Category: iodides-buliding-blocks

Synthetic Route of 42048-11-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42048-11-3, name is 2-Chloro-6-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 55 (RR,SS)(3-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]-2-[(2-methoxyphenyl)(1-naphthyl)methyl]-2-methyl-3-oxopropanenitrile) A mixture of 2-[(2-methoxy-phenyl)-naphthalen-1-yl-methyl]-2-methyl-3-oxo-3-piperazin-1-yl-propionitrile (442 mg, 1.05 mmol), 1-chloro-3-iodo-2-methyl-benzene (258 mg, 1.02 mmol), NaOtBu (140 mg, 1.45 mmol), Pd2(dba)3 (27 mg, 0.029 mmol), racemic BINAP (39 mg, 0.06 mmol) in toluene (5 mL) in a Carius tube was degassed with argon. The tube was sealed and placed in a preheated oil bath (80) for 21 hours. The sample was cooled, diluted with isopropyl acetate (50 mL), washed with brine then water, was dried over Na2SO4, filtered and concentrated to an oil. Chromatography on silica gel using 15% isopropyl acetate/hexane provided a foam which was recrystallized from ethyl acetate/hexane to provide 220 mg of the title compound as an amorphous white powder. 1H NMR 500 MHz (DMSO-D6): delta 7.99 (d, 1H, J=7.18 Hz), 7.88 (m, 2H), 7.80 (d, 1H, J=8.24 Hz), 7.55 (t, 1H, J=7.63 Hz), 7.42 (m, 2H), 7.23 (dt, 1H, J=8.56, 1.53 Hz), 7.14 (m, 4H), 7.12 (brs, 1H), 6.80 (t, 1 h, J=7.48 Hz), 4.01 (s, 3H), 2.26 (s, 3H), 1.64, (s, 3H); MS (ESI) m/z 538 ([M+H]+); Anal. calcd for C33H32ClN3O2: C, 73.66; H, 5.99; N, 7.81. Found: C, 73.98; H, 6.33; N, 7.46.

The synthetic route of 2-Chloro-6-iodotoluene has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 136618-42-3, name is Benzyl 4-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 136618-42-3

General procedure: To a DMF solution (10 mL) of benzyl iodobenzoate (100 mg, 4 mmol), tetrabutylammonium chloride (1.7 g), NaHCO3(0.9 g, 11 mmol) and palladium acetate (80 mg) at 0C, a solution of allyl alcohol (0.41 mL, 6 mmol) in DMF (2 mL) was added. The reaction mixture wasallowed to warm slowly to room temperature, heated at 50Cfor 2 h, diluted with 3N HCl (50 mL), and extracted with EtOAc (5 × 15 mL).The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The product containing1h-1or1r-1was used as such for the next reaction.To a solution of (2-carboxyethyl) triphenylphosphonium bromide (4 mmol) in THF (30 mL), a solution of 2 M lithium bis(trimethylsilyl)amide (LHMDS) (10 mmol, 5 mL THF) was slowly added under nitrogen atmosphere at -78C. The reaction mixture was stirred at -78C for 15 mins, and allowed to warm slowly to 0C for 0.5 h. After being stirred at 0C for 1 h, a solution of appropriate1h-1or1r-1in THF (2 mL) was slowly added at -78C. The reaction mixture was allowed to warm slowly to 0C and stirred at the same temperature for 18 h. The reaction was quenched with 30 mL aqueous 4 M HCl and extracted with EtOAc (3 × 15 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to afford the mixture of isomers1h-2and1r-2.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 136618-42-3.

Reference of 141738-80-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141738-80-9 as follows.

General procedure: A mixture of 2-(3,5-dichloro-pyridin-4-yl)-7-ethynyl-4,4-dimethyl-1,4-dihydro-chromeno[3,4-d] imidazole 19a (0.1 g, 0.270 mmol), tetrabutylammonium fluoride (0.255 g, 0.810 mmol), dichlorobis- (triphenylphosphine)palladium (II) (15 mg, 0.021 mmol), 1-chloro-2-iodo-4-trifluoromethyl-benzene (0.125 g, 0.405 mmol) was heated in dry-DMSO (4.0 mL) at 80 C for 4-6 h. The reaction mass was quenched with water and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate, concentrated under reduced pressure and purified by flash chromatography to afford compound 20a (0.06 g, 42%) as brown solid.

