Category: iodides-buliding-blocks

Eosin-Mediated Alkylsulfonyl Cyanation of Olefins was written by Pirenne, Vincent;Kurtay, Gulbin;Voci, Silvia;Bouffier, Laurent;Sojic, Neso;Robert, Frederic;Bassani, Dario M.;Landais, Yannick. And the article was included in Organic Letters in 2018.Category: iodides-buliding-blocks This article mentions the following:

Eosin-Y (EY)-mediated alkylsulfonyl cyanation of olefins was shown to afford alkylsulfonyl nitriles in good yields. On the basis of transient absorption spectroscopy, the reaction was shown to proceed via photoinduced electron transfer from ³EY* to an O-cyanated derivative of the photocatalyst, formed in situ, with generation of the corresponding sulfinate that is oxidized by EY^â€?+ into a sulfonyl radical. Addition of the latter on the olefin, followed by a radical cyano group transfer, then furnished the nitrile along with a RSO₂ radical sustaining the radical chain. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Category: iodides-buliding-blocks).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed Site-Selective Benzocylization of Aromatic Acids with o-Fluoro-Substituted Diaryliodonium Salts toward 3,4-Benzocoumarins was written by Pan, Cheng;Wang, Limin;Han, Jianwei. And the article was included in Organic Letters in 2020.Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene This article mentions the following:

By using 2-fluoro-substituted diaryliodonium salts, a novel benzocylization has been accomplished for the synthesis of 3,4-benzocoumarin derivatives via a cascade of ortho-arylation and defluorination in the presence of palladium catalysts. The reaction exhibits a broad compatibility of readily available aromatic acids with an excellent level of site-selectivity. Mechanistic investigations revealed a unique reactivity of carboxylic acid directed arylation by followed nucleophilic substitution of aromatic fluoride in the present system. In the experiment, the researchers used many compounds, for example, 1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene).

1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Examination of the New α-(2’Z-Fluoro)vinyl Trigger with Lysine Decarboxylase: The Absolute Stereochemistry Dictates the Reaction Course was written by Karukurichi, Kannan R.;De la Salud-Bea, Roberto;Jahng, Wan Jin;Berkowitz, David B.. And the article was included in Journal of the American Chemical Society in 2007.Electric Literature of C4H8ClI This article mentions the following:

The first examination of a terminal α-fluorovinyl trigger in an amino acid decarboxylase (LDC) active site is reported. To investigate the enantiospecificity of inactivation with this new AADC trigger, an enantioselective synthesis of L-α-(2’Z-fluoro)vinyllysine and its D-antipode has been developed. Control of stereochem. is achieved through introduction of the amino acid side chain via alkylation of a chiral vinylglycine-derived dienolate. Facial selectivity is conferred by a trans-2′(β-naphthyl)-2′-propylcyclohexyl ester auxiliary, available in both antipodal forms (Comins protocol). The alkylation employs a new electrophile, N-p-methoxybenzyl-N-(2′-trimethylsilylethanesulfonyl)-4-iodobutylamine, for convergent installation of the lysine side chain. Vinyl to 2′-fluorovinyl interconversion then provides L– and D-α-(2’Z-fluoro)vinyllysine in 97-99% ee, as demonstrated by chiral HPLC. Both time-dependent enzyme kinetics and ¹⁹F NMR reveal striking differences in the behavior of these two antipodes in the lysine decarboxylase active site. The L-antipode displays time dependent inactivation (t_1/2 = 3±1 min; K_I = 86±22 μM), whereas the D-antipode behaves as a substrate, being completely turned over to α-(2’Z-fluoro)vinylcadaverine. Titration of LDC with varying amounts of L-α-(2’Z-fluoro)vinyllysine provides an estimate of 20±3 for the partition ratio for this antipode. ¹⁹F NMR provides a more detailed account of the inactivation with the L-antipode, revealing that 1 in 3.4 turnovers of this mechanism-based inhibitor results in errant protonation (required by design), with 1 in 5 errant protonation events leading to LDC inactivation. This gives an overall partition ratio of 16±2. Fluoride-selective electrode measurements are in agreement with ¹⁹F NMR estimates of [fluoride] released. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Electric Literature of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Electric Literature of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The carboxyl group. Infrared absorption and ionization was written by Peltier, Daniel;Pichevin, Annick. And the article was included in Bulletin de la Societe Chimique de France in 1960.COA of Formula: C8H7IO2 This article mentions the following:

PK, ν_OH(monomeric), and ν_C:O (monomeric and dimeric) values of 17 substituted benzoic, 34 o-toluic, 17 m-toluic, and 12 p-toluic acids, as well as the ν_C:O values of 55 Me and Et esters were tabulated. For all the acids except the 6-substituted o-toluic acids (6-NO₂, I, Br, Cl, OH, NH₂), ν_OH (cm.^-1) = 3498 + 9pK. The ν_C:O (monomeric) of the o-OH and o-NH₂ acids were on the average 55 cm.^-1 lower and those of nonchelated, 6-substituted o-toluic acids were approx. 5 cm.^-1 higher than calculated from the appropriate equations (CA 53, 17954e). For acids free of chelation and steric effects, ν_OH = 5,028 – 0.857 ν_C:O (monomeric) (cm.^-1). For 3-, 4-, and 5-substituted o-toluic acids, ν_OH = 5053 – 0.874 ν_C:O. The carbonyl frequencies of the Et esters were approx. 5 cm.^-1 lower than those of the corresponding Me esters. These results are explained by electronic effects of H or alkyl group on the carbonyl group. 6-HO(or H₂N)-2-MeC₆H₃CO₂Me exhibited 2 carbonyl frequencies related to chelated and nonchelated forms. Similar data were presented for 2,3- (I), 2,4-, and 2,6-(MeO)MeC₆H₃CO₂H, and o-MeOC₆H₄CO₂H. The dimeric carbonyl absorptions were weak, the ν_OH were lower, and the ν_C:O were higher, based on the relations with pK, than expected for nonchelated acids. I was exceptional, as it gave a strong dimeric carbonyl absorption. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1COA of Formula: C8H7IO2).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma was written by Desbois, Nicolas;Gardette, Maryline;Papon, Janine;Labarre, Pierre;Maisonial, Aurelie;Auzeloux, Philippe;Lartigue, Claire;Bouchon, Bernadette;Debiton, Eric;Blache, Yves;Chavignon, Olivier;Teulade, Jean-Claude;Maublant, Jean;Madelmont, Jean-Claude;Moins, Nicole;Chezal, Jean-Michel. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Electric Literature of C7H6INO2 This article mentions the following:

Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [¹²⁵I]NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumor-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumor concentrations together with an in vivo kinetic profile favorable to application in targeted radionuclide therapy. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Electric Literature of C7H6INO2).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C7H6INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Crystal Growth, Structure, and Polymorphic Behavior of an Ionic Liquid: Phthalate Derivative of N-Butyl,N-methylimidazolium Hexafluorophosphate was written by Brandel, Clement;Gbabode, Gabin;Cartigny, Yohann;Martin, Claudette;Gouhier, Geraldine;Petit, Samuel;Coquerel, Gerard. And the article was included in Chemistry of Materials in 2014.Reference of 10297-05-9 This article mentions the following:

