate phosphonate tetraphenyladamantane complex preparation crystal structure, magnetic property manganese lanthanum tetrazolate phosphonate functionalized tetraphenyladamantane complex and other aspects.Recommanded Product: 144970-30-9

Boldog, Ishtvan; Domasevitch, Konstantin V.; Baburin, Igor A.; Ott, Holger; Gil-Hernandez, Beatriz; Sanchiz, Joaquin; Janiak, Christoph published an article in 2013, the title of the article was A rare alb-4,8-Cmce metal-coordination network based on tetrazolate and phosphonate functionalized 1,3,5,7-tetraphenyladamantane.Recommanded Product: 144970-30-9 And the article contains the following content:

Sym. tetrahedral ligands are prominent, but somewhat under-studied building blocks for the generation of coordination polymeric networks. Coordination networks [Mn5Cl2(L1)2(H2O)4(DMF)4]·3H2O·7DMF, 1 and the [La2(H5L2)2(H2O)6], 2 were synthesized under mild solvothermal methods in DMF from the adamantane-based tetrahedral ligands, 1,3,5,7-tetrakis(4-phenyltetrazol-5-yl)adamantane (H4L1), reported for the first time, and 1,3,5,7-tetrakis(4-phenylphosphonic acid)adamantane (H8L2), resp. Compounds 1 and 2 are based on completely different pentanuclear and binuclear secondary metal building units, resp., and have different symmetries, but demonstrate an interesting coincidence of underlying topologies, which could be interpreted as a directing or imprinting’ effect of the symmetry of the rigid tetrahedral ligands. Both structures represent examples of a rarely observed (4,8)-coordinated net. The χMT product for 1 at room temperature is slightly lower than the expected for five Mn(II) ions with S = 5/2 and g ≈ 1.98 and on lowering the temperature χMT approaches the expected value for a single Mn(II) as a result of the antiferromagnetic coupling through the tetrazolate bridges. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Recommanded Product: 144970-30-9

The Article related to manganese lanthanum tetrazolate phosphonate tetraphenyladamantane complex preparation crystal structure, magnetic property manganese lanthanum tetrazolate phosphonate functionalized tetraphenyladamantane complex and other aspects.Recommanded Product: 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Plietzsch, Oliver et al. published their research in Organic & Biomolecular Chemistry in 2009 |CAS: 144970-30-9

The Article related to tetrahedral methane adamantane tecton triazole preparation, amine azidation azide alkyne click chem, dipolar cycloaddition copper catalyst, dna dimer dinucleotide preparation azidonucleoside phosphoramidite and other aspects.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

On November 21, 2009, Plietzsch, Oliver; Schilling, Christine Inge; Tolev, Mariyan; Nieger, Martin; Richert, Clemens; Muller, Thierry; Brase, Stefan published an article.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Four-fold click reactions: Generation of tetrahedral methane- and adamantane-based building blocks for higher-order molecular assemblies. And the article contained the following:

A modular concept for the generation of achiral and chiral non-racemic tetrahedral tectons from common precursors was developed. The tectons presented here are based on tetraphenylmethane or 1,3,5,7-tetraphenyladamantane core structures. They are obtained through high-yielding four-fold click reactions, using either the tetraazido or the tetraalkyne precursors. In most cases, the tetratriazoles are obtained as pure products after simple washing with water and methanol. The side chains of the tectons prepared include a self-complementary DNA dimer, obtained from a 3′-azidonucleoside and a phosphoramidite. The concept allows for a variation of the “sticky ends”, leading to tecton or ligand libraries. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to tetrahedral methane adamantane tecton triazole preparation, amine azidation azide alkyne click chem, dipolar cycloaddition copper catalyst, dna dimer dinucleotide preparation azidonucleoside phosphoramidite and other aspects.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru et al. published their research in Angewandte Chemie, International Edition in 2016 |CAS: 364-12-5

The Article related to silylbenzotrifluoride preparation defluorinative monoallylation allyltrimethylsilane trityl cation, fluorobutenyl fluorosilylarene preparation, c−f activation, allylation, fluorine, silanes, trityl cation and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Yoshida, Suguru; Shimomori, Ken; Kim, Youngchan; Hosoya, Takamitsu published an article in 2016, the title of the article was Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group.Quality Control of 5-Bromo-2-iodobenzotrifluoride And the article contains the following content:

The transformation of a single C-F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C-F bond functionalization, for example, by allylation, carboxylation, or chlorination. Further derivatization of the resulting fluorosilylarenes afforded various aromatic difluoromethylene compounds The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

