Category: iodides-buliding-blocks

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Name: 2-Iodoacetamide.

Zhang, Li;Xu, Shichen;Cheng, Xian;Zheng, Jiangxia;Wang, Yunping;Wu, Jing;Wang, Xiaowen;Wu, Liying;Yu, Huixin;Bao, Jiandong research published 《 Diallyl trisulphide, a H₂S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells by targeting AKT-SOX2 axis》, the research content is summarized as follows. It is widely accepted that anaplastic thyroid carcinoma (ATC), a rare, extremely aggressive malignant, is enriched by cancer stem cells (CSCs), which are closely related to the pathogenesis of ATC. In the present study, we demonstrated that diallyl trisulfide (DATS), a well-known hydrogen sulfide (H₂S) donor, suppressed sphere formation and restored the expression of iodide-metabolizing genes in human ATC cells, which were associated with H₂S generation. Two other H₂S donors, NaHS and GYY4137, could also suppress the self-renewal properties of ATC cells in vitro. Compared with normal thyroid tissues and papillary thyroid carcinomas (PTCs), the elevated expressions of SOX2 and MYC, two cancer stem cell markers, in ATCs were validated in the combined Gene Expression Omnibus (GEO) cohort. DATS decreased the expression of SOX2, which was mediated by H₂S generation. Furthermore, knockdown of AKT or inhibition of AKT by DATS led to a decrease of SOX2 expression in ATC cells. AKT knockdown phenocopied restoration of thyroid-specific gene expression in ATC cells. Our data suggest that H₂S donors treatment can compromise the stem cell phenotype and restore thyroid-specific gene expression of ATC cells by targeting AKT-SOX2 pathway, which may serve as a therapeutic strategy to intervene the CSC progression of ATC.

144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., Name: 2-Iodoacetamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Electric Literature of 626-01-7.

Zhang, Tao;Wang, Yanhong;Wang, Bin;Jin, Weiwei;Xia, Yu;Liu, Chenjiang;Zhang, Yonghong research published 《 Visible-Light-Induced Oxidation of Diazenyl-Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams》, the research content is summarized as follows. A visible-light-induced oxidation of diazenyl-protected tetrahydroisoquinolines and isoindolines for the synthesis of structurally diverse lactams I [R = H, 4-Me, 4-Et, etc.; R¹ = H, 6-Br, 5-Br, 6,7-di-MeO; n = 1, 2] was developed. The reaction was carried out with Eosin Y-Na₂ as an organic photocatalyst and mol. oxygen as an oxidant, and the desired functionalized N-aryldiazenyl-lactams were obtained under mild and transition metal-free conditions. The utility of this method was showcased by the gram-scale synthesis and deprotection of the N-aryldiazenyl-lactam product.

Electric Literature of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Product Details of C6H6IN.

Zhang, Xianwen;Li, Ping;Xu, Bin;Wang, Jingxia;Fan, Guangyin;Zhang, Xiaobin;Liu, Xiaoqiang;Zhang, Kaiming;Jiang, Weidong research published 《 In Situ Hydrogen Activation Inspiring Efficient One-Pot Hydrogenation of Halogenated Nitrobenzenes over Ni-Co-Based Composites》, the research content is summarized as follows. Selective hydrogenation of halogenated nitrobenzenes (XNBs) to halogenated amines (XANs) is of great importance for practical applications. Non-noble metal-based catalysts have shown prominent advantages in price and reserves accompanying low activity and selectivity toward the hydrogenation of halogenated nitrobenzenes (XNBs) even under harsh conditions. In this work, inexpensive Ni-Co-based composites (N_xCC) were prepared for in situ tandem hydrogenation of XNBs to XANs by using hydrogen released from ammonia borane (AB) hydrolysis under ambient pressure. The results show these N_xCC samples exhibited superior catalytic performance against Co₃O₄ or NiO samples. A selected N_0.2CC catalyst as the mainly screened one can quant. convert XNBs to XANs with unprecedented activity with 100% XAN conversion. This catalyst can completely convert m-chloronitrobenzene (m-CNB) to m-chloroaniline (m-CAN), suggesting N_0.2CC efficiently suppresses the further dichlorination of m-CAN. Recycling test shows the N_0.2CC possesses higher stability and recyclability. The N_0.2CC catalyst was found to be a dual catalyst that synergistically catalyzes both the AB dehydrogenation (about 1735 mL min^-1 g^-1 of hydrogen generation rate) and the subsequent hydrogenation (almost 100% conversion) of XNBs. Notably, it is the first time that the rapid in situ hydrogen activation (IHA) which facilely arouses the efficient hydrogenation of adsorbed substrate on the surface of catalyst has been elaborated. From a unique perspective, distinctive and simple control experiments were innovatively designed for testifying the advantage of tandem hydrogenation in contrast with traditional hydrogenation. This work presents an efficient and environmental strategy to selectively produce XANs from XNBs using high-performance non-noble metal composites.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., Product Details of C6H6IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Product Details of C6H6IN.

