Category: iodides-buliding-blocks

Synthesis of diaryl ethers from tyrosine derivatives was written by Crimmin, Michael J.;Brown, Allan G.. And the article was included in Tetrahedron Letters in 1990.Related Products of 2314-37-6 This article mentions the following:

Diaryl ethers of tyrosine, maintaining optical activity, have been formed through the reaction of a tyrosine derivative with an aryl iodonium salt. Thus, iodonium salt I was treated with tyrosine derivative II in refluxing DMF to give 59% ether III. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Related Products of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Related Products of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) was written by Lagu, Bharat;Kluge, Arthur F.;Tozzo, Effie;Fredenburg, Ross;Bell, Eric L.;Goddeeris, Matthew M.;Dwyer, Peter;Basinski, Andrew;Senaiar, Ramesh S.;Jaleel, Mahaboobi;Tiwari, Nirbhay Kumar;Panigrahi, Sunil K.;Krishnamurthy, Narasimha Rao;Takahashi, Taisuke;Patane, Michael A.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Recommanded Product: 15813-09-9 This article mentions the following:

Arylheterocyclylmethylphenoxyalkanoic and -alkenoic acids such as I were prepared as selective activators of PPARδ for potential use in improving mitochondrial function and for treatment of Duchenne muscular dystrophy (DMD); the heterocyclyl moiety was designed to mimic the cis-amide conformation found in the crystal structure of a previously prepared PPARδ activator to the ligand binding domain of PPARδ. The activation of PPARδ, selectivities for PPARδ over PPARα and PPARγ, and pharmacokinetics (half-lives, clearance, and AUC) in mice were determined for the compounds I (MA-0204) was a potent, selective PPARδ modulator with good pharmacokinetic properties. I was tested in vivo in mice and in myoblasts isolated from a DMD patient; I altered the expression of PPARδ target genes and improved fatty acid oxidation, indicating that I may be useful for treating DMD. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed enantioselective C(sp²)-H arylation of ferrocenyl ketones enabled by a chiral transient directing group was written by Xu, Jiancong;Liu, Yang;Zhang, Jinling;Xu, Xiaohua;Jin, Zhong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Electric Literature of C11H14INO This article mentions the following:

Palladium-catalyzed enantioselective C(sp²)-H activation of ferrocenyl ketones is achieved through utilizing catalytic, inexpensive L-tert-leucine as a chiral transient directing group. The transformation allows rapid access to ferrocene scaffolds simultaneously possessing planar- and stereogenic central chirality, widely applied in the ferrocene-based chiral ligand families. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Electric Literature of C11H14INO).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C11H14INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

TCDA: Practical Synthesis and Application in the Trifluoromethylation of Arenes and Heteroarenes was written by Wang, Jian;Zhang, Xiaomin;Wan, Zehong;Ren, Feng. And the article was included in Organic Process Research & Development in 2016.Formula: C8H9IO2 This article mentions the following:

A practical synthesis of the reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported on a 50 g scale. The trifluoromethylation with TCDA was optimized, and the reaction shows very broad scope with respect to electron-deficient, -neutral, -rich aryl/heteroaryl iodides, as well as excellent functional group tolerability, such as ester, amide, aldehyde, hydroxyl, and carboxylic acid. The reagent was also applied to the late-stage trifluoromethylation of three medicinally relevant compounds Addnl., the building block trifluoromethylpyridine and one drug related mol. Boc-Fluoxetin were synthesized in 10 g scale by this method, demonstrating its practical applications in process chem. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives was written by Morgentin, Remy;Barlaam, Bernard;Foote, Kevin;Hassall, Lorraine;Hawkins, Janet;Jones, Clifford D.;Le Griffon, Antoine;Peru, Aurelien;Ple, Patrick. And the article was included in Synthetic Communications in 2012.Category: iodides-buliding-blocks This article mentions the following:

