Category: iodides-buliding-blocks

Electric Literature of 61203-48-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61203-48-3, name is 2-Iodo-4,5-dimethoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of benzonitrile(2.0 mmol) and o-iodobenzoic acid (2.0 mmol) and [bmIm]OH (35mol) was stirred at room temperature for (3-5) h. After completion of reaction as indicated byTLC, 20mL of water was added to the reaction mixture and stirred well. The product was extracted with ether (3¡Á20 mL). The combined organic layers were dried over anhydrous Na2SO4 to afford the crude product, this crude product was taken to column in order to obtain analytically pure compound 4(a-m)(77-91%). After isolation of the product, the remaining aqueous layer containing the ionic liquid was washed with ether (2x10mL) to remove organic impurity and filtered. The filtrate was extracted with dichloromethane(2¡Á10mL), dried over MgSO4 and evaporated under reduced pressure to afford [bmIm]OH, which was reused five times in subsequent runs without further purification.

The synthetic route of 2-Iodo-4,5-dimethoxybenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Waseem, Malik Abdul; Shireen; Srivastava, Anjali; Srivastava, Arjita; Rahila; Siddiqui; Tetrahedron Letters; vol. 55; 44; (2014); p. 6072 – 6076;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-Bromo-1-iodo-2-nitrobenzene

Dissolving 50 g of 2-naphthalene boronic acid, 94 g of 2-nitro-4-bromo-1-iodobenzene, and 10 g of Pd(PPh3)4 In a mixed solvent of 300 mL of THF and 50 mL of H2O, the mixture was reacted at 80 C for 24 hours under a nitrogen atmosphere. The solvent was dried and extracted with dichloromethane.Washing liquid, column chromatography to obtain intermediate M2.

The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Huarui Optoelectric Materials Co., Ltd.; Pan Junyou; Zhang Chen; Jiang Guangtao; You Xueqiang; Huang Hong; (40 pag.)CN109705100; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 618-91-7, name is Methyl 3-iodobenzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-iodobenzoate

General procedure: A mixture ofmethyl 3-iodobenzoate (1 mmol), corresponding amine (3 mmol), K2CO3(4 mmol), CuI (0.2 mmol) and L-proline (0.4 mmol) in 15 mL of DMSO was heatedat 60 C for 8 h. The cooled mixture was pour into 150 ml water, and extractedwith ethyl acetate (3 ¡Á 15 mL), the organic fractions were combined, washedwith saturated brine (2 ¡Á 15 ml) prior to drying over anhydrous sodium sulfate.After filtration and concentrate using a rotary evaporator, the residue was purified by silica gel column chromatographyusing a mixture of petroleum ether/ethyl acetate (20 : 1, v/v) as eluent toafford the desired product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Zheng; Pan, Miaobo; Su, Xin; Dai, Yuxuan; Fu, Mian; Cai, Xingguang; Shi, Wei; Huang, Wenlong; Qian, Hai; Bioorganic and Medicinal Chemistry; vol. 24; 9; (2016); p. 1981 – 1987;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7681-82-5, Recommanded Product: Sodium iodide