According to the analysis of related databases, 141738-80-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 133232-56-1, name is 3-Iodo-2-methylbenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133232-56-1, Computed Properties of C8H7IO2

To a solution of compound 2 (63.0 g, 0.24 mol) in MeOH (300 mL) was added dropwise a freshly prepared solution of SOCI2 (52 mL, 0.72 mol) in MeOH (100 mL) at 0 0C. The mixture was heated to reflux for 3 hours. TLC (petroleum ether: ethyl acetate = 10:1) showed the reaction was complete, then the mixture was concentrated in vacuo. The residue was purified by column chromatography (petroleum ether) to afford compound 3 (60 g, 92%) as brown oil. 1H NMR (400 MHz, CDCI3): delta 7.94-7.96 (d, J = 8.0 Hz, 1 H), 7.71-7.73 (d, J = 8.0 HzJ H), 6.87- 6.91 (t, J = 8.0 Hz, 1 H), 3.88 (s, 3H), 2.65 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 136618-42-3, These common heterocyclic compound, 136618-42-3, name is Benzyl 4-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the 6-methyl-1 H-indazol-4-amine (8.26g, 54.2mmol) in dry DMF (100ml) was added iodobenzoic acid benzyl ester (19g, 56.2mmol) followed by potassium carbonate (8.15g, 59mmol), 1 /?,2/?-lambda/,lambda/’-dimethyl-1 ,2-cyclohexanediamine (0.425g, 3.0mmol) and copper (I) iodide (0.284g, 1.5mmol). The mixture was heated to 11 O0C for 5hr when LCMS showed ca. 50% conversion. Potassium carbonate (8.15g, 59mmol) was added followed by copper (I) iodide (0.284g, 1.5mmol) and 1 /?,2/?-lambda/,lambda/’-dimethyl-1 ,2-cyclohexanediamine (0.425g, 3.0mmol) and the mixture was heated to 1 1O0C for 5hr when LCMS showed absence of starting materials. The majority or the solvent was removed in vacuo and the residue was partitioned between ethyl acetate (500ml) and water (500ml). The emulsion which ensued was filtered through celite and separated. The organics were washed with saturated sodium thiosulphate solution (250ml) then brine (250ml) and dried (sodium sulphate). The mixture was filtered and concentrated in vacuo. The residue (ca. 22g) was dissolved in DCM (100ml), placed on a silica (50Og) column, pre-eluted with cyclohexane and eluted with DCM (500ml), 2% ethyl acetate/DCM (1000ml), 3% ethyl acetate/DCM (2000ml), 4% ethyl acetate/DCM (1000ml), 5% ethyl acetate/DCM (2000ml) then 10% ethyl acetate/DCM (1000ml) to give the title compound as a pale yellow solid (5.6g, 27.9%). LCMS: tRET = 3.72min, MH+ 358.1H NMR (400 MHz, CHLOROFORM-d) deltappm 8.24 (d, 2H) 8.1 1 (s, 1 H) 7.85 (d, 2H) 7.49 (d, 2H) 7.35 – 7.45 (m, 3H) 7.00 (s, 1 H) 6.32 (s, 1 H) 5.41 (s, 2H) 2.40 (s, 3H).The impure fractions (10g) were purified by CombiFlash Companion XL using a RediSep cartridge (75Og silica) eluting with a gradient of DCM/20% ethyl acetate/DCM over eight column volumes. This gave additional product (1.5g, 7.47%). 1H NMR (400 MHz, CHLOROFORM-d) deltappm 8.37 (s, 1 H) 8.22 (d, 2H) 7.99 (d, 2H)7.48 (d, 2H) 7.35 – 7.45 (m, 3H) 6.99 (s, 1 H) 6.15 (s, 1 H) 5.40 (s, 2H) 2.37 (s, 3H).

Statistics shows that Benzyl 4-iodobenzoate is playing an increasingly important role. we look forward to future research findings about 136618-42-3.

Synthetic Route of 14192-12-2,Some common heterocyclic compound, 14192-12-2, name is 2,5-Diiodobenzoic acid, molecular formula is C7H4I2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 : A RBF equipped with a reflux condenser was charged with 4-bromophenol (15.5 g, 89.4 mmol), 2,5-diiodobenzoic acid (25.700 g, 68.7 mmol), EtOAc (0.337 ml, 3.44 mmol), and toluene (100 mL). Cs2C03 (44.8 g, 137 mmol) was carefully added portion- wise. After stirring at RT for 1 min, the mixture was heated to 50 C for 40 min and then heated to 100 C for 20 hrs. The reaction mixture was allowed to cool to RT. The mixture was filtered through Celite and the solids were washed with EtOAc. The filtrate was diluted with water (200 mL), acidified with 2N HC1 (300 mL), and extracted with EtOAc (4 x 500 mL). The organic extract was washed with brine and dried over sodium sulfate. The organic fraction was concentrated under reduced pressure to afford crude 2- (4-bromophenoxy)-5-iodobenzoic acid (31.1 g) as a tan oil that solidified upon standing

The synthetic route of 14192-12-2 has been constantly updated, and we look forward to future research findings.

