Category: iodides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 401-81-0

6b (458 mg, 2.00 mmol) in 1.0 ml of dry THF was initially introduced into a dry 10 ml microwave tube filled with argon and with a magnetic stirrer core and septum, and Zn(TMP)2.2LiCl.2MgCl2 in THF (3.2 ml, 0.37 M, 0.60 equivalent) was added at 25 C. The microwave tube was closed and the reaction was started. After 2 h in the microwave oven (120 W, 80 C.) the metallization was complete (GC analysis of reaction samples to which a solution of I2 in THF had been added indicated a conversion of more than 98%). After the reaction mixture had been cooled to room temperature, this was added to a solution of 3-CF3-C6H4-I (680 mg, 1.2 equivalents), Pd(dba)2 (5 mol %) and Tfp (10 mol %) in dry THF (2.5 ml). After stirring at 25 C. for 15 h, the reaction was ended by addition of saturated NH4Cl solution (30 ml). The aqueous phase was extracted with ethyl acetate (5¡Á30 ml), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by filter column chromatography (silica gel; Et2O/pentane 1:15); 7b (680 mg, 76%) was obtained as a yellow oil.

According to the analysis of related databases, 401-81-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ludwig Maximilians Universitat Munchen; US2010/160632; (2010); A1;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 869500-07-2, name is 1-Bromo-2-iodo-3-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 869500-07-2, name: 1-Bromo-2-iodo-3-methylbenzene

A mixture of 1-bromo-2-iodo-3-methylbenzene (0.46g), {3-[(ethyloxy)- carbonyl] phenyl}boronic acid (0.20g), tetrakis(triphenylphosphine)palladium(0) (60mg), potassium carbonate (0.71g), toluene (6ml) and ethanol (6ml) was stirred under reflux under nitrogen for 3h. The mixture was partitioned between water (40ml) and ether (40ml) and the aqueous layer extracted with ether (15ml). The combined ether extracts were dried (MgS04), evaporated and the residue purified by flash chromatography eluting with 2% ethyl acetate in isohexane to afford the title compound (0.22g). LC/MS Rt = 4.1 min, [MH+] 319/321.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/108369; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 31827-94-8,Some common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, molecular formula is C8H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The appropriate carbonyl compound (50 mmol) was dissolved in 50 mL of ethanol and magnetically stirred with an equimolar quantity of thiosemicarbazide for 24 h at room temperature with catalytic amounts of acetic acid. The desired thiosemicarbazone precipitated from reaction mixture, was filtered, crystallized from suitable solvent, and dried. Equimolar quantities of 4-iodo-acetophenone and bromine, both dissolved in chloroform, were stirred for 4 h at room temperature until the presence of HBr disappeared. The solution was evaporated under vacuum and the obtained pale yellow solid was washed with petroleum ether to give alpha-bromo-4-iodo-acetophenone in good yield (94%). Equimolar amounts of the prepared thiosemicarbazone (50 mmol) and alpha-bromo-4-iodo-acetophenone (50 mmol), both suspended in 50 mL of ethanol, were reacted at room temperature under magnetic stirring for 10 h. The precipitate was filtered and purified by chromatography to give compounds 1-25 in high yield.

The synthetic route of 31827-94-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Secci, Daniela; Bizzarri, Bruna; Bolasco, Adriana; Carradori, Simone; D’Ascenzio, Melissa; Rivanera, Daniela; Mari, Emanuela; Polletta, Lucia; Zicari, Alessandra; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 246 – 253;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 181765-86-6, Recommanded Product: Methyl 5-bromo-2-iodobenzoate

The intermediate 1 – 2 (4.0 g, 16.8 mmol) and 5 – bromo -2 – iodo benzoic acid methyl ester (6.3 g, 18.5 mmol) dissolved in 50 ml in tetrahydrofuran and then potassium carbonate (4.56 g, 33.6 mmol), 25 ml water mixed together in single-port is added to the flask. Under the protection of argon, and then added to the mixture (triphenylphosphine) palladium four (0.28 g, 0 . 24 mmol), heating reflux for 4 hours. After the reaction, the reaction mixture can be cooled to the room temperature, and steaming and remove the tetrahydrofuran, then washing, dichloromethane extraction three times (each 10 ml). The combined organic phase, anhydrous sodium sulfate drying, the crude product is used good column chromatography purification, get 5.67 g, yield of 82.7%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (27 pag.)CN107163066; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 696-41-3, name is 3-Iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Iodobenzaldehyde

