Category: iodides-buliding-blocks

In 2022,He, Hua-Feng; Wang, Yuwan; Zou, Chun; Tu, Zheng; Xu, Yongquan; Yin, Junfeng published an article in ACS Omega. The title of the article was 《Ag2O-mediated Tandem Reaction between Terminal Alkyne and o-Iodibenzoic Acid: Construction of 3-Ethylideneisobenzofuran-1(3H)-ones》.Application In Synthesis of 2-Iodobenzoic acid The author mentioned the following in the article:

Taking aryl propargyl ether and o-iodibenzoic acid as substrates, a series of aryl cyclolactones bearing an exocyclized C=C bond were constructed with moderate to good yields. Diverse substituent groups could be tolerant in the reaction, which indicated excellent compatibility of the reaction. In this tandem reaction, Ag2O was employed as the media and Et3N was screened as the base to facilitate the reaction. A concise mechanism was proposed on the basis of the expansion of the substrates and theor. anal. Sonogashira type coupling coupled with intramol. nucleophilic addition in one pot to construct the product, 3-ethylideneisobenzofuran-1(3H)-one.2-Iodobenzoic acid(cas: 88-67-5Application In Synthesis of 2-Iodobenzoic acid) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application In Synthesis of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Tang, Baoxin; Hua, Ruimao published an article in Molecules. The title of the article was 《Cu(I)/Pd(II)-Catalyzed Intramolecular Hydroamidation and C-H Dehydrogenative Coupling of ortho-Alkynyl-N-arylbenzamides for Access to Isoindolo[2,1-a]Indol-6-Ones》.Quality Control of 2-Iodobenzoic acid The author mentioned the following in the article:

An efficient, atom-economic and one-pot synthesis of isoindolo[2,1-a]indol-6-ones I [R = H, 9-F, 9-MeO; R1 = H, 2-Me, 2-i-Pr, 2-MeO, 2-CF3, 2-CN; Ar = Ph, 2-MeC6H4, 4-MeOC6H4, etc.] via CuI/Pd(OAc)2-catalyzed intramol. hydroamidation of alkynyl group, and C-H dehydrogenative coupling of ortho-alkynyl-N-arylbenzamides had been developed. This transformation occurs with the use of oxygen as the oxidant, and water was the only byproduct. The reaction showed a high tolerance to a variety of functional groups, and affords isoindolo[2,1-a]indol-6-ones I in good to high yields. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Quality Control of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dalal, Arup; Babu, Srinivasarao Arulananda published their research in Synthesis in 2021. The article was titled 《Pd(II)-Catalyzed Directing-Group-Aided C-H Arylation and Alkylation of Pyrene Core: Synthesis of C1,C2- and C1,C10-Disubstituted Pyrene Motifs》.Related Products of 625-99-0 The article contains the following contents:

The application of the Pd(II)-catalyzed, directing-group-aided C-H arylation/alkylation tactics to functionalize the pyrene core, especially, the relatively inaccessible C2 I (R = H; R1 = quinolin-8-yl, 2-(methylsulfanyl)phenyl) and K-region C10 II (R2 = H) positions of the pyrene core and augmentation of the library of pyrene derivatives with C1,C2- I (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, thiophen-2-yl, etc.) and C1,C10-disubstituted pyrene II (R2 = 3,4-dimethylphenyl, 5-bromopyridin-2-yl, Ph, etc.) motifs was reported. The Pd(II)-catalyzed β-C-H arylation/alkylation of the C2-position of pyrene-1-carboxamide I possessing an 8-aminoquinoline directing group yielded various C1,C2-disubstituted pyrenes I. Similarly, the Pd(II)-catalyzed selective γ-C-H arylation/alkylation of the C10-position of N-(pyren-1-yl)picolinamide, possessing a picolinamide directing group, yielded various C1,C10-disubstituted pyrenes II. Examples of C(9)-H arylation of pyrene-1-carboxamide I (R1 = tert-butyl) and the removal of the directing group after the C-H arylation/alkylation reactions were also shown. The structures of representative pyrene derivatives were confirmed by the X-ray structure anal. Given the importance of the pyrene derivatives in various fields of chem. sciences, this report is a contribution towards augmentation of the library of pyrene derivatives with C1,C2- I and C1,C10-disubstituted pyrene amide motifs II. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Related Products of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Gold(I)-catalyzed domino reaction for furopyrans synthesis》 was written by Ruch, Marie; Brach, Nicolas; Galea, Romeric; Wagner, Patrick; Blond, Gaelle. Recommanded Product: 1-Bromo-3-iodobenzene And the article was included in Molecules in 2020. The article conveys some information:

Herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction were reported. The cascade reaction started with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type ragmentation and a hetero Diels-Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center were formed.1-Bromo-3-iodobenzene(cas: 591-18-4Recommanded Product: 1-Bromo-3-iodobenzene) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Recommanded Product: 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Alkyl Tosylates as Alkylating Reagents in the Catellani Reaction》 was published in Synthesis in 2020. These research results belong to Gao, Qianwen; Liu, Ze-Shui; Hua, Yu; Zhou, Siwei; Cheng, Hong-Gang; Zhou, Qianghui. Recommanded Product: 1-Iodonaphthalene The article mentions the following:

A cooperative catalytic system involving a Pd/XPhos complex and inexpensive 5-norbornene-2-carbonitrile that enabled the use of alkyl tosylates as alkylating reagents in the Catellani reaction was developed. This mild, scalable protocol was compatible with a range of readily available functionalized aryl iodides and alkyl tosylates, as well as terminating olefins (45 examples, up to 97% yield). The experimental part of the paper was very detailed, including the reaction process of 1-Iodonaphthalene(cas: 90-14-2Recommanded Product: 1-Iodonaphthalene)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 1-Iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Synlett included an article by Wu, Xiang-mei; Yan, Guo-bing. Related Products of 591-18-4. The article was titled 《Copper-Catalyzed Synthesis of S-Aryl Dithiocarbamates from Tetraalkylthiuram Disulfides and Aryl Iodides in Water》. The information in the text is summarized as follows:

An efficient approach for the copper-catalyzed synthesis of aryl dithiocarbamates R1SC(S)N(R2)2 (R1 = 2-BrC6H4, 1,3,5-(Me)3C6H2, thiophen-2-yl, etc.; R2 = Me, Et) from aryl iodides R1I and tetraalkylthiuram disulfides N((R2)2)C(S)SSC(S)N((R2)2) in water is described. Without addnl. ligand and organic solvent, the coupling reaction could provide a series of S-aryl dithiocarbamates in moderate to good yields. In the experimental materials used by the author, we found 1-Bromo-3-iodobenzene(cas: 591-18-4Related Products of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Related Products of 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases》 was written by Dao, Viet Hung; Ourliac-Garnier, Isabelle; Loge, Cedric; McCarthy, Florence O.; Bach, Stephane; da Silva, Teresinha Goncalves; Denevault-Sabourin, Caroline; Thiefaine, Jerome; Baratte, Blandine; Robert, Thomas; Gouilleux, Fabrice; Brachet-Botineau, Marie; Bazin, Marc-Antoine; Marchand, Pascal. HPLC of Formula: 626-02-8 And the article was included in Molecules in 2021. The article conveys some information:

Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematol. malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets for antitumor therapy. In this context, our combined efforts in natural product-inspired library generation and screening furnished very promising dibenzo[b,d]furan derivatives derived from cercosporamide. Among them, lead compound 44 was highlighted as a potent Pim-1/2 kinases inhibitor with an addnl. nanomolar IC50 value against CLK1 (cdc2-like kinases 1) and displayed a low micromolar anticancer potency towards the MV4-11 (AML) cell line, expressing high endogenous levels of Pim-1/2 kinases. The design, synthesis, structure-activity relationship, and docking studies are reported herein and supported by enzyme, cellular assays, and Galleria mellonella larvae testing for acute toxicity. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8HPLC of Formula: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Photocatalytic CO2 reduction of C/ZnO nanofibers enhanced by an Ni-NiS cocatalyst》 was published in Nanoscale in 2020. These research results belong to Deng, Hongzhao; Xu, Feiyan; Cheng, Bei; Yu, Jiaguo; Ho, Wingkei. Safety of 1-Iodopyrrolidine-2,5-dione The article mentions the following:

The photocatalytic reduction of CO2 into valuable hydrocarbon fuels via solar energy is a promising strategy for carbon utilization. In the present paper, a hierarchical Ni-NiS/C/ZnO photocatalyst was prepared via the in situ photodeposition of compact Ni-NiS nanosheets onto C/ZnO electrospun nanofibers. The existence of metallic Ni and NiS was confirmed by XPS. Photoluminescence (PL) and time-resolved PL spectra revealed that the cocatalyst Ni-NiS enhanced the charge separation efficiency of the C/ZnO nanofibers. The as-prepared Ni-NiS/C/ZnO showed enhanced CO2 reduction activity, with CO and CH4 production rates 10 and 15 times greater than those of pristine C/ZnO under 350 W visible light illumination. The intermediates of CH3O-, HCHO, and HCOO- were detected by in situ Fourier transform IR spectroscopy, confirming that CO2 reduction is a complex reaction with multiple steps. The 13C isotopic tracer method proved that CH4 and CO were obtained from the reduction of CO2 rather than from other carbon species in the environment. The amorphous carbon in C/ZnO could promote optical absorption, improve conductivity and reduce the interfacial charge transport resistance. Ni-NiS improved the electron-hole-pair separation of the C/ZnO nanofibers. The observed enhancement in photocatalytic activity was largely attributed to higher light utilization and effective electron-hole separation This work proves that Ni-NiS is a promising cocatalyst to ZnO for photocatalytic CO2 reduction In the experiment, the researchers used many compounds, for example, 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Safety of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Safety of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Immobilization of palladium nanoparticles on Metformin-functionalized graphene oxide as a heterogeneous and recyclable nanocatalyst for Suzuki coupling reactions and reduction of 4-nitrophenol》 were Hemmati, Saba; Mehrazin, Lida; Pirhayati, Mozhgan; Veisi, Hojat. And the article was published in Polyhedron in 2019. Reference of 1-Iodo-4-methylbenzene The author mentioned the following in the article:

In this study, Pd nanoparticles supported on Metformin modified graphene oxide (GO-Met-Pd) is proposed as a green heterogeneous catalyst. The structural properties of the as-synthesized nanocatalyst were determined by X-ray diffraction (XRD), Fourier transformed IR (FT-IR) spectroscopy, transmission electron microscopy (TEM), field emission SEM (FESEM), energy dispersive X-ray spectroscopy (EDS), wavelength-dispersive X-ray spectroscopy (WDX) and inductively coupled plasma (ICP). Activity of the catalyst was investigated by focusing on the Suzuki-Miyaura coupling reaction and room-temperature reduction of 4-nitrophenol (4-NP), as model reactions. The catalyzed reactions provided high yields of biphenyl compounds through the Suzuki-Miyaura reaction and outlined highly efficient conversion of 4-NP to its reduced form. Moreover, no significant Pd leaching was detected in the reaction solutions and the catalyst could be recovered, at least, 6 times without any considerable loss of its catalytic activity. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Reference of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Reference of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Straightforward sequential and one-pot synthesis of a pentasaccharide repeating unit corresponding to the cell wall O-antigen of Shigella boydii type 18》 were Shit, Pradip; Gucchait, Arin; Misra, Anup Kumar. And the article was published in Tetrahedron in 2019. Application of 516-12-1 The author mentioned the following in the article:

Synthesis of a pentasaccharide repeating unit corresponding to the cell of wall O-antigen Shigella boydii type 18 has been achieved by sequential as well as iterative glycosylation in one-pot. Use of p-methoxybenzyl group (PMB) as an in situ removable protecting group allowed obtaining the desired pentasaccharide derivative in a generalized glycosylation condition and in one-pot condition. Synthesis of a beta-L-rhamnosidic linkage present in the mol. has been successfully achieved using L-rhamnosyl thioglycoside donor having a picoloyl group at remote C-3 position influencing beta selectivity in the glycosylation. A combination of N-iodosuccinimide (NIS) and perchloric acid supported over silica (HClO4-SiO2) has been used as thiophilic glycosylation promoter in all glycosylation reactions. TEMPO mediated selective oxidation of the primary hydroxyl group has been carried out at the late stage of the synthetic strategy.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Application of 516-12-1) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Application of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com