Complex [Pd(P,P)Cl2] (0.070?g, 0.113?mmol) was dissolved at room temperature in aceton (10?mL), followed by the addition of NaI in stoichiometric excess (0.070?g, 0.452?mmol), affording a dark yellow solution, which was stirred at room temperature for 24?h. The reaction mixture was then concentrated to dryness and the solid residue was re-dissolved in dichloromethane (10?mL). This solution was filtrated through celite in order to remove the remaining NaI or NaCl formed during the reaction. The filtrate was concentrated to 4?mL, n-hexane (10?mL) were then added to allow precipitation of the expected product, that was collected by filtration, and dried under vacuum to afford 0.060?g (67% yield) of a dark yellow powder, m.p. (dec.)?>?200?C. IR (KBr, cm-1): 506 (s), 528 (m), 562 (s), 591 (m), 692 (s), 748 (s), 867 (s) nu(P-N-P), 995 (m), 1101 (s), 1097 (s), 1176 (s), 1224 (s), 1245 (s), 1307 (w), 1375 (m), 1434 (s) nu(P-Ph), 1457 (s), 1480 (s). 1H NMR (600?MHz, CDCl3): delta 8.23 (m, 8H, Ar), 7.68-7.65 (m, 4H, Ar), 7.61-7.59 (m, 8H, Ar), 0.96 (s, 9H, tBu). 31P{1H} NMR (121.5?MHz, CDCl3): delta 25.09. HRMS (positive ESI-MS): calcd for C28H29INP2Pd [M?-?I]+ 673.9849, found 673.9877; calcd for C28H29I2NNaP2Pd [M+Na]+ 823.8792, found 823.8830.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Reference:
Article; Ioannou, Polydoros-Chrysovalantis; Arbez-Gindre, Cecile; Zoumpanioti, Maria; Raptopoulou, Catherine P.; Psycharis, Vassilis; Kostas, Ioannis D.; Kyritsis, Panayotis; Journal of Organometallic Chemistry; vol. 879; (2019); p. 40 – 46;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 699016-40-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 699016-40-5, name is 2-Fluoro-4-iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Step 1-B: To a solution of 2-fluoro-4-iodo-benzaldehyde (17.40 g, 69.60 mmol) in anhydrous tetrahydrofuran (300 mL) at -10 C. under an atmosphere of nitrogen was added 3.0 M methylmagnesium chloride in tetrahydrofuran (27.84 mL, 83.52 mmol) via syringe at such a rate as to maintain the temperature of the reaction mixture below 0 C. The reaction was stirred for 30 minutes while warming to room temperature. Saturated aqueous ammonium chloride solution was added and the mixture was diluted with ethyl acetate (200 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (2*50 mL). The organic extracts were combined, washed with water (1*50 mL), brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by chromatography over silica gel gradient eluted with 15 to 40% v/v ethyl acetate/hexanes to give 1-(2-fluoro-4-iodo-phenyl)-ethanol (15.50 g, 84%).

The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-4-iodobenzaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chen, Shaoqing; Huby, Nicholas J.S.; Kong, Norman; Moliterni, Jonh Anthony; Morales, Omar Jose; US2009/170920; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18698-96-9, category: iodides-buliding-blocks

2-(2-Iodophenyl)acetamide (107-2). HATU (50.8 g, 134 mmol) was added to a stirred solution of 107-1 (28 g, 107 mmol), NH3 (321 ml, 160 mmol, 0.5 M/dioxane), iV-methylmorpholine (23.5 ml, 214 mmol) in . DMF (300 ml). The mixture was stirred for 16 hours and then was diluted with EtOAc and washed with H2O, sat NaHCO3, brine, dried over anhydrous MgSO4, filtered and 2/3 solvent was removed in vacuo. The solid was collected, washed with diethyl ether and dried in vacuo to afford 29-2 11.2g, 40.2percent) as a white solid.1H NMR (500 MHz, CDCl3) delta7.i (d, 1 H, J = 8 Hz), 7.36 (m, 2 H), 7.00 (m, 1 H), 5.38 (s, 2 H), 3.75 (s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK & CO., INC.; WO2008/51532; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2265-93-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2265-93-2, name is 2,4-Difluoroiodobenzene, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of (3S)-piperidin-3-ol hydrochloride (0.50 g, 0.0036 mol), l,3-difl’uoro-4- iodobenzene (0.522 mL, 0.00436 mol), copper(I) iodide (140 mg, 0.00073 mol), potassium phosphate (3.08 g, 0.0145 mol), and 1 ,2-ethanediol (0.810 mL, 0.0145 mol) in 1-butanol (7.28 mL, 0.0796 mol) was heated at 100 0C under nitrogen for 2 nights. The reaction mixture was treated with water, and then extracted with EtOAc. The organic layers were combined, washed with brine, dried and evaporated to dryness. The residue was used directly in next step without further purifications (529 mg, 69%). LCMS (M+H): 214.2.

