Category: iodides-buliding-blocks

Related Products of 69113-59-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69113-59-3, name is 3-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N-(3-Cyanophenyl)benzylamine (, entry 14) The general procedure under argon was followed using copper(I) iodide (10 mg, 0.05 mmol), K3PO4 (425 mg, 2.00 mmol), benzylamine (131 muL, 1.20 mmol), 3-iodobenzonitrile (229 mg, 1.00 mmol), ethylene glycol (111 muL, 2.00 mmol) and 2-propanol (1.0 mL). Column chromatography using a solvent mixture (hexane/ethyl acetate=5/1, Rf=0.5) afforded N-(3-cyanophenyl)benzylamine (165 mg, 80% isolated yield) as light yellow solid. The spectral data (1H NMR) matched with the literature references and GC analysis indicated >95% purity.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.; US2003/65187; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 64248-58-4, A common heterocyclic compound, 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, molecular formula is C6H3F2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 33b, 4-Methyl-2-(5-piperidin-3-yl-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid ethyl ester (110 mg, 0.25 mmol) in dimethylsulfoxide (0.2 ml) was added L-proline (4.4 mg, 0.04 mmol), potassium carbonate (52.5 mg, 0.38 mmol), and copper iodine (3.6 mg, 0.02 mmol). The reaction was degassed under nitrogen and 1,2-difluoro-4-iodobenzene (45.4 mg, 0.19 mmol), was added, the reaction was again degassed and then heated to 90 C. The reaction was stirred over 48 hours. The reaction was partitioned between EtOAc/H2O, washed with H2O (3×) and brine (1×). Purification by silica gel chromatography (Isco) gave the desired product, (39 mg, 37%). Calcd for C32H34F5NO2 (M+H) 559.60, Found 560.4.

The synthetic route of 64248-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HO, Chih Yung; US2009/105275; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 76801-93-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1Ten experiments were made, each of which used two parallel crystallisers (reactors A and B) where one had mother liquor distilled off and one had not. The solutions of crude Compound A were in all cases made the following way.Compound B was acetylated by a mixture of acetic anhydride and acetic acid (concentration about 91 v/v %, 2.0 L/kg Compound B) at 50-125 C. in the presence of catalytic amounts of p-toluene sulphonic acid. Excess acetic anhydride and acetic acid were distilled off under reduced pressure, and the resulting viscous solution diluted with methanol and water and hydrolysed by addition of aqueous sodium hydroxide at 50-60 C. to a stable pH of about 12. Hydrochloric acid (17.5 w/w %) was added to a pH of about 10.5-11.5 at 60 C. Then, seeds of crystalline Compound A (0.004 kg/kg Compound B) were added, and pH was further adjusted to 6.5-7.5 by hydrochloric acid (17.5 w/w %). At this stage the solvent composition was approximately 25% methanol and 75% water, with a total mother liquor volume of about 3.8 L/kg Compound A.In reactor A of each experiment a certain fraction of the mother liquor volume was removed by distillation, either at atmospheric or reduced pressure (95-100 C. at atmospheric pressure, 55-60 C. under reduced pressure). In reactor B nothing was distilled off. The content of both reactors were then allowed to cool gradually to 15 C. over 10-12 hours before filtration, wash with methanol and drying under reduced pressure and elevated temperature. The purity of the crystals was measured by HPLC. The following results were obtained: Water Reduction Water Reduction Isolated content in of mother content in of mother yield mother Compound liquor mother Compound liquor increase, liquor, B purity, volume, liquor, B purity, volume, reactor B vs. reactor A reactor A reactor A reactor B reactor B reactor B reactor A 1 81% 99.6% 11% 76% 99.6% None 1.3% 2 84% 99.6% 11% 76% 99.6% None 1.4% 3 85% 99.5% 14% 78% 99.5% None 1.7% 4 84% 99.5% 17% 73% 99.6% None 1.9% 5 83% 99.5% 14% 75% 99.5% None 1.6% 6 88% 99.5% 27% 77% 99.4% None 2.9% 7 91% 99.5% 24% 80% 99.5% None 2.5% 8 89% 99.5% 36% 76% 99.5% None 2.9% 9 85% 99.4% 28% 74% 99.5% None 2.4% 10 89% 99.4% 32% 75% 99.5% None 3.1%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GE HealthCare AS; US7754920; (2010); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82998-57-0, name is 3-Iodo-4-methylbenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-Iodo-4-methylbenzoic acid