The Article related to silylbenzotrifluoride preparation defluorinative monoallylation allyltrimethylsilane trityl cation, fluorobutenyl fluorosilylarene preparation, c−f activation, allylation, fluorine, silanes, trityl cation and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dohi, Toshifumi et al. published their research in Chemical & Pharmaceutical Bulletin in 2006 |CAS: 144970-30-9

The Article related to pyrrole cyanation silyl cyanide recyclable hypervalent iodine reagent, thiophene cyanation silyl cyanide recyclable hypervalent iodine reagent, cyano heteroaromatic compound pyrrole thiophene preparation and other aspects.Application of 144970-30-9

On November 30, 2006, Dohi, Toshifumi; Morimoto, Koji; Takenaga, Naoko; Maruyama, Akinobu; Kita, Yasuyuki published an article.Application of 144970-30-9 The title of the article was A facile and clean direct cyanation of heteroaromatic compounds using a recyclable hypervalent iodine(III) reagent. And the article contained the following:

The facile and clean direct cyanating reaction of pyrroles and thiophenes was achieved using a recyclable hypervalent iodine(III) reagent by a simple solid-liquid separation of the products and the reagent. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application of 144970-30-9

The Article related to pyrrole cyanation silyl cyanide recyclable hypervalent iodine reagent, thiophene cyanation silyl cyanide recyclable hypervalent iodine reagent, cyano heteroaromatic compound pyrrole thiophene preparation and other aspects.Application of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Yuyan team published research in Microporous and Mesoporous Materials in 2022 | 626-01-7

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., COA of Formula: C6H6IN

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. COA of Formula: C6H6IN.

Zhang, Yuyan;Shamzhy, Mariya;Kubu, Martin;Cejka, Jiri research published 《 Nanosponge hierarchical micro-mesoporous MFI zeolites as a high-performance catalyst for the hydroamination of methyl acrylate with aniline》, the research content is summarized as follows. Zeolites catalyze the hydroamination of alkenes, alkynes and dienes, yielding valuable amines, enamines and imines with high efficiency and chemoselectivity (i.e., Markovnikov or anti-Markovnikov products) thanks to the architecture of their pore system and tunable acidity. However, their micropores may impose mass-transfer constraints on reaction rates. Nevertheless, the high external surface area of hierarchical micro-mesoporous zeolites should enable them to outperform conventional zeolites. To test our hypothesis, we compared the activity of hierarchical MFI zeolites of different crystal morphologies (i.e., nanosponge, nanosheet and microcrystalline desilicated samples) with that of conventional medium- (MFI) and large-pore (MOR and Beta) zeolites in the hydroamination of Me acrylate with aniline. The results showed that nanosponge MFI had the highest activity (TOF = 32.9 h-1), reaching 57% yield of the anti-Markovnikov product N-[2-(methoxycarbonyl)ethyl]aniline. Furthermore, our kinetic study revealed a pseudo-second-order rate law with respect to aniline over the most active nanosponge MFI catalyst, with an apparent activation energy of 68.9 kJ/mol. The high external surface of this catalyst (371 m2/g) and its developed inter-crystalline mesopores (4.8 nm) suggest a kinetic-driven hydroamination reaction. Therefore, hierarchical nanosponge aluminosilicate MFI zeolites stand out as promising heterogeneous catalysts of hydroamination reactions involving bulky substrates.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., COA of Formula: C6H6IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Bin team published research in Tetrahedron Letters in 2021 | 626-01-7

Reference of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Reference of 626-01-7.

Zhao, Bin;Hammond, Gerald B.;Xu, Bo research published 《 Modulation of photochemical oxidation of thioethers to sulfoxides or sulfones using an aromatic ketone as the photocatalyst》, the research content is summarized as follows. An eco-friendly and chemo-selective photocatalytic synthesis of sulfoxides, e.g., 2-(methylsulfinyl)quinoline or sulfones, e.g., 2-(methylsulfonyl)quinoline via oxidation of sulfides, e.g., 2-(methylthio)quinoline (thioethers) at ambient temperature using air or O2 as the oxidant has been described. An inexpensive thioxanthone was used as the photocatalyst. This method offers excellent chem. yields and good functional group tolerance. The hydrogen bonding between hexafluoro-2-propanol (HFIP) and sulfoxides may play an important role in minimizing the over-oxidization of sulfoxides.

Reference of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Lei team published research in Journal of Organic Chemistry in 2021 | 1120-90-7

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Electric Literature of 1120-90-7

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Electric Literature of 1120-90-7.