Related Products of 42048-11-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42048-11-3 name is 2-Chloro-6-iodotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Specific operation: In a 25 mL reaction flask equipped with a magnetic stirrer, a metal catalyst palladium acetate (6.7 mg, 0.03 mmol), triphenylphosphine (20.0 mg, 0.075 mmol) was added,S-2-bromophenyl-S-methyliminosulfanone (70.0 mg, 0.3 mmol), norbornene (56.4 mg, 0.6 mmol), potassium carbonate (82.8 mg, 0.6 mmol),Protect with nitrogen (at least three nitrogen cycles), add acetonitrile (3 ml) and 2-chloro-6-iodotoluene (90.9 mg, 0.36 mmol) successively in a nitrogen stream and close the vessel.The reaction solution was heated to 80 C. for about 12 h, and the reaction was complete by TLC.After the treatment, the reaction solution was first diluted with 15 ml of ethyl acetate, and then the inorganic substances such as the catalyst and the alkali were removed by suction filtration through a sand funnel containing silica gel.The resulting filtrate was separated by flash column chromatography to give the pure product 8-chloro-5,7-dimethyldibenzo[c,e][1,2]thiazine-5-oxide compound 3i. Yield: 45%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-iodotoluene, and friends who are interested can also refer to it.

Related Products of 172681-47-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 172681-47-9, name is 2-Amino-6-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 3-iodo-2-methylbenzenamine (4.45 g, 19.1 mmol, 1.0 equiv), bis(pinacolato)diboron (5.80 g, 22.91 mmol, 1.2 equiv), and potassium acetate (5.60 g, 57.3 mmol, 3.0 equiv) in DMSO (70 mL), was added dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct (421 mg, 0.573 mmol, 0.03 equiv). The mixture was heated at 80 C. until the starting material was consumed. The solvent was removed in vacuo and the residue taken up in EtOAc (ca. 200 ml) and washed with water and brine. After drying with Na2SO4 and concentrating in vacuo, the residue was purified by silica gel chromatography (3:1 hexanes:EtOAc to 1:3 hexanes:EtOAc) to provide 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine. MS (M+H+) 234; Calculated for C13H20BNO2: 233.2

The synthetic route of 2-Amino-6-iodotoluene has been constantly updated, and we look forward to future research findings.

Related Products of 5469-33-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5469-33-0, name is (Iodomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE J-1 Procedure for Preparation of 4(5)-cyclohexylmethyl-1H-imidazole: Procedure- 2-Tert-butyldimethylsilyl-1-dimethylsulfamoyl imidazole (1) (4.1 g, 14.2 mmol) is taken up in 47 mL of anhydrous THF and cooled to -20 C. n-BuLi (8.9 mL, 14.2 mmol) is added dropwise to the solution of (1). The resultant solution is stirred at -20 C. for 45 min. Cyclohexylmethyl iodide (2) (3.14 g, 14 mmol) is then added dropwise to the reaction mixture. Then reaction is warmed to rt and stirred overnight. The next day the reaction is quenched with saturated ammonium chloride and diluted with water. The mixture is extracted with ethyl acetate (3*100 mL). The organic layers are combined and washed with water followed by brine. The organic phase is dried over sodium sulfate and the solvent removed under reduced pressure. Flash chromatography (4:1 ethyl acetate/hexane) affords 2.26 g (5.6 mmol) of 5-cyclohexylmethyl-2-tert-butyldimethylsilyl-1-dimethylsulfamoyl imidazole (3).

The chemical industry reduces the impact on the environment during synthesis (Iodomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 481075-59-6, name is 1-Bromo-3-iodo-5-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Bromo-3-iodo-5-(trifluoromethyl)benzene

Step 1: To a solution of 1-bromo-3-iodo-5-(trifluoromethyl)benzene (55) (2.0 g, 5.7 mmol), thiobenzoic acid (56), (0.67 ml, 5.7 mmol), 1,10-phenanthroline (0.21 g, 1.08 mmol) in toluene were added DIPEA (2 ml) and CuI (0.11 g, 0.57 mmol). The resulting mixture was degassed by bubbling argon for 2 min and stirred at 110 C. for 24 hrs under argon. The reaction mixture was filtered through Celite and concentrated under reduced pressure. Purification by flash chromatography (5% to 15% EtOAc hexanes gradient) gave benzothioate 57 as a light yellow oil. Yield (1.7 g, 82%); 1H NMR (400 MHz, CD3OD) delta 7.96-8.04 (m, 4H), 7.80-7.83 (m, 1H), 7.69 (tt, J=6.0, 1.6 Hz, 1H), 7.53-7.58 (m, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 481075-59-6.