Category: iodides-buliding-blocks

Reference of 49827-15-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49827-15-8, name is tert-Butyl 2-iodoacetate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 44 (3.8 g, 1.83 mmol) in anhydrous THF 60 mL under Argon was added NaHMDS (2.2 mL 2.2 mmol, pre-cooled to -78° C.) in THF 30 mL slowly at -78° C. via cannula and the mixture was stirred for 2 min. at -78° C. ICH2CO2tBu (2.35 g, 9.713 mmol) in THF 10 mL was added slowly to the above mixture at -78° C. The dry ice/acetone bath was removed and the stirring was continued for 30 minutes and was poured into NH4Cl aq. solution. The extractive work-up with EA and purification by column chromatography gave 45-1 (upper spot on TLC plate) and 45-2 (lower spot on TLC plate) as two diastereomers about 1:1 mixture (2.9 g, 61percent, combined yield) as yellow oil. 1H NMR (45-1, CDCl3) 7.28-7.22 (9H, m), 6.08 (1H, m), 5.20-5.16 (2H, m), 4.92 (1H, dd, J=2.4 and 8.4 Hz), 4.78 (1H, m), 4.17 (1H, t, J=8.6 Hz), 3.95 (1 H, dd, J=2.7 and 8.8 Hz), 3.35 (1H, t, J=10.0 Hz), 3.15-2.98 (2H, m), 2.75 (1H, dd, J=11.5 and 17.6 Hz), 2.61 (1H, dd, J=3.7 and 17.2 Hz), 1.51 (9H, s), 1.41 (3H, d, J=13.7 Hz), 1.30 (9H, s). 1H NMR (45-2, CDCl3) 7.34-7.15 (9H, m), 6.07 (1H, m), 5.19-5.15 (2 H, m), 4.87 (1H, m), 4.78 (1H, m), 4.05 (1H, t, J=8.4 Hz), 3.96 (1H, m), 3.38 (1H, t, J=9.4 Hz), 3.3.15-3.00 (2H, m), 2.74 (1H, dd, J=11.2 and 17.2 Hz), 2.57 (1H, dd, J=3.9 and 17.4 Hz), 1.51 (9H, s), 1.38 (3H, d, J=13.7 Hz), 1.30 (9H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-iodoacetate, other downstream synthetic routes, hurry up and to see.

Application of 83863-33-6,Some common heterocyclic compound, 83863-33-6, name is 5-Iodo-2-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Production Example 15-1 6-Iodo-1H-indazole An aqueous solution (4 mL) of sodium nitrite (1.1 g) was dropwise added to an acetic acid solution (360 mL) of (5-iodo-2-methylphenyl)amine, and after the addition, this was stirred overnight at room temperature. The solvent was evaporated off under reduced pressure, the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1 to 4:1) to obtain the entitled compound (1 g) as an orange powder.

The synthetic route of 83863-33-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3930-83-4, name is 2-Iodobenzamide, A new synthetic method of this compound is introduced below., name: 2-Iodobenzamide

General procedure: 2-Iodobenzamide 1a (1.0 equiv.), 2-aminoisovaleric acid 2a (3.0 equiv.), Cs2CO3 (3.0 equiv.) and GO/Fe3O4-CuI (Cu+ 0.03 equiv.) were added to DMSO/ethylene glycol (60:1, v/v) in a round bottom flask. The reaction was monitored by TLC. The product was purified by column chromatography with petroleum ether/ethyl acetate (3:1, v/v) to give pure white solid 3a.

The synthetic route of 3930-83-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 103440-52-4, name is Methyl 2-Iodo-5-methylbenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103440-52-4, name: Methyl 2-Iodo-5-methylbenzoate

General procedure: This kind of general experimental procedure is based on our already published procedure.13 The general procedure (GP) was carried out with ortho-iodoester 1a-d (105.0-136.0 mg, 0.40 mmol) and aldehyde 2a-k (195.0-313.0 mg, 1.6 mmol) in the presence of Pd(OAc)2 (5.0 mg, 5 mol%), Ag2O (111.3 mg, 0.48 mmol), and TBHP (257.1 mg, 2.0 mmol) allowing the reaction mixture to stir at 120 C for 12-20 h. Progress of the reaction was monitored by TLC until the ortho-iodoester 1a-d had completely reacted. Then the reaction mixture was removed from the oil bath and allowed to reach r.t. DCE (2 mL) and concd H2SO4 (1.0 mL) were added and the mixture was stirred at 60 C for 5 min to 2 h. Progress of the product formation was monitored by TLC until the reaction was complete. The mixture was quenched by the addition of aq NaHCO3 and then extracted with CH2Cl2 (3 * 15 mL). The combined organic layers were washed with brine, dried (Na2SO4), and filtered. Evaporation of the solvent under reduced pressure and purification of the crude material by silica gel column chromatography (PE/EtOAc) furnished the products 3 (57.0-86.0 mg, 55-69%). The products 3aa, 3ac, 3ai, 3aj, 3ak, 3ba, 3bc, 3be, and 3bj are reported in the literature.9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromo-1-(4-iodophenyl)ethanone