Zhao, Lei;Yang, Hongyi;Li, Ruikun;Tao, Ye;Guo, Xiao-Feng;Anderson, Edward A.;Whiting, Andrew;Wu, Na research published 《 Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water》, the research content is summarized as follows. Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Electric Literature of 1120-90-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Zesheng team published research in Tetrahedron Letters in 2022 | 5029-67-4

Name: 2-Iodopyridine, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Name: 2-Iodopyridine.

Zhao, Zesheng;Wang, Jie;Zhang, Xiaoli;Lin, Taofeng;Ren, Jianwei;Pang, Wan research published 《 Pd nanoparticles embedded into MOF-808: An efficient and reusable catalyst for Sonogashira and Heck cross-coupling reactions》, the research content is summarized as follows. In this work, the Pd@MOF-808 composite was prepared to effectively catalyze the Sonogashira and Heck reactions without the presence of organic phosphine ligands. The results showed that the developed catalyst provided an environment-friendly reaction condition for these two reactions with the existence of a variety of functional groups and substrates. In addition, the Pd@MOF-808 catalyst could be easily recovered and reused for up to 5 times with less deterioration of catalytic performance.

Name: 2-Iodopyridine, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zheng, Qiangqiang team published research in Theranostics in 2021 | 144-48-9

144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., Application In Synthesis of 144-48-9

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Application In Synthesis of 144-48-9.

Zheng, Qiangqiang;Shen, Haotian;Tong, Zongrui;Cheng, Linxiang;Xu, Yuzi;Feng, Zhiyun;Liao, Shiyao;Hu, Xiaojian;Pan, Zongyou;Mao, Zhengwei;Wang, Yue research published 《 A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway》, the research content is summarized as follows. Lumbar disk degeneration is a common cause of chronic low back pain and an important contributor to various degenerative lumbar spinal disorders. However, currently there is currently no effective therapeutic strategy for treating disk degeneration. The pro-inflammatory cytokine interleukin-1β (IL-1β) mediates disk degeneration by inducing apoptotic death of nucleus pulposus (NP) cells and degradation of the NP extracellular matrix. Here, we confirmed that extracellular secretion of IL-1β via secretory autophagy contributes to disk degeneration, and demonstrate that a thermosensitive reactive oxygen species (ROS)-responsive hydrogel loaded with a synthetic growth hormone-releasing hormone analog (MR409) can protect against needle puncture-induced disk degeneration in rats. The expression levels of proteins related to secretory autophagy such as tripartite motif-containing 16 (TRIM16) and microtubule-associated protein light chain 3B (LC3B) were examined in human and rat disk tissues by histol. and immunofluorescence. The effects of TRIM16 expression level on IL-1β secretion were examined in THP-1 cells transfected with TRIM16 plasmid or siRNA using ELISA, immunofluorescence, and immunoblotting. The in vitro effects of MR409 on IL-1β were examined in THP-1 cells and primary rat NP cells using ELISA, immunofluorescence, immunoblotting, and qRT-PCR. Further, MR409 was s.c. administered to aged mice to test its efficacy against disk degeneration using immunofluorescence, X-ray, micro-CT, and histol. To achieve controllable MR409 release for intradiscal use, MR409 was encapsulated in an injectable ROS-responsive thermosensitive hydrogel. Viscosity, rheol. properties, release profile, and biocompatibility were evaluated. Thereafter, therapeutic efficacy was assessed in a needle puncture-induced rat model of disk degeneration at 8 and 12 wk post-operation using X-ray, magnetic resonance (MR) imaging, histol. anal., and immunofluorescence. Secretory autophagy-related proteins TRIM16 and LC3B were robustly upregulated in degenerated disks of both human and rat. Moreover, while upregulation of TRIM16 facilitated, and knockdown of TRIM16 suppressed, secretory autophagy-mediated IL-1β secretion from THP-1 cells under oxidative stress, MR409 inhibited ROS-induced secretory autophagy and IL-1β secretion by THP-1 cells as well as IL-1β-induced pro-inflammatory and pro-catabolic effects in rat NP cells. Daily s.c. injection of MR409 inhibited secretory autophagy and ameliorated age-related disk degeneration in mice. The newly developed ROS-responsive MR409-encapsulated hydrogel provided a reliable delivery system for controlled MR409 release, and intradiscal application effectively suppressed secretory autophagy and needle puncture-induced disk degeneration in rats. Secretory autophagy and associated IL-1β secretion contribute to the pathogenesis of disk degeneration, and MR409 can effectively inhibit this pathway. The ROS-responsive thermosensitive hydrogel encapsulated with MR409 is a potentially efficacious treatment for disk degeneration.

144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., Application In Synthesis of 144-48-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com