Category: iodides-buliding-blocks

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Quality Control of 1120-90-7.

Konishi, Hideyuki;Fujita, Ririka;Yamaguchi, Miyuki;Manabe, Kei research published 《 Synthesis of Symmetrical Sulfides Enabled by a Sulfur Dioxide Surrogate Acting as a Divalent Sulfur Source》, the research content is summarized as follows. A safe and practical methodol. for synthesizing sym. sulfides using iodoarenes and potassium metabisulfite (K₂S₂O₅) was presented. While K₂S₂O₅ was known as a convenient sulfur dioxide surrogate, here it acted as a divalent sulfur source, pioneering its potential utility. The reaction exhibited wide substrate generality in which even highly bulky substrates can be applied to afford sterically congested sulfides.

Quality Control of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. SDS of cas: 144-48-9.

Kudriaeva, Anna A.;Livneh, Ido;Baranov, Mikhail S.;Ziganshin, Rustam H.;Tupikin, Alexey E.;Zaitseva, Snizhana O.;Kabilov, Marsel R.;Ciechanover, Aaron;Belogurov, Alexey A. Jr. research published 《 In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking》, the research content is summarized as follows. Despite almost 40 years having passed from the initial discovery of ubiquitin (Ub), fundamental questions related to its intracellular metabolism are still enigmatic. Here we utilized fluorescent tracking for monitoring ubiquitin turnover in mammalian cells, resulting in obtaining qual. new data. In the present study we report (1) short Ub half-life estimated as 4 h; (2) for a median of six Ub mol. per substrate as a dynamic equilibrium between Ub ligases and deubiquitinated enzymes (DUBs); (3) loss on average of one Ub mol. per four acts of engagement of polyubiquitinated substrate by the proteasome; (4) direct correlation between incorporation of Ub into the distinct type of chains and Ub half-life; and (5) critical influence of the single lysine residue K27 on the stability of the whole Ub mol. Concluding, our data provide a comprehensive understanding of ubiquitin-proteasome system dynamics on the previously unreachable state of the art.

144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., SDS of cas: 144-48-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Quality Control of 5029-67-4.

Kuliukhina, D. S.;Averin, A. D.;Panchenko, S. P.;Abel, A. S.;Savelyev, E. N.;Orlinson, B. S.;Novakov, I. A.;Correia, C. R. D.;Beletskaya, I. P. research published 《 CuI and Copper Nanoparticles in the Catalytic Amination of 2-Halopyridines》, the research content is summarized as follows. The N-heteroarylation of n-octylamine and adamantane-containing amines with 2-iodopyridine and 2-bromopyridine and its fluorinated derivatives under the catalysis of CuI and copper nanoparticles in DMSO in the presence of various ligands was studied. 2-Isobutyrylcyclohexanone was found to be the most efficient ligand in the reactions catalyzed by CuI. In the reactions catalyzed by copper nanoparticles, 2-isobutyrylcyclohexanone or L-proline turned to be most active. The yields of the reactions catalyzed by copper nanoparticles were better than or equal to those in the CuI-catalyzed processes. The possibility of nanocatalyst recycling was studied, and its reuse in 6 cycles without loss of activity was demonstrated.

5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., Quality Control of 5029-67-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Application In Synthesis of 626-01-7.

Kumao, Ren;Miyatake, Kenji research published 《 Sulfonated and Fluorinated Aromatic Terpolymers as Proton Conductive Membranes: Synthesis, Structure, and Properties》, the research content is summarized as follows. We designed and synthesized a series of sulfonated terpolymers, SPP-PQP and SPP-BQP, containing sulfophenylene, quinquephenylene (QP) and perfluoroalkylene (PAF) or hexafluoroisopropylidene (BAF) groups whose compositions were optimized to achieve high-performance proton conductive membranes. In both series, the terpolymers were obtained as high-mol.-weight (Mn = 19.0-32.9 kDa, Mw = 99.9-198 kDa) providing bendable and transparent membranes with supposed ion exchange capacity (IEC) values (2.41-2.68 meq. g-1) by solution casting. SPP-PQP membranes exhibited higher water uptake, higher proton conductivity, and larger strain at break with increasing the PAF composition In contrast, the membrane properties were less sensitive to the composition in the SPP-BQP membranes. Among the terpolymer membranes investigated, SPP-PQP50 showed the best-balanced properties in terms of low water uptake, high proton conductivity, and high mech. properties probably because highly hydrophobic aliphatic PAF and more rigid QP groups both contributed to those relevant properties. Overall, the combination of different hydrophobic components in the terpolymers was effective in improving the properties of proton conductive membranes, that could not be achieved with the corresponding copolymer membranes.