General procedure: A mixture of 2-acetyl-5-chlorothiophene (0.01 mol) and substituted benzaldehyde (0.01 mol) wasdissolved in methanol (20 mL). A catalytic amount of NaOH was added to the solution dropwise withvigorous stirring. The reaction mixture was stirred for about 3-4 h at room temperature. The resultantcrude products were filtered, wash successively with distilled water and recrystallized from ethanol to get the corresponding chalcone. Crystals suitable for X-ray diffraction studies were obtained by the slowevaporation technique using a suitable solvent.

According to the analysis of related databases, 696-41-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chidan Kumar; Loh, Wan-Sin; Ooi, Chin Wei; Quah, Ching Kheng; Fun, Hoong-Kun; Molecules; vol. 18; 10; (2013); p. 11996 – 12011;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 624-75-9, name is 2-Iodoacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Iodoacetonitrile

Compound 6 (prepared according to B2. b) (30 mg) was dissolved in 20 ml of MECN, and iodo acetonitrile (1.0 eq. ) and K2CO3 (3 eq, 29 mg) were added. Stirring for 17 days at 20C. The MECN was evaporated and the residue was purified by preparative TLC using CHCL2/MEOH (9/1) as the eluent. Yield: compound 60 (52 %).

According to the analysis of related databases, 624-75-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; ARTS, Frank, Xavier, Jozef, Herwig; WO2005/28479; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 791642-68-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 5-bromo-2-iodoanisole (0.5 g, 1.6 mmol), morpholine (0.14 mL, 1.6 mmol), Pd2(dba)3 (0.04 g, 0.048 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.08 g, 0.144 mmol) and sodium tert-butoxide (0.46 g, 4.79 mmol) in toluene (10 mL) was heated to 70 C for 20 h. The reaction was diluted with water, extracted with EtOAc, dried and evaporated. The crude product was purified by flash silica chromatography eluting with 0-30% EtOAc/cyclohexane. Pure fractions were evaporated to dryness to give 4-(4-bromo-2- methoxy-phenyl)morpholine, (0.24g, 56%). m/z ES+ [M+H]+ 272/274; 1H NMR (400 MHz, DMSO-d6) d 7.10- 7.04 (m, 2H), 6.82 (d, J = 8.4 Hz, 1H), 3.80 (s, 3H), 3.74- 3.66 (m, 4H), 2.96- 2.89 (m, 4H).

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-iodo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARTIOS PHARMA LIMITED; BLENCOWE, Peter; CHARLES, Mark; CRIDLAND, Andrew; EKWURU, Tennyson; HEALD, Robert; MACDONALD, Ellen; MCCARRON, Hollie; RIGOREAU, Laurent; (200 pag.)WO2020/30925; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 2468-56-6, The chemical industry reduces the impact on the environment during synthesis 2468-56-6, name is 6-Iodohex-1-yne, I believe this compound will play a more active role in future production and life.

To a solution of 3,5-dihydroxybenzaldehyde (552 mg, 4 mmol) in DMF (5 mL) at 0 C under argon was added NaH (164 mg, 4.1 mmol, 60% in mineral oil). The mixture was stirred for 30 min at r. t. and a solution of hex-5-ynyl iodide (390 mg, 1.9 mmol) in DMF (5 mL) was added. The reaction mixture was stirred for 18 h at r. t. The reaction was quenched with 1 M HCl, extracted with EtOAc (3 times). The combined organic phases were washed with H20 (2 times), dried over Na2S04, concentrated under reduced pressure and the residue was separated by column chromatography (hexane: EtOAc = 10 : 1 to 1 : 1) yielding the desired product (240 mg, 58%) as a colorless solid. – 1H NMR (500 MHz, CD3OD): 9.84 (s, 1 H), 6.96 – 6.93 (m, 1 H), 6.92 – 6.90 (m, 1 H), 6.65 (t, J= 2.3 Hz, 1 H), 4.03 (t, J= 6.3 Hz, 2 H), 2.32 – 2.21 (m, 3 H), 1.95 – 1.87 (m, 2 H), 1.75 – 1.67 (m, 2 H). – 13C NMR (125 MHz, DMSO-d6): 192.63, 160.86, 159.14, 138.64, 108.46, 107.85, 105.98, 83.28, 68.47, 67.36, 27.94, 24.88, 17.40.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Iodohex-1-yne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TECHNISCHE UNIVERSITAeT MUeNCHEN; FETZER, Christian; KOROTKOV, Vadim; SIEBER, Stephan; (95 pag.)WO2018/114965; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1320266-94-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1320266-94-1, name is 1-Iodo-3-isopropylimidazo[1,5-a]pyrazin-8-amine, This compound has unique chemical properties. The synthetic route is as follows.

