Category: iodides-buliding-blocks

Pan, Lei team published research in ACS Sustainable Chemistry & Engineering in 2022 | 1120-90-7

Category: iodides-buliding-blocks, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Category: iodides-buliding-blocks.

Pan, Lei;Kelley, Alexandra S.;Cooke, Maria Victoria;Deckert, Macy M.;Laulhe, Sebastien research published 《 Transition-Metal-Free Photoredox Phosphonation of Aryl C-N and C-X Bonds in Aqueous Solvent Mixtures》, the research content is summarized as follows. Herein, the authors present an efficient and mild methodol. for the synthesis of aromatic phosphonate esters in good to excellent yields using 10H-phenothiazine, an inexpensive commodity chem., as a photoredox catalyst. The reaction exhibits wide functional group compatibility enabling the transformation in the presence of ketone, amide, ester, amine, and alc. moieties. Importantly, the reaction proceeds using a green solvent mixture primarily composed of H2O, thus lowering the environmental footprint of this transformation compared to current methods. The transformation also proceeds under atm. conditions, which further differentiates it from current methods that require inert atm. Mechanistic work using fluorescence quenching experiments and radical trapping approaches support the proposed mechanism.

Category: iodides-buliding-blocks, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pan, Lei team published research in Advanced Synthesis & Catalysis in 2022 | 1120-90-7

Reference of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Reference of 1120-90-7.

Pan, Lei;Cooke, Maria Victoria;Spencer, Amara;Laulhe, Sebastien research published 《 Dimsyl Anion Enables Visible-Light-Promoted Charge Transfer in Cross-Coupling Reactions of Aryl Halides》, the research content is summarized as follows. A methodol. is reported for visible-light-promoted synthesis of unsym. chalcogenides enabled by dimsyl anion in the absence of transition-metals or photoredox catalysts. The cross-coupling reaction between aryl halides and diaryl dichalcogenides proceeds with electron-rich, electron-poor, and heteroaromatic moieties. Mechanistic investigations using UV-Vis spectroscopy, time-dependent d. functional theory (TD-DFT) calculations, and control reactions suggest that dimsyl anion forms an electron-donor-acceptor (EDA) complex capable of absorbing blue light, leading to a charge transfer responsible for generation of aryl radicals from aryl halides. This previously unreported mechanistic pathway may be applied to other light-induced transformations performed in DMSO in the presence of bases and aryl halides.

Reference of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pan, Pan team published research in Chemical Science in 2022 | 1120-90-7

Related Products of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Related Products of 1120-90-7.

Pan, Pan;Liu, Shihan;Lan, Yu;Zeng, Huiying;Li, Chao-Jun research published 《 Visible-light-induced cross-coupling of aryl iodides with hydrazones via an EDA-complex》, the research content is summarized as follows. A visible-light-induced, transition-metal and photosensitizer-free cross-coupling of aryl iodides RI (R = Ph, naphthalen-1-yl, thiophen-3-yl, 4-phenylmorpholine, etc.) with hydrazones R1CH=NNH2 (R1 = Ph, naphthalen-1-yl, pyridin-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) was developed. In this strategy, hydrazones were used as alternatives to organometallic reagents, in the absence of a transition metal or an external photosensitizer, making this cross-coupling mild and green. The protocol was compatible with a variety of functionalities, including Me, methoxy, trifluoromethyl, halogen, and heteroaromatic rings. Mechanistic investigations showed that the association of the hydrazone anion with aryl halides formed an electron donor-acceptor complex, which when excited with visible light generated an aryl radical via single-electron transfer.

Related Products of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Park, Byoung Yong team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | 1120-90-7

Category: iodides-buliding-blocks, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Category: iodides-buliding-blocks.

Park, Byoung Yong;Lim, Taeho;Han, Min Su research published 《 A simple and efficient in situ generated copper nanocatalyst for stereoselective semihydrogenation of alkynes》, the research content is summarized as follows. (Z)-selective semihydrogenation of alkynes were achieved using a copper nanocatalyst which was generated in situ by adding ammonia borane to an ethanol solution of copper sulfate. Different types of alkynes including aryl-aryl, aryl-alkyl, and aliphatic alkynes were selectively reduced to (Z)-alkenes affording up to 99% isolated yield. The semihydrogenation of terminal alkynes to alkenes and gram-scale applications were also reported. In addition to eliminating catalyst preparation, the proposed approach were simple and practical and served as a suitable alternative method to the conventional Lindlar catalyst.

