Category: iodides-buliding-blocks

Butler, Jeffrey D. published the artcileA Facile Synthesis of New 5H-Indazolo[3,2-b]benzo[d]-1,3-oxazines via One-Pot Intramolecular Bis-heterocyclizations, Safety of (2-Amino-5-iodophenyl)methanol, the publication is Journal of Organic Chemistry (2008), 73(1), 234-240, database is CAplus and MEDLINE.

The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle (I) as well as a series of novel analogs have been synthesized utilizing two subsequent intramol. heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biol. screening (no data).

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Safety of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileStudies on the synthesis and spectral behaviour of polyfunctional heterocycle cyanine dyes, Computed Properties of 606-55-3, the publication is Aswan Science & Technology Bulletin (2002), 22-35, database is CAplus.

Unsym. (sym.) incorporated cyano pyrazolo (pyrazolium) (4,5-d)oxazine (quinoxaline) 6[2(4)] or 3[4(1)] mono- and bis-3,6[4(2)] monomethine and/or substituted cyano pyrazolo(4,5-d)oxazine [quinoxaline-6-imine (one)]-N-bridgehead heterocyclic zero methine cyanine dyes were prepared The new synthesized cyanines were established by elemental and spectral anal. The spectral behavior in the visible absorption region was discussed on the basis of color – structure relationships.

Aswan Science & Technology Bulletin published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Page, J. E. published the artcilePharmacology of diethylamine salt of 3,5-diiodo-4-pyridone-N-acetic acid, Related Products of iodides-buliding-blocks, the publication is Quarterly Journal of Pharmacy and Pharmacology (1948), 283-91, database is CAplus.

The diethylamine salt (I) is more toxic to mice than the diethanolamine salt (II) intravenously. The cardiac, blood pressure, and respiratory effects of the 2 salts are closely similar. The rate of excretion of I is slower than that of II.

Quarterly Journal of Pharmacy and Pharmacology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Muanprasat, Chatchai published the artcileDiscovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy, Related Products of iodides-buliding-blocks, the publication is Journal of General Physiology (2004), 124(2), 125-137, database is CAplus and MEDLINE.

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated epithelial Cl^– channel that, when defective, causes cystic fibrosis. Screening of a collection of 100,000 diverse small mols. revealed four novel chem. classes of CFTR inhibitors with K_i < 10 μM, one of which (glycine hydrazides) had many active structural analogs. Anal. of a series of synthesized glycine hydrazide analogs revealed maximal inhibitory potency for N-(2-naphthalenyl) and 3,5-dibromo-2,4-dihydroxyphenyl substituents. The compound N-(2-naphthalenyl)-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide (GlyH-101) reversibly inhibited CFTR Cl^– conductance in <1 min. Whole-cell current measurements revealed voltage-dependent CFTR block by GlyH-101 with strong inward rectification, producing an increase in apparent inhibitory constant K_i from 1.4 μM at + 60 mV to 5.6 μM at – 60 mV. Apparent potency was reduced by lowering extracellular Cl^– concentration Patch-clamp experiments indicated fast channel closures within bursts of channel openings, reducing mean channel open time from 264 to 13 ms (-60 mV holding potential, 5 μM GlyH-101). GlyH-101 inhibitory potency was independent of pH from 6.5-8.0, where it exists predominantly as a monovalent anion with solubility ∼1 mM in water. Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibited forskolin-induced hyperpolarization in nasal potential differences. In a closed-loop model of cholera, intraluminal GlyH-101 (2.5 μg) reduced by ∼80% cholera toxin-induced intestinal fluid secretion. Compared with the thiazolidinone CFTR inhibitor CFTR_inh-172, GlyH-101 has substantially greater water solubility and rapidity of action, and a novel inhibition mechanism involving occlusion near the external pore entrance. Glycine hydrazides may be useful as probes of CFTR pore structure, in creating animal models of CF, and as antidiarrheals in enterotoxic-mediated secretory diarrheas.

Journal of General Physiology published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Masunari, Andrea published the artcileGeneration and analysis of interaction energy maps of p-substituted benzoic acid N’-(5-nitrothiophen-2-yl)methylenehydrazides active against multidrug-resistant Staphylococcus aureus, Category: iodides-buliding-blocks, the publication is Anti-Infective Agents in Medicinal Chemistry (2010), 9(1), 1-8, database is CAplus.

Studies in 3D mol. fields generally contain a large amount of data, some of which are redundant or not relevant. The program Volsurf, a quite fast method, is able to compress the relevant information present in 3D mol. structures into a few descriptors that represent the physicochem. properties. In this study eighteen p-substituted benzoic acid N’-(5-nitrothiophen-2-yl)methylenehydrazides with antimicrobial activity were evaluated against multidrug-resistant Staphylococcus aureus, correlating the three-dimensional characteristics of the ligands with their resp. bioactivities. Structures were obtained by CORINA program, and using a GRID force field, the following probes have been used to generate their corresponding 3D interaction energies (MIFs): water, DRY, carbonyl oxygen atom and amide NH group. Calculations using Volsurf resulted in a statistically consistent model with 48 structural descriptors showing that hydrophobicity is a fundamental property in the analyzed biol. response. Results have shown the potential of studied compounds as alternatives to the treatment of infections caused by multidrug-resistant Staphylococcus aureus.