We have developed two different approaches in parallel to rapidly access 2,4-bis(aminoaryl)pyridine compounds, e.g., I, from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis(aminoaryl)pyridine compounds In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Category: iodides-buliding-blocks).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-Catalyzed Asymmetric Hydrogenation of Cyclic Alkenyl Sulfones, Benzo[b]thiophene 1,1-Dioxides, with Mechanistic Studies was written by Liu, Gongyi;Tian, Kui;Li, Chenzong;You, Cai;Tan, Xuefeng;Zhang, Heng;Zhang, Xumu;Dong, Xiu-Qin. And the article was included in Organic Letters in 2021.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A highly efficient catalytic system based on the cheap transition metal nickel for the asym. hydrogenation of challenging cyclic alkenyl sulfones, 3-substituted benzo[b]thiophene 1,1-dioxides, was first successfully developed. A series of hydrogenation products, chiral 2,3-dihydrobenzo[b]thiophene 1,1-dioxides I [R = H, OMe; R¹ = Et, Ph, 2-MeC₆H₄, etc.] was obtained in high yields (95-99%) with excellent enantioselectivities (90-99% ee). According to the results of nonlinear effect studies, deuterium-labeling experiments, and DFT calculation investigations, a reasonable catalytic mechanism for this nickel-catalyzed asym. hydrogenation was provided, which displayed that the two added hydrogen atoms of the hydrogenation products could be from H₂ through the insertion of Ni-H and subsequent hydrogenolysis. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium-Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines was written by Marquise, Nada;Nguyen, Tan Tai;Chevallier, Floris;Picot, Laurent;Thiery, Valerie;Lozach, Olivier;Bach, Stephane;Ruchaud, Sandrine;Mongin, Florence. And the article was included in Synlett in 2015.COA of Formula: C4H2ClIN2 This article mentions the following:

The synthesis of triaryl methanols was investigated by reacting different 4-metalated 2-substituted pyrimidines with diaryl ketones, the latter being generated by deprotocupration-aroylation of azine and diazine substrates. Cyclization of the triaryl methanols thus obtained afforded pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines, which were evaluated for kinase inhibition and antiproliferative activities in melanoma cells. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-iodopyrimidine (cas: 395082-55-0COA of Formula: C4H2ClIN2).

2-Chloro-4-iodopyrimidine (cas: 395082-55-0) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C4H2ClIN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita was written by Chen, Xiulei;Zhou, Zhen;Li, Zhong;Xu, Xiaoyong. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020.Product Details of 20776-54-9 This article mentions the following:

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO₂, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO₂, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L^-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L^-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Product Details of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand was written by Aberg, Ola;Stevens, Marc;Lindh, Jonas;Wallinder, Charlotta;Hall, Hakan;Monazzam, Azita;Larhed, Mats;Langstrom, Bengt. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2010.Safety of N,N-Diethyl-4-iodobenzamide This article mentions the following:

Three ¹¹C-radiolabeled high-affinity nonpeptide AT₂ receptor-selective ligands were synthesized, and one of these was evaluated as positron emission tomog. (PET) tracer. The labeling reaction was performed via Pd(0)-mediated aminocarbonylation of the aryl iodide substrate using ¹¹CO as the labeled precursor. As an example, starting with 10.0 GBq ¹¹CO, 1.10 GBq of the product N-butoxycarbonyl-3-[4-(N-benzyl-[¹¹C]carbamoyl)phenyl]-5-isobutylthiophene-2-sulfonamide was obtained in 36% decay-corrected radiochem. yield (from ¹¹CO), 42 min from end of bombardment with a specific activity of 110 GBq μmol^-1. The N-isopropyl-[¹¹C]carbamoyl analog (radiochem. purity >95%) was studied employing autoradiog., organ distribution, and small animal PET. In vitro autoradiog. showed specific binding in the pancreas and kidney. Organ distribution in rats revealed a high uptake in liver, intestine, kidney, and adrenals. Small animal PET showed rapid and reversible uptake in the kidneys followed by accumulation in the urinary bladder suggesting fast renal excretion of the tracer. In addition, high accumulation was also seen in the liver. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Safety of N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metalation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids was written by Epsztajn, J.;Plotka, M. W.;Grabowska, A.. And the article was included in Synthetic Communications in 1997.Electric Literature of C6H4INO2 This article mentions the following:

The synthesis of the halogenated picolin- and isonicotinanilides I (R = Cl, Br, iodo, X = N, Y = CH; X = CH, Y = N) (II) via metalation (n-BuLi) of the anilides I (R = H) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl₃-CCl₃, CH₂Br-CH₂Br, I₂) followed by subsequent acidic hydrolysis of II, as a way of regiospecific transformation of picolinic and isonicotinic acids into their C³-halogenated derivatives, is described. In the experiment, the researchers used many compounds, for example, 3-Iodopicolinic acid (cas: 73841-32-4Electric Literature of C6H4INO2).

3-Iodopicolinic acid (cas: 73841-32-4) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Electric Literature of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com