Category: iodides-buliding-blocks

64248-58-4, name is 1,2-Difluoro-4-iodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H3F2I

Add bis (triphenylphosphine) palladium (II) dichloride (110 mg, 0. 15 mmol), copper (I) iodide (57 mg, 0. 30 mmol), and 3-ethynyl-5-methoxypyridine, (prepared as described in PREPARATION 10), (400 mg, 3. 0 mmol) to a solution of 1, 2-difluoro-4- iodobenzene (0. 43 mL, 3. 6 mmol) in triethylamine (6. 3 mL, 45. 0 mmol) and heat at 60 C for 20 h. Cool to room temperature and concentrate. Purify the residue by silica gel chromatography, eluting with 100 : 0 to 65 : 35 hexanes : ethyl acetate, followed by a second silica gel chromatography, eluting with 100 : 0 to 80 : 20 dichloromethane : ethyl acetate, to give the title compound as a white solid (690 mg, 94%). 1H NMR (300 MHz, CDCl3) 6 3. 89 (s, 3H), 7. 11-7. 21 (m, 1H), 7. 28-7. 40 (m, 3H), 8. 27- 8. 30 (d, J = 2. 9 Hz, 1H), 8. 34-8. 37 (d, J = 1. 6 Hz, 1H), MS (APCI) : m/z = 246 [M+H] +.

The synthetic route of 64248-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H9IO2

An ice-cooled solution of 1-iodo-3,5-dimethoxybenzene (8.42 g,31.9 mmol) in DMF (60 mL) was treated under argon atmosphere with freshly distilled POCl3(14 mL, 150 mmol). The mixture was stirred for 30 min at 0 C, then 30 min at roomtemperature and finally heated at 100 C for 5h. The mixture was cooled at room temperatureand was poured with stirring into ice and water (1.5 L). After being stirred for 2h, theresulted suspension was filtered to give a light brown solid. This residue was purified by ashort plug of silica gel using diethyl ether as eluent afforded 1-iodo-3,5-dimethoxybenzaldehyde as a beige solid (5.2 g, 56% yield).1H NMR (300 MHz, CDCl3): delta = 10.1 (s, 1H), 7.13 (d, J = 2.2 Hz, 1H), 6.48 (d, J = 2.2 Hz,1H), 3.89 (s, 3H), 3.86 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Petrignet, Julien; Inack Ngi, Samuel; Abarbri, Mohamed; Thibonnet, Jerome; Tetrahedron Letters; vol. 55; 5; (2014); p. 982 – 984;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61272-76-2, name is 4-Fluoro-2-iodoaniline, A new synthetic method of this compound is introduced below., Product Details of 61272-76-2

General procedure: An oven-dried flask was charged with o-iodoaniline (13 mmol), the corresponding benzyl bromide(10 mmol), NaHCO3 (20 mmol), and DMF (20 mL). The mixture was stirred at 50 °C under air for 3-4 h.After the completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambienttemperature and 15 mL water was added to the mixture, then extracted by EtOAc for 3 times (3 × 30 mL).The combined extracts were washed with brine, dried over Na2SO4, and the solvent was removed in vacuoto provide a crude product, which was purified by column chromatography on silica gel to afford pure product.

The synthetic route of 61272-76-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Zhengkai; Li, Hongli; Cao, Gangjian; Xu, Jianfeng; Miao, Maozhong; Ren, Hongjun; Synlett; vol. 28; 4; (2017); p. 504 – 508;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 98-61-3,Some common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 7 (1.0 eq) and triethylamine (3.5 eq) in dichloromethane (10 volume), substituted sulphonyl chloride (1.2 eq) was added at 5-10 C and stirred overnight at room temperature.The completion of the reaction was confirmed by TLC. The reaction mixture was poured into separating funnel washed with water followed by brine solution, dried over anhydrous sodium sulphate and concentrated to syrup. Crude syrup was purified by crystallization using dichloromethane and petroleum ether to yield the oxadiazole substituted sulfonamide as white to white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobenzenesulfonyl chloride, its application will become more common.