The chemical industry reduces the impact on the environment during synthesis 2,4-Difluoroiodobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; INCYTE CORPORATION; WO2007/89683; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, molecular formula is C5H10I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1,5-Diiodopentane

[00118] Dimethoxycurcumin (8) will be prepared via condensation of 3,4- dimethoxybenzaldehyde and 2,4-pentanedione according to the procedure of Venkateswarlu. Treatment of 8 with potassium carbonate in the presence of a suitable alkylating agent is expected to affect the desired disubstitution reactions. Alkylation with the diiodoalkanes should result in formation of the spirocyclic products.[00119] As noted in Example I, the inventors now prepared derivatives FLLL31 (Ib, R = methyl) and FLLL32 (6b, cyclohexyl) in this way. Interestingly, O-alkylation of the enolate generated from 8 is also observed in both cases, although the yield of this product is relatively low (<;10%) and can be readily separated via column chromatography. These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 628-77-3, its application will become more common. Reference:
Patent; THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION; LI, Pui-Kai; LI, Chenglong; LIN, Jiayuh; FUCHS, James, R.; WO2010/121007; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 328-73-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 328-73-4 as follows.

To 60 mL of dry THF containing 3,5-dibromo-2-cyclohexyloxythiophene [S1] (1.2 g; 3.4 mmol) was added 1.6 M n-BuLi hexane solution (2.4 mL; 3.8 mmol) at -78 C under argon atmosphere, and the solution was stirred for 1 h at the low temperature. Tri-n-butyl borate (1.1 mL; 4.1 mmol) was slowly added to the reaction mixture at -78 C, and the mixture was stirred for 1 h at that temperature. After warming the solution up to room temperature, 20 wt% Na2CO3(aq) (6.0 mL), 3,5-bis(trifluoromethyl)-1-iodobenzene (1.2 g; 3.4 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.080 g) were added to the reaction mixture. The mixture was refluxed overnight at 80 C. The product was extracted with ether. The organic layer was dried over MgSO4, filtered, and concentrated.The residue was purified by silica gel column chromatography using n-hexane as the eluent and by HPLC to give 1.1 g of 3-bromo-2-cyclohexyloxy-5-(3,5-bis(trifluoromethyl)phenyl)thiophene in 66% yield.

According to the analysis of related databases, 328-73-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sato, Yuta; Kitagawa, Daichi; Kobatake; Tetrahedron; vol. 75; 35; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Iodo-4-(trifluoromethoxy)benzene

Example 59. Preparation of 3-bromo-l-(4-(trifluoromethoxy)phenyl)-lH-l,2,4-triazole (B61) To a 250 mL reaction flask was added 3-bromo-lH-l,2,4-triazole (5 g, 33.8 mmol), copper(I) iodide (0.644 g, 3.38 mmol) and cesium carbonate (11.01 g, 33.8 mmol). The flask was evacuated/backfilled with N2, then DMSO (33.8 ml) and l-iodo-4-(trifluoromethoxy)benzene (4.87 g, 16.90 mmol) were added. The reaction mixture was heated to 100 ¡ãC for 20 h. The reaction was cooled to room temperature, diluted with EtOAc and filtered through a plug of Celite. The Celite was further washed with EtOAc. Water was added to the combined organics, and the layers were separated. The aqueous phase was neutralized to pH 7, and further extracted with EtOAc. The combined organics were concentrated in vacuo. Purification via flash chromatography (silica/EtO Ac/Hex) yielded 3-bromo-l-(4- (trifluoromethoxy)phenyl)-lH-l,2,4-triazole as an off white solid (3.78 g, 12.27 mmol, 72.6percent): mp 69-70 ¡ãC; ]H NMR (400 MHz, CDC13) delta 8.44 (s, 1H), 7.70 (d, / = 8.9 Hz, 2H), 7.38 (d, J = 8.5 Hz, 2H); 19F NMR (376 MHz, CDC13) delta -58.04; EIMS m/z 307.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 103962-05-6.

Reference:
Patent; DOW AGROSCIENCES LLC; CROUSE, Gary D.; DEMETER, David A.; SPARKS, Thomas C.; WANG, Nick X.; DENT, William Hunter; DEAMICIS, Carl; NIYAZ, Noormohamed M.; BAUM, Erich W.; FISCHER, Lindsey G.; GIAMPIETRO, Natalie C.; FRITZ, Amanda E.; WO2014/11429; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com