Category: iodides-buliding-blocks

Yagi, Yoshiharu published the artcileChemistry of halogens and of polyhalides. XXVI. Infrared absorption spectra of iodine bromide and its complexes, Recommanded Product: Pyridine Iodochloride complex, the publication is Journal of Physical Chemistry (1967), 71(8), 2439-44, database is CAplus.

The influence of complexation on the frequency of the I-Br fundamental stretching vibration in iodine bromide complexes has been investigated. The frequency and the intensity of this band are strongly influenced by the strength of the iodine bromide-electron donor interaction. The position of the IBr band varies from 261 cm.-1 in CCl4 solutions to 205 cm.-1 for the pyridine-IBr complex dissolved in benzene. In solid complexes the IBr band is split into a doublet. The changes in frequency are analyzed to obtain changes in force constants Some attempt is made to interpret these results. 31 references.

Journal of Physical Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C39H35N5O8, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zhe published the artcileFluorinated triphenylenes and a path to short tailed discotic liquid crystals: synthesis, structure and transport properties, COA of Formula: C6H13I, the publication is Materials Advances (2022), 3(1), 534-546, database is CAplus.

A new synthetic approach for fluorinated alkoxytriphenylene discotic liquid crystals is presented. This methodol. exploits the previously described photocyclodehydrofluorination (PCDHF) reaction for the preparation of fluorinated triphenylene derivatives coupled with a variety of nucleophilic aromatic substitution (S_NAr) reactions. This particular combination of reactions provides a versatile route to discotic materials with carefully controlled core fluorine and alkoxy tail content. In the course of these studies, new discotic materials with minimal tail content have been revealed. The mesogenic properties of these materials are reported, and their charge transport properties are measured using the time of flight technique.

Materials Advances published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

McDermott, Todd S. published the artcileProcess research and initial scale-up of ABT-839: A farnesyl-transferase inhibitor, Name: Dimethyl 2-iodoterephthalate, the publication is ACS Symposium Series (2004), 59-69, database is CAplus.

The antitumor compound ABT-839 was synthesized in eight steps from com. available starting materials. The synthesis was carried out with a single purification prior to final salt isolation. The key sequence is an efficient bromination and a novel bis-coupling strategy that transforms the bi-aryl core to the penultimate ester in a single operation with no isolation in 94% yield. After bisulfate salt formation, the product was isolated as a crystalline solid. The synthesis was carried out on kilogram scale and gave an overall yield of 43%.

ACS Symposium Series published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Name: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schmidt, Stefanie published the artcileDual IGF-1R/SRC inhibitors based on a N’-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure, SDS of cas: 39115-95-2, the publication is European Journal of Medicinal Chemistry (2011), 46(7), 2759-2769, database is CAplus and MEDLINE.

The N’-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series, I, produced a selective growth inhibition in a panel of cultivated cancer cell lines.

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suga, Takeo published the artcileCathode- and Anode-Active Poly(nitroxylstyrene)s for Rechargeable Batteries: p- and n-Type Redox Switching via Substituent Effects, Formula: C7H3BrF3I, the publication is Macromolecules (Washington, DC, United States) (2007), 40(9), 3167-3173, database is CAplus.

Three polystyrenes bearing redox-active nitroxide radical(s) in each repeating unit, poly[4-(N-tert-butyl-N-oxylamino)styrene] (1), poly[3,5-di(N-tert-butyl-N-oxylamino)styrene] (2), and poly[4-(N-tert-butyl-N-oxylamino)-3-trifluoromethylstyrene] (3), were synthesized via free radical polymerization of protected precursor styrenic derivatives and subsequent chem. oxidation The radicals in these polymers were robust at ambient conditions, and the polymers possessed radical densities of 2.97 × 10²¹, 4.27 × 10²¹, and 1.82 × 10²¹ unpaired electrons/g for 1-3, resp., resulting in an electrode-active material with a high charge/discharge capacity. Particularly, the dinitroxide functional polymer 2 possessed the highest radical d. Cyclic voltammetry of the poly(nitroxylstyrene) 1 revealed a reversible redox at 0.74 V vs. Ag/AgCl, which was assigned to the oxidation of the nitroxide radical to form the oxoammonium cation (p-type doped state). However, the poly(nitroxylstyrene) ortho-substituted with the electron-withdrawing trifluoromethyl Group 3 showed a reversible redox at -0.76 V, ascribed to the n-type redox pair between the nitroxide radical and the aminoxy anion. Thus, the nitroxide radical polymer could be switched from p-type material suitable for a cathode to n-type material (anode-active) via altering the electron-withdrawing character of the substituents on the poly(nitroxylstyrene). This is the 1st report of an n-type radical polymer and the 1st report of using substituent effects to switch the redox behavior of the polymer. This versatile switching ability enables these polymers to function as components of metal-free electrodes in rechargeable batteries.

Macromolecules (Washington, DC, United States) published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C9H7NO2, Formula: C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yaddanapudi, Kavitha published the artcileControl of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor, SDS of cas: 41270-96-6, the publication is Journal of Immunology (2013), 190(6), 2984-2993, database is CAplus and MEDLINE.