1 -(4-(8-amino-3 -isopropylimidazo[ 1 ,5-a]pyrazin- 1 -yl)naphthalen- 1 -yl)-3 -(3- (trifluoromethyl)phenyl)urea (KIRA3). A mixture of compound 1 (12.0 mg, 0.040 mmol), compound 3 (21.9 mg, 0.048 mmol), tetrakis(triphenylphosphine)palladium (1.4 mg, 1.2 muetaiotaomicroniota) and sodium carbonate (9.3 mg, 0.088 mmol) was dissolved in a 3 : 1 mixture of DME/water (160 uL). The mixture was heated overnight at 85 C. The crude mixture was cooled to room temperature, diluted in a mixture of acetonitrile/water and purified by reverse phase chromatography (HPLC) to obtain 12.3 mg of GP146 (61% yield). TLC (CH2C12:MeOH, 95:5 v/v): Rf = 0.4; 1H MR (300 MHz, MeOD): delta 8.27-8.22 (m, 1H), 8.02-7.96 (m, 2H), 7.90-7.86 (m, 1H), 7.83-7.79 (m, 1H), 7.72-7.49 (m, 5H), 7.37-7.32 (m, 1H), 7.04-6.99 (m, 1H), 3.66-3.55 (m, 1H), 1.54-1.48 (m, 6H); 13C NMR (500 MHz, MeOD): delta 154.9, 151.6, 149.8, 140.2, 135.9, 132.9, 129.4, 128.7, 128.7, 127.1, 126.6, 126.6, 125.8, 125.7, 121.9, 121.9, 121.8, 120.2, 1 18.7, 118.7, 1 15.1, 1 14.6, 1 12.9, 108.4, 25.8, 19.6; [M+l]+ found, 505.4. HPLC Purification Conditions: C18 column (250 x 21 mm), CH3CN/H2O-0.1% CF3C02H = 1 :99 to 100:0 over 78 min; 8 mL/min; 220 nm and 254 nm detection for 78 min. The purity of GP146 was determined to be >98% by analytical HPLC in two different solvent systems.

The chemical industry reduces the impact on the environment during synthesis 1-Iodo-3-isopropylimidazo[1,5-a]pyrazin-8-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MALY, Dustin J.; BACKES, Bradley, J.; OAKES, Scott, A.; PAPA, Feroz, R.; GHOSH, Rajarshi; WANG, Likun; (220 pag.)WO2016/4254; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 4028-63-1, These common heterocyclic compound, 4028-63-1, name is 2,4,6-Trimethyliodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The reaction was generally performed with 2.0 equivalents of TfOH. m-CPBA (65%active oxidant, 2.6 mmol) and aryl iodide (2.3 mmol) were dissolved in DCM (20 mL)in a sealed tube. The arene (2.6 mmol) was added and the solution was cooled to 0 oC,followed by dropwise addition of TfOH (4.6 mmol), and resulted in a colouredsolution. The reaction mixture was stirred for about 2 h, subsequently concentratedunder vacuum. Et2O was added and the mixture was stirred at room temperature for30 mins to precipitate out an off-white solid.

Statistics shows that 2,4,6-Trimethyliodobenzene is playing an increasingly important role. we look forward to future research findings about 4028-63-1.

Reference:
Article; Liu, Qi-Sheng; Wang, De-Yin; Yang, Jin-Fei; Ma, Zhong-Yi; Ye, Mengchun; Tetrahedron; vol. 73; 26; (2017); p. 3591 – 3595;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com