To a solution of 3-iodo-4-methylbenzoic acid (15 g, 57.14 mmol) in methanol, concentrated sulfuric acid was slowly added dropwise. The reaction solution was allowed to exotherm. After addition, the solution was heated to 70 C. the reaction monitored by TLC was completed 48 h later. The methanol was evaporated under reduced pressure to give brown oil which was slowly poured into 200 mL of water, and the mixture was milk white with heat emission. The aqueous phase was extracted with DCM twice. The DCM layer combined was washed successively with aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution, water once. The DCM layer was dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure to give the title product as a yellowish brown oil.

The synthetic route of 82998-57-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Si Chuan University; Yang, Shengyong; Wei, Yuquan; (168 pag.)US2017/305920; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 7681-82-5,Some common heterocyclic compound, 7681-82-5, name is Sodium iodide, molecular formula is INa, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a round-bottomed flask were added dichloride(pentamethylcyclopentadienyl)iridium(III) dimer (0.1 mmol, 79.5 mg) and sodium iodide (1 mmol, 150 mg). The round-bottomed flask was equipped with a reflux condenser and capped with a rubber septum. An ultrapure argon flow was passed through the system for 30 min. Then, anhydrous acetone (10 mL) was added using syringe and needle, the ultrapure argon flow was reduced, and the reaction mixture was refluxed under stirring for 3 h. Afterwards, the solvent was evaporated under reduced pressure to give a solid which was dissolved in CH2Cl2 (20 mL), washed with distilled water (3 x 10 mL), and dried over Na2SO4. After filtration, the solvent was evaporated under reduced pressure, affording the desired catalyst. Yield: 107 mg (92%); reddish solid; Rf = 0.41 (eluent: dichloromethane); 1H NMR (300 MHz, CDCl3): delta 1.76 (s, 30H); 13C NMR (75 MHz, CDCl3): delta 88.8, 10.7; IR (KBr, cm-1) 3442.9, 2918.3, 1629.9; HRMS (ESI): m/z [M – I]+ calcd for C20H30I3Ir2: 1036.8740; found: 1036.8713

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Sodium iodide, its application will become more common.

Reference:
Article; Correa, Bianca K.; Silva, Tamiris R.C.; Raminelli, Cristiano; Tetrahedron Letters; vol. 59; 39; (2018); p. 3583 – 3585;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 124700-41-0, The chemical industry reduces the impact on the environment during synthesis 124700-41-0, name is 2-Fluoro-5-iodobenzoic acid, I believe this compound will play a more active role in future production and life.

2-Fluoro-5-iodobenzoic acid (10.000 g, 37.592 mmol) was dissolved in 40 mL of dichloromethane and 1 mL of N,N-dimethylformamide, and stirred at room temperature to dissolve oxalyl chloride (3.800 mL, 45.110 mmol) 10 mL of dichloromethane was added dropwise to the reaction system, and the mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was spun dry and replaced with anhydrous toluene three times to obtain an oily liquid thirteenth Compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-5-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing Institute of Technology; Liang Jianhua; Ma Congxuan; (37 pag.)CN109942654; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 52548-63-7, These common heterocyclic compound, 52548-63-7, name is 5-Fluoro-2-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Method CTo the stirred solution of starting material (0.10 mmol, 1 equiv.) in DMF (8 mL) were added the acid (0.11 mmol, 1.1 equiv.), HATU (0.12 mmol, 1.2 equiv.) and DIPEA (0.40 mmol, 4 equiv.) at 0 C. After stirring for 30 min at room temperature, the reaction mixture was diluted with water (10 mL) and then extracted with ethyl acetate (10 mL x 2). The combined organic layers were washed with brine (10 mL) and dried over Na2S04. After removal of solvent under reduced pressure, the residue was purified by either column chromatography (silica gel, petroleum ether/ethyl acetate: 5/1) or prep-HPLC to afford the target.

