Category: iodides-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 89488-57-3, name is 1,4-Diiodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89488-57-3, COA of Formula: C6H3I2NO2

(RS)-1-(4-Iodo-2-nitrophenyl)-2,2-dimethyl-1-propanol: Under a nitrogen atmosphere a solution of 1,4-diiodo-2-nitrobenzene (3.0 g, 8.0 mmol) in anhydrous THF (20 mL) was cooled to minus 40 C., and then a solution of phenylmagnesium chloride (2 M in THF, 4.8 mL, 9.6 mmol) was added dropwise at a rate that the temperature would not exceed minus 35 C. Upon completion of the addition the mixture was stirred for ten minutes, followed by addition of trimethylacetaldehyde (1.2 mL, 11.2 mmol), and the mixture was stirred for 30 minutes at minus 40 C. The mixture was gradually warmed up to room temperature, quenched with saturated ammonium chloride (60 mL), poured into water (120 mL), and extracted with ethyl acetate twice (60 mL each). The combined organic phase was washed with water (60 mL), dried over Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography to yield racemic (RS)-1-(4-iodo-2-nitrophenyl)-2,2-dimethyl-1-propanol (2.17 g, 81%) as a brown oil. 1H NMR (400 MHz, CDCl3): delta 8.04 (d, 1 H, J=1.6 Hz, Ph-H), 7.88 (dd, 1 H, J=1.6 and 8.4 Hz, Ph-H), 7.51 (d, 1 H, J=8.4 Hz, Ph-H), 5.28 (d, 1 H, J=3.6 Hz, Ph-CH), 2.29 (d, 1 H, J=3.6 Hz, OH), 0.85 (s, 9 H, C(CH3)3). 13C NMR (100 MHz, CDCl3): delta 149.87 (C), 141.0 (CH), 136.2 (C), 132.3 (CH), 131.63 (CH), 91.85 (C), 74.33 (CH), 36.81 (C), 25.6 (CH3).

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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6940-76-7 as follows. SDS of cas: 6940-76-7

(b) 4-(3-Chloro-propane-1-sulfonyl)-1,2-difluoro-benzene To 3,4-difluoro-benzenesulfinic acid (500 mg, 2.81 mmol) and triethylamine (0.43 ml, 3.10 mmol) in 10 ml DMF was added 1-chloro-3-iodopropane (1.43 g, 7.00 mmol) and the mixture heated at 65 C. for 3 h. The reaction mixture was then poured onto water and extracted three times with ethyl acetate. The combined organic phases were then washed with saturated aq. NaCl solution, dried over Na2SO4, and concentrated in vacuo. The residue was chromatographed over SiO2 (ethyl acetate/heptane 1:50) to afford the title compound (300 mg, 42%) as an off-white crystalline solid. MS (ISP): 257.2 {37Cl}MH+, 255.1{35Cl}MH+

According to the analysis of related databases, 6940-76-7, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H5IO2

General procedure: 2-Phenylindole (408 mg, 2.0 mmol, 1 equiv), aryl iodide (2.0 mmol, 1 equiv), NaOt-Bu (288mg, 3.0 mmol,, 1.5 equiv), CNT-CuO (contained Cu 9.1 %, 70 mg, 5.0 mol%), were reacted in DMSO (10.0 mL) at 120 C for 12 h. The mixture charged to separating funnel added water, extracted with EtOAc. The organic layer washed with water many times for removing water, dried over magnesium sulfate. Evaporation of the solvent under reduced pressure provided the crude product, which was purified by column chromatography on silica gel.(eluent : hexane / ethyl acetate = 10 / 1).

The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 64248-58-4, These common heterocyclic compound, 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 50- mL RB-flask was added [3- (4-HYDROXYPHENYL)] propionic acid (1.66 g, [10.] 0 mmol), 3,4-difluoroiodobenzene (2.40 g, 10.0 mmol), copper (I) bromide (0.100 g), potassium carbonate (2.76 g, 20.0 [MMOL),] and [N-METHYL-2-PYRROLIDONE] (20 [ML)] as solvent. The mixture was stirred for 5 min at room temperature and then heated to [140 C] (oil bath). After being stirred for 12 hours at [140 C,] the reaction mixture was cooled to room temperature and diluted with [ETOAC] (100 mL). The diluted mixture was washed with citric acid (aq, 30 mL), water (3 x 50 mL, brine and dried over [MGS04. THE] removal of solvent in vacuo afforded crude which was purified by chromatography (0.901 g, [32%)] : [1H] NMR (400 MHz, CDCl3) 8 11.44-11. 06 (br, 1H), 7.24-7. 14 (m, 2H), 7.14-7. 00 (m, [1H),] 7.00-6. 86 (m, 2H), 6.86-6. 75 (m, 1H), 6.75-6. 61 (m, 1H), 2.94 (t, 2H, J = 7.6 Hz), 2.68 (t, 2H, [J = 7.] 6 Hz); ESMS [M/E] : 277.2 (M-H+).

