Category: iodides-buliding-blocks

Electron transfer mechanism for periodic acid oxidation of aromatic substrates was written by Bhatt, M. V.;Hosur, B. M.. And the article was included in Indian Journal of Chemistry in 1986.Quality Control of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Oxidation of phenolic ethers, e.g. I (R = Me, R¹ = H) with 1 equiv of H₅IO₆ gave the iodinated product I (R = Me, R¹ = iodo). Use of 2 equiv of oxidant gave I (R = CHO, R¹ = iodo) in which the side chain was oxidized. Oxidation of binaphthyl II with either H₅IO₆ or ceric ammonium nitrate in MeOH gave the same cyclized product III. ESR signals were found for the H₅IO₆ oxidation of 11 aromatic substrates. The ESR data and addnl. chem. evidence suggest a radical cation mechanism for the oxidation In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Quality Control of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective angiotensin II AT₂ receptor agonists: Benzamide structure-activity relationships was written by Wallinder, Charlotta;Botros, Milad;Rosenstroem, Ulrika;Guimond, Marie-Odile;Beaudry, Helene;Nyberg, Fred;Gallo-Payet, Nicole;Hallberg, Anders;Alterman, Mathias. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: N,N-Diethyl-4-iodobenzamide This article mentions the following:

In the investigation of the structure-activity relationship of nonpeptide AT₂ receptor agonists, a series of substituted benzamide analogs of the selective nonpeptide AT₂ receptor agonist M024 have been synthesized. In a second series, the biphenyl scaffold was compared to the thienylphenyl scaffold and the impact of the iso-Bu substituent and its position on AT₁/AT₂ receptor selectivity was also investigated. Both series included several compounds with high affinity and selectivity for the AT₂ receptor. Three of the compounds were also proven to function as agonists at the AT₂ receptor, as deduced from a neurite outgrowth assay, conducted in NG108-15 cells. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Recommanded Product: N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Development of a Palladium-Catalyzed Carbonylative Coupling Strategy to 1,4-Diketones was written by Yin, Hongfei;Nielsen, Dennis U.;Johansen, Mette K.;Lindhardt, Anders T.;Skrydstrup, Troels. And the article was included in ACS Catalysis in 2016.COA of Formula: C8H9IO2 This article mentions the following:

We report on a three-component palladium-catalyzed coupling strategy for accessing a wide range of 1,4-diketones, which represent important precursors to heterocycles. Our method relies on a carbonylative Heck reaction employing substituted allylic alcs., aryl iodides, and carbon monoxide. The reaction conditions are mild and do not require high CO pressure, and a wide functional group tolerance is revealed, providing the desired 1,4-diketones in moderate to good yields. Furthermore, the methodol. is adaptable to the selective installment of ¹³C-carbon isotopes at either one or both of the carbonyl positions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents was written by Tan, Hanyi;Liu, Yue;Gong, Chaochao;Zhang, Jiawei;Huang, Jian;Zhang, Qian. And the article was included in European Journal of Medicinal Chemistry in 2021.HPLC of Formula: 1012785-51-1 This article mentions the following:

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized according to the E-pharmacophores generated by docking a library of 667 fragments into the ATP pocket of the co-crystal complex of FAK and PF-562271 (PDB ID: 3BZ3). The 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine derivatives demonstrated excellent activity against FAK and the cell lines SMMC7721 and YY8103. 2-((2-((3-(Acetamidomethyl)phenyl)amino)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide (I) was selected for further bioactivity evaluations in vivo, including preliminary pharmacokinetic profiling in rats and toxicity assays in mice, and tumor growth inhibition studies in a xenograft tumor model. The results showed that I did not affect the body weight gain of the animals up to a dose of 200 mg/kg, and significantly inhibited tumor growth with a tumor growth inhibition rate of 78.6% compared with the neg. control group. Furthermore, phosphoantibody array analyses of a sample of the tumor suggested that I inhibited the malignant proliferation of hepatocellular carcinoma (HCC) cells through decreasing the phosphorylation in the FAK cascade. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1HPLC of Formula: 1012785-51-1).