Reference:
Article; Harish, Kikkeri P.; Mohana, Kikkeri N.; Mallesha, Lingappa; Prasanna Kumar, Basavapatna N.; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 276 – 283;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Iodo-1,3-dimethylbenzene

General procedure: Heck coupling reactions were carried out using aryl iodides (3a-j) (1 mmol), 2-Vinyl-N-Boc-piperidine (2) (1.2 mmol), and Et3N as base (2 mmol) dissolved in 10 ml of aq.ethanol (water/ethanol = 9:1). An appropriate amount of NHC precursor (i) (0.1 mmol), Pd(OAc)2 (0.05 mmol), and TBAB (0.025 mmol) were added to this mixture. The reaction mixture was heated to 80 C for 5 hrs. The coupled product was extracted with DCM (2 x 20 ml). The combined organic layers were dried (anhydrous Na2SO4) and evaporated under reduced pressure to afford a crude product which was subjected to column chromatography to afford pure E-Olefins (4a-j).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 608-28-6.

Reference:
Article; Kankala, Shravankumar; Kankala, Ranjith Kumar; Balaboina, Ramesh; Thirukovela, Narasimha Swamy; Vadde, Ravinder; Vasam, Chandra Sekhar; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1180 – 1183;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 887266-99-1, name is 3-Fluoro-4-iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 887266-99-1, COA of Formula: C7H3FIN

General procedure: The tetrazole compounds were prepared by a modified literature reported protocol.3 Thus, the aromatic nitrile (1.0 equiv), TBAF.3H2O (0.5 equiv) and TMS-N3 (1.5 equiv) were taken in a screw capped vial equipped with a magnetic stirrer and the resulting mixture was stirred vigorously at 85 oC. The reaction mixture was then transferred to a seperatory funnel and TBAF was removed by washing the organic phase with 1M aqueous HCl solution (20 ml). The organic phase was separated, washed with brine (20 ml) and dried over Na2SO4 and then concentrated in a rotary evaporator. The products were then purified by silica-gel (60-120 mesh) column chromatography or for some cases by recystallisation. Compound 2L was used as a crude mixture for further reaction. The compounds were then characterized by IR, NMR spectroscopy and mass spectrometry. Compounds 2A-B and 2H are reported compounds3 whereas 2C- 2G and 2I- 2L are new.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Bag, Subhendu Sekhar; Talukdar, Sangita; Anjali; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2044 – 2050;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 452-82-4,Some common heterocyclic compound, 452-82-4, name is 1-Fluoro-2-iodo-4-methylbenzene, molecular formula is C7H6FI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 8A 4-fluoro-3-iodobenzaldehyde A mixture of 4-fluoro-3-iodotoluene (5.0 g, 21.2 mmol) and NBS (4.2 g, 23.3 mmol) in 50 mL of CCl4 was refluxed under N2 with benzoyl peroxide (250 mg, 1.03 mmol) was heated for 3 hours. The reaction mixture was cooled to room temperature and filtered through celite, washed with benzene. The filtrate was evaporated and pumped to give the benzylbromide as a crude light brown oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-2-iodo-4-methylbenzene, its application will become more common.

