Category: iodides-buliding-blocks

El Nemr, Ahmed; Eleryan, Ahmed; Mashaly, Mohammad; Khaled, Azza published their research in Polymer Bulletin (Heidelberg, Germany) in 2021. The article was titled 《Comparative study of synthesis of cellulose propionate from different sources using NIS as a new catalyst》.Name: 1-Iodopyrrolidine-2,5-dione The article contains the following contents:

Propylation of cellulose from different sources with propionic anhydride using N-iodosuccinimide (NIS) under solvent-free condition was tested. It was done in the presence of NIS as a new catalyst for propylation using three different amounts of catalyst under mild reaction conditions. The degree of substitution by propionate was exptl. calculated and confirmed by FTIR and 1H NMR analyses. The propylation yields varied from 71.54 to 88.37% with the degree of substitution (DS) ranged from 1.32 to 2.80 for com. cotton cellulose, 1.76-3.00 for rice husk cellulose, and 1.60-3.0 for wheat straw cellulose. The DS were easily controlled by changing the reaction duration (2-6 h) and the amount of the NIS catalyst (50, 75, and 100 mg for each 1.0 g of cellulose) in 25 mL of propionic anhydride. Prolonging the reaction’s duration has no favorable effect on the propylation process and led to decrease in the cellulose propionate (CP). Also, increasing the amount of NIS catalyst results in decrease the DS and CP yield. NIS was recognized as a novel and more successful catalyst for propylation of the hydroxyl groups of cellulose from different sources in high degree of substitution. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Name: 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Name: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Saha, Debarshi; Maajid Taily, Irshad; Banerjee, Prabal published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Electricity Driven 1,3-Oxohydroxylation of Donor-Acceptor Cyclopropanes: a Mild and Straightforward Access to β-Hydroxy Ketones》.Reference of Trimethylsulfoxonium iodide The article contains the following contents:

An unprecedented external oxidant-free electrochem. protocol for 1, 3-oxohydroxylation of donor-acceptor cyclopropanes is disclosed. The strategy encompasses the activation of the labile π-electron cloud of the aryl ring to cleave the strained Csp3-Csp3 bond of cyclopropane to afford the β-hydroxy ketones via insertion of mol. oxygen. More significantly, based on the detailed mechanistic investigations and cyclic voltammetry experiments, a plausible mechanism is proposed. The experimental part of the paper was very detailed, including the reaction process of Trimethylsulfoxonium iodide(cas: 1774-47-6Reference of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Reference of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Haoyu; Tang, Xinxin; Pang, Jia Hao; Wu, Xiangyang; Yeow, Edwin K. L.; Wu, Jie; Chiba, Shunsuke published their research in Journal of the American Chemical Society in 2021. The article was titled 《Polysulfide anions as visible light photoredox catalysts for aryl cross-couplings》.Electric Literature of C10H18INO2 The article contains the following contents:

Polysulfide anions are endowed with unique redox properties, attracting considerable attentions for their applications in alkali metals-sulfur batteries. However, the employment of these anionic species in redox catalysis for small mol. synthesis remains underdeveloped due to their moderate-poor electrochem. potential in the ground state, whereas some of them are characterized by photoabsorptions in visible spectral regions. Herein, we disclose the use of polysulfide anions as visible light photoredox catalysts for aryl cross-coupling reactions. The reaction design enables single-electron reduction of aryl halides upon the photoexcitation of tetrasulfide dianions (S42-). The resulting aryl radicals are engaged in (hetero)biaryl cross-coupling, borylation, and hydrogenation in a redox catalytic regime involving S4• -/S42- and S3• -/S32- redox couples. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Electric Literature of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Electric Literature of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《meta-Selective C-H Arylation of Fluoroarenes and Simple Arenes》 was written by Liu, Luo-Yan; Qiao, Jennifer X.; Yeung, Kap-Sun; Ewing, William R.; Yu, Jin-Quan. Name: 1-Chloro-3-iodobenzene And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Fluorine is known to promote ortho-C-H metalation. Based upon this reactivity, we employed an activated norbornene that traps the ortho-palladation intermediate and is then relayed to the meta position, leading to meta-selective C-H arylation of fluoroarenes. Deuterium experiment suggests that this meta-arylation is initiated by ortho C-H activation and the catalytic cycle is terminated by C-2 protonation. A dual-ligand system is crucial for the observed high reactivity and site selectivity. Applying this approach to simple benzene or other arenes also affords arylation products with good yield and site selectivity. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0Name: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Name: 1-Chloro-3-iodobenzene Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Self-assembly of coordination polyhedra with highly entangled faces induced by metal-acetylene interactions》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Domoto, Yuya; Abe, Masahiro; Kikuchi, Takashi; Fujita, Makoto. HPLC of Formula: 591-18-4 The article mentions the following:

The self-assembly of nanostructures is dominated by a limited number of strong coordination elements. Herein, we show that metal-acetylene π-coordination of a tripodal ligand (L) with acetylene spacers gave an M3L2 double-propeller motif (M=CuI or AgI), which dimerized into an M6L4 interlocked cage (M=CuI). Higher (M3L2)n oligomers were also selectively obtained: an M12L8 truncated tetrahedron (M=CuI) and an M18L12 truncated trigonal prism (M=AgI), both of which contain the same double-propeller motif. The higher oligomers exhibit multiply entangled facial structures that are classified as a trefoil knot and a Solomon link. The inner cavities of the structures encapsulate counter anions, revealing a potential new strategy towards the synthesis of functional hollow structures that is powered by mol. entanglements. The experimental process involved the reaction of 1-Bromo-3-iodobenzene(cas: 591-18-4HPLC of Formula: 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.HPLC of Formula: 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Green and Efficient Liquid-Phase Exfoliation of BiI3 Nanosheets for Catalytic Carbon-Carbon Cross-Coupling Reactions》 was published in ACS Sustainable Chemistry & Engineering in 2020. These research results belong to Wang, Huiyong; Song, Tao; Su, Xin; Li, Zhiyong; Wang, Jianji. Quality Control of 4-Iodobenzoic acid The article mentions the following:

BiI3 nanosheet dispersions were prepared by ultrasound-mediated exfoliation of BiI3 in the green solvents Me salicylate, triacetin, di-Et phthalate, Et benzoate, or in mixtures of the solvents. BiI3 nanosheets were formed in up to 30% yields and as dispersions containing up to 1.56 mg/mL of BiI3; the thickness of the BiI3 nanosheets is 5-10 nm and their lateral dimensions are around 1μm. Solvent-cosolvent interactions in the mixed solvents are a critical factor in the liquid-phase exfoliation. The BiI3 nanosheets were used as a catalyst for the Suzuki coupling of aryl iodides with phenylboronic acid mediated by TMEDA and KOH in THF to yield 4-substituted biphenyls in 75-91% yields. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzoic acid(cas: 619-58-9Quality Control of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Quality Control of 4-Iodobenzoic acid In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides》 was published in Journal of the American Chemical Society in 2020. These research results belong to Nishii, Yuji; Ikeda, Mitsuhiro; Hayashi, Yoshihiro; Kawauchi, Susumu; Miura, Masahiro. Recommanded Product: 516-12-1 The article mentions the following:

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray anal. A preliminary computational study disclosed that the π system of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity. In the experiment, the researchers used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis and Structure of Tin and Germanium Complexes as Precursors Containing Alkoxyaminoalkoxide Ligands for Thin Film Transistors》 was published in European Journal of Inorganic Chemistry in 2020. These research results belong to Lee, Ga Yeon; Lee, Ji Hun; Han, Seong Ho; Park, Bo Keun; Son, Seung Uk; Kim, Chang Gyoun; Jeon, Dong Ju; Chung, Taek-Mo. HPLC of Formula: 1774-47-6 The article mentions the following:

This paper describes the preparation of four novel Sn and Ge complexes containing alkoxyaminoalkoxide type ligands {L1H = 1-[methoxy(methyl)amino]-2-methylpropan-2-ol; L2H = 1-[methoxy(methyl)amino]-2-methylbutan-2-ol} for potential use as precursors for thin film transistors. All compounds were prepared at room temperature by stirring a solution containing Sn(btsa)2 [btsa = bis(trimethylsilyl)amide] or Ge(btsa)2 with two equivalent of L1H or L2H to form Sn(L1)2 (1), Sn(L2)2 (2), Ge(L1)2 (3) and Ge(L2)2 (4). All of the complexes were characterized by NMR and FTIR spectroscopy as well as elemental and thermogravimetric analyses. When the more sym. and compact ligand L1H was applied, solid products 1 and 3 were generated and their structures were studied using x-ray diffraction. Applying the strategy of ligand design at the mol. level, the sym. ligand was changed to an asym. one, replacing one of the two neighboring Me groups of the amino alc. group with an Et group, and forming liquid complexes 2 and 4 for both metals. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6HPLC of Formula: 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.HPLC of Formula: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Polarity Umpolung Strategy for the Radical Alkylation of Alkenes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Liu, Jige; Wu, Shuo; Yu, Jiajia; Lu, Chenxi; Wu, Zhen; Wu, Xinxin; Xue, Xiao-Song; Zhu, Chen. SDS of cas: 301673-14-3 The article mentions the following:

Free radical mediated alkylation of alkenes is a challenging and largely unmet goal. Disclosed here is a conceptually novel “”polarity umpolung”” strategy for radical alkylation of alkenes using a portfolio of easily accessed, difunctional alkylating reagents. This strategy is achieved by substituting inherently nucleophilic alkyl radicals with electrophilic sulfone-bearing surrogates, thus inverting the usual mode of reactivity. Along with alkylation, either an heteroaryl or oximino group is concurrently incorporated into the alkenes by a consecutive docking and migration process, leading to valuable products. The reaction displays a broad functional-group tolerance under mild reaction conditions. The protocol opens new vistas for the late-stage modification of complex natural products and drug mols. containing alkene moieties. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3SDS of cas: 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.SDS of cas: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《A novel strategy of transferring NIS protein to cells using extracellular vesicles leads to increase in iodine uptake and cytotoxicity》 were Son, Seung Hyun; Gangadaran, Prakash; Ahn, Byeong-Cheol. And the article was published in International Journal of Nanomedicine in 2019. Recommanded Product: 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

Background: This study was designed to explore a novel approach for transferring NIS protein to cells using extracellular vesicle (EV) and enhancing iodine avidity in hepatocellular carcinoma (HCC) cells. Methods: We transfected the HCC cells (Huh7) with NIS gene, designated as Huh7/NIS, and isolated the EVs from them. Presence of NIS protein in EVs and EV-mediated transport of NIS protein to recipient Huh7 cells were tested using Western blotting. We also examined radioiodine uptake in Huh7 cells treated with EV-Huh7/NIS. Results: Successful transfer of NIS protein into Huh7 cells was confirmed by WB and microscopy. EVs showed high levels of NIS protein in them. Treatment of Huh7 cells with EV-Huh7/NIS increased the NIS protein level and enhanced 125I uptake in recipient Huh7 cells. In addition, EV-huh7/NIS pre-treatment enhanced the cytotoxicity of 131I therapy against Huh7 cells by inducing increased DNA damage/increased γH2A.X foci formation. Conclusion: This is the first-of-its-kind demonstration of successful transportation of the NIS protein to cells via EVs, which increased radioiodine uptake. This approach can revert radioiodine-resistant cancers into radioiodine-sensitive cancers.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 1-Iodopyrrolidine-2,5-dione) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com