Application In Synthesis of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. COA of Formula: C2H4INO.

Kuznetsova, Ksenia G.;Levitsky, Lev I.;Pyatnitskiy, Mikhail A.;Ilina, Irina Y.;Bubis, Julia A.;Solovyeva, Elizaveta M.;Zgoda, Victor G.;Gorshkov, Mikhail V.;Moshkovskii, Sergei A. research published 《 Cysteine alkylation methods in shotgun proteomics and their possible effects on methionine residues》, the research content is summarized as follows. In order to optimize sample preparation for shotgun proteomics, we compared four cysteine alkylating agents: iodoacetamide, chloroacetamide, 4-vinylpyridine and Me methanethiosulfonate, and estimated their effects on the results of proteome anal. Because alkylation may result in methionine modification in vitro, proteomics data were searched for methionine to isothreonine conversions, which may mimic genomic methionine to threonine substitutions found in proteogenomic analyses. We found that chloroacetamide was superior to the other reagents in terms of the number of identified peptides and undesirable off-site reactions. Among the reagents evaluated, iodoacetamide increased the rate of methionine-to-isothreonine conversion, especially if the sample was prepared in gel. The presence of proline following methionine in a protein sequence increased the modification rate as well. Generally, the methionine-to-isothreonine conversion events were relatively rare, but should be taken into account in proteogenomic studies when searching for single nucleotide polymorphism events at the protein level. Addnl., we have evaluated other methionine modifications, such as oxidation and carbamidomethylation. We found that carbamidomethylation may affect up to 80% of peptides containing methionine under the condition of iodoacetamide alkylation. In this case, carbamidomethylation of methionine is more common than oxidation and should be accounted for as a variable modification during proteomic search. One of the most trending questions in bottom-up proteomics is the depth of proteome profiling, in other words, the coverage of proteins by identified tryptic peptides. In proteogenomics, where the identification of a single peptide, e.g. bearing an amino acid substitution, may be of interest, high sequence coverage is especially important. Chem. modifications during sample preparation may mimic biol. significant coding mutations at the proteome level. A typical example of such modification is methionine to isothreonine conversion during alkylation, which mimics methionine to threonine substitution in protein sequences due to resp. genomic mutations. Therefore, the studies on the proper selection of alkylating reagents which balance the cysteine alkylation efficiency and the extent of methionine conversion upon conventional proteomic sample preparation workflow are crucial for the outcome of proteogenomic analyses and should present a general interest for the proteomic community.

COA of Formula: C2H4INO, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Related Products of 1120-90-7.

Lakshmidevi, Jangam;Naidu, Bandameeda Ramesh;Venkateswarlu, Katta research published 《 CuI in biorenewable basic medium: Three novel and low E-factor Suzuki-Miyaura cross-coupling reactions》, the research content is summarized as follows. Three inexpensive and novel copper-catalyzed C(sp²)-C(sp²) coupling reactions of substituted aryl/heteroaryl halides with arylboronic acids was described by employing water extract of pomegranate ash (WEPA) as biorenewable base and aqueous reaction medium. CuI/WEPA, CuI/WEPA/DABCO, CuI/WEPA/SPhos Catalytic systems were developed for the present Suzuki-Miyaura coupling. WEPA was found to be the effective base and reaction medium for copper-catalyzed Suzuki-Miyaura reactions with and without ligands to provide good to high yields of coupling products. This method had remarkable advantages like inexpensive and waste-derived biorenewable base, low catalyst loading, moderate temperature, replacement of precious palladium with abundant copper, no or negligible contamination of copper in products, low E-factor, high chemoselectivity and a large substrate scope.