Reference:
Patent; Xin, Zhili; Liu, Gang; Pei, Zhonghua; Szczepankiewicz, Bruce G.; Serby, Michael D.; Zhao, Hongyu; US2004/167188; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 77317-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 77317-55-6, name is Methyl 2-amino-5-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of CuI (110 mg, 0.58 mmol), Pd(OAc)2 (60 mg, 0.27 mmol), and Ph3P (130 mg, 0.49 mmol) in MeCN (30 mL) deaerated (UST) under argon atmosphere was stirred at 20 C for 20 min. Iodide 6 (1.39 g, 5.0 mmol), Et3N (1.53 g, 15.11 mmol, 2.1 mL), H2O (0.15 g, 8.33 mmol), and finely ground CaC2 (1.0 g, 15.60 mmol) were then added. The reaction mixture was stirred for 7 h and concentrated in vacuo; the residue was extracted with hot EtOAc. The extract was filtered and concentrated in vacuo, the residue was purified by chromatography on SiO2 using gradient elution of PhH -> PhH/EtOAc (4 : 1). Diarylalkyne 2a (0.57 g, 70%) was isolated as yellow crystals, m.p. 245-249 C. HRMS (ESI), found m/z: 325.1179, 347.0997; C18H16N2O4; calculated 325.1183 [M + H]+, 347.1002 [M + Na]+. IR (KBr), nu/cm-1:788, 834, 985, 1103, 1162, 1235, 1300, 1430, 1506-1663, 1688, 2342, 2361, 2838-3033, 3367, 3464. 1H NMR (DMSO-d6), delta: 3.82 (s, 6 H, 2 MeO); 6.75 (d, 2 H, HC(5), HC(5), J = 8.6 Hz); 7.26 (dd, 2 H, HC(4), HC(4), J = 8.6 Hz, J = 1.9 Hz); 7.83 (d, 2 H, HC(2), HC(2), J = 1.9 Hz). 13C NMR (DMSO-d6), delta: 51.3 (Me, Me); 86.9 (CC); 108,8 (C(5), C(5)); 109.0 (C(3), C(3)); 116.9 (C(1), C(1)); 133.9 (C(2), C(2)); 136.0 (C(4), C(4)); 150.8 (C(6), C(6)); 167.1 (CO, CO).

The synthetic route of Methyl 2-amino-5-iodobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lozanova; Stepanov; Mel?nik; Zlokazov; Veselovsky; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 64 – 67; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 64 – 67,4;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of 8-aminoquinoline (0.4mmol), an appropriate carbonyl chloride (0.4mmol), an appropriate aryl iodide (0.16-0.24mmol, 4-6 equiv), Pd(OAc)2 (10mol %) and Ag2CO3 (0.6-0.8mmol, 1.5-2 equiv) was heated in o-xylene (2mL) at 110 C for an appropriate reaction period (12-36 h). Then, reaction mixture was cooled to rt and the solvent evaporated in vacuo to give the crude product, which was purified by chromatography to give the corresponding C-H arylated products (see the respective Tables 1-4/Scheme 2 for the specific entries and reaction conditions).

The synthetic route of 1,2-Dichloro-4-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mohan, Sruthi; Gopalakrishnan, Bojan; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 72; 39; (2016); p. 5853 – 5863;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, A new synthetic method of this compound is introduced below., Product Details of 148836-41-3

Step B: Preparation of l -Bromo-4-chloro-2-(3,3,3-triethoxyprop- l -ynyl)benzene; [08941 lambda mixture of l -bromo-4-chloro-2-iodoben/cne ( 1 0 g. 32 mmol) in 100 mL degassed ACN and TEA (29 g. 284 mmol), was treated with 3.3,3- triethoyprop- l -ync (6.0 g, 35 mmol), copper(l) iodide (0.60 g. 3.2 mmol), and dichltheta.Obis(triphenylphosphine)palladium(H) ( 1. 1 g, 1 .6 mmol). The mixture was stirred at room temperature for 2 hours at room temperature (the mixture turned dark green after 5 minutes). TLC showed that all starting material was converted, and a new spot was produced. The mixture was concentrated in vacuo. The residue was diluted with 100 ml. ether, washed with H2O (2 20 mL), 5% ammonia water (2 x 20 ml.), brine (20 ml.), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was purified by column chromatography pretreated with TEA and eluted with 0-15 % EtOAc/hexane to give 7.6 g of the product as a pale yellow oil. The oil solidified after it was stored in the refrigerator.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com