After the multistep synthesis of an original imidazolium hexafluorophosphate ionic liquid, [pbmim][PF₆], two polymorphic forms were isolated from methanolic solution and characterized by XRPD, DSC, and Raman spectroscopy. Stable Form A (mp 90.3 °C) was obtained by conventional crystallization at a moderate cooling rate (<10 K/min), whereas metastable Form B (mp 83.2 °C) was spontaneously produced from a liquid-liquid demixing (oiling out) when a faster cooling rate (>10 K/min) was applied. Structural analyses carried out by using single-crystal (Form A) and powder (Form B) X-ray diffraction revealed a rotational disorder of anionic octahedrons and, more interestingly, large conformational differences between cationic moieties caused by their mol. flexibility. Crystal growth of [pbmim][PF₆] (Form A) in methanol often leads to numerous crystal defects and revealed that most of them consist of liquid inclusions. The supersaturation ratio (β) appeared to be the predominant factor influencing the crystal growth behavior under isothermal and stagnant conditions. At low β values, a morphol. transition from rod-shaped crystals to platelets was observed, presumably caused by a change in the growth mechanism of specific faces. Using high β values promotes either the formation of microscopic (<5 μm) liquid inclusions that become easily detectable upon heating or the appearance of macroscopic inclusions with an hourglass shape. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Influence of the Bridging Elements on the Optical Properties of Linked 9,10-Dihydro-9,10-diboraanthracenes was written by Januszewski, Estera;Bolte, Michael;Lerner, Hans-Wolfram;Wagner, Matthias. And the article was included in Organometallics in 2012.Related Products of 3268-21-1 This article mentions the following:

Starting from the monofunctionalized 9,10-dihydro-9,10-diboraanthracene derivatives MesB(C₆H₄)₂BX (X = H, Br), the bridged systems MesB(C₆H₄)₂B-L-B(C₆H₄)₂BMes have been synthesized with L = -C(H):C(H)(p-C₆Me₄)C(H):C(H)- (5), -CC(p-C₆Me₄)CC- (6), and -(p-C₆H₄)(p-C₆Me₄)(p-C₆H₄)- (7). The compounds were characterized by NMR, IR, UV/vis, and fluorescence spectroscopy. The vinyl- and phenylboranes 5 and 7 are pale yellow solids, whereas the alkynylborane 6 possesses a bright yellow color. The emission maxima of 5–7 in toluene are λ_max(em) 477, 460, and 461 nm with quantum yields ϕ_f of 0.02, 0.30, and 0.04, resp. Alkynylborane 6 was the least air- and moisture-sensitive of the three derivatives In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Related Products of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Related Products of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl Electrophiles was written by Tong, Xiaoyu;Schneck, Felix;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2022.SDS of cas: 10297-05-9 This article mentions the following:

Herein the achievement of this objective, demonstrating that a nickel catalyst could accomplish enantioselective intermol. alkylations of racemic Reformatsky reagents with unactivated electrophiles; the resulting α-alkylated carbonyl compounds could be converted in one addnl. step into a diverse array of ubiquitous families of chiral mols was described. Applying a broad spectrum of mechanistic tools, have gained insight into key intermediates (including the alkylnickel(II) resting state) and elementary steps of the catalytic cycle. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aromatic iodination in aqueous solution. A new lease of life for aqueous potassium dichloroiodate was written by Garden, S. J.;Torres, J. C.;de Souza Melo, S. C.;Lima, A. S.;Pinto, A. C.;Lima, E. L. S.. And the article was included in Tetrahedron Letters in 2001.COA of Formula: C3H2I2N2 This article mentions the following:

A re-investigation of the use of aqueous KICl₂ as an iodinating agent for aromatic compounds has found the reagent to be more generally applicable than previously known. The reagent gives excellent yields of iodinated heterocyclic compounds, such as isatin, imidazole, and pyrazole. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9COA of Formula: C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Approach to the synthesis of bryophyte constituents was written by Sagrera, G. J.;Lopez, G. V.;Pandolfi, E. M.;Seoane, G. A.;Eicher, T.. And the article was included in Informacion Tecnologica in 1998.Recommanded Product: 2314-37-6 This article mentions the following:

The synthesis of 2,2-bilunularin (I), a bis(bibenzyl)phenolic compound isolated from bryophytes, is described. The main transformations involve the formation of an aromatic carbon-carbon bond by Ullmann’s reaction and the formation of aliphatic carbon-carbon bonds by Wittig’s reactions. A simple model structure was used to optimize the cyclization conditions to obtain flavanone. Based on the results, biflavanone was synthesized, an advanced intermediate for the preparation of some flavonoids isolated from bryophytes. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Recommanded Product: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com