Category: iodides-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 19393-94-3, name is 2,4-Dibromo-1-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19393-94-3, COA of Formula: C6H3Br2I

Into a 100ml two-necked flask feed 2, 4-dibromo-1-iodobenzene (3.6g), trimethylsilylacetylene (1. 1g), CuI (O.11g), Pd(PPh3)2C12 (0.21g) molar ratio is based on 1:1.1 :0.06:0.03, solvent selection as 50ml anhydrous tetrahydrofuran, anhydrous anaerobic conditions are controlled at 0 C, stir for 30 minutes, distillation under reduced pressure and then obtained 3.16g of ((2,4-dibromophenyl) ethynyl) trimethylsilane, yield is 95%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dibromo-1-iodobenzene, and friends who are interested can also refer to it.

Synthetic Route of 52914-23-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52914-23-5 name is 2-(4-Iodophenyl)ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of N,N(-bis(tert-butoxycarbonyl)-S-methylisothiourea (937 mg, 3.2 mmol), triphenylphosphine (5.0 g, 18 mmol) and 2-[(4-iodophenyl)ethyl]alcohol (1a, 800 mg, 3.2 mmol) were stirred in anhydrous THF (16 mL) at room temperature under nitrogen atmosphere. DIAD (3.8 ml, 18 mmol) was slowly added to reaction mixture and reaction was stirred at room temperature for 24 h. The reaction mixture was filtered through a Celite pad with washing CH2Cl2 and the solvent was removed under reduced pressure. The residue was purified by flash column chromatography (silica gel, 5% ethyl acetate in hexane) to afford the product 2 (1.1 g, 66%) as a colorless oil; 1H NMR (400 MHz, CDCl3) (7.61 (d, J = 8.4 Hz, 2H), 6.98 (d, J = 8.0 Hz, 2H), 3.72-3.64 (m, 2H), 2.96-2.88 (m, 2H), 2.37 (s, 3H), 1.51 (s, 9H), 1.48 (s, 9H); 13C NMR (100 MHz, CDCl3) (162.7, 158.0, 151.8, 138.2, 137.7, 131.1, 91.8, 82.7, 82.1, 50.1, 34.9, 28.2, 28.1, 15.8; HRMS (FAB) calcd for C20H30IN2O4S (M+) 521.0971, found 521.0966.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Iodophenyl)ethanol, and friends who are interested can also refer to it.

Related Products of 447464-03-1, A common heterocyclic compound, 447464-03-1, name is 2-Fluoro-3-iodobenzoic acid, molecular formula is C7H4FIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0459] A solution of Example 73a (3.0 g, 11.2 mmol) and KBr03 (3.7 g, 22.0 mmol) in 15 mL of cone. H2S04. The reaction mixture was stirred for 2 h at 90C; LC-MS (BD01052-127) analysis showed Example 73a was consumed; the mixture was poured into 250 mL water and stirred for 10 min. The mixture was extracted with EA (250 mL * 3). The combined organic phase was dried over Na2S04, filtrated and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the desired product (Example 73b, 3.5 g, yield: 65%) as a yellow solid.LCMS [M+l]+ = 344.0

The synthetic route of 447464-03-1 has been constantly updated, and we look forward to future research findings.

Application of 689260-53-5,Some common heterocyclic compound, 689260-53-5, name is 2-Bromo-5-iodo-1,3-dimethylbenzene, molecular formula is C8H8BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2,5-dibromo-1 ,3-dimethylbenzene (2.00 g), 1 -furan-3-ylboronic acid (856 mg), and 2 M aqueous Na2CO3 solution (1 1 ml_) in 1 ,4-dioxane (40 ml_) is purged with argon for 5 min. Tetrakis-triphenylphosphine-palladium-(O) (270 mg) is added and the mixture is stirred at 100 C over n ight. More tetrakis- triphenylphosphine-palladium-(O) (50 mg) is added and the mixture is stirred for another 5 h at 100 C. After cooling to room temperature the mixture is diluted with ethyl acetate and aqueous NH CI solution. The aqueous phase is extracted with ethyl acetate and the combined extracts are washed with brine, dried over MgSO4 and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 100:0?90:10) to give the title compound. LC (method 7): tR = 1 .22 min; Mass spectrum (Epsilon ): m/z = 250 [M]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-5-iodo-1,3-dimethylbenzene, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 117832-17-4 as follows. COA of Formula: C8H10IN