Anti-Infective Agents in Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nagrimanov, Ruslan N. published the artcileAdditive scheme of solvation enthalpy for halogenated aliphatic hydrocarbons at 298.15 K., Safety of 1-Iodohexane, the publication is Thermochimica Acta (2022), 179155, database is CAplus.

In this work, an additive scheme for the estimation of solvation enthalpy of halogenated aliphatic hydrocarbons in n-heptane was developed. The proposed structural fragments for halogen group contributions are dependent on the nature of neighboring atoms. A linear relationship between solvation and vaporization enthalpy at 298.15 K for mono- and di-α,ω-halogen aliphatic compounds was found. These relationships can be used for the quick estimation of standard vaporization and solution enthalpies at 298.15 K. Proposed approaches for estimation of solvation, solution and vaporization enthalpies at 298.15 K were verified by conventional methods. In most cases, absolute deviations between exptl. and estimated values for halogenated aliphatic hydrocarbons do not exceed 1-2 kJ mol^-1.

Thermochimica Acta published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pelcman, Benjamin published the artcile3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1, Computed Properties of 141998-77-8, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(15), 3024-3029, database is CAplus and MEDLINE.

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Addnl. halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about 141998-77-8. 141998-77-8 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Ester,Pyrazole, name is Ethyl 5-iodo-1H-pyrazole-3-carboxylate, and the molecular formula is C6H7IN2O2, Computed Properties of 141998-77-8.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ramos, S. S. published the artcileSome new symmetric rigidified triheterocyclic heptamethinecyanine dyes absorbing in the near infrared, Computed Properties of 606-55-3, the publication is Dyes and Pigments (2002), 53(2), 143-152, database is CAplus.

Several new rigidified heptamethine cyanine dyes bearing different N-alkyl chains were readily prepared by a novel semi-catalyzed method. All dyes displayed absorption within the so-called “phototherapeutic window”. In order to improve the structural versatility of the dyes, a Cl atom was incorporated in the exocyclic conjugated bridge present in the polymethine chain. In some cases the Cl underwent an unexpected in-situ substitution by a third oxygenated heterocyclic group, depending on the solubility of the chloro dye in the reaction solvent. Two possible mechanisms for the formation of these triheterocyclic dyes are proposed. The full spectroscopic characterization of all the cyanines synthesized is described.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Benoit, Adam R. published the artcileSynthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity, SDS of cas: 165534-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(14), 3014-3017, database is CAplus and MEDLINE.

A series of 9-(alkylamino)acridine derivatives was prepared and evaluated for activity against two strains of methicillin-resistant and one strain of methicillin-sensitive Staphylococcus aureus. Results are presented that show a clear structure activity relationship between the N-alkyl chain length and antibacterial activity with peak MIC₉₉ values of 2-3 μM for alkyl chains ranging from 10 to 14 carbons in length. Although prior work has linked the function of acridine-based compounds to intercalation and topoisomerase inhibition, the present results show that 9-(alkylamino)acridine derivatives likely function as amphiphilic membrane-active disruptors potentially in a similar manner as quaternary ammonium antimicrobial agents. The synthesis of the target compounds was achieved by a reaction (substitution) of 9-(phenoxy)acridine or (4-methyl-1-piperazinyl)(9-phenoxy-3-acridinyl)methanone or 9,10-dihydro-9-oxo-3-acridinecarboxylic acid (amidation) with 1-alkanamine derivatives The title compounds thus formed included N-(alkyl)-9-acridinamine derivatives and (4-methyl-1-piperazinyl)[9-[(alkyl)amino]-3-acridinyl)methanone derivatives and 9,10-dihydro-9-oxo-N-alkyl-3-acridinecarboxamide derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, SDS of cas: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Brian P. published the artcileThe synthesis of an aminohexyl-containing analog of the chromanol leukotriene B₄ receptor antagonist CP-195543: a scaffold for the preparation of derivatized analogs, Safety of Dimethyl 2-iodoterephthalate, the publication is Heterocycles (2000), 53(8), 1713-1724, database is CAplus.

In order to allow the preparation of labeled derivatives of the leukotriene B₄ (LTB₄) antagonist CP-195543 for the study and/or “visualization” of LTB₄ receptors in in vitro and in vivo settings, we have synthesized an aminohexyl-containing analog as a scaffold from which the requisite compounds can be prepared The key reactions in the preparation of the analog include the DAST-mediated introduction of a difluoromethylene group in the presence of an azide and a Suzuki coupling between this highly functionalized benzoate and a chromanol-derived boronic acid. 2-(3S,4R)-(3-Benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoro-7-methanesulfonamidoheptyl)benzoic acid, prepared from the analog by methanesulfonylation and saponification, is a potent LTB₄ receptor antagonist but displays a high degree of non-specific binding.

Heterocycles published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com