Category: iodides-buliding-blocks, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Chi-Hang et al. published their research in Tetrahedron in 2010 |CAS: 144970-30-9

The Article related to bipyridineethynylphenyladamantane carboxylate derivative preparation ruthenium complex, electrochem ruthenium bipyridineethynylphenyladamantane carboxylic ester complex, fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid complex, quenching fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid titanium dioxide and other aspects.Computed Properties of 144970-30-9

On May 29, 2010, Lee, Chi-Hang; Zhang, Yongyi; Romayanantakit, Apiwat; Galoppini, Elena published an article.Computed Properties of 144970-30-9 The title of the article was Modular synthesis of ruthenium tripodal system with variable anchoring groups positions for semiconductor sensitization. And the article contained the following:

The authors describe an improved synthetic approach to access tripodal compounds with variable footprints and anchor groups. Two Ru(II) bipyridine tripodal complexes with three carboxylic acid groups in meta (Ru-m-COOH, 1; I) and para (Ru-p-COOH, 2; II) positions, and with large (180-250 Å2) footprints were synthesized and bound to the surface of nanostructured TiO2. Selected properties of 1 and 2 in solution and bound are reported. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Computed Properties of 144970-30-9

The Article related to bipyridineethynylphenyladamantane carboxylate derivative preparation ruthenium complex, electrochem ruthenium bipyridineethynylphenyladamantane carboxylic ester complex, fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid complex, quenching fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid titanium dioxide and other aspects.Computed Properties of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Vasylyev, Maxym et al. published their research in Journal of Molecular Structure in 2003 |CAS: 144970-30-9

The Article related to structure control organic cation polyoxometalate salt, crystal structure trisdimethylaminoethylbenzenetricarboxamide phosphotungstate, silicotungstate tetrakismethylpyridiniumylvinylphenyladamantane salt preparation, tungstate phospho silico organic cation preparation structure control, microporous polyoxometalate organic cation structure control and other aspects.Synthetic Route of 144970-30-9

On August 27, 2003, Vasylyev, Maxym; Popovitz-Biro, Ronit; Shimon, Linda J. W.; Neumann, Ronny published an article.Synthetic Route of 144970-30-9 The title of the article was Inorganic-organic hybrid materials based on Keggin type polyoxometalates and organic polyammonium cations. And the article contained the following:

Co-crystallization of a triammonium cation with short and somewhat flexible ‘arms’, [N,N,N-tris[2-(dimethylamino)ethyl]-1,3,5-benzenetricarboxamide]3+, with a polyoxometalate trianion, PW12O403-, yielded an insoluble channeled or microporous structure (crystal data reported). The polyoxometalate clusters are arranged in a layered and zigzag fashion along the xy plane. Looking along the x-axis, channels of a dimension of ∼3.5×∼6.5 Å are observed C-H···O bonds aided in determining the crystal packing by providing directionality to the anion-cation interaction. However, the co-crystallization of a tetraammonium cation with an extended and rigid tetrahedral configuration, 1,3,5,7-tetrakis{4-[(E)-2(N-methylpyridinium-4-yl)vinyl]phenyl}adamantane tetraiodide, with a polyoxometalate tetracation, SiW12O404-, yielded a lamellar structure with alternating layers with spacing of 16.6 Å of the inorganic-organic hybrid material. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Synthetic Route of 144970-30-9

The Article related to structure control organic cation polyoxometalate salt, crystal structure trisdimethylaminoethylbenzenetricarboxamide phosphotungstate, silicotungstate tetrakismethylpyridiniumylvinylphenyladamantane salt preparation, tungstate phospho silico organic cation preparation structure control, microporous polyoxometalate organic cation structure control and other aspects.Synthetic Route of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Valera, Silvia et al. published their research in Journal of Organic Chemistry in 2014 |CAS: 144970-30-9