General procedure: To a two-necked round-bottomed flask fitted with a guard tube, PBr3 (2.7mmol, 0.26 mL), DMF (3 mmol, 0.23 mL) and chloroform (0.80 mL) were added, allowed to cool to 0 C and stirred for 0.5 h. After formation of colourless solid complex, 2-Iodo-4-methyl-phenylamine 2b (1 mmol) in chloroform (5 mL) was added and the reaction mixture was allowed to stir at r.t. for another 1-2 h. After completion, the reaction mixture was neutralized by adding saturated NaHCO3 solution and then extracted with DCM (3X 20 mL). Combined organic layer was washed with brine and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was purified through column chromatography using silica gel (60-120 mesh) and petether/EtOAc (5:1) as eluent.

According to the analysis of related databases, 117832-17-4, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 29289-13-2, name is 2-Iodo-4-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 29289-13-2

General procedure: A mixture of 2-iodoaniline (0.5 mmol), isothiocyanate (0.6 mmol), CuO nanoparticles (0.05 mmol), and Cs2CO3 (1.5 mmol) in PEG-400 (3mL) was stirred at 80C for 8h (Scheme 1). After the reaction, the reaction mixture was centrifuged and catalyst was separated from the reaction mixture and then followed by washing with ethyl acetate and acetone, dried in vacuo and used directly for further catalytic reactions. The cooled solution was partitioned between ethyl acetate and water, and the organic layer was washed with water and brine, and then dried over Na2SO4. After the removal of the solvent in vacuo, the residue was purified by silica-gel chromatography to give the desired N-substituted-2-aminobenzothiazoles. All the compounds were characterized by comparison with authentic samples [41].

The synthetic route of 2-Iodo-4-methylaniline has been constantly updated, and we look forward to future research findings.

Synthetic Route of 19099-54-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19099-54-8, name is 1-Iodo-2-isopropylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 7-(2-isopropyl)-phenylamino-9,9-diethylfluorene-2-nitrile (7.6 g, 19.97 mmol), 2-isopropyliodobenzene (24.88 g, 101 m·mol), copper powder (3.13 g, 49.25 mmol), potassium carbonate (12.71 g, 92 mmol), 18-crown-6 (0.34 g, 1.29 mmol) and xylenes (5 mL) was held at 165-175 C. for 19 hours cooled, diluted with toluene and filtered. The filtrate was washed with water, dried and concentrated. The residual liquid (27.15 g) was chromatographed over silica gel, and elution with 3:1 heptane-toluene recovering first the unreacted iodobenzene. The product came out in 1:1 and 65% toluene-heptane eluates, and was recrystallized from isopropanol, 6.82 g (68%), m.p. 179.2-180.4 C. Mass spec: m/z 498 (M+). Analysis: Calcd for C36H38N2: C, 86.70; H, 7.68 and N, 5.62%. Found: C, 86.61; H, 7.68, and N, 5.41%. 1H NMR (CDCl3) delta ppm: 0.27 (t, 6H, 7.32 Hz), 1.04 (d, 12H, 6.36 Hz), 1.89 (m, 4H), 3.26 (q, 2H, 6.6 Hz), 6.67 (m, 2H), 6.97 (d, 2H, 7.64 Hz), 7.17 (m 2H), 7.21 (m, 2H), 7.35 (dd, 2H, 1.28 and 7.72 Hz), 7.49 (t, 2H, 5 Hz), 7.54 (m, 2H). 13C NMR delta ppm: 8.32, 23.48, 27.42, 32.44 and 56.36 (5 sp3C), 108.15, 118.98, 120.14, 121.15, 125.87, 126.07, 126.73, 127.59, 128.36, 131.39, 132.18, 145.37, 146.37, 149.96, 151.91 and 152.55 (16 sp2 and sp C).