2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.HPLC of Formula: 1012785-51-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans was written by Csekei, Marton;Novak, Zoltan;Kotschy, Andras. And the article was included in Tetrahedron in 2008.Name: 4-Bromo-2-iodophenol This article mentions the following:

An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Name: 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Name: 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New methods of imidazole functionalization – from imidazole to marine alkaloids was written by Du, Hongwang;He, Yong;Rasapalli, Sivappa;Lovely, Carl J.. And the article was included in Synlett in 2006.Application In Synthesis of 4,5-Diiodo-1H-imidazole This article mentions the following:

The pyrrole-imidazole family of marine alkaloids, the so-called oroidin natural products, exhibits an impressive diversity of structural motifs. The majority of these natural products contain one or more imidazole moieties intricately embedded within a polycyclic framework and thus present significant challenges to extant synthetic methods. Our approach to this problem has centered on the development of methods for the elaboration of simple imidazoles. This review describes the results of these efforts leading to the development of a variety of methods, including cycloadditions, oxidative and transition-metal-catalyzed reactions (e.g., with π-allylpalladium). In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Application In Synthesis of 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application In Synthesis of 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

TosMIC and its derivatives as versatile sulfonylating agents for the synthesis of p-toluenesulfonylarenes from aryl halides and arylboronic acids was written by Ravi Kumar, G.;Ramesh, B.;Banik, Swarnayu;Subba Reddy, B. V.. And the article was included in Tetrahedron in 2020.HPLC of Formula: 5460-32-2 This article mentions the following:

An efficient copper(II) catalyzed sulfonyation of aryl halides had been achieved using TosMIC (p-toluenesulfonylmethyl isocyanide) as a sulfonylating agent. This newly developed sulfonylation approach provided an easy access for the synthesis of diaryl sulfones I [Ar = Ph, 4-MeOC₆H₄, 2-pyridyl, etc.] from aryl bromides, iodides and boronic acids with TosMIC under neutral conditions. This method was useful for the sulfonylation of aryl boronic acids under similar conditions. This was the first report on the sulfonylation of aryl bromides, iodides and boronic acids using TosMIC. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2HPLC of Formula: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium Nanoparticle-Catalyzed Stereoselective Domino Synthesis of All-Carbon Tetrasubstituted Olefin Containing Oxindoles via Carbopalladation/C-H Activation was written by Parveen, Naziya;Sekar, Govindasamy. And the article was included in Journal of Organic Chemistry in 2020.SDS of cas: 5460-32-2 This article mentions the following:

The binaphthyl stabilized palladium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis of sym. and unsym. all-carbon tetrasubstituted olefin containing oxindoles from readily accessible anilides has been developed. The Pd-BNP catalyst showed a wide range of functional group tolerance that enabled building a library of heteroaromatics This reusable Pd catalyst reflected its utility in the synthesis of biol. important AMP-activated protein kinase deprived of any metal Pd contamination. The nanocatalyst was easily recovered and reused five times without any appreciable loss in particle size or catalytic activity. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Encapsulation of polyoxotungstate into dendrimers by ionic bonding and their use as oxidation catalyst was written by Jahier, Claire;Plault, Lauriane;Nlate, Sylvain. And the article was included in Israel Journal of Chemistry in 2009.Related Products of 10297-05-9 This article mentions the following:

A family of 36-armed dendrimers containing six internal amino groups was synthesized and used to incorporate polyoxometalates (POMs) into their structures by ionic bonding. Allyl-terminated dendrimer 17 (with oxidizable end groups) and methylphenyl-terminated dendrimer 18 (with non-oxidizable end groups) were used for these studies. It was found that the electrostatic incorporation of the tri-anionic POM [PO₄{WO(O₂)₂}₄]^3- into the methylphenyl-terminated dendrimer 18, in an acidic medium, leads to the dendritic POM hybrid 19, bearing two POM units in its structure. In contrast, attempts to encapsulate POMs into allyl-terminated dendrimer 17 gave unsatisfactory results. Indeed, the epoxidation kinetics of the 36-olefinic terminated dendrimer 17 was too slow, and the expected 36-epoxy-dendritic POM framework 20 was not obtained. Lengthening the reaction up to six hours led to the decomposition of POM species. The solubility in organic solvents of the dendritic POM hybrid 19, combined with its NMR and IR data, indicate that POM units are clearly connected to the dendritic structure. The catalytic performance of this hybrid material in the oxidation of cyclooctene shows that the properties of POM are retained. The POM-encapsulated dendrimer 19 was found to be an effective catalyst in the oxidation of cyclooctene. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Related Products of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Related Products of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration was written by Ruzi, Rehanguli;Ma, Junyang;Yuan, Xiang-Ai;Wang, Wenliang;Wang, Shanshan;Zhang, Muliang;Dai, Jie;Xie, Jin;Zhu, Chengjian. And the article was included in Chemistry – A European Journal in 2019.Application of 20776-54-9 This article mentions the following:

An unprecedented deoxygenative arylation of aromatic carboxylic acids was achieved, allowing the construction of an enhanced library of unsym. diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chem. allows for precise cleavage of a stronger C-O bond and formation of a weaker C-C bond by 1,5-aryl migration under mild reaction conditions. This new protocol was independent of substrate redox-potential, electronic, and substituent effects. It afforded a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Application of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com