Statistics shows that 1,2-Difluoro-4-iodobenzene is playing an increasingly important role. we look forward to future research findings about 64248-58-4.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H4F3I

General procedure: General procedure: A 25 mL two-necked, round bottomed flask equipped with a water condenser, nitrogen gas inlet, Teflon coated magnetic stir bar, and a rubber septum port was charged with Pd(PPh3)4 (0.48 g, 3?5 molpercent), Cu(I)I (0.87 g, 4.6 mmol), and 10 mL of dry DMF. Next, 3-iodobenzotrifluorine (2.28 g, 8.30 mmol) was added to the solution via syringe. Then, 2 (3.93 g, 9.22 mmol) was slowly added to this solution by syringe. The reaction mixture was stirred 12 h at room temperature. To remove the ISnBu3-n, the reaction mixture was stirred with Cu(OAc)2 (3.36 g, 18.4 mmol) and 5 mL of extra DMF for 2 h. Alternately, dry KF (0.58 g, 9.9 mmol) was added to the reaction flask and the mixture was stirred overnight. The reaction mixture was then poured over water (25 mL) in a separatory funnel and extracted with ether (3× 25 mL). The combined ether layers were washed with water (2× 25 mL). The organic layer was dried over MgSO4, filtered, and the solvent was removed by rotary evaporation. The crude product was purified by silica gel column chromatography using hexanes as eluent to give 4 (2.90 g, 82percent isolated yield, Rf (hexanes) = 0.36, purity by GLPC analysis = 98percent): 19F NMR (CDCl3) ?63.4 ppm (s, 3F), ?143.3 ppm (dt, 1F, 3JFF = 122.6 Hz, 3JFH = 23.9 Hz), ?159.8 ppm (dt, 1F, 3JFF = 123.7 Hz, 4JFH = 4.6 Hz); 19F{H} NMR (CDCl3): ?63.4 ppm (s, 3F), ?143.3 ppm (d, 1F, 3JFF = 122.9 Hz), ?159.8 ppm (d, 1F, 3JFF = 123.4); 1H NMR (CDCl3): 7.9 ppm (s, 1H), 7.8 ppm (d, 1H, 3JHH = 7.9 Hz), 7.6 ppm (dd, 1H, 3JHH = 9.0 Hz, 3JHH = 7.8 Hz), 7.5 ppm (d, 1H, 3JHH = 7.7 Hz), 5.9 ppm (ddt, 1H, 3JHH = 17.0 Hz, 3JHH = 10.2 Hz, 3JHH = 6.4 Hz), 5.3 ppm (dm, 1H, 3JHH = 17.1 Hz), 5.2 ppm (dd, 1H, 3JHH = 10.1 Hz, 2JHH = 1.3 Hz), 3.3 ppm (ddddd, 2H, 3JHF = 23.3 Hz, 3JHH = 6.5 Hz, 4JHH = 5.3 Hz, 4JHH = 1.4 Hz, 4JHH = 1.3 Hz); 13C NMR (CDCl3): 151.51 ppm (dd, 1JCF = 251.6 Hz, 2JCF = 55.9 Hz), 146.00 ppm (dd, 1JCF = 225.2 Hz, 2JCF = 43.3 Hz), 131.11 ppm (qd, 2JCF = 32.0 Hz, 4JCF = 2.7 Hz), 130.96 ppm (dd, 3JCF = 1.9 Hz, 4JCF = 1.8 Hz), 130.64 ppm (dd, 2JCF = 25.8 Hz, 3JCF = 6.6 Hz), 129.03 ppm (d, 4JCF = 2.0 Hz), 128.35 ppm (ddm, 3JCF = 8.5 Hz, 4JCF = 1.4 Hz), 125.16 ppm (m), 124.04 ppm (q, 1JCF = 272.3 Hz), 122.11 ppm (m), 118.43 ppm (s), 32.13 ppm (d, 2JCF = 22.8 Hz); GC?MS, m/z (relative intensity): 248 (M+, 100.00), 213 (62.76), 201 (62.15), 179 (85.05), 177 (57.02) 164 (92.70), 159 (70.96), 151 (98.55); HRMS: C12H9F5 (calculated: 248.0624, observed: 248.0620).