Zhang, Xuejie;Zhou, Yebin;Li, Guowei;Zhang, Lei;Yin, Chunyu;Yang, Yuanyuan;Wang, Hongzheng;Feng, Feng;Wei, Linwei;Zhang, Qunfeng;Yang, Feng;Lin, Lili;Lu, Chunshan;Li, Xiaonian research published 《 A highly sulfur resistant and stable heterogeneous catalyst for liquid-phase hydrogenation》, the research content is summarized as follows. Developing sulfur resistant and stable hydrogenation catalysts with a high activity is of great economic and environmental interest for the production of value-added fine chems., as it allows the use of crude industrial level raw materials as reactant, prevents environmental unfriendly stoichiometric reduction and cuts down energy-intensive separation/purification procedures. Here the authors show the metallic Ni nanoparticle well-enclosed in multilayer N doped graphene shells for the catalytic hydrogenation of nitrobenzene derivatives The nickel core promoted multilayer N doped graphene shell not only maintains the hydrogenation ability but also create a differentiate surface electronic state preventing the poisoning of vulnerable metal by S impurities. The catalytic performance has met the product requirement of hydrogenation of industrial raw materials including 4.00 weight% inorganic/organic sulfur poisoning substances, excessive acid residue and concentrated salts.

Product Details of C6H6IN, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Electric Literature of 144-48-9.

Wu, Shang-Chuen;Paul, Anu;Cummings, Richard D;Feasley, Christa L;Arthur, Connie M;Stowell, Sean R research published 《 Alkylation of Galectin-1 with Iodoacetamide and Mass Spectrometric Mapping of the Sites of Incorporation.》, the research content is summarized as follows. Galectins can display unique sensitivity to oxidative changes that result in significant conformational alterations that prevent carbohydrate recognition. While a variety of approaches can be utilized to prevent galectin oxidation, several of these require inclusion of reducing agents that not only prevent galectins from undergoing oxidative inactivation but can also interfere with normal redox potentials required for fundamental cellular processes. To overcome the limitations associated with placing cells in an artificial reducing environment, cysteine residues on galectins can be directly alkylated with iodoacetamide to form a stable thioether adduct that is resistant to further modification. Iodoacetamide alkylated galectin remains stable over prolonged periods of time and retains the carbohydrate binding and biological activities of the protein. As a result, this approach allows examination of the biological roles of a stabilized form of galectin-1 without introducing the confounding variables that can occur when typical soluble reducing agents are employed.

Electric Literature of 144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Computed Properties of 626-01-7.

Wu, Xiaofeng;Yang, Mengyao;Kim, Ji Seon;Wang, Rui;Kim, Gyoungmi;Ha, Jeongsun;Kim, Heejeong;Cho, Yejin;Nam, Ki Taek;Yoon, Juyoung research published 《 Reactivity Differences Enable ROS for Selective Ablation of Bacteria》, the research content is summarized as follows. An effective strategy to engineer selective photodynamic agents to surmount bacterial-infected diseases, especially Gram-pos. bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof-of-concept study where reactive differences in reactive oxygen species (ROS) can induce selective ablation of Gram-pos. bacteria. Sulfur-replaced phenoxazinium (NBS-N) mainly generates a superoxide anion radical capable of selectively killing Gram-pos. bacteria, while selenium-substituted phenoxazinium (NBSe-N) has a higher generation of singlet oxygen that can kill both Gram-pos. and Gram-neg. bacteria. This difference was further evidenced by bacterial fluorescence imaging and morphol. changes. Moreover, NBS-N can also successfully heal the Gram-pos. bacteria-infected wounds in mice. We believe that such reactive differences may pave a general way to design selective photodynamic agents for ablating Gram-pos. bacteria-infected diseases.