Statistics shows that 5-Fluoro-2-iodobenzoic acid is playing an increasingly important role. we look forward to future research findings about 52548-63-7.

Reference:
Patent; EOLAS THERAPEUTICS, INC.; KAMENECKA, Theodore M.; HE, Yuanjun; (105 pag.)WO2016/25669; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 167479-01-8,Some common heterocyclic compound, 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, molecular formula is C8H16INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under a nitrogen atmosphere, cesium carbonate (10.13 g, 31.07 mmol) was added to a suspension of 2-propyl[l,3]thiazolo[4,5-c]quinolin-7-ol (5.06 g, 20.7 mmol) in DMF (110 mL), and the reaction mixture was heated at 65 0C. A solution of tert-butyl 3- iodopropylcarbamate (7.08 g, 24.8 mmol) in DMF (20 mL) was added dropwise with stirring. The reaction mixture was stirred at 65 C overnight. The solvent was then removed under reduced pressure at 65 0C. The resulting solid was partitioned between dichloromethane (250 mL) and water (250 mL). The organic layer was washed EPO sequentially with saturated aqueous sodium thiosulfate (100 mL), water (100 mL), and brine (100 mL); dried over magnesium sulfate; filtered; and concentrated under reduced pressure. The resulting solid was purified by column chromatography on silica gel (eluting with 0 to 4% methanol in chloroform) to provide 5.36 g of tert-butyl 3-[(2- propyl[l,3]thiazolo[4,5-c]quinolin-7-yl)oxy]propylcarbamate as a light yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (3-iodopropyl)carbamate, its application will become more common.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2006/86449; (2006); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 199786-58-8, name is (5-Bromo-2-iodophenyl)methanol, A new synthetic method of this compound is introduced below., COA of Formula: C7H6BrIO

To a stirred solution of PDC (11.0 g, 0.0288 mol) in CH2Cl2 (60 mL) was added a solution of 11 (4.50 g, 0.0144 mol) in CH2Cl2 (20 mL). The mixed content was stirred for 4 h at rt. The solvent was then removed under vacuum to give the crude product of 12, which was purified by silica flash column chromatography (hexanes/CH2Cl2, 7:3) to give compound 12 (4.40 g, 0.0142 mol, 98%) as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhou, Ningzhang; Wang, Li; Thompson, David W.; Zhao, Yuming; Tetrahedron; vol. 67; 1; (2011); p. 125 – 143;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 52548-63-7, A common heterocyclic compound, 52548-63-7, name is 5-Fluoro-2-iodobenzoic acid, molecular formula is C7H4FIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B: The product of Step A (9.0 g, 34 mmol) was dissolved in tetrahydrofuran (50 mL) and cooled in an ice bath under nitrogen. A 2.0 M solution of borane-methyl-sulfide complex (42 mL, 8.5 mmol) in tetrahydrofuran was added dropwise and the mixture was stirred for 30 minutes. The ice bath was removed and the reaction mixture was refluxed for 2 hours at 70 C. The solvent was concentrated in vacuo and the residue was dissolved in saturated ammonium chloride and extracted twice with methylene chloride. The organic extract was washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to afford the desired product (6.2 g, 73%) as an off-white solid: 1H NMR (500 MHz, CDCl3) delta 7.78-7.69 (m, 1H), 7.31-7.22 (m, 1H), 6.83-6.75 (m, 1H), 4.64 (s, 2H), 2.04 (s, 1H).

The synthetic route of 52548-63-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.; US2006/52378; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com