The synthetic route of 1-Iodo-2-isopropylbenzene has been constantly updated, and we look forward to future research findings.

Reference of 364-75-0,Some common heterocyclic compound, 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-FLUORO-3-NITRO-1-CYCLOPROPYLBENZENE was prepared FROM 2-FLUORO-5-IODO-1- nitrobenzene and tricyclopropylindium according to the method described in J. Am. Chem. Soc. 2001,123, 4155-4160.

The synthetic route of 364-75-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 702641-04-1, name is 2-Iodo-5-(trifluoromethyl)benzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 702641-04-1

Intermediate 37a and 37b: 2-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)benzoic acid (Intermediate 37a) and 2-(1H-1,2,3-Triazol-1-yl)-5-(trifluoromethyl)benzoic acid (Intermediate 37b) To a solution of 2H-1,2,3-triazole (CAS number 288-36-8; 1.0 g, 10.86 mmol) in DMF (4 ml) at 0-10 C. was added cesium carbonate (4.71 g, 14.49 mmol), copper (I) iodide (68 mg, 0.36 mmol), trans-1-N,2-N-dimethylcyclohexane-1,2-diamine (200 mg, 1.44 mmol) and 2-iodo-5-(trifluoromethyl)benzoic acid (CAS number 702641-04-1; 2.28 g, 7.24 mmol). The reaction was subjected to microwave irradiation at 120 C. for 15 minutes and was then partitioned between ethyl acetate (2×100 ml) and water (50 ml). The aqueous layer was acidified with HCl (aq, 2M) to give pH 2 and the organics were extracted with ethyl acetate (3×100 ml). The combined organics were washed with brine, dried over sodium sulfate and concentrated in vacuo. The resulting residue was purified by column chromatography (silica, 0-3% methanol/DCM) to afford 2-(2H-1,2,3-triazol-2-yl)-5-(trifluoromethyl)benzoic acid (Intermediate 37a; also commercially available CAS number 1384066-81-2). The mixed fractions were further purified by column chromatography (silica, 0-3% methanol/DCM) followed by reverse phase preparative HPLC (eluted with acetonitrile/water containing 0.1% formic acid) to afford 2-(1H-1,2,3-triazol-1-yl)-5-(trifluoromethyl)benzoic acid (Intermediate 37b). Intermediate 37a 1H NMR (400 MHz, DMSO) delta ppm 8.07-8.08 (m, 3H), 8.20 (s, 2H), 13.57 (bs, 1H) MS ES+: 258 Intermediate 37b 1H NMR (400 MHz, DMSO) delta ppm 7.90-7.97 (m, 2H), 8.16-8.21 (m, 2H), 8.65 (s, 1H), 13.65 (bs, 1H) MS ES+: 258

The synthetic route of 702641-04-1 has been constantly updated, and we look forward to future research findings.

Related Products of 19718-49-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19718-49-1 name is Methyl 4-amino-3-iodobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of methyl 4-amino-3-iodobenzoate (100 mg,0.36 mmol) and triethylamine (101 mu, 0.72 mmol) in DCM (3 ml) was added dropwise to a cooled (0 C) solution of trifluoroacetic acid anhydride (127 mu, 0.90 mmol) in DCM (1 ml). The cooling bath was removed and the mixture was stirred for 1.5 h. The crude product was poured into cold water and DCM was added. The phases were separated; solvents were removed in vacuo and the crude product taken to the next step without further purification. Yield: 129 mg (96%); white solid. MS (ESI+) m z 374 [M+H]+. HPLC purity: 96%. 1H NMR (600 MHz, CDC13) delta ppm 8.51 (d, J=1.83 Hz, 1 H) 8.47 (br. s., 1 H) 8.36 (d, J=8.54 Hz, 1 H) 8.08 (dd, J=8.85, 1.83 Hz, 1 H) 3.93 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-amino-3-iodobenzoate, and friends who are interested can also refer to it.