Step l-515a. Into a mixture of 2-bromo-l-(4-iodophenyl)ethanone (5g, 15.4 mmol) and (S)-l-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (3.48g, 16.1 mmol) in acetonitrile (40 mL) was added diisopropylethylamine (2.4 mL, 17 mmol). The resulting mixture was stirred at rt for 3 hours before being partitioned between EtOAc and aqueous NaHCO3. The organic phase was separated, dried (Na2SOzI) and concentrated to afford a brown oil. It was purified by flash column chromatography (silica, hexane-EtOAc) to give the desired product as light yellow oil (6.0 g, 86%). ESIMS m/z = 481.94 [M+Naf.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 620-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 620-05-3, name is (Iodomethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a flame-dried round-bottom flask, beta-amidoester (9) (1 mmol; 1 equiv) was taken in DMF (5 mL) at room temperature. To this reaction mixture KOt-Bu (1.2 mmol; 1.2 equiv) was added. After 5 minutes of stirring at same temperature alkyl halide (1.05 mmol; 1.05 equiv) was added and stirring was continued for 15 minutes. Upon completion of the alkylation (judged by TLC), it was diluted with 10 mL of EtOAc and quenched with water. The organic extracts were dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by flash chromatography (hexane and EtOAc as eluents) to afford compounds 10.

The synthetic route of (Iodomethyl)benzene has been constantly updated, and we look forward to future research findings.

333447-42-0, name is 1,5-Difluoro-2-iodo-4-methylbenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 333447-42-0

Step B – Synthesis of Compound 29B; A solution of compound 29A (7.11 g, 28.0 mmol), zinc cyanide (1.97 g, 16.8 mmol) and tetrakis(triphenylphosphine)palladium(0) (3.23 g, 2.80 mmol) in DMF (30 mL) was heated to 90 0C and allowed to stir at this temperature for 1.5 hours. The reaction mixture was concentrated in vacuo and the residue obtained was taken up in water (400 mL) and extracted with ether (400 mL). The organic extract was washed with aqueous ammonium hydroxide solution (IN)- The organic layer was dried (MgSO4) filtered, concentrated in vacuo to provide a residue that was purified using flash column chromatography (SiO2, EtOAc/Hexanes) to provide a mixture that contained product and triphenylphosphine. This mixture was further purified using sublimation at 1 mm/Hg at 45 0C to provide compound 29B (1.8 g; Yield = 42%).

The synthetic route of 333447-42-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 249647-24-3, These common heterocyclic compound, 249647-24-3, name is Methyl 3-bromo-4-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of methyl 3-bromo-4-iodobenzoate (4.3 g, 12.6 mmol) in CH2Cl2 was cooled, under N2, to -78 C. DIBAL-H (25.2 mL of a 1M solution in CH2Cl2) was added slowly to the solution, which was stirred at -78 C. for 45 minutes and then allowed to come to room temperature. Next, the reaction mixture was diluted with 1M HCL (40 mL) and stirred for 30 minutes. The reaction was further diluted with water and extracted with CH2Cl2. The organic phase was dried (Na2SO4) and concentrated under vacuum to afford the intermediate (3.2 g, 82%) as a solid. 1HNMR (CDCl3) delta ppm: 7.85 (1H), 7.67 (1H), 7.02 (1H), 4.65 (2H), 1.76 (1H, OH).

The synthetic route of 249647-24-3 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

To a solution of 5-{4-[(S)-1-(3-fluoropropyl)pyrrolidin-3-yloxy]phenyl}-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-8,9-dihydro-7H-benzocyclohepten-2-ol (D’) (100.3 mg, 197.66 mumol), in dioxane (1 ml) and water (0.5 ml), was added 3-chloro-2-fluoroiodobenzene (60.83 mg, 237.19 mumol), Cs2CO3 (128.93 mg, 395.31 mumol) and Pd(dppf)Cl2 (9.68 mg, 11.86 mumol). The reaction mixture was heated at 70° C. for 6 hours, and partitioned between DCM and water. The aqueous phase was washed with DCM and organic phases were dried and concentrated under reduced pressure. The residue was purified by column chromatography eluting with a gradient of MeOH in DCM (0percent to 10percent) to give a solid which was further purified on strong cation exchange (SCX) column to give 18 mg (18percent) of 6-(3-chloro-2-fluorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulen-2-ol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 72373-82-1, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H7IO2

Thionyl chloride (8.2 ml,112.5 mmol) was added to a solution of 3-iodo-4-methyl-benzoic acid (18.5 g, 75 mmol) In 100 ml of chloroform,The reaction was stirred at 60 C for 16 hours.The solvent was concentrated under reduced pressure,Excessive dichlorosulfoxide with 30 cents Rose to azeotropically remove,To give the product 19.5 g,93% yield,Can be used directly for the next step.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.