Related Products of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Name: 3-Iodopyridine.

Lakshmidevi, Jangam;Naidu, Bandameeda Ramesh;Reddy, S. Siva Sankara;Venkateswarlu, Katta research published 《 Oxidative Iododeborylation Reaction of (Hetero)arylboronic Acids in Water Extract of Pomegranate Ash: A Novel and Sustainable Synthesis of Iodo(hetero)arenes》, the research content is summarized as follows. A mild and effective process for the (H)AIs synthesis RI (R = 4-nitrophenyl, 2-methoxyphenyl, pyridin-3-yl, etc.) via ipso-functionalization of (H)ABAs RB(OH)₂using water extract of pomegranate peel ash (WEPA) and environmentally benign iodinating agent such as mol. iodine (I₂) under external oxidant/(transition)metal/base/additive/organic solvent-free conditions have been disclosed. The (H)AIs are formed with high regioselctivity using this protocol that operational simplicity and displays exceptional functional group compatibility. Present (H)AIs synthesis avoid addnl. substances (including metals) as oxidizing reagents, additives/surfactants and catalysts, thus making this procedure as a highly sustainable asset using biorenewable waste based aqueous extract as catalytic media.

Name: 3-Iodopyridine, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Quality Control of 1120-90-7.

Landge, Vinod G.;Maxwell, Justin M.;Chand-Thakuri, Pratibha;Kapoor, Mohit;Diemler, Evan T.;Young, Michael C. research published 《 Palladium-Catalyzed Regioselective Arylation of Unprotected Allylamines》, the research content is summarized as follows. A simple protocol for the arylation of cinnamylamines and the diarylation of terminal allylamines to generate a of 3,3-diarylallylamine products using a Pd^II precatalyst was described. Key features of the method were the ability to access relatively mild conditions that facilitate a broad substrate scope as well as direct diarylation of terminal allylamine substrates. In addition, several complex and therapeutically relevant mols. were included to demonstrate the utility of the transformation.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Quality Control of 1120-90-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. SDS of cas: 5029-67-4.

Ishida, Naoyoshi;Adachi, Takuya;Iwamoto, Hiroaki;Ohashi, Masato;Ogoshi, Sensuke research published 《 Copper(I)-mediated C-N/C-C Bond-forming Reaction with Tetrafluoroethylene for the Synthesis of N-Fluoroalkyl Heteroarenes via an Azacupration/Coupling Mechanism》, the research content is summarized as follows. A novel copper(I)-mediated C-N/C-C bond-forming reaction involving tetrafluoroethylene (TFE), imidazolide or benzimidazolide salts I (R = Et, H, i-Pr, n-undecyl; X = Na, K) sodium benzimidazolide, and aryl iodides ArI (Ar = 4-trifluorophenyl, 4-chlorophenyl, pyridin-2-yl, etc.) has been developed. This three-component coupling reaction can provide highly functionalized N-fluoroalkyl heteroaromatic compounds II and 1-(1H-benzimidazolyl)-2-(p-trifluoromethylphenyl)-1,1,2,2-tetrafluoroethane in up to 98% yield via a one-pot procedure. The azacupration of TFE with the copper(I) imidazolide species to afford the fluoroalkylcopper(I) complex is the key process in the transformation.

SDS of cas: 5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Product Details of C2H4INO.

Itsumi, Momoe;Shiota, Masaki;Kajioka, Shunichi;Eto, Masatoshi research published 《 Profile of androgen receptor activators identified using high-throughput screen》, the research content is summarized as follows. In this study using distinct system, effectors on dopamine signalling were identified as candidates that prominently increase AR activity. Then, this study suggested novel function on AR signalling in several compounds, which may be useful or harmful in organs where AR signalling play a role. In conclusion, various candidates for AR activation were identified using high-throughput screening.

Product Details of C2H4INO, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com