Category: iodides-buliding-blocks

Pd/Cu bimetallic catalyst immobilized on PEI capped cellulose-polyamidoamine dendrimer was written by Fan, Xuetao;Lin, Dongtao;Xu, Zhian;Li, Yiqun. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application of 207115-22-8 This article mentions the following:

Polyamidoamine dendrimer (PAMAM) is an efficient material for immobilization of Pd(II) complex due to its unique tree-like structure and properties. To the purpose of enhancing of the loading of Cu(II) ions, a polyethyleneimine end-capped microcrystn. cellulose-polyamidoamine dendrimer (G2.5) (MCC-PAMAMG2.5-PEI) was designed and synthesized. The resultant MCC-PAMAMG2.5-PEI was furtherly treated by PdCl₂ and CuSO₄ solution to afford the corresponding dendrimer-supported Pd/Cu bimetallic catalyst (Pd/[email protected]). As a result, both Pd(II) and Cu(II) ions were well selectively immobilized within the interior architectures and exterior PEI layers of dendrimers, resp. The as-prepared catalyst was fully characterized by elemental anal. (EA), inductively coupled plasma at. emission spectrometry (ICP-AES), Fourier transform IR spectrometer (FTIR), XPS, X-ray diffraction (XRD), field emission SEM (FESEM), elemental mappings, energy-dispersive X-ray spectra (EDX), field emission transmission electron microscopy (FETEM), and thermogravimetry anal. (TGA) techniques. The presence of required Pd and Cu elements were confirmed from ICP-AES, XPS, EDX, and elemental mappings anal., resp. The synergetic effect between Pd and Cu can be observed by comparing it to the dendrimer supported monometallic Pd and Cu as well as the mixture of dendrimer supported Pd and Cu. The catalyst showed excellent performance in the synthesis of alkynes and benzofurans via Sonogashira reactions and could be reused for seven successive runs without any noteworthy loss of activity. Moreover, its efficiency was compared with other reported catalysts in the same transformations. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Isoquinolinium Dichromate and Chlorochromate as Efficient Catalysts for Oxidative Halogenation of Aromatic Compounds Under Acid-Free Conditions was written by Rao, A. Sambashiva;Rajanna, K. C.;Reddy, K. Rajendar;Kulkarni, Subhash. And the article was included in Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry in 2016.Reference of 207115-22-8 This article mentions the following:

Isoquinolinium dichromate and isoquinolinium chlorochromate were found as efficient catalysts to trigger oxidative bromination and iodination of aromatic hydrocarbons with KBr/KI and KHSO₄ under acid-free conditions. Reaction times reduced highly significantly under sonication, followed by corresponding mono bromo derivatives in very good yield with high regioselectivity. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Reference of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Reference of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ruthenium piano-stool complexes bearing imidazole-based PN ligands was written by Kunz, Peter C.;Thiel, Indre;Noffke, Anna Louisa;Reiss, Guido J.;Mohr, Fabian;Spingler, Bernhard. And the article was included in Journal of Organometallic Chemistry in 2012.Application of 15813-09-9 This article mentions the following:

A variety of piano-stool complexes of cyclopentadienyl Ru(II) with imidazole-based PN ligands were synthesized starting from the precursor complexes [CpRu(C₁₀H₈)]PF₆, [CpRu(NCMe)₃]PF₆ and [CpRu(PPh₃)₂Cl]. PN ligands used are imidazol-2-yl, -4-yl and -5-yl phosphines. Depending on the ligand and precursor different types of coordination modes were observed; in the case of polyimidazolyl PN ligands these were κ¹P-monodentate, κ²P,N-, κ²N,N- and κ³N,N,N-chelating and μ-κP:κ²N,N-bridging. The solid-state structures of [CpRu(1a)₂Cl]·H₂O (5·H₂O, 1a = imidazol-2-yldiphenylphosphine), [{CpRu(μ-κP:κ²N,N-2b)}₂](C₆H₅PO₃H)₂(C₆H₅PO₃H₂)₂ (2b = bis(1-methylimidazol-2-yl)phenylphosphine), a hydrolysis product of the as well determined [{CpRu(μ-κP:κ²N,N-2b)}₂](PF₆)₂·2MeCN (7b·2MeCN), [CpRu(κ¹P-3a)(PPh₃)]Cl·CH₂Cl₂ (9·CH₂Cl₂, 3a = tris(imidazol-2-yl)phosphine) and [CpRu(PPh₃)₂Cl]·CHCl₃ were determined Furthermore, [CpRu(L)₂]PF₆ (L = imidazol-2-yl or imidazol-4-yl phosphine) were screened for their catalytic activity in the hydration of 1-octyne. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Application of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Application of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Solid-state organic reactions proceeding by pulverization of inorganic solid-supports. Reactions of iodosobenzene with unsaturated hydrocarbons on acid-treated silica gel was written by Sohmiya, Hajime;Kimura, Takahide;Bauchat, Patrick;Fujita, Mitsue;Ando, Takashi. And the article was included in Chemistry Letters in 1991.COA of Formula: C10H12I2 This article mentions the following:

Pulverization of solid mixtures of hydrogen halide-treated silica gels, PhIO, and alkenes or an alkyne in the absence of a solvent causes smooth and rapid reaction to give halogenated or oxidized products in good yields. Thus, treating trans-PhCH:CHPh with HCl-treated silica gel and PhIO in the solid state gives meso– and dl-PhCCl:CClPh in 65% overall yield. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1COA of Formula: C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes was written by Tian, Zhi-Xiong;Qiao, Jin-Bao;Xu, Guang-Li;Pang, Xiaobo;Qi, Liangliang;Ma, Wei-Yuan;Zhao, Zhen-Zhen;Duan, Jicheng;Du, Yun-Fei;Su, Peifeng;Liu, Xue-Yuan;Shu, Xing-Zhong. And the article was included in Journal of the American Chemical Society in 2019.Related Products of 877264-43-2 This article mentions the following:

Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, the authors report an enantioselective cross-electrophile aryl-alkenylation reaction of unactivated alkenes. This method provides access to a number of biol. important chiral mols. such as dihydrobenzofurans, indolines, and indanes. The incorporated alkenyl group is suitable for further reactions that can increases mol. diversity and complexity. The reaction proceeds under mild conditions at room temperature, and an easily accessible chiral pyrox ligand was used to afford products with high enantioselectivity. The synthetic utility of this method is demonstrated by enabling the modification of complex mols. such as peptides, indometacin, and steroids. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Related Products of 877264-43-2).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Related Products of 877264-43-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photophysical and Photoredox Characteristics of a Novel Tricarbonyl Rhenium(I) Complex Having an Arylborane-Appended Aromatic Diimine Ligand was written by Ito, Akitaka;Kang, Yuanyuan;Saito, Shota;Sakuda, Eri;Kitamura, Noboru. And the article was included in Inorganic Chemistry in 2012.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

We report the synthesis and photophys./photoredox characteristics of a novel tricarbonyl rhenium(I) complex having a (dimesityl)boryldurylethynyl (DBDE) group at the 4-position of a 1,10-phenanthroline (phen) ligand, [Re(CO)₃(4-DBDE-phen)Br] (ReB). ReB in THF at 298 K showed the metal-to-ligand charge transfer (MLCT) emission at around 681 nm with the lifetime (τ^em) of 900 ns. The relatively long emission lifetime of ReB compared with that of [Re(CO)₃(phen)Br] (RePhen, τ^em = 390 ns) was discussed on the basis of the temperature dependent τ^em and Franck-Condon anal. of the emission spectra of the two complexes. Emission quenching studies of both ReB and RePhen by a series of electron donors revealed that the photoinduced electron transfer (PET) quenching rate constant of ReB was faster than that of RePhen at a given Gibbs free energy change of the PET reaction (ΔG_ET⁰ > -0.5 eV). All of the results on ReB were discussed in terms of the contribution of the CT interaction between the π-orbital(s) of the aryl group(s) and the vacant p-orbital on the boron atom in DBDE to the MLCT state of the complex. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

