Category: iodides-buliding-blocks

Huang, Qi published the artcileA Giese reaction for electron-rich alkenes, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Chemical Science (2021), 12(6), 2225-2230, database is CAplus and MEDLINE.

A general method for the hydroalkylation of electron-rich terminal and non-terminal alkenes such as enol esters, alkenyl sulfides, enol ethers, silyl enol ethers, enamides and enecarbamates has been developed. The reactions are carried out at room temperature under air initiation in the presence of triethylborane acting as a chain transfer reagent and 4-tert-butylcatechol (TBC) as a source of hydrogen atom. The efficacy of the reaction is best explained by very favorable polar effects supporting the chain process and minimizing undesired polar reactions. The stereoselective hydroalkylation of chiral N-(alk-1-en-1-yl)oxazolidin-2-ones takes place with good to excellent diastereocontrol.

Chemical Science published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Povie, Guillaume published the artcileRadical chain repair: The hydroalkylation of polysubstituted unactivated alkenes, COA of Formula: C5H9IO2, the publication is Science Advances (2018), 4(7), eaat6031, database is CAplus and MEDLINE.

The concept of repair is widely used by nature to heal mols. such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chem., can be used in a radical chain reaction to enable notoriously intractable transformations. By overcoming the radical chain inhibitor properties of substituted alkenes, the radical-mediated hydroalkylation of mono-, di-, tri-, and even tetrasubstituted unactivated olefins could be performed under mild conditions. With a remarkable functional group tolerance, this reaction provides a general coupling method for the derivatization of olefin-containing natural products.

Science Advances published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schaefer, Bernhard published the artcileDitopic Hexadentate Ligands with a Central Dihydrobenzo-diimidazole Unit Forming a [2×2] Zn₄ Grid Complex, Formula: C6H13I, the publication is European Journal of Organic Chemistry (2021), 2021(16), 2301-2310, database is CAplus.

A family of ditopic hexadentate ligands based on the parent compound 2,6-bis(6-(pyrazol-1-yl)pyridin-2-yl)-1,5-dihydrobenzo[1,2-d:4,5-d’]diimidazole (L) was developed and synthesized by using a straightforward condensation reaction, which forms the interlinking central benzo[1,2-d:4,5-d’]diimidazole bridge in the ligand backbone. The two secondary amine groups of the benzodiimidazole unit tautomerize and allow the formation of two tauto-conformers, which upon treatment with metal salts forms different isomeric coordination complexes. Here authors report six new derivatives (1–6) that can tautomerize (varying the pyrazolylpyridine part) and 14 derivatives (7–13) with different alkyl and benzyl substitution on secondary amino groups (of L) that prevent the tautomerization. This way, it is possible to study the properties of isomeric coordination complexes and their intrinsic cooperativity by the example of [2×2] grid complexes in the future. A [2×2] Zn₄ complex of the ligand L was synthesized and structurally characterized.

European Journal of Organic Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watanabe, Daisuke published the artcileSynthesis of desmosine-d₄: Improvement of isotopic purity by D-H exchange of amino groups, Computed Properties of 161370-66-7, the publication is Tetrahedron Letters (2017), 58(12), 1194-1197, database is CAplus.

Desmosine is a crosslinking pyridinium amino acid of elastin, which is a useful biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD) by LC-MS/MS anal. We previously reported a synthesis of desmosine-d₄, which is useful as an internal standard for quant. LC-MS/MS anal. of desmosines, by deuterogenation of an alkyne group; however, the isotopic purity of the desmosine-d₄ was only ca. 50%. The present report describes a new synthesis of desmosine-d₄ that improves the isotopic purity to ca. 90% by exchanging the protons of the amino groups to deuterium using deuterogenation.

Tetrahedron Letters published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C12H15BF2O2, Computed Properties of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Amino, Yusuke published the artcileSynthesis and evaluation of L-cystathionine as a standard for amino acid analysis, Safety of (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, the publication is Bioscience, Biotechnology, and Biochemistry (2017), 81(1), 95-101, database is CAplus and MEDLINE.