The Article related to rigid methylpyrrolinyloxy diradical triradical tetraradical preparation cw epr spectrum, nitroxide rigid diradical triradical tetraradical preparation, esterification polyphenol methylpyrrolinyloxycarboxylic acid modular preparation polyradical, methylpyrrolinyloxycarboxylate resorcinol phloroglucinol ester mol crystal structure and other aspects.Category: iodides-buliding-blocks

On September 5, 2014, Valera, Silvia; Taylor, James E.; Daniels, David S. B.; Dawson, Daniel M.; Athukorala Arachchige, Kasun S.; Ashbrook, Sharon E.; Slawin, Alexandra M. Z.; Bode, Bela E. published an article.Category: iodides-buliding-blocks The title of the article was A Modular Approach for the Synthesis of Nanometer-Sized Polynitroxide Multi-Spin Systems. And the article contained the following:

Rigid sym. poly(tetramethylpyrrolinyloxy) radicals such as I were prepared for studying the effect of distance on interradical interactions; their room temperature continuous wave (CW) EPR spectra are reported. The nitroxide polyradicals were prepared using the esterification of the tetramethylpyrrolinyloxycarboxylic acid II with polyphenols as a key step. Sym. di- and trinitroxides with aromatic cores and a tetranitroxide with an adamantane core were prepared by this method. The structures of I and a bis(tetramethylpyrrolidinecarboxylate) diester of resorcinol were determined by X-ray crystallog. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

The Article related to rigid methylpyrrolinyloxy diradical triradical tetraradical preparation cw epr spectrum, nitroxide rigid diradical triradical tetraradical preparation, esterification polyphenol methylpyrrolinyloxycarboxylic acid modular preparation polyradical, methylpyrrolinyloxycarboxylate resorcinol phloroglucinol ester mol crystal structure and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Grigg, Ronald et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2012 |CAS: 144970-30-9

The Article related to adamantane z alkene organic tecton stereoselective preparation, adamantanamine iodoarene allene palladium multicomponent catalytic diastereoselective cascade, iodophenyladamantane amine amino acid allene palladium multicomponent diastereoselective cascade, multicomponent catalytic diastereoselective cascade catalyst palladium and other aspects.Application of 144970-30-9

Grigg, Ronald; Elboray, Elghareeb E.; Aly, Moustafa F.; Abbas-Temirek, Hussien H. published an article in 2012, the title of the article was Exploiting adamantane as a versatile organic tecton: multicomponent catalytic cascade reactions.Application of 144970-30-9 And the article contains the following content:

3- And 9-component Pd(0) catalyzed assembly of allenes, aryl iodides and N-nucleophiles with concomitant installation of trisubstituted Z-alkenes is readily achieved. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application of 144970-30-9

The Article related to adamantane z alkene organic tecton stereoselective preparation, adamantanamine iodoarene allene palladium multicomponent catalytic diastereoselective cascade, iodophenyladamantane amine amino acid allene palladium multicomponent diastereoselective cascade, multicomponent catalytic diastereoselective cascade catalyst palladium and other aspects.Application of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Katherine M. E. et al. published their research in CrystEngComm in 2006 |CAS: 144970-30-9

The Article related to phosphonophenyladamantane hydrate chloroform crystal self assembly preparation structure, adamantane tetrakisphosphonophenyl diamondoid net hydrogen bonded water cluster preparation, crystal structure phosphonophenyladamantane hydrate chloroform assembly, mol structure phosphonophenyladamantane hydrate chloroform assembly and other aspects.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Jones, Katherine M. E.; Mahmoudkhani, Amir H.; Chandler, Brett D.; Shimizu, George K. H. published an article in 2006, the title of the article was An adamantane-based tetraphosphonic acid that forms an open diamondoid net via a hydrogen-bonded phosphonic acid-water cluster.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane And the article contains the following content:

An adamantane-based tetraphosphonic acid (1,3,5,7-tetrakis(4-phosphonophenyl)adamantane·4H2O·2CHCl3) H-bonds into unprecedented tetrahedral clusters with H2O to form a 4-fold interpenetrated diamondoid net, incorporating both hydrophobic and hydrophilic domains. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to phosphonophenyladamantane hydrate chloroform crystal self assembly preparation structure, adamantane tetrakisphosphonophenyl diamondoid net hydrogen bonded water cluster preparation, crystal structure phosphonophenyladamantane hydrate chloroform assembly, mol structure phosphonophenyladamantane hydrate chloroform assembly and other aspects.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Saavedra, Oscar Mario et al. published their patent in 2007 |CAS: 70931-59-8

The Article related to thienopyridine preparation pharmaceutical composition, thienopyrimidine preparation vegf hgf receptor signaling inhibitor, thieno pyridine preparation vegf hgf receptor signaling inhibitor, pyridine thieno preparation treatment proliferative disease, pyrimidine thieno preparation treatment proliferative disease and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

On May 18, 2007, Saavedra, Oscar Mario; Claridge, Stephen William; Zhan, Lijie; Raeppel, Franck; Vaisburg, Arkadii; Raeppel, Stephane; Deziel, Robert; Mannion, Michael; Zhou, Nancy Z.; Isakovic, Ljubomir published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Thienopyridine and thienopyrimidine derivatives and their preparation, pharmaceutical compositions, and use as inhibitors of VEGF receptor and HGF receptor signaling for treatment of proliferative diseases. And the patent contained the following:

The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling. The invention provides compounds of formula I and methods for inhibiting VEGF receptor signaling and HGF receptor signaling for treatment of proliferative diseases. Compounds of formula I, wherein T is (un)substituted (hetero)aryl(alkyl), cycloalkyl or heterocyclyl; W is O, S, NH, or NMe; Z is O, S, or NH; X and X1 are independently H, (un)substituted C1-6 alkyl, halo, CN, or NO2; or X and X1 together may form C3-7 cycloalkyl; R1, R2, R3, R4 are independently H, halo, trihalomethyl, CN, NO2, NH2 and derivatives, OH and derivatives, CO2H and derivatives, COH and derivatives, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; R5 is H, CN, (un)substituted (CH2)2-5 (hetero)aryl, (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl, C2-6 alkynyl, CH2(CH2)0-4T2, (un)substituted C1-4 alkylcarbonyl, (un)saturated 3- to 7-membered carboxycyclic or heterocyclic group; where T2 is OH, OMe, OEt, NH2, NHMe, or NMe2; Q is CH2, O, S, NH, N(C1-6 alkyl), N(alkyl)aryl, NOMe, NCH2OMe, or NBn; D is C-E or N; L is N or CR where R is H, halo, CN, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; E is E1, E2 or E3 wherein E1 is H, halo, NO2, azido, (un)substituted C1-6 alkyl, C3-10 cycloalkyl, etc.; E2 is (un)substituted alkynes; E3 is (un)substituted heterocyclyl(ene); and the pharmaceutically acceptable salts and complexes thereof are claimed in this invention. Example compound II was prepared by chlorination of thieno[3,2-b]pyridine-7-ol followed by carboxylation and the resulting lithium carboxylate was converted into the corresponding acid chloride, which reacted with dimethylamine to give compound III; compound III underwent coupling with 2-fluoro-4-nitrophenol, and the resulting 7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthienopyridinecarboamide was reduced to give the corresponding arylamine, which was reacted with phenylacetyl isocyanate to give example compound II. Addnl. 329 examples were prepared in this invention. The example compounds were tested for their in vitro HGF receptor and VEGF receptor signaling inhibition and solid tumor growth inhibition. The invention compounds showed inhibitory activity and was reported to have IC50 values less than 50 nM, ≥50 but <250 nM, ≥250 but <500 nM, ≥ 500 nM, or no activity in various assays. Example compound II showed and IC50 of >50 nM for inhibition of VEGF receptors, and this compound also showed tumor growth inhibition (TGI) against several types of tumors. Example compound II had greater than 100% TGI against U87MG, which indicated tumor shrinkage. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to thienopyridine preparation pharmaceutical composition, thienopyrimidine preparation vegf hgf receptor signaling inhibitor, thieno pyridine preparation vegf hgf receptor signaling inhibitor, pyridine thieno preparation treatment proliferative disease, pyrimidine thieno preparation treatment proliferative disease and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com