Category: iodides-buliding-blocks

Self-Assembly of M₃₀L₆₀ Icosidodecahedron was written by Fujita, Daishi;Ueda, Yoshihiro;Sato, Sota;Yokoyama, Hiroyuki;Mizuno, Nobuhiro;Kumasaka, Takashi;Fujita, Makoto. And the article was included in Chem in 2016.Synthetic Route of C10H12I2 This article mentions the following:

Self-assembly is invaluable in the construction of giant mol. structures via a bottom-up approach. Although living organisms naturally make the most use of self-assembly and freely handle the mechanism at will, scientists are still far behind the level of nature. Inspired by the elegant structures of virus capsids, the authors have previously constructed roughly spherical giant metal complexes with the symmetry of an octahedron, cuboctahedron, and rhombicuboctahedron M₆L₁₂, M₁₂L₂₄, and M₂₄L₄₈, resp. Here, the authors report the 1st successful synthesis of an M₃₀L₆₀ mol. icosidodecahedron that consists of âˆ?00 components: 30 Pd(II) ions and 60 (2,5-bis(4-pyridyl-1,4-tetramethylphenylene)thiophene) ligands that assemble into the largest well-defined spherical macromol. to date (diameter of âˆ?.2 nm). Tuning the flexibility of the ligand was the key for successful self-assembly. A highly complex but sym. organized structure was identified through x-ray crystallog. anal. The interior space of the mol. complex is large enough (157,000 ų) to enclose proteins. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Synthetic Route of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Synthetic Route of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts was written by Caspers, Lucien D.;Spils, Julian;Damrath, Mattis;Lork, Enno;Nachtsheim, Boris J.. And the article was included in Journal of Organic Chemistry in 2020.Name: (5-Fluoro-2-iodophenyl)methanol This article mentions the following:

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates, e.g., I, are described. Strong Bronsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alc. derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and d. functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Name: (5-Fluoro-2-iodophenyl)methanol).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Name: (5-Fluoro-2-iodophenyl)methanol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed synthesis of benzo[d][1,3]dioxin-4-ones via tandem Ar-halogen bond hydroxylation and dichloromethane-based double Williamson etherification was written by Liu, Yunyun;Huang, Meiying;Wei, Li. And the article was included in New Journal of Chemistry in 2017.Recommanded Product: 13420-63-8 This article mentions the following:

The reactions of o-halobenzoic acids, dichloromethane and potassium hydroxide providing benzo[d][1,3]dioxin-4-ones was reported via the catalysis of Cu(OAc)₂. Tandem Ar-X (X = I, Br) bond hydroxylation and double Williamson etherification on dichloromethane were involved during the construction of the target products. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Recommanded Product: 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 1,2,4-Triazoles, N-Fused 1,2,4-Triazoles and 1,2,4-Oxadiazoles via Molybdenum Hexacarbonyl-Mediated Carbonylation of Aryl Iodides was written by Nakka, Mangarao;Tadikonda, Ramu;Nakka, Srinivas;Vidavalur, Siddaiah. And the article was included in Advanced Synthesis & Catalysis in 2016.Reference of 5460-32-2 This article mentions the following:

A convenient and efficient protocol was developed for the synthesis of 1,2,4-triazoles, N-fused 1,2,4-triazoles and 1,2,4-oxadiazoles from aryl iodides and amidrazones, 2-hydrazinylpyridine, 2-hydrazinylpyrazine or amidoximes using molybdenum hexacarbonyl which acts as a convenient and reliable solid source of carbon monoxide. This procedure provided an easy access to a library of 1,2,4-triazole, N-fused 1,2,4-triazole and 1,2,4-oxadiazole derivatives in fair to good yields without the need of gaseous carbon monoxide and palladium catalysts. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Reference of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides was written by Molander, Gary A.;Argintaru, O. Andreea;Aron, Ioana;Dreher, Spencer D.. And the article was included in Organic Letters in 2010.Formula: C4H8ClI This article mentions the following:

A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp³)-Br bonds in the presence of C(sp²)-Br bonds was achieved. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Late-stage functionalization of peptides and cyclopeptides using organozinc reagents was written by Leroux, Marcel;Vorherr, Thomas;Lewis, Ian;Schaefer, Michael;Koch, Guido;Karaghiosoff, Konstantin;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2019.Synthetic Route of C4H8ClI This article mentions the following:

We report a new late-stage functionalization of small peptides and cyclopeptides relying on the Negishi cross-coupling of readily prepared iodotyrosine- or iodophenylalanine-containing peptides with aryl-, heteroaryl-, and alkylzinc pivalates or halides. In silico and in vitro determinations of membrane permeability parameters of the modified cyclopeptides showed that in most cases, the solubility was improved by the introduction of polar pyridyl units while the cell-membrane permeability was maintained. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Synthetic Route of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Polyiodoimidazoles and their nitration products was written by Katritzky, A. R.;Cundy, D. J.;Chen, J.. And the article was included in Journal of Energetic Materials in 1993.Electric Literature of C3H2I2N2 This article mentions the following:

The preparations of 4,5-diiodoimidazole and 2,4,5-triiodoimidazole from imidazole were reinvestigated and convenient procedures with excellent yields described. 2,4,5-Triiodoimidazole can be selectively converted to 2,4(5)-dinitro-5(4)-iodoimidazole and 2,4,5-trinitroimidazole by nitrolysis. 2,4(5)-Dinitroimidazole was converted by nitration into 2,4,5-trinitroimidazole and isolated as the imidazolium and potassium salts in 38% and 15% yields resp. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Electric Literature of C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Electric Literature of C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 8-(3″-formyl-6″-methoxyphenyl)-5,7,4′-trimethoxyflavone was written by Khan, Hamid A.;Ahmad, Faizan;Rahman, W.. And the article was included in Indian Journal of Chemistry in 1978.Formula: C8H7IO2 This article mentions the following:

The iodoflavone I and 3,4-I(MeO)C₆H₃CHO were coupled by heating at 230-5° for 45 min in the presence of activated Cu to give 34% (formylphenyl)flavone II and a trace of biflavone III. III was the main product when DMF was the solvent for the coupling reaction. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation was written by Oslob, Johan D.;Johnson, Russell J.;Cai, Haiying;Feng, Shirley Q.;Hu, Lily;Kosaka, Yuko;Lai, Julie;Sivaraja, Mohanram;Tep, Samnang;Yang, Hanbiao;Zaharia, Cristiana A.;Evanchik, Marc J.;McDowell, Robert S.. And the article was included in ACS Medicinal Chemistry Letters in 2013.Formula: C8H7IO2 This article mentions the following:

Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochem. activities. The most potent analog (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Formula: C8H7IO2).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Empowering Transition-Metal-Free Cascade Protocol for the Green Synthesis of Biaryls and Alkynes was written by Walia, Preet Kamal;Kumar, Manoj;Bhalla, Vandana. And the article was included in ACS Omega in 2018.Application of 5460-32-2 This article mentions the following:

The work being presented in this manuscript demonstrates the simple and efficient ‘transition-metal-free’ and ‘light-mediated’ synthetic protocol for the synthesis of aryl iodides/biaryls/alkynes from aryl bromides. Under UV irradiation and in basic aqueous media, aryl bromides undergo transformation into aryl iodides which efficiently couple via a cascade reaction with a wide range of terminal alkynes/unactivated arenes to generate target mols. under green conditions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com