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 622-50-4, name is N-(4-Iodophenyl)acetamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-50-4, Quality Control of N-(4-Iodophenyl)acetamide

General procedure: Under nitrogen atmosphere, Cu2O (10 mol %), DABCO (25 mol %), and a stirring bar were added into a 10 mL oven-dried sealed glass tube (as shown in Figure S1). Then NMP (0.5 mL), aryl iodides (0.125 mmol, 1.0 equiv.) and PhSiH3 (0.75 mmol, 6 equiv.) were injected by syringe. The tube was then sealed and CO2 (0.67 mmol, 5.4 equiv., 15 mL) as well as NH3 (0.67 mmol, 5.4 equiv., 15 mL) were injected by syringe after N2 was removed under vacuum. Finally, the mixture was stirred for 24 hr in a pre-heated-to-130 C alloyed block. After the reaction was finished, the tube was cooled to room temperature and the pressure was carefully released. The yield of were measured by GC analysis using dodecane as the internal standard or by flash chromatography on silica gel (petroleumether/ethyl acetate).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-(4-Iodophenyl)acetamide, and friends who are interested can also refer to it.

Reference of 13421-13-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13421-13-1 name is 4-Chloro-2-iodobenzoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Iodo-4-chlorobenzoic acid (10 g, 35.5 mmol) and HBTU (17.5 g, 46 mmol) were added to DMF (100 ml), followed by cyclopropylamine (2.6 g, 46 mmol) and DIPEA (17.5 ml, 92 mmol). The reaction was stirred overnight before being quenched with 2.0 NaOH (100 ml), extracted with DCM (3 x 200 ml), dried and solvent removed in vacuo to yield a dark yellow solid. This was passed through a pad of silica, eluting with DCM, the filtrate was concentrated in vacuo to yield a yellow solid. Ether (200 ml) Was added, the slurry was sonicated for 20 mins, iso-hexane (100 ml) was then added and the system was stirred for 10 mins, filtered and dried to give a colourless solid (9.3 g, 82%). NMR (CDCl3) 7.82 (s, IH), 7.34 (d, IH), 7.28 (d, IH), 5.99 (s, IH), 2.94 – 2.84 (m, IH), 0.91 – 0.84 (m, 2H), 0.71 – 0.66 (m, 2H); m/z 322.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-2-iodobenzoic acid, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88-67-5, name is 2-Iodobenzoic acid, A new synthetic method of this compound is introduced below., Computed Properties of C7H5IO2

General procedure: Hydrazides (30-58) were synthesized by one pot conventionalmethod24 Benzoic acid or its derivative (10 mmol) was dissolvedin ethanol (20 mL). Sulfuric acid (3 N, 2 mL) was added and thereaction contents were refluxed for six hours. The reaction wasmonitored with TLC. After the completion of the reaction, the reactionmixture was neutralized by adding solid NaHCO3, and filteredto remove excess of NaHCO3. In the neutralized reaction mixture which contains ethyl ester, hydrazine monohydrate (1.5 mL,3 mmol) was added and refluxed for 3-6 h to complete the reaction.Ethanol and unreacted hydrazine were removed by distillationupto 1/3 volume. The reaction contents were cooled, filteredand recrystallized from methanol to obtain the desired hydrazidecrystals (see Supporting information).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 34270-90-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34270-90-1 as follows.

Preparation of Compounds 1002 – 1005: NaH (28.03 mg, 60%) was added into a solution of 2-(4-fluorophenyl)-5-hydroxy-N-methylbenzofuran-3-carboxamide (50 mg) and (E)-1,4-dibromobut-2-ene (75 mg) inPhH. The reaction was heated at 85C for 4 – 7 days. The reaction was quenched withMeOH and solvents were removed under vaccum to give a residue which was purified bypreparative HPLC._Compounds 1003 – 1015 and 2001 – 2005 were prepared using the sameprocedure for compound 1002, using the corresponding di-electrophiles. LC condition for compounds 1003 – 1015 and 2001 – 2005 was the same as for compound 1002.

According to the analysis of related databases, 34270-90-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-Iodo-1,3-dimethylbenzene

General procedure: Iodobenzene (1.2 mmol) and [Pd(pp3S4)(dba)] (1 mol %) were stirred in isopropanol (2.5 ml). Alcohol (1 mmol) followed by Cs2CO3 (5 mol %) were added to the above solution in the atmosphere of air. The mixture was heated to 80 C and the progress of the reaction was monitored by TLC. Rest of the procedure is same as described above.

According to the analysis of related databases, 608-28-6, the application of this compound in the production field has become more and more popular.