Tumor stromal alternatively activated macrophages are important determinants of antitumor T lymphocyte responses, intratumoral neovascularization, and metastatic dissemination. Our recent efforts to investigate the mechanism of macrophage migration inhibitory factor (MIF) in antagonizing antimelanoma immune responses reveal that macrophage-derived MIF participates in macrophage alternative activation in melanoma-bearing mice. Both peripheral and tumor-associated macrophages (TAMs) isolated from melanoma bearing MIF-deficient mice display elevated proinflammatory cytokine expression and reduced anti-inflammatory, immunosuppressive, and proangiogenic gene products compared with macrophages from tumor-bearing MIF wild-type mice. Moreover, TAMs and myeloid-derived suppressor cells from MIF-deficient mice exhibit reduced T lymphocyte immunosuppressive activities compared with those from their wild-type littermates. Corresponding with reduced tumor immunosuppression and neo-angiogenic potential by TAMs, MIF deficiency confers protection against transplantable s.c. melanoma outgrowth and melanoma lung metastatic colonization. Finally, we report for the first time, to our knowledge, that our previously discovered MIF small mol. antagonist, 4-iodo-6-phenylpyrimidine, recapitulates MIF deficiency in vitro and in vivo, and attenuates tumor-polarized macrophage alternative activation, immunosuppression, neoangiogenesis, and melanoma tumor outgrowth. These studies describe an important functional contribution by MIF to TAM alternative activation and provide justification for immunotherapeutic targeting of MIF in melanoma patients.

Journal of Immunology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C18H20N2O12, SDS of cas: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ragan, J. A. published the artcileCross-Coupling Methods for the Large-Scale Preparation of an Imidazole-Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine, Related Products of iodides-buliding-blocks, the publication is Organic Process Research & Development (2003), 7(5), 676-683, database is CAplus.

The multihundred-gram synthesis of imidazolyl-substituted thienopyridine I was developed utilizing a Stille cross-coupling of iodothienopyridine II with 5-(tributylstannyl)-1-methylimidazole. Several cross-coupling methods were evaluated for the conversion of II to (imidazolyl)thienopyridine III, but only two were effective: the Stille coupling and a Negishi cross-coupling of II with the organozinc reagent derived from 2-(tert-butyldimethylsilyl)-1-methylimidazole. The latter procedure worked well on laboratory scale (<50 g), but was capricious upon scale-up. The issues with scale-up of an organostannane reagent are discussed, including control and anal. of organotin levels.

Organic Process Research & Development published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H3ClINS, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dhote, Pawan S. published the artcileInterrupting the [Au]-Catalyzed Nitroalkyne Cycloisomerization: Trapping the Putative α-Oxo Gold Carbene with Benzo[c]isoxazole, Application In Synthesis of 101420-79-5, the publication is Organic Letters, database is CAplus and MEDLINE.

The [Au]-catalyzed nitroalkyne cycloisomerization of 2-alkynylnitrobenzenes such as 2-O₂NC₆H₄CCEt leading to anthranils has been interrupted by possible trapping of the postulated intermediate α-oxo gold carbene with an external nucleophile such as a benzo[c]isoxazole (anthranil). At the outset, this provides a simple synthesis of highly functionalized 3-acyl-(2-formylphenyl)-2H-indazoles such as I with the sequential C-O, C-N, and N-N bond formations. This provides indirect support for the existence of α-oxo gold carbenes in the [Au]-catalyzed internal redox processes of nitroalkynes.

Organic Letters published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Application In Synthesis of 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Heidbrink, Jenny L. published the artcilePolar Effects Control Hydrogen-Abstraction Reactions of Charged, Substituted Phenyl Radicals, Product Details of C7H3BrF3I, the publication is Journal of Physical Chemistry A (2001), 105(33), 7875-7884, database is CAplus.

The rate of hydrogen atom abstraction from tributyltin hydride, benzeneselenol, thiophenol, and THF was measured in the gas phase for charged Ph radicals with different neutral substituents at the meta- or ortho-position. A charged pyridinium substituent (meta or para) allowed the manipulation of the radicals in the Fourier transform ion cyclotron resonance mass spectrometer that was used to carry out the experiments All the reaction rates were found to be similarly affected by substituents on the radical: meta, H < Br ∼ Cl < CN (most reactive); ortho, H < CF₃ ∼ Cl ∼ F. The exptl. observations parallel the transition-state energies calculated for hydrogen abstraction from methanol. However, the calculated reaction exothermicities do not correlate with the reactivity trends. Instead, a correlation exists between the reactivity and electron affinity of the radicals. We conclude that the electron-withdrawing substituents studied here lower the reaction barrier by increasing the polarity of the transition state, without an associated increase in reaction exothermicity. The increase in the electron affinity (ΔEA) of the radical caused by a given substituent provides a sensitive probe for the substituent’s barrier-lowering effect (in the few cases studied in detail, the barrier is lowered by about 10% of ΔEA_v). Another way to lower the barrier involves lowering the ionization energy of the substrate. Indeed, all the radicals follow the reactivity trend of thiophenol > 4-fluorothiophenol > pentafluorothiophenol. This trend reflects the decreasing ionization energies of the three substrates rather than the decreasing reaction exothermicities or increasing homolytic bond-dissociation energies (4-fluorothiophenol > thiophenol > pentafluorothiophenol). Apparently, the polar control overrides the enthalpic control in this case. The results reported for radicals with different distances between the radical site and the charged group suggest that similar substituent effects are expected for neutral Ph radicals, and that the hydrogen abstraction ability of heteroaromatic radicals is likely to be tunable by pH.

Journal of Physical Chemistry A published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Product Details of C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pardal, A. C. published the artcileSynthesis and spectroscopic characterization of N-alkyl quaternary ammonium salts, typical precursors of cyanines, Product Details of C12H14IN, the publication is Molecules [online computer file] (2002), 7(3), 320-330, database is CAplus.

Title salts I (R = Et, pentyl, hexyl, decyl; X = S, Se, O, CMe₂, CH:CH) were prepared by quaternization of the heterocycles with RI. I, bearing an activated Me group in the 2-position, are typical precursors of cyanine dyes.

Molecules [online computer file] published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com