F^– Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF₃-Substituted Indenes was written by Tang, Hai-Jun;Zhang, Yu-Feng;Jiang, Yi-Wen;Feng, Chao. And the article was included in Organic Letters in 2018.Quality Control of (5-Fluoro-2-iodophenyl)methanol This article mentions the following:

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes, e.g., I. The success of this strategy hinged upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same mol., as well as a smooth transmetalation step, which delicately joined together these two different metallic intermediates. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Quality Control of (5-Fluoro-2-iodophenyl)methanol).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Quality Control of (5-Fluoro-2-iodophenyl)methanol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

N³-Substituted thymidine analogues. Part III: radiosynthesis of N³-[(4-[¹⁸F]fluoromethyl-phenyl)butyl]thymidine ([¹⁸F]-FMPBT) and N³-[(4-[¹⁸F]fluoromethyl-phenyl)pentyl] thymidine ([¹⁸F]-FMPPT) for PET was written by Ghosh, Pradip;Gelovani, Juri G.;Alauddin, Mian M.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2007.Reference of 10297-05-9 This article mentions the following:

Radiosyntheses of two N³-substituted thymidine analogs, N³-[(4-[¹⁸F]fluoromethyl-phenyl)butyl- and -pentyl]thymidine ([¹⁸F]FMPBT and [¹⁸F]FMPPT, resp.), are reported. The precursor compounds, tetrahydropyranyl ether-protected chloromethyl compounds, were synthesized in six steps and the unlabeled standard compounds were synthesized from these precursors. For radiosynthesis, the precursors were fluorinated with Bu₄N[¹⁸F] and subsequently hydrolyzed by acid. The crude products were purified by HPLC to obtain [¹⁸F]FMPBT and [¹⁸F]FMPPT. The average decay-corrected radiochem. yield for [¹⁸F]FMPBT was 15% in 5 runs, and that for [¹⁸F]FMPPT was 10% in 4 runs. The radiochem. purity was >99% and the specific activity was >74 GBq/μmol at the end of synthesis. The synthesis time was 80-90 min from the end of bombardment. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis was written by Ruff, Yves;Martinez, Roberto;Pelle, Xavier;Nimsgern, Pierre;Fille, Pascale;Ratnikov, Maxim;Berst, Frederic. And the article was included in ACS Combinatorial Science in 2020.Synthetic Route of C6H4INO2 This article mentions the following:

The use of DNA-encoded libraries has emerged as a powerful hit generation technol. Combining the power of combinatorial chem. to enumerate large compound collections with the efficiency of affinity selection in pools, the methodol. makes it possible to interrogate vast chem. space against biol. targets of pharmaceutical relevance. Thus, the chem. transformations employed for the synthesis of encoded libraries play a crucial role in the identification of diverse and drug-like starting points. Currently established transformations have mostly been limited to water-compatible reactions to accommodate the growing oligonucleotide tag. Herein, we describe the development of a practical catch-and-release methodol. utilizing a cationic, amphiphilic PEG-based polymer to perform chem. transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (amphiphilic polymer-facilitated transformations under anhydrous conditions) approach by performing several challenging transformations on DNA-conjugated small mols. in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in THF, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane, and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Synthetic Route of C6H4INO2).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tributyltin hydride and 1-ethylpiperidine hypophosphite mediated intermolecular radical additions to 2,4,6-trichlorophenyl vinyl sulfonate was written by Edetanlen-Elliot, Oluwabusola;Fitzmaurice, Richard J.;Wilden, Jonathan D.;Caddick, Stephen. And the article was included in Tetrahedron Letters in 2007.Computed Properties of C4H8ClI This article mentions the following:

2,4,6-Trichlorophenyl vinyl sulfonate smoothly undergoes intermol. radical addition under mild initiation conditions mediated by tributyltin hydride and 1-ethylpiperidine hypophosphite (EPHP) to generate a range of functionalized alkyl sulfonamide precursors. This methodol. can be used to prepare bifunctional pentafluorophenyl/2,4,6-trichlorophenyl sulfonates in good yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com