Computed Properties of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Application of C5H4IN.

Wu, Xiaoqiang;Zheng, Purui;Li, Wanfang;Tao, XU research published 《 Reductive cross-coupling to access C-N bonds from aryl halides and diazoesters under dual nickel/photoredox-catalyzed conditions》, the research content is summarized as follows. A reductive cross-coupling reaction to access C(sp²)-N bonds via dual Ni/photoredox-catalyzed systems has been reported for the first time. By utilizing the easily available diazo compounds RC(=N₂)C(O)₂Et (R = C₆H₅, 3-FC₆H₄, 4-ClC₆H₄, etc.) as a nitrogen source, aryl hydrazones (E/Z)-ArNHN=C(R)C(O)₂Et (Ar = C₆H₅, 2-naphthyl, 3-pyridyl, etc.) can be readily obtained under exceptionally mild conditions (visible light, ambient temperature, and no strong base). This method accommodates a broad scope of many functional groups and provides a novel route to deliver this type of product which can be further transformed into several kinds of nitrogen-containing heterocycles like 3,5-dimethyl-1-(4-trifluoromethylphenyl)-1H-pyrazole and 7-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-carbazole.

Application of C5H4IN, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Synthetic Route of 626-01-7.

Xiang, Qiuping;Luo, Guolong;Zhang, Cheng;Hu, Qingqing;Wang, Chao;Wu, Tianbang;Xu, Hongrui;Hu, Jiankang;Zhuang, Xiaoxi;Zhang, Maofeng;Wu, Shuang;Xu, Jinxin;Zhang, Yan;Liu, Jinsong;Xu, Yong research published 《 Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors》, the research content is summarized as follows. TRIM24 (tripartite motif-containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are epigenetics “readers” and potential therapeutic targets for cancer and other diseases. Here we describe the structure-guided design of 1-(indolin-1-yl)ethan-1-ones as novel TRIM24/BRPF1 bromodomain inhibitors. The representative compound 20l (Y08624) is a new TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, resp. Cellular activity of 20l was validated by viability assay in prostate cancer (PC) cell lines. In PC xenograft models, 20l suppressed tumor growth (50 mg/kg/day, TGI = 53%) without exhibiting noticeable toxicity. Compound 20l represents a versatile starting point for the development of more potent TRIM24/BRPF1 inhibitors.

Synthetic Route of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C5H4IN.

Xiao, Yan;Pu, Xiangling;Lu, Fuqing;Wang, Yanmin;Xu, Yongnan;Zhang, Hui;Liu, Yajun research published 《 L-cysteine as sustainable and effective sulfur source in the synthesis of diaryl sulfides and heteroarenethiols》, the research content is summarized as follows. L-cysteine, a natural and essential amino acid, was employed as novel sulfur source in the synthesis of sym. diaryl sulfides from a variety of aryl iodides in moderate to excellent yields. A tandem three steps reactions including C(sp²)-S bond formation, C(sp³)-S bond cleavage and another C(sp²)-S bond formation were proposed to be involved in this conversion. This protocol was featured by broad substrate scope and good functional group tolerance. In addition, heteroarenes including benzothiazoles and benzoxazoles were successfully converted into the corresponding heteroarenethiols using L-cysteine as C-H mercaptalization reagent.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Category: iodides-buliding-blocks.

Xiao, Yan;Pu, Xiangling;Lu, Fuqing;Wang, Yanmin;Xu, Yongnan;Zhang, Hui;Liu, Yajun research published 《 L-cysteine as sustainable and effective sulfur source in the synthesis of diaryl sulfides and heteroarenethiols》, the research content is summarized as follows. L-cysteine, a natural and essential amino acid, was employed as novel sulfur source in the synthesis of sym. diaryl sulfides from a variety of aryl iodides in moderate to excellent yields. A tandem three steps reactions including C(sp²)-S bond formation, C(sp³)-S bond cleavage and another C(sp²)-S bond formation were proposed to be involved in this conversion. This protocol was featured by broad substrate scope and good functional group tolerance. In addition, heteroarenes including benzothiazoles and benzoxazoles were successfully converted into the corresponding heteroarenethiols using L-cysteine as C-H mercaptalization reagent.

Category: iodides-buliding-blocks, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com