L-Cystathionine is a key nonprotein amino acid related to metabolic conditions. The quant. determination of L-cystathionine in physiol. fluids by amino acid anal. is important for clin. diagnosis; however, certified reference material for L-cystathionine with satisfactory purity, content, and quantity has been unavailable until recently. Consequently, a practical and simple method for the preparation of L-cystathionine was examined, which involves thioalkylation of N-tert-butoxycarbonyl-L-cysteine tert-Bu ester, derived from L-cystine, with (2S)-2-(tert-butoxycarbonyl)amino-4-iodobutanoic acid tert-Bu ester, derived from L-aspartic acid, to obtain L-cystathionine with protecting groups, followed by single-step deprotection under mild conditions. This method produces L-cystathionine in high purity (99.4%) and having sufficient percentage content according to amino acid anal., which could be used as a standard for the amino acid anal. of physiol. fluids.

Bioscience, Biotechnology, and Biochemistry published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Safety of (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru published the artcileSingle C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group, Product Details of C7H3BrF3I, the publication is Angewandte Chemie, International Edition (2016), 55(35), 10406-10409, database is CAplus and MEDLINE.

The transformation of a single C-F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C-F bond functionalization, for example, by allylation, carboxylation, or chlorination. Further derivatization of the resulting fluorosilylarenes afforded various aromatic difluoromethylene compounds

Angewandte Chemie, International Edition published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C14H28O5S, Product Details of C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tsuboi, Sadao published the artcileNew synthesis of (±)-menthofuran, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (1980), 45(8), 1517-20, database is CAplus.

(±)-Menthofuran [(±)-I] was prepared in 3 steps from Et 4-methyl- 2-oxo-1-cyclohexanecarboxylate (II) in a reasonable overall yield. Reaction of II with MeCHICO₂Et gave Et 2-(1-ethoxycarbonyl-4-methyl-2-oxocyclohexyl)propionate, which was converted directly to 3,6-dimethyl-2,4,5,6,7,7a-hexahydro-2-benzofuranone (III) by refluxing with concentrate HCl; reduction with LiAlH₄-Me₂CHOH at -60 to -50° gave (±)-I. The reduction of III at room temperature gave 2-(4-methyl-1-cyclohexenyl)-1,2-propanediol.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C17H14F3N3O2S, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileStudies on some new bridgehead nitrogen heterocyclic cyanine dyes, COA of Formula: C12H14IN, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1999), 111(6), 709-724, database is CAplus.

New asym. mono-(tri)-methine and azomethine cyanine dyes of pyrazolo[5,4-b]quinolino[a,b]-1,4-pyra-(oxa)-zinium bromide salts were prepared The newly synthesized cyanines were identified by elemental and spectral analyses. The visible absorption spectra of some selected dyes were investigated in single and mixed solvents, and also in aqueous buffer solutions The spectral shifts were studied in relation to mol. structure and in terms of medium effects. Mol. complex formation with DMF was verified through mixed-solvent studies.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, COA of Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileSome new nitrogen bridgehead heterocyclic cyanine dyes, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemical Papers (2000), 54(2), 78-86, database is CAplus.

New monomethine, trimethine, and azomethine cyanine dyes of pyrazolo[4′,5′:5,6](pyrazinio/1,4-oxazinio)[2,3,4-i,j]quinolin-11-ium bromides were prepared These cyanines were identified by elemental and spectral analyses. The visible absorption spectra of some selected dyes were investigated in single and mixed solvents, and also in aqueous buffer solutions The spectral shifts are discussed in relation to mol. structure and in terms of medium effects. Mol. complex formation with DMF was verified through mixed-solvent studies.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileOrientation in the synthesis and absorption spectra of 1H-pyrazolo[4,3-d][1,3]oxazole methine cyanine dyes, Quality Control of 606-55-3, the publication is Chemical Papers (1998), 52(6), 762-770, database is CAplus.

3,5-Dimethyl-1-phenyl-1H-pyrazolo[4,3-d][1,3]oxazole was prepared and oriented as starting material in the synthesis of some mono-, di, and trimethine cyanine dyes. The new cyanines were characterized by IR and ¹H NMR spectral data. The visible absorption spectra of the